Published online before print February 6, 2006, doi: 10.1161/CIRCULATIONAHA.105.591602
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2006;113:851-855.)
© 2006 American Heart Association, Inc.
Valvular Heart Disease |
Percutaneous Transvenous Mitral Annuloplasty
Initial Human Experience With Device Implantation in the Coronary Sinus
From St Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada (J.G.W., B.I.M., M.C., C.R.T., J.M.), and University Hospital of Lund, Lund, Sweden (J.H., P.O.K., J.O.S.).
Correspondence to John G. Webb, MD, Director of Interventional Cardiology, St. Paul’s Hospital, Room 5202A, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6. E-mail webb{at}providencehealth.bc.ca
Received September 26, 2005; revision received November 9, 2005; accepted December 2, 2005.
 |
Abstract |
|---|
 Top Abstract IntroductionMethodsResultsDiscussionConclusionsReferences |
|---|
Background— Mitral annuloplasty is the most common surgical procedure performed for ischemic mitral regurgitation (MR). Surgical mitral annuloplasty is limited by morbidity, mortality, and MR recurrence. We evaluated the safety and feasibility of a transvenous catheter-delivered implantable device to provide a percutaneous alternative to surgical mitral annuloplasty.
Methods and Results— Five patients with chronic ischemic MR underwent percutaneous transvenous implantation of an annuloplasty device in the coronary sinus. Implantation was successful in 4 patients. Baseline MR in the entire group was grade 3.0±0.7 and was reduced to grade 1.6±1.1 at the last postimplantation visit when the device was intact or the last postprocedural visit in the patient in whom the device was not successfully implanted. Separation of the bridge section of the device occurred in 3 of 4 implanted devices and was detected at 28 to 81 days after implantation. There were no postprocedural device-related complications.
Conclusions— Percutaneous implantation of a device intended to remodel the mitral annulus is feasible. Initial experience suggests a possible favorable effect on MR. Percutaneous transvenous mitral annuloplasty warrants further evaluation as a less invasive alternative to surgical annuloplasty.
Key Words: annuloplasty • coronary sinus • heart failure • mitral valve • regurgitation
|
Introduction |
|---|
|
TopAbstractIntroductionMethodsResultsDiscussionConclusionsReferences |
|---|
Mitral regurgitation (MR) is common after myocardial infarction1,2 and may lead to progressive ventricular and annular dilation, worsening regurgitation, and heart failure.2,3 MR severity is an independent predictor of prognosis in patients with ischemic heart disease,4–6 even when MR is moderate or mild,2 particularly in the presence of congestive failure.2,7 When MR is severe, prognosis is poor,8 even when asymptomatic.4,9 MR as a consequence of ischemic disease most often occurs despite the presence of structurally normal mitral valve leaflets. Left ventricular dysfunction or remodeling can result in annular dilation or papillary muscle displacement with incomplete mitral leaflet apposition or restricted mitral leaflet motion.10
Editorials pp 771 and 774 Clinical Perspective p 855
Surgical approaches to MR include mitral valve replacement and repair. Recent literature favors early repair in structural MR when feasible or in patients with ischemic MR and symptomatic heart failure.4,11 However, morbidity, mortality, and late recurrent MR limit widespread application of surgical repair.12–16 Although surgical mitral repair may be sophisticated and complex, most repairs currently consist of simple annuloplasty.17
Should percutaneous repair prove efficacious and safe, then it might have a potential role early in the natural history of MR. The proximity of the coronary sinus to the mitral annulus has been the basis for a number of approaches to percutaneous transvenous mitral valve annuloplasty (PTMA). Animal studies have demonstrated the potential to remodel the mitral annulus, reduce mitral anteroposterior diameter, improve leaflet coaptation, and reduce regurgitation.18–21 Temporary intraprocedural placement of a coronary sinus annuloplasty device in humans has been shown to have the potential to decrease mitral annular diameter and insufficiency.19,22 We report here the first experience with PTMA device implantation in humans.
|
Methods |
|---|
|
TopAbstractIntroductionMethodsResultsDiscussionConclusionsReferences |
|---|
Study Design
The primary objective of this study was to evaluate the acute safety of PTMA in patients with chronic ischemic MR. Patients were enrolled at 2 sites, St Paul’s Hospital (Vancouver, British Columbia, Canada) and Lund University Hospital (Lund, Sweden). The protocol was approved by the appropriate institutional ethics committees. Informed consent was obtained. Candidates had functional MR
2+ on a scale of 4+ in the setting of prior myocardial infarction. Exclusion criteria included left ventricular ejection fraction <30%, structural mitral valve disease, mitral annular calcification, prior endocarditis or mitral surgery, creatinine >2.0 mg/dL, coronary sinus pacing leads, anticipated revascularization, inability to take aspirin or clopidogrel, or a life expectancy <1 year.
Device Description
The Percutaneous Mitral Annuloplasty System (Viking, Edwards Lifesciences Inc) consists of a 12F-outer-diameter guide catheter and dilator, a 9F delivery catheter, and a nickel-titanium alloy (nitinol) implant (Figure 1). The implant itself is made up of 3 sections: a distal self-expanding anchor, a springlike "bridge," and a proximal self-expanding anchor. The distal anchor is deployed in the great cardiac vein; the proximal anchor is deployed in the proximal coronary sinus. The bridge has shape-memory properties that result in shortening forces at body temperature. The anchors draw the proximal coronary sinus and distal great cardiac vein together while the bridge section tenses and straightens, indirectly displacing the posterior annulus anteriorly and reducing mitral annulus diameter and septal-lateral distance.
|
Procedure
The procedure was performed in the catheterization laboratory in patients under local anesthesia. Patients were premedicated with clopidogrel 300 mg and aspirin 325 mg and subsequently continued on clopidogrel 75 mg daily for 3 months and aspirin indefinitely. Heparin (50 U/kg IV) was administered after jugular puncture.
The coronary sinus was cannulated with a standard 6F coronary catheter. An exchange wire (0.035 in [260 cm], Magic Torquewire, Boston Scientific Inc) was advanced into the distal vessel. A measurement catheter (Royal Flush, Cook Inc) with radiopaque 1-cm markers was advanced over the wire to the level of the great cardiac vein. The coronary venous system was opacified by injections through the measurement catheter, the guiding catheter, or a catheter placed in the left coronary artery. The length of the vessel available for device implantation was determined by counting the radiopaque markers, thus avoiding underestimation of vessel length as a result of foreshortening of the coronary veins on the fluoroscopic image. Vessel diameter was determined by calibration against the known diameter of the angiographic catheter using standard catheterization laboratory quantitative angiographic software (Figure 2).
|
A suitable device was selected on the basis of the measured length and diameter of the target segment. A range of devices were available. The 12F guiding catheter was advanced over a guidewire well into the coronary sinus. The device delivery catheter was then passed over the wire, through the guiding catheter, and into the coronary venous system. The distal anchor was placed in the desired location using radiopaque markers on the delivery catheter, previously identified landmarks, retrograde injections through the guiding catheter, and left coronary arterial injections. Once correctly positioned, the distal anchor was released by retracting the outer restraining sheath with the thumb slider mechanism on the delivery catheter handle. After release of the distal anchor, slack was removed from the bridge element by withdrawing and tensioning the delivery catheter. With the proximal anchor correctly positioned just within the coronary sinus ostium, the restraining outer sheath was completely retracted. The delivery catheter and coaxial wire were removed (Figure 3).
|
Postprocedural Evaluation
Patients were evaluated at baseline, 24 hours, and 30, 90, and 180 days with a clinical examination, chest x-ray, and transthoracic echocardiogram. Creatine kinase and creatine kinase-MB were measured every 8 hours for 24 hours after the procedure. Coronary angiography was performed before the procedure and 3 months after implantation. Transesophageal echocardiograms were obtained before the procedure and at 3 months. Echocardiograms were reviewed by an independent core laboratory (Cardiovascular Research Institute, Washington, DC). The authors had full access to the data and take responsibility for its integrity. All authors have read and agree to the manuscript as written.
|
Results |
|---|
|
TopAbstractIntroductionMethodsResultsDiscussionConclusionsReferences |
|---|
Two clinical sites enrolled 5 patients with chronic, ischemic MR and normal valve leaflets. Age was 67±10 years; 3 were male, and 2 were female.
Device implantation was successful in 4 of 5 patients. In 1 patient (patient 2), the device could not be advanced fully into the coronary sinus because of difficulty in obtaining coaxial guide position. Attempts to implant the device led to wire perforation of the anterior interventricular vein and pericardial effusion. A repeated attempt 1 month later was uneventful but also unsuccessful. A second patient developed transient atrial fibrillation during cannulation of the coronary sinus.
Positioning of the distal anchor was adequately assessed with the aid of fluoroscopic landmarks and left coronary artery injections. Visible shortening of the coronary sinus system was evident during device tensioning before proximal anchor release. In all patients who received implants, the anchors were correctly placed at the desired locations. Fluoroscopy time was 36±22 minutes, and contrast use was 312±95 mL.
At the 3-month follow-up, all patients remained alive. There was 1 late death (day 148) caused by progressive heart failure. This patient was considered a nonsurgical candidate because of morbid obesity and other comorbidities. Postmortem examination showed a well-positioned device, a patent coronary sinus with complete neointimal coverage, and a patent circumflex artery.
Coronary angiograms were obtained at 3 months in the other 3 patients who received implants. There was no evidence of compromise of the circumflex coronary artery as a result of the device implanted in the adjacent great cardiac vein. Coronary sinus patency was documented in all patients.
Separation of the nitinol bridge segment was documented in 3 of 4 patients who had received implants on routine follow-up chest radiographs at 22, 28, and 81 days. Migration of the anchors was not observed. Although there were no adverse clinical events associated with device separation, feasibility study enrollment was discontinued.
Mitral annulus diameter at baseline was 36±3 mm and at the 3-month follow-up was 35±1 mm. No significant transmitral gradients were documented at any point during follow-up. Left ventricular ejection fraction at baseline was 42±11% and at the 3-month follow-up was 50±6%. NYHA failure class at baseline was 2.4±0.5 and at the 3-month follow-up was 2±0.7.
Three of 4 patients in whom the device was implanted had a reduced MR grade at hospital discharge. Baseline MR in the entire group was grade 3.0±0.7 and was reduced to grade 1.6±1.1 at the last postimplantation visit when the device was intact or at the last postprocedural visit in the patient in whom the device was not successfully implanted. MR grade at follow-up as reported by the core echocardiographic laboratory is shown in Figure 4.
|
The relationship between device shortening, bridge separation, and MR grade is notable, as illustrated in Figure 4. In patient 1, MR was reduced from grade 4 to 0 at 1 month. Device separation with a relatively short 9-mm gap between the proximal anchor and the shortened bridge was documented at 22 days. In patient 3, MR grade was essentially unchanged in the presence of a greater amount (30 mm) of separation documented at 28 days. In patient 5, MR was reduced from grade 3 to 1 at 1 and 2 months, at which time the device remained intact. However, documentation of late bridge separation with a large 41-mm gap at day 81 was associated with the return of grade 3 MR.
|
Discussion |
|---|
|
TopAbstractIntroductionMethodsResultsDiscussionConclusionsReferences |
|---|
Procedural Issues
Coronary venous anatomy is highly variable. A relatively constant feature is the coronary sinus, which opens into the posteromedial right atrium.23 The major tributary of the coronary sinus is the great cardiac vein, which travels in the left AV groove alongside the circumflex coronary artery. A major tributary is the relatively constant anterior interventricular vein running parallel to the left anterior descending artery in the anterior interventricular sulcus. Together, the coronary sinus, great cardiac vein, and proximal anterior interventricular vein follow the course of the posterior mitral annulus nearly from commissure to commissure.24
Three-dimensional angiographic modeling, multidetector-row cardiac-gated CT, and MRI appear promising for the assessment of coronary venous anatomy and dimensions23–25 (Figure 5). Visualization of the coronary veins can be accomplished immediately after coronary arterial contrast injections, a technique sometimes helpful during coronary sinus cannulation. Retrograde coronary venography is limited by vigorous backwash resulting from normal venous flow.23 Consequently, venous opacification is best accomplished with retrograde cannulation of the coronary veins and distal contrast injections. Temporary balloon occlusion of the coronary sinus during venous injections may further improve opacification. Delayed imaging during a coronary CT angiogram also can provide images of a contrast-opacified coronary sinus.
|
As with coronary arterial imaging, multiple fluoroscopic angulations may be helpful. The left anterior oblique view is helpful in cannulation of the coronary sinus. Cranial angulation may assist cannulation of the anterior interventricular vein, and right anterior oblique angulation may help in appreciation of the course of this vein as it passes along the anterior interventricular sulcus.
Percutaneous Annuloplasty
In the near future, it is unlikely that percutaneous approaches to mitral annuloplasty will reproduce the excellent results of complex surgical repair.26 However, most surgical repair procedures are not complex, consisting of simple annuloplasty alone.17 Percutaneous coronary sinus approaches to mitral annuloplasty have been reported to reduce MR in animal models of global left ventricular dysfunction,19 acute ischemia,21 and chronic infarction.18 Several devices (Mitralife Inc, Cardiac Dimensions Inc,19,20 and Viacor Inc18) have been reported to remodel the mitral annulus and reduce annular anteroposterior diameter in animal models. Pathological examination showed no significant coronary sinus injury,18,19 although circumflex artery compression was reported in 1 study.20 Temporary intraprocedural placement of the C-Cure device in humans confirmed a change in mitral annular shape and mitral insufficiency.19,22 To date, there are no published reports of implantation of percutaneous mitral annulus remodeling devices in humans.
Evidence for Effect
It appeared that PTMA was associated with a slight reduction in MR grade immediately after implantation, possibly because of the acute cinching effect of the device. A further reduction in MR grade was observed while the device remained intact, as shown in Figure 4. There was evidence consistent with loss of effect when bridge separation occurred, particularly if a large gap between the bridge segments was observed. Of particular interest was the initial marked reduction in MR documented in patient 5 with recurrence of severe MR after bridge separation. This very limited experience is consistent with, but does not prove, a favorable device effect on functional MR.
Study Limitations
This pilot study was small. Pharmacological management varied throughout the course of the study period. Device failure resulting from separation of the bridge element limits assessment of efficacy. Long-term efficacy and safety remain unknown. Implications for subsequent coronary sinus pacing, retrograde cardioplegia, and mitral valve surgery are unknown.
|
Conclusions |
|---|
|
TopAbstractIntroductionMethodsResultsDiscussionConclusionsReferences |
|---|
Percutaneous transvenous implantation of a device in the coronary sinus for the purpose of remodeling the mitral valve annulus is feasible. Initial experience is consistent with a potential beneficial effect on functional MR and warrants further investigation if problems with device separation can be overcome.
|
Acknowledgments |
|---|
Disclosures
Drs Harnek, Kimblad, Munt, Solem, and Webb are consultants to Edwards Lifesciences, Irvine, Calif.
|
References |
|---|
|
TopAbstractIntroductionMethodsResultsDiscussionConclusionsReferences |
|---|
1. Salukhe TV, Henein MY, Sutton R. Ischemic mitral regurgitation and its related risk after myocardial infarction. Circulation. 2005; 111: 254–256.
2. Lamas GA, Mitchell GF, Flaker GC, Smith SC Jr, Gersh BJ, Basta L, Moye L, Braunwald E, Pfeffer MA. Clinical significance of mitral regurgitation after acute myocardial infarction: Survival and Ventricular Enlargement Investigators. Circulation. 1997; 96: 827–833.
3. Trichon BH, O’Connor CM. Secondary mitral and tricuspid regurgitation accompanying left ventricular systolic dysfunction: is it important, and how is it treated? Am Heart J. 2002; 144: 373–376.[CrossRef][Medline] [Order article via Infotrieve]
4. Enruiqez-Sarano M, Avierinos J, Messika-Zeitoun D, Detaint D, Capps M, Nkomo V, Scott C, Schaff HV, Tajik AJ. Quantitative determinants of the outcome of asymptomatic mitral regurgitation. N Engl J Med. 2005; 352: 875–883.
5. Bursi R, Enruizez-Serano M, Nkomo V, Jacobson SJ, Weston SA, Meverden RA, Roger VL. Heart failure and death after myocardial infarction in the community: the emerging role of mitral regurgitation. Circulation. 2005; 111: 295–301.
6. Grigioni F, Enruizez-Serano M, Zehr KJ, Bailey KR, Tajik AJ. Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation. 2001; 103: 1759–1764.
7. Robbins JD, Maniar PB, Cotts W, Pancer MA, Bonow RO, Gheorghiade M. Presence and severity of mitral regurgitation in chronic systolic heart failure. Am J Cardiol. 2003; 91: 360–362.[CrossRef][Medline] [Order article via Infotrieve]
8. Tcheng JE, Jackman JD, Nelson CL, Gardner LH, Smith LR, Rankin JS, Califf RM, Stack RS. Outcome of patients sustaining acute ischemic mitral regurgitation during myocardial infarction. Ann Intern Med. 1992; 117: 18–24.
9. Delahaye JP, Gare JP, Viguier E, Delahaye F, De Gevigny G, Milon H. Natural history of severe mitral regurgitation. Eur Heart J. 1991; 12 (suppl B): 5–9.
10. Miller DC. Ischemic mitral regurgitation redux: to repair or to replace? J Thorac Cardiovasc Surg. 2003; 125: S58–S61.
11. Otto CM, Salerno CT. Timing of surgery in asymptomatic mitral regurgitation. N Engl J Med. 2005; 352: 928–929.
12. Lim E, Ali ZA, Barlow CW, Hosseinpour AR, Wisbey C, Charman SC, Wells FC, Barlow JB. Determinants and assessment of regurgitation after mitral valve repair. J Thorac Cardiovasc Surg. 2002; 124: 911–917.
13. Gillinov AM, Faber C, Houghtaling PL, Blackstone EH, Lam B, Diaz R, Lyttle BW, Sabik JF III, Cosgrove DM. Repair versus replacement for degenerative mitral valve disease with coexisting ischemic heart disease. J Thorac Cardiovasc Surg. 2003; 125: 1350–1362.
14. Grossi EA, Goldberg JD, LaPietra A, Ye X, Zakow P, Sussman M, Delianides J, Culliford AT, Esposito RA, Ribakove GH, Galloway AC, Colvin SB. Ischemic mitral valve reconstruction and replacement: comparison of long-term survival and complications. J Thorac Cardiovasc Surg. 2001; 122: 1107–1124.
15. Dahlberg PS, Orsulak TA, Mullany CJ, Daly RC, Enruizez-Serano M, Schaff HV. Late outcome of mitral valve surgery for patients with coronary artery disease. Ann Thorac Surg. 2003; 76: 1539–1547.
16. McGee EC, Gillinov AM, Blackstone EH, Rajeswaran J, Cohen G, Najam F, Shiota T, Sabik JF, Lytle BW, McCarthey PM, Cosgrove DM. Recurrent mitral regurgitation after annuloplasty for functional ischemic mitral regurgitation. J Thorac Cardiovasc Surg. 2004; 128: 916–924.
17. Savage EB, Ferguson B Jr, DiSesa VJ. Use of mitral valve repair: analysis of contemporary United States experience reported to the Society of Thoracic Surgeons National Cardiac Database. Ann Thorac Surg. 2003; 75: 820–825.
18. Daimon M, Shiota T, Gillinov M, Hayase M, Ruel M, Cohn WE, Blacker SJ, Liddicoat JR. Percutaneous mitral valve repair for chronic ischemic mitral regurgitation. Circulation. 2005; 111: 2183–2189.
19. Kaye DM, Byrne M, Alferness C, Power J. Feasibility and short-term efficacy of percutaneous mitral annular reduction for the therapy of heart failure-induced mitral regurgitation. Circulation. 2003; 108: 1795–1797.
20. Maniu CV, Patel JB, Reuter DG, Meyer DM, Edwards WD, Rihal CS, Redfield MM. Acute and chronic reduction of functional mitral regurgitation in experimental heart failure by percutaneous mitral annuloplasty. J Am Coll Cardiol. 2004; 44: 1652–1661.
21. Liddicoat JR, MacNeill BD, Gillinov AM, Cohn WE, Chin CH, Prado AD, Pandian NG, Oesterle SN. Percutaneous mitral valve repair: a feasibility study in an ovine model of acute ischemic mitral regurgitation. Cathet Cardiovasc Diagn. 2003; 60: 410–416.
22. Condado JA, Velez-Gimon M. Catheter based approach to mitral regurgitation. J Interv Cardiol. 2003; 16: 523–534.[CrossRef][Medline] [Order article via Infotrieve]
23. Singh JP, Houser S, Heist K, Ruskin JN. The coronary venous anatomy: a segmental approach to aid cardiac resynchronization therapy. J Am Coll Cardiol. 2005; 46: 68–74.
24. Mao S, Shinbane JS, Girsky MJ, Child J, Carson S, Oudiz RJ, Budoff MJ. Coronary venous imaging with electron beam computed tomographic angiography: three-dimensional mapping and relationship with coronary arteries. Am Heart J. 2005; 150: 315–322.[CrossRef][Medline] [Order article via Infotrieve]
25. Jongbloed MRM, Lamb HJ, Bax JJ, Schuijf JD, de Roos A, van der Wall EE, Schalij MJ. Noninvasive visualization of the cardiac venous system using multislice computed tomography. J Am Coll Cardiol. 2005; 45: 749–753.
26. Block PC. Percutaneous mitral repair: are they changing the guard? Circulation. 2005; 111: 2154–2156.
 |
|
 |
|
  P. P. Agarwal, P. N. Cascade, and F. Pagani Novel Treatment Options for Chronic Heart Failure: A Radiologist's Perspective Am. J. Roentgenol., July 1, 2009; 193(1): W14 - W24. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Piazza, A. Asgar, R. Ibrahim, and R. Bonan Transcatheter Mitral and Pulmonary Valve Therapy J. Am. Coll. Cardiol., May 19, 2009; 53(20): 1837 - 1851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Suzuki, A. C. Yeung, and F. Ikeno The Pre-Clinical Animal Model in the Translational Research of Interventional Cardiology J. Am. Coll. Cardiol. Intv., May 1, 2009; 2(5): 373 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-B. Masson and J. G. Webb Percutaneous Treatment of Mitral Regurgitation Circ Cardiovasc Intervent, April 1, 2009; 2(2): 140 - 146. [Full Text] [PDF]
|
|
|
|
 |
|
 R D Christofferson, S R Kapadia, V Rajagopal, and E M Tuzcu Emerging transcatheter therapies for aortic and mitral disease Heart, January 15, 2009; 95(2): 148 - 155. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Plass, I. Valenta, O. Gaemperli, P. Kaufmann, H. Alkadhi, G. Zund, J. Grunenfelder, and M. Genoni Assessment of coronary sinus anatomy between normal and insufficient mitral valves by multi-slice computertomography for mitral annuloplasty device implantation Eur. J. Cardiothorac. Surg., April 1, 2008; 33(4): 583 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. K. Rosengart, T. Feldman, M. A. Borger, T. A. Vassiliades Jr, A. M. Gillinov, K. J. Hoercher, A. Vahanian, R. O. Bonow, and W. O'Neill Percutaneous and Minimally Invasive Valve Procedures: A Scientific Statement From the American Heart Association Council on Cardiovascular Surgery and Anesthesia, Council on Clinical Cardiology, Functional Genomics and Translational Biology Interdisciplinary Working Group, and Quality of Care and Outcomes Research Interdisciplinary Working Group Circulation, April 1, 2008; 117(13): 1750 - 1767. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Agricola, M. Oppizzi, M. Pisani, A. Meris, F. Maisano, and A. Margonato Ischemic mitral regurgitation: mechanisms and echocardiographic classification Eur J Echocardiogr, March 1, 2008; 9(2): 207 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W.M. Fedak, P. M. McCarthy, and R. O. Bonow Evolving Concepts and Technologies in Mitral Valve Repair Circulation, February 19, 2008; 117(7): 963 - 974. [Full Text] [PDF]
|
|
|
|
|
|
M. Enriquez-Sarano, D. F. Loulmet, and D. Burkhoff The conundrum of functional mitral regurgitation in chronic heart failure. J. Am. Coll. Cardiol., January 29, 2008; 51(4): 487 - 489. [Full Text] [PDF]
|
|
|
|
 |
|
 L. F. Tops, S. C. Krishnan, J. D. Schuijf, M. J. Schalij, and J. J. Bax Noncoronary applications of cardiac multidetector row computed tomography. J. Am. Coll. Cardiol. Img., January 1, 2008; 1(1): 94 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Davidson and D. S. Baim Percutaneous Catheter-Based Mitral Valve Repair Card. Surg. Adult, January 1, 2008; 3(2008): 1101 - 1108. [Full Text]
|
|
|
|
|
|
T. Feldman and M. B. Leon Prospects for Percutaneous Valve Therapies Circulation, December 11, 2007; 116(24): 2866 - 2877. [Full Text] [PDF]
|
|
|
|
|
|
S. R. Dixon, C. L. Grines, and W. W. O'Neill The Year in Interventional Cardiology J. Am. Coll. Cardiol., July 17, 2007; 50(3): 270 - 285. [Full Text] [PDF]
|
|
|
|
|
|
L. Coats and P. Bonhoeffer NEW PERCUTANEOUS TREATMENTS FOR VALVE DISEASE Heart, May 1, 2007; 93(5): 639 - 644. [Full Text] [PDF]
|
|
|
|
|
|
L. F. Tops, N. R. Van de Veire, J. D. Schuijf, A. de Roos, E. E. van der Wall, M. J. Schalij, and J. J. Bax Noninvasive Evaluation of Coronary Sinus Anatomy and Its Relation to the Mitral Valve Annulus: Implications for Percutaneous Mitral Annuloplasty Circulation, March 20, 2007; 115(11): 1426 - 1432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G.F. Cleland, A. P. Coletta, A. T. Abdellah, M. Nasir, N. Hobson, N. Freemantle, and A. L. Clark Clinical trials update from the American Heart Association 2006: OAT, SALT 1 and 2, MAGIC, ABCD, PABA-CHF, IMPROVE-CHF, and percutaneous mitral annuloplasty Eur J Heart Fail, January 1, 2007; 9(1): 92 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B Munt and J Webb Percutaneous valve repair and replacement techniques Heart, October 1, 2006; 92(10): 1369 - 1372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Maselli, F. Guarracino, F. Chiaramonti, F. Mangia, G. Borelli, and G. Minzioni Percutaneous Mitral Annuloplasty: An Anatomic Study of Human Coronary Sinus and Its Relation With Mitral Valve Annulus and Coronary Arteries Circulation, August 1, 2006; 114(5): 377 - 380. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. St. John Sutton and R. C. Gorman Surgery for Asymptomatic Severe Mitral Regurgitation in the Elderly: Early Surgery or Wait and Watch? Circulation, July 25, 2006; 114(4): 258 - 260. [Full Text] [PDF]
|
|
|
|
 |
|
 Percutaneous Treatment of Valvular Heart Disease Journal Watch Cardiology, March 23, 2006; 2006(323): 3 - 3. [Full Text]
|
|
|
|
|
|
T. Feldman Percutaneous Valve Repair and Replacement: Challenges Encountered, Challenges Met, Challenges Ahead Circulation, February 14, 2006; 113(6): 771 - 773. [Full Text] [PDF]
|
|
|
|
|
|
R. J. Shemin Percutaneous Valve Intervention: A Surgeon's Perspective Circulation, February 14, 2006; 113(6): 774 - 775. [Full Text] [PDF]
|
|
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||