Circulation. 2006;113:597
(Circulation. 2006;113:597.)
© 2006 American Heart Association, Inc.
Issue Highlights
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PATIENTS WITH ACUTE CORONARY SYNDROME SHOW OLIGOCLONAL T-CELL RECRUITMENT WITHIN UNSTABLE PLAQUE: EVIDENCE FOR A LOCAL, INTRACORONARY IMMUNOLOGIC MECHANISM, by De Palma et al.
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Do immune cells influence the stability of atherosclerotic plaques
and contribute to myocardial infarction? In this issue of
Circulation,
De Palma and colleagues address this question by studying whether
immune-driven T-lymphocyte recruitment occurs in unstable plaque
of patients with acute coronary syndromes. By examining blood
and coronary plaques obtained by atherectomy, the authors compared
the T-cells in patients with either unstable or chronic stable
angina. They report that unstable plaques have markedly increased
T-cell infiltration and that this observation did not require
a systemic immunologic activation. These findings demonstrate
the complex inflammatory response that occurs in unstable coronary
plaque and suggest potential new targets for intervention and
prevention. See p
640.
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PROGNOSTIC VALUE OF AORTIC PULSE WAVE VELOCITY AS INDEX OF ARTERIAL STIFFNESS IN THE GENERAL POPULATION, by Willum Hansen et al.
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As part of the aging process, the aorta stiffens, and the forward
pulse wave travels faster with resultant higher systolic and
lower diastolic blood pressure. The aortic pulse wave velocity
(APWV) is a measure of central arterial stiffness and can be
measured easily at the bedside by recording the arterial wave
simultaneously at the left common carotid and femoral arteries.
This study of 1678 individuals from the general Danish population
evaluated the prognostic value of APWV. Over a median follow-up
of 9.4 years, 154 cardiovascular events occurred, and higher
APWV was associated with a greater incidence of cardiovascular
events after adjusting for other risk factors. This study adds
to the previous literature on the utility of APWV in patients
with hypertension, diabetes, and end-stage renal disease and
elderly hospitalized patients; it also provides important new
information about the prognostic importance of measurements
of arterial stiffness in the general population. See p
664.
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ADMINISTRATION OF HEMATOPOIETIC CYTOKINES IN THE SUBACUTE PHASE AFTER CEREBRAL INFARCTION IS EFFECTIVE FOR FUNCTIONAL RECOVERY FACILITATING PROLIFERATION OF INTRINSIC NEURAL STEM/PROGENITOR CELLS AND TRANSITION OF BONE MARROW–DERIVED NEURONAL CELLS, by Kawada et al.
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Cytokine therapy is neuroprotective in the setting of cerebral
infarction. In this issue of
Circulation, Kawada and colleagues
show that delivery of granulocyte colony-stimulating factor
and stem cell factor in the subacute phase (11–20 days)
after middle cerebral artery ligation leads to better motor
performance and higher brain function than delivery in the acute
phase (1–10 days). The improvements in the subacute phase
coincided with increased homing of bone marrow-derived progenitor
cells to the infarct region and the proliferation of intrinsic
neuronal progenitor cells. These data suggest that hematopoietic
cytokine therapy could be more effective in treating stroke
when it is administered at later time points when acute inflammation
recedes. See p
701.
Visit http://circ.ahajournals.org:
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Images in Cardiovascular Medicine
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Culprit Lesion Seen 1 Hour Before Occlusion: Limits of Coronary
Angiography in Detecting Vulnerable Plaques. See p
e61.
The Blue Man: Amiodarone-Induced Skin Discoloration. See p e63.
Intra-Arterial Thrombolysis for Left Middle Cerebral Artery Embolic Stroke During Coronary Angiography. See p e64.
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Book Review
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Platelet Function: Assessment, Diagnosis, and Treatment. See
p
e67.
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Correspondence
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See p
e68.
Related Articles:
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Patients With Acute Coronary Syndrome Show Oligoclonal T-Cell Recruitment Within Unstable Plaque: Evidence for a Local, Intracoronary Immunologic Mechanism
- Raffaele De Palma, Francesco Del Galdo, Gianfranco Abbate, Massimo Chiariello, Raffaele Calabró, Lavinia Forte, Giovanni Cimmino, Maria Francesca Papa, Maria Giovanna Russo, Giuseppe Ambrosio, Claudio Giombolini, Isabella Tritto, Salvatore Notaristefano, Liberato Berrino, Francesco Rossi, and Paolo Golino
Circulation 2006 113: 640-646.
[Abstract]
[Full Text]
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Prognostic Value of Aortic Pulse Wave Velocity as Index of Arterial Stiffness in the General Population
- Tine Willum Hansen, Jan A. Staessen, Christian Torp-Pedersen, Susanne Rasmussen, Lutgarde Thijs, Hans Ibsen, and Jørgen Jeppesen
Circulation 2006 113: 664-670.
[Abstract]
[Full Text]
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Administration of Hematopoietic Cytokines in the Subacute Phase After Cerebral Infarction Is Effective for Functional Recovery Facilitating Proliferation of Intrinsic Neural Stem/Progenitor Cells and Transition of Bone Marrow-Derived Neuronal Cells
- Hiroshi Kawada, Shunya Takizawa, Tomomi Takanashi, Yuko Morita, Jun Fujita, Keiichi Fukuda, Shigeharu Takagi, Hideyuki Okano, Kiyoshi Ando, and Tomomitsu Hotta
Circulation 2006 113: 701-710.
[Abstract]
[Full Text]
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Culprit Lesion Seen 1 Hour Before Occlusion: Limits of Coronary Angiography in Detecting Vulnerable Plaques
- Enrico Romagnoli, Francesco Burzotta, Floriana Giannico, and Filippo Crea
Circulation 2006 113: e61-e62.
[Extract]
[Full Text]
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The Blue Man: Amiodarone-Induced Skin Discoloration
- Frank Enseleit, Christophe A. Wyss, Firat Duru, Georg Noll, and Frank Ruschitzka
Circulation 2006 113: e63.
[Extract]
[Full Text]
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Intra-Arterial Thrombolysis for Left Middle Cerebral Artery Embolic Stroke During Coronary Angiography
- Patrizia Presbitero, Gabriele L. Gasparini, and Paolo Pagnotta
Circulation 2006 113: e64-e66.
[Extract]
[Full Text]
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Platelet Function: Assessment, Diagnosis, and Treatment
- Jane E. Freedman
Circulation 2006 113: e67.
[Extract]
[Full Text]
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Letter Regarding Article by Norman et al, "Novel Mutation in Desmoplakin Causes Arrhythmogenic Left Ventricular Cardiomyopathy" • Response
- Cristina Basso, Gaetano Thiene, Andrea Nava, Guy Hugues Fontaine, Paul Fornès, Srijita Sen-Chowdhry, Petros Syrris, William J. McKenna, Mark Norman, Jens Mogensen, Anthony Shaw, Edward Rowland, Michael Simpson, Andrew Crosby, and Siân Hughes
Circulation 2006 113: e68-e69.
[Extract]
[Full Text]
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