(Circulation. 2006;113:156-175.)
© 2006 American Heart Association, Inc.
ACC/AHA/SCAI Practice Guideline |



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In preparing this update, the committee was guided by the following principles:
The classification of recommendations and levels of evidence are expressed in the ACC/AHA format as follows:
Classification of Recommendations
Level of Evidence
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| Footnotes |
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Former Task Force Member during this writing effort. ![]()
Acknowledgment: The ACC and AHA recognize Dr J. Ward Kennedy for his dedicated service on developing ACC/AHA guidelines for PTCA and PCI since their inception in 1986 and for his counsel and advice in the preparation of this guideline.
This document was approved by the American College of Cardiology Foundation Board of Trustees in September 2005, by the American Heart Association Science Advisory and Coordinating Committee in September 2005, and by the Society for Cardiovascular Angiography and Interventions in September 2005.
The ACC/AHA Task Force on Practice Guidelines makes every effort to avoid any actual or potential conflicts of interest that might arise as a result of an outside relationship or personal interest of a member of the writing panel. Specifically, all members of the writing panel are asked to provide disclosure statements of all such relationships that might be perceived as real or potential conflicts of interest. These statements are reviewed by the parent task force, reported orally to all members of the writing panel at the first meeting, and updated as changes occur. The relationship with industry information for writing committee members, as well as peer reviewers of the document, is located in an appendix of the full-text guideline, which is available on the ACC, AHA, and SCAI Web sites.
When citing this document, the American Heart Association requests that the following citation format be used: Smith SC Jr, Feldman TE, Hirshfeld JW Jr, Jacobs AK, Kern MJ, King SB III, Morrison DA, ONeill WW, Schaff HV, Whitlow PL, Williams DO. ACC/AHA/SCAI 2005 guideline update for percutaneous coronary interventionsummary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to Update the 2001 Guidelines for Percutaneous Coronary Intervention). Circulation. 2006;113:156175.
Copies: This document is available on the World Wide Web sites of the American College of Cardiology (www.acc.org), the American Heart Association (www.americanheart.org), and the Society for Cardiovascular Angiography and Interventions (www.scai.org). Single copies of this document are available by calling 1-800-253-4636 or writing the American College of Cardiology Foundation, Resource Center, at 9111 Old Georgetown Road, Bethesda, MD 20814-1699. Ask for reprint number 71-0346. To obtain a copy of the full text published in the January 3, 2006, issue of the Journal of the American College of Cardiology, the January 3, 2006, issue of Circulation, and the January 2006, issue of Catheterization and Cardiovascular Interventions, ask for reprint number 71-0347. To purchase bulk reprints (specify version and reprint number): Up to 999 copies, call 1-800-611-6083 US only) or fax 413-665-2671; 1000 or more copies, call 214-706-1789, fax 214-691-6342, or e-mail pubauth@heart.org.
Permissions: Multiple copies, modification, alteration, enhancement, and/or distribution of this document are not permitted without the express permission of the American College of Cardiology Foundation. Please direct requests to copyright_permissions@acc.org.
© 2006 by the American College of Cardiology Foundation and the American Heart Association, Inc.
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Y. Onuma, N. Kukreja, J. Daemen, H. M. Garcia-Garcia, N. Gonzalo, J. M. Cheng, P. H. van Twisk, R. van Domburg, P. W. Serruys, and on behalf of the Interventional Cardiologists of T Impact of Sex on 3-Year Outcome After Percutaneous Coronary Intervention Using Bare-Metal and Drug-Eluting Stents in Previously Untreated Coronary Artery Disease: Insights From the RESEARCH (Rapamycin-Eluting Stent Evaluated at Rotterdam Cardiology Hospital) and T-SEARCH (Taxus-Stent Evaluated at Rotterdam Cardiology Hospital) Registries J. Am. Coll. Cardiol. Intv., July 1, 2009; 2(7): 603 - 610. [Abstract] [Full Text] [PDF] |
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M. Busk, A. Kaltoft, S. S. Nielsen, M. Bottcher, M. Rehling, L. Thuesen, H. E. Botker, J. F. Lassen, E. H. Christiansen, L. R. Krusell, et al. Infarct size and myocardial salvage after primary angioplasty in patients presenting with symptoms for <12 h vs. 12-72 h Eur. Heart J., June 1, 2009; 30(11): 1322 - 1330. [Abstract] [Full Text] [PDF] |
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D. Tousoulis, A. Briasoulis, S. S Dhamrait, C. Antoniades, and C. Stefanadis Effective platelet inhibition by aspirin and clopidogrel: where are we now? Heart, May 1, 2009; 95(10): 850 - 858. [Full Text] [PDF] |
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G. A. Donnan and S. M. Davis Combined Aspirin Plus Warfarin: Recent Evidence and Residual Questions Stroke, May 1, 2009; 40(5): 1946 - 1946. [Full Text] [PDF] |
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M. J. Eisenberg, P. R. Richard, D. Libersan, and K. B. Filion Safety of Short-Term Discontinuation of Antiplatelet Therapy in Patients With Drug-Eluting Stents Circulation, March 31, 2009; 119(12): 1634 - 1642. [Abstract] [Full Text] [PDF] |
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J.-C. Tardif, P. Ponikowski, T. Kahan, and for the ASSOCIATE study Investigators Efficacy of the If current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4-month, randomized, placebo-controlled trial Eur. Heart J., March 1, 2009; 30(5): 540 - 548. [Abstract] [Full Text] [PDF] |
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C. R. Smith Surgery, Not Percutaneous Revascularization, Is the Preferred Strategy for Patients With Significant Left Main Coronary Stenosis Circulation, February 24, 2009; 119(7): 1013 - 1020. [Full Text] [PDF] |
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P. S. Teirstein Percutaneous Revascularization Is the Preferred Strategy for Patients With Significant Left Main Coronary Stenosis Circulation, February 24, 2009; 119(7): 1021 - 1033. [Full Text] [PDF] |
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R. Iijima, G. Ndrepepa, J. Mehilli, R. A. Byrne, S. Schulz, F.-J. Neumann, G. Richardt, P. B. Berger, A. Schomig, and A. Kastrati Profile of bleeding and ischaemic complications with bivalirudin and unfractionated heparin after percutaneous coronary intervention Eur. Heart J., February 1, 2009; 30(3): 290 - 296. [Abstract] [Full Text] [PDF] |
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F.L. Lucas, A.E. Siewers, D.J. Malenka, and D.E. Wennberg Diagnostic-Therapeutic Cascade Revisited: Coronary Angiography, Coronary Artery Bypass Graft Surgery, and Percutaneous Coronary Intervention in the Modern Era Circulation, December 16, 2008; 118(25): 2797 - 2802. [Abstract] [Full Text] [PDF] |
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R. J. Shemin Coronary Artery Bypass Grafting Versus Stenting for Unprotected Left Main Coronary Artery Disease: Where Lies the Body of Proof? Circulation, December 2, 2008; 118(23): 2326 - 2329. [Full Text] [PDF] |
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J. Rodes-Cabau, J. DeBlois, O. F. Bertrand, S. Mohammadi, J. Courtis, E. Larose, F. Dagenais, J.-P. Dery, P. Mathieu, M. Rousseau, et al. Nonrandomized Comparison of Coronary Artery Bypass Surgery and Percutaneous Coronary Intervention for the Treatment of Unprotected Left Main Coronary Artery Disease in Octogenarians Circulation, December 2, 2008; 118(23): 2374 - 2381. [Abstract] [Full Text] [PDF] |
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L. H. Piers, R. Dikkers, T. P. Willems, B. J.G.L. de Smet, M. Oudkerk, F. Zijlstra, and R. A. Tio Computed tomographic angiography or conventional coronary angiography in therapeutic decision-making Eur. Heart J., December 1, 2008; 29(23): 2902 - 2907. [Abstract] [Full Text] [PDF] |
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J. M. Miller, C. E. Rochitte, M. Dewey, A. Arbab-Zadeh, H. Niinuma, I. Gottlieb, N. Paul, M. E. Clouse, E. P. Shapiro, J. Hoe, et al. Diagnostic Performance of Coronary Angiography by 64-Row CT N. Engl. J. Med., November 27, 2008; 359(22): 2324 - 2336. [Abstract] [Full Text] [PDF] |
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R. J. Gibbons Noninvasive Diagnosis and Prognosis Assessment in Chronic Coronary Artery Disease: Stress Testing With and Without Imaging Perspective Circ Cardiovasc Imaging, November 1, 2008; 1(3): 257 - 269. [Full Text] [PDF] |
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V. Rudolph, T. K. Rudolph, F. J. Schopfer, G. Bonacci, D. Lau, K. Szocs, A. Klinke, T. Meinertz, B. A. Freeman, and S. Baldus Bivalirudin Decreases NO Bioavailability by Vascular Immobilization of Myeloperoxidase J. Pharmacol. Exp. Ther., November 1, 2008; 327(2): 324 - 331. [Abstract] [Full Text] [PDF] |
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C. Wu, E. L. Hannan, G. Walford, and D. P. Faxon Utilization and Outcomes of Unprotected Left Main Coronary Artery Stenting and Coronary Artery Bypass Graft Surgery Ann. Thorac. Surg., October 1, 2008; 86(4): 1153 - 1159. [Abstract] [Full Text] [PDF] |
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T. A. Bass and P. Capranzano Managing Patients With Intermediate In-Stent Restenotic Lesions: Is It "Prime Time" for Intravascular Ultrasound Imaging? Circ Cardiovasc Interv, October 1, 2008; 1(2): 90 - 92. [Full Text] [PDF] |
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T. Kimura, T. Morimoto, Y. Furukawa, Y. Nakagawa, S. Shizuta, N. Ehara, R. Taniguchi, T. Doi, K. Nishiyama, N. Ozasa, et al. Long-Term Outcomes of Coronary-Artery Bypass Graft Surgery Versus Percutaneous Coronary Intervention for Multivessel Coronary Artery Disease in the Bare-Metal Stent Era Circulation, September 30, 2008; 118(14_suppl_1): S199 - S209. [Abstract] [Full Text] [PDF] |
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W. S. Weintraub, W. E. Boden, Z. Zhang, P. Kolm, Z. Zhang, J. A. Spertus, P. Hartigan, E. Veledar, C. Jurkovitz, J. Bowen, et al. Cost-Effectiveness of Percutaneous Coronary Intervention in Optimally Treated Stable Coronary Patients Circ Cardiovasc Qual Outcomes, September 1, 2008; 1(1): 12 - 20. [Abstract] [Full Text] [PDF] |
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A. Chieffo, S.-J. Park, E. Meliga, I. Sheiban, M. S. Lee, A. Latib, Y.-H. Kim, M. Valgimigli, D. Sillano, V. Magni, et al. Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry Eur. Heart J., September 1, 2008; 29(17): 2108 - 2115. [Abstract] [Full Text] [PDF] |
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W. S. Weintraub, J. A. Spertus, P. Kolm, D. J. Maron, Z. Zhang, C. Jurkovitz, W. Zhang, P. M. Hartigan, C. Lewis, E. Veledar, et al. Effect of PCI on Quality of Life in Patients with Stable Coronary Disease N. Engl. J. Med., August 14, 2008; 359(7): 677 - 687. [Abstract] [Full Text] [PDF] |
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M. S. Lee, C.-H. Tseng, C. M. Barker, V. Menon, D. Steckman, R. Shemin, and J. S. Hochman Outcome After Surgery and Percutaneous Intervention for Cardiogenic Shock and Left Main Disease Ann. Thorac. Surg., July 1, 2008; 86(1): 29 - 34. [Abstract] [Full Text] [PDF] |
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J. G. Tejada, F. Hernandez, J. Chimeno, M. A. Alonso, R. Martin, and T. Bastante Acute Pancreatitis Mimicking Acute Inferior Myocardial Infarction Angiology, July 1, 2008; 59(3): 365 - 367. [Abstract] [PDF] |
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M. J. Zellweger, C. Kaiser, H. P. Brunner-La Rocca, P. T. Buser, S. Osswald, P. Weiss, J. Mueller-Brand, M. E. Pfisterer, and for the BASKET Investigators Value and Limitations of Target-Vessel Ischemia in Predicting Late Clinical Events After Drug-Eluting Stent Implantation J. Nucl. Med., April 1, 2008; 49(4): 550 - 556. [Abstract] [Full Text] [PDF] |
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A. D. Michelson P2Y12 Antagonism: Promises and Challenges Arterioscler Thromb Vasc Biol, March 1, 2008; 28(3): s33 - s38. [Abstract] [Full Text] [PDF] |
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R Zahn, M Gottwik, M Hochadel, J Senges, U Zeymer, A Vogt, T Meinertz, R Dietz, K E Hauptmann, E Grube, et al. Volume-outcome relation for contemporary percutaneous coronary interventions (PCI) in daily clinical practice: is it limited to high-risk patients? Results from the Registry of Percutaneous Coronary Interventions of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausarzte (ALKK) Heart, March 1, 2008; 94(3): 329 - 335. [Abstract] [Full Text] [PDF] |
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R. Qayyum, M. R. Khalid, J. Adomaityte, S. P. Papadakos, and F. C. Messineo Systematic Review: Comparing Routine and Selective Invasive Strategies for the Acute Coronary Syndrome Ann Intern Med, February 5, 2008; 148(3): 186 - 196. [Abstract] [Full Text] [PDF] |
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R. J. Gibbons and S. D. Fihn Coronary Revascularization: New Evidence, New Challenges Ann Intern Med, November 20, 2007; 147(10): 732 - 734. [Full Text] [PDF] |
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G. A. Diamond and S. Kaul COURAGE Under Fire: On the Management of Stable Coronary Disease J. Am. Coll. Cardiol., October 16, 2007; 50(16): 1604 - 1609. [Abstract] [Full Text] [PDF] |
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A. Colombo and A. Chieffo Drug-Eluting Stent Update 2007: Part III: Technique and Unapproved/Unsettled Indications (Left Main, Bifurcations, Chronic Total Occlusions, Small Vessels and Long Lesions, Saphenous Vein Grafts, Acute Myocardial Infarctions, and Multivessel Disease) Circulation, September 18, 2007; 116(12): 1424 - 1432. [Full Text] [PDF] |
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J. Daemen and P. W. Serruys Drug-Eluting Stent Update 2007: Part II: Unsettled Issues Circulation, August 21, 2007; 116(8): 961 - 968. [Full Text] [PDF] |
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F. Airoldi, A. Colombo, N. Morici, A. Latib, J. Cosgrave, L. Buellesfeld, E. Bonizzoni, M. Carlino, U. Gerckens, C. Godino, et al. Incidence and Predictors of Drug-Eluting Stent Thrombosis During and After Discontinuation of Thienopyridine Treatment Circulation, August 14, 2007; 116(7): 745 - 754. [Abstract] [Full Text] [PDF] |
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M. Moscucci Behavioral Factors, Bias, and Practice Guidelines in the Decision to Use Percutaneous Coronary Interventions for Stable Coronary Artery Disease Arch Intern Med, August 13, 2007; 167(15): 1573 - 1575. [Full Text] [PDF] |
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T. C. Gerber, B. Kantor, and P. Chareonthaitawee Coronary computed tomographic angiography and exercise electrocardiography: a great match or unequal partners? Eur. Heart J., August 1, 2007; 28(15): 1787 - 1789. [Full Text] [PDF] |
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C. Bode Introduction Eur. Heart J. Suppl., August 1, 2007; 9(suppl_D): D1 - D2. [Full Text] [PDF] |
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C. Bode and M. Zehender The use of antiplatelet agents following percutaneous coronary intervention: focus on late stent thrombosis Eur. Heart J. Suppl., August 1, 2007; 9(suppl_D): D10 - D19. [Abstract] [Full Text] [PDF] |
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C. B. Granger, T. D. Henry, W. E. R. Bates, B. Cercek, W. D. Weaver, and D. O. Williams Development of Systems of Care for ST-Elevation Myocardial Infarction Patients: The Primary Percutaneous Coronary Intervention (ST-Elevation Myocardial Infarction Receiving) Hospital Perspective Circulation, July 10, 2007; 116(2): e55 - e59. [Full Text] [PDF] |
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A. Chieffo, S. J. Park, M. Valgimigli, Y. H. Kim, J. Daemen, I. Sheiban, A. Truffa, M. Montorfano, F. Airoldi, G. Sangiorgi, et al. Favorable Long-Term Outcome After Drug-Eluting Stent Implantation in Nonbifurcation Lesions That Involve Unprotected Left Main Coronary Artery: A Multicenter Registry Circulation, July 10, 2007; 116(2): 158 - 162. [Abstract] [Full Text] [PDF] |
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M. W. Krucoff, A. Boam, and D. G. Schultz Drug-Eluting Stents "Deliver Heartburn": How Do We Spell Relief Going Forward? Circulation, June 12, 2007; 115(23): 2990 - 2994. [Full Text] [PDF] |
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N. H.J. Pijls, P. van Schaardenburgh, G. Manoharan, E. Boersma, J.-W. Bech, M. van't Veer, F. Bar, J. Hoorntje, J. Koolen, W. Wijns, et al. Percutaneous Coronary Intervention of Functionally Nonsignificant Stenosis: 5-Year Follow-Up of the DEFER Study J. Am. Coll. Cardiol., May 29, 2007; 49(21): 2105 - 2111. [Abstract] [Full Text] [PDF] |
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O. Gaemperli, T. Schepis, I. Valenta, L. Husmann, H. Scheffel, V. Duerst, F. R. Eberli, T. F. Luscher, H. Alkadhi, and P. A. Kaufmann Cardiac Image Fusion from Stand-Alone SPECT and CT: Clinical Experience J. Nucl. Med., May 1, 2007; 48(5): 696 - 703. [Abstract] [Full Text] [PDF] |
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A. Abbate, G. G.L. Biondi-Zoccai, P. Agostoni, M. J. Lipinski, and G. W. Vetrovec Recurrent angina after coronary revascularization: a clinical challenge Eur. Heart J., May 1, 2007; 28(9): 1057 - 1065. [Abstract] [Full Text] [PDF] |
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W. E. Boden, R. A. O'Rourke, K. K. Teo, P. M. Hartigan, D. J. Maron, W. J. Kostuk, M. Knudtson, M. Dada, P. Casperson, C. L. Harris, et al. Optimal Medical Therapy with or without PCI for Stable Coronary Disease N. Engl. J. Med., April 12, 2007; 356(15): 1503 - 1516. [Abstract] [Full Text] [PDF] |
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W. H. Maisel Unanswered Questions -- Drug-Eluting Stents and the Risk of Late Thrombosis N. Engl. J. Med., March 8, 2007; 356(10): 981 - 984. [Full Text] [PDF] |
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D. J. Angiolillo, S. B. Shoemaker, B. Desai, H. Yuan, R. K. Charlton, E. Bernardo, M. M. Zenni, L. A. Guzman, T. A. Bass, and M. A. Costa Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease: Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) Study Circulation, February 13, 2007; 115(6): 708 - 716. [Abstract] [Full Text] [PDF] |
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J. R Burton, I. Burton, and G. J Pearson Clopidogrel-Precipitated Rhabdomyolysis in a Stable Heart Transplant Patient Ann. Pharmacother., January 1, 2007; 41(1): 133 - 137. [Abstract] [Full Text] [PDF] |
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V. J. Dzau, E. M. Antman, H. R. Black, D. L. Hayes, J. E. Manson, J. Plutzky, J. J. Popma, and W. Stevenson The Cardiovascular Disease Continuum Validated: Clinical Evidence of Improved Patient Outcomes: Part I: Pathophysiology and Clinical Trial Evidence (Risk Factors Through Stable Coronary Artery Disease) Circulation, December 19, 2006; 114(25): 2850 - 2870. [Full Text] [PDF] |
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D. P. Taggart Coronary Artery Bypass Grafting is Still the Best Treatment for Multivessel and Left Main Disease, But Patients Need to Know Ann. Thorac. Surg., December 1, 2006; 82(6): 1966 - 1975. [Full Text] [PDF] |
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J. J Y Sung Combining aspirin with antithrombotic agents. BMJ, October 7, 2006; 333(7571): 712 - 713. [Full Text] [PDF] |
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C. Spaulding, M.-C. Morice, B. Lancelin, S. El Haddad, E. Lepage, S. Bataille, J.-P. Tresca, X. Mouranche, S. Fosse, M. Monchi, et al. Is the volume-outcome relation still an issue in the era of PCI with systematic stenting? Results of the greater Paris area PCI registry Eur. Heart J., May 1, 2006; 27(9): 1054 - 1060. [Abstract] [Full Text] [PDF] |
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A. K. Jacobs Regionalized Care for Patients With ST-Elevation Myocardial Infarction: It's Closer Than You Think Circulation, March 7, 2006; 113(9): 1159 - 1161. [Full Text] [PDF] |
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Guidelines: Percutaneous Coronary Intervention Journal Watch Cardiology, January 12, 2006; 2006(112): 2 - 2. [Full Text] |
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