Circulation. 2005;112:1917
(Circulation. 2005;112:1917.)
© 2005 American Heart Association, Inc.
Issue Highlights
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EFFECT OF FISH OIL ON HEART RATE IN HUMANS: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS, by Mozaffarian et al.
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Heart rate is determined by the complex interplay of sympathetic
and parasympathetic stimulation with sinus node automaticity.
Faster heart rates are associated with increasing mortality
and cardiovascular risk, consistent with the observations that
increased sympathetic tone activation is not only a marker of
risk but also has direct adverse effects. ß-Adrenergic-blocking
agents and physical conditioning slow the heart rate and are
beneficial. Mozaffarian and colleagues show that consumption
of fish oil also slows heart rate. In a meta-analysis of randomized
trials including 1678 subjects who ingested fish oil for 4 to
52 weeks, heart rate slowed by 1.6 beats per minute. Whether
this is mediated by an alteration in cardiac lipid membranes
that affects ion channel function, as has been previously hypothesized,
or a reduction in sympathetic tone through some other mechanism
remains to be established. The findings suggest potential mechanisms
for cardiovascular benefits of fish or fish oil consumption.
See p
1945.
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COMPARISON OF PERCUTANEOUS CORONARY INTERVENTION AND CORONARY ARTERY BYPASS GRAFTING AFTER ACUTE MYOCARDIAL INFARCTION COMPLICATED BY CARDIOGENIC SHOCK: RESULTS FROM THE SHOULD WE EMERGENTLY REVASCULARIZE OCCLUDED CORONARIES FOR CARDIOGENIC SHOCK (SHOCK) TRIAL, by White et al.
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Despite advances in reperfusion therapies, the incidence of
cardiogenic shock has not changed, and it remains the most common
cause of death in patients hospitalized with acute myocardial
infarction. In the SHOCK trial, emergency revascularization,
as compared with medical stabilization, resulted at 1 year in
130 lives saved per 1000 patients. Furthermore, most survivors
had a good quality of life. To achieve this result, almost 40%
of patients had emergency revascularization surgery. The SHOCK
investigation compared the outcomes according to choice of PCI
or CABG, which was done by site investigators. Patients treated
with CABG had a greater prevalence of diabetes and more advanced
coronary diseases than did patients treated with PCI. However,
survival rates at 12 months were similar. See p
1992.
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COLCHICINE IN ADDITION TO CONVENTIONAL THERAPY FOR ACUTE PERICARDITIS: RESULTS OF THE COPE TRIAL, by Imazio et al.
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The treatment of acute pericarditis is based predominantly on
observational data. For the problematic group of patients with
recurrent symptoms of pericarditis after the initial episode,
some studies have suggested colchicine to be effective. In this
issue of
Circulation, Imazio and colleagues report the results
of a prospective, randomized trial of colchicine in patients
with acute pericarditis. Over 18 months of follow-up, the rate
of recurrent symptoms was reduced by 70%. Moreover, colchicine
therapy started during the acute episode resulted in more rapid
resolution of the initial symptoms. These data provide an evidence
base that can inform therapeutic decisions for clinicians in
the treatment of acute pericarditis. See p
2012.
Visit http://www.circ.ahajournals.org:
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Cardiology Patient Page
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Cardiac Resynchronization Therapy: A Better and Longer Life
for Patients With Advanced Heart Failure. See p
e236.
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Images in Cardiovascular Medicine
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Development of a Cardiac Neocavity After Mechanic Double-Valve
Replacement: Evaluation by Cardiac Magnetic Resonance Imaging.
See p
e238.
Periaortic Valve Abscess Presenting as Unstable Angina. See p e240.
Late Enhancement of a Left Ventricular Cardiac Fibroma Assessed With Gadolinium-Enhanced Cardiovascular Magnetic Resonance. See p e242.
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Correspondence
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See p
e244.
Related Articles:
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Comparison of Percutaneous Coronary Intervention and Coronary Artery Bypass Grafting After Acute Myocardial Infarction Complicated by Cardiogenic Shock: Results From the Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock (SHOCK) Trial
- Harvey D. White, Susan F. Assmann, Timothy A. Sanborn, Alice K. Jacobs, John G. Webb, Lynn A. Sleeper, Cheuk-Kit Wong, James T. Stewart, Philip E.G. Aylward, Shing-Chiu Wong, and Judith S. Hochman
Circulation 2005 112: 1992-2001.
[Abstract]
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Colchicine in Addition to Conventional Therapy for Acute Pericarditis: Results of the COlchicine for acute PEricarditis (COPE) Trial
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Cardiac Resynchronization Therapy: A Better and Longer Life for Patients With Advanced Heart Failure
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Circulation 2005 112: e236-e237.
[Full Text]
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Development of a Cardiac Neocavity After Mechanic Double-Valve Replacement: Evaluation by Cardiac Magnetic Resonance Imaging
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Circulation 2005 112: e238-e239.
[Full Text]
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Periaortic Valve Abscess Presenting as Unstable Angina
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Circulation 2005 112: e240-e241.
[Full Text]
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- Francesco De Cobelli, Antonio Esposito, Renata Mellone, Marco Papa, Tiziana Varisco, Roberto Besana, and Alessandro del Maschio
Circulation 2005 112: e242-e243.
[Full Text]
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Letter Regarding Article by Sega et al, "Prognostic Value of Ambulatory and Home Blood Pressures Compared With Office Blood Pressure in the General Population" • Response
- Tine Willum Hansen, Jørgen Jeppesen, Hans Ibsen, Eamon Dolan, Eoin T. O’Brien, Jan A. Staessen, Takayoshi Ohkubo, Yutaka Imai, Roberto Sega, Rita Facchetti, Michele Bombelli, Giancarlo Cesana, Giovanni Corrao, Guido Grassi, and Giuseppe Mancia
Circulation 2005 112: e244-e246.
[Full Text]
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Effect of Fish Oil on Heart Rate in Humans: A Meta-Analysis of Randomized Controlled Trials
- Dariush Mozaffarian, Anouk Geelen, Ingeborg A. Brouwer, Johanna M. Geleijnse, Peter L. Zock, and Martijn B. Katan
Circulation 2005 112: 1945-1952.
[Abstract]
[Full Text]
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EFFECT OF FISH OIL...
COMPARISON OF PERCUTANEOUS...