Circulation. 2005;111:119
(Circulation. 2005;111:119.)
© 2005 American Heart Association, Inc.
Issue Highlights
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CLINICAL PROGRESSION OF INCIDENTAL, ASYMPTOMATIC LESIONS DISCOVERED DURING CULPRIT VESSEL CORONARY INTERVENTION, by Glaser et al.
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"To intervene or not to intervene" remains one of the outstanding
questions for the interventional cardiologist when incidental
nontarget lesions are identified during coronary angiography.
Recent advances in vascular biology have contributed to our
understanding of the vulnerable plaque and suggest that early
intervention of these lesions may improve long-term outcomes.
Furthermore, in the drug-eluting stent era, restenosis rates
have declined to the single digits, and data now exist to demonstrate
that these results remain durable over several years. In this
issue of
Circulation, Glaser et al provide the final piece of
the puzzle: Data from the National Heart, Lung and Blood Institute
Dynamic Registry are used to determine how many patients annually
have progression of nontarget lesions resulting in clinical
events. See p
143.
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MESENCHYMAL STEM CELLS DIFFERENTIATE INTO AN ENDOTHELIAL PHENOTYPE, ENHANCE VASCULAR DENSITY, AND IMPROVE HEART FUNCTION IN A CANINE CHRONIC ISCHEMIA MODEL, by Silva et al.
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Bone marrow–derived stem cells have been carefully studied
for use as potential regenerative therapy for myocardial infarction.
Cell populations generally have been heterogeneous, and most
studies have been performed in the setting of acute myocardial
infarction or in the early post–myocardial infarction
phase. In this issue, Silva and colleagues advance the field
by isolating mesenchymal stem cells for intramyocardial injection,
and use a canine model of chronic ischemia, representing hibernation
and chronic ischemic cardiomyopathy. They report that the cell
therapy reversed the progressive decline in left ventricular
function at rest and during stress, and that the cells differentiated
into smooth muscle cells and endothelial cells rather than myocytes,
resulting in increased vascularity. These data advance our understanding
of the fate of injected stem cells and extend the potential
therapeutic indications to the chronic ischemic state. See p
150.
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CARDIOVASCULAR MAGNETIC RESONANCE IN CARDIAC AMYLOIDOSIS, by Maceira et al.
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Detection of cardiac involvement in amyloidosis can be a vexing
clinical challenge and often relies on combinations of signs
from ECG and echocardiography or on invasive myocardial biopsy.
In this issue, Maceira and colleagues report on the use of cardiovascular
magnetic resonance to define patterns of gadolinium enhancement
and gadolinum kinetics in patients with cardiac amyloidosis.
They report that diffuse subendocardial enhancement is commonly
seen. Moreover, relaxation times were distinct in amyloid patients
compared with those with nonamyloid hypertrophy, and were correlated
with markers of amyloid burden. These data set the stage for
wider investigations of cardiovascular magnetic resonance in
populations with suspected amyloid heart disease, as well as
serial follow-up of disease burden and potential response to
therapy. See p
186.
Visit www.circ.ahajournals.org:
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Cardiology Patient Page
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Red Wine and Your Heart. See p
e10.
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Images in Cardiovascular Medicine
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Singular Coronary Artery Aneurysm: Imaging With Coronary Angiography
Versus 16-Slice Computed Tomography, Transesophageal Echocardiography,
and Magnetic Resonance Tomography. See p
e12.
False Aneurysm of the Ascending Aorta Caused by a Sternal Wire. See p e14. 
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Correspondence
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See p
e15.
Related Articles:
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Clinical Progression of Incidental, Asymptomatic Lesions Discovered During Culprit Vessel Coronary Intervention
- Ruchira Glaser, Faith Selzer, David P. Faxon, Warren K. Laskey, Howard A. Cohen, James Slater, Katherine M. Detre, and Robert L. Wilensky
Circulation 2005 111: 143-149.
[Abstract]
[Full Text]
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Mesenchymal Stem Cells Differentiate into an Endothelial Phenotype, Enhance Vascular Density, and Improve Heart Function in a Canine Chronic Ischemia Model
- Guilherme V. Silva, Silvio Litovsky, Joao A.R. Assad, Andre L.S. Sousa, Bradley J. Martin, Deborah Vela, Stephanie C. Coulter, Jing Lin, Judy Ober, William K. Vaughn, Rodrigo V.C. Branco, Edie M. Oliveira, Rumin He, Yong-Jian Geng, James T. Willerson, and Emerson C. Perin
Circulation 2005 111: 150-156.
[Abstract]
[Full Text]
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Cardiovascular Magnetic Resonance in Cardiac Amyloidosis
- Alicia Maria Maceira, Jayshree Joshi, Sanjay Kumar Prasad, James Charles Moon, Enrica Perugini, Idris Harding, Mary Noelle Sheppard, Philip Alexander Poole-Wilson, Philip Nigel Hawkins, and Dudley John Pennell
Circulation 2005 111: 186-193.
[Abstract]
[Full Text]
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Red Wine and Your Heart
- Paul E. Szmitko and Subodh Verma
Circulation 2005 111: e10-e11.
[Extract]
[Full Text]
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Singular Coronary Artery Aneurysm: Imaging With Coronary Angiography Versus 16-Slice Computed Tomography, Transesophageal Echocardiography, and Magnetic Resonance Tomography
- Hans-Peter Dübel, Volker Gliech, Adrian Borges, Marc Dewey, Dietmar Kivelitz, and Wolfgang Rutsch
Circulation 2005 111: e12-e13.
[Extract]
[Full Text]
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False Aneurysm of the Ascending Aorta Caused by a Sternal Wire
- Markus F. Müller and Judit Ferencz
Circulation 2005 111: e14.
[Extract]
[Full Text]
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Letters Regarding Article by Bibbons-Domingo et al, "B-Type Natriuretic Peptide and Ischemia in Patients With Stable Coronary Disease: Data From the Heart and Soul Study"
- Toshio Nishikimi and Hiroaki Matsuoka
Circulation 2005 111: e15.
[Extract]
[Full Text]
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