Circulation. 2005;111:2015
(Circulation. 2005;111:2015.)
© 2005 American Heart Association, Inc.
Issue Highlights
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CLINICAL AND ECHOCARDIOGRAPHIC DETERMINANTS OF LONG-TERM SURVIVAL AFTER SURGICAL MYECTOMY IN OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY, by Woo et al.
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The study by Woo et al is an update of the important surgical
experience with septal myectomy for obstructive hypertrophic
cardiomyopathy (HCM) over 25 years at Toronto General Hospital,
with an experienced operating surgeon. This is one of the most
important consecutive single-center surgery series for this
disease worldwide, representing the standard for surgical outcomes
for HCM. The clinical and echocardiographic predictors of long-term
survival and freedom from cardiovascular morbidity after myectomy
were (1) female gender (OR 3.3; 95% CI 2.0–5.4;
P<0.0001),
(2) history of preoperative atrial fibrillation (OR 1.9; 95%
CI 1.1–3.3;
P=0.02), and (3) preoperative left atrial
diameter
46 mm (OR 2.5; 95% CI 1.5–4.3;
P=0.0008). Myectomy
provided excellent relief for left ventricular outflow tract
obstruction in patients with HCM. Preoperative clinical and
echo variables help predict the long-term outcome after myectomy.
See p
2033.
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PIVOTAL ROLE FOR ENDOTHELIAL TETRAHYDROBIOPTERIN IN PULMONARY HYPERTENSION, by Khoo et al.
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Loss of endothelial nitric oxide bioavailability has been implicated
in the pathogenesis of pulmonary hypertension. Recent evidence
suggests that the cofactor tetrahydrobiopterin (BH4) is an important
regulator of nitric oxide synthase enzymatic function. Khoo
and colleagues use a range of complementary gene-modified murine
models to demonstrate that endothelial BH4 availability in the
pulmonary circulation regulates the pathophysiological response
to hypoxia, providing evidence for a novel and important role
for endothelial BH4 in the pulmonary vasculature. Endothelial
BH4 availability appears to be important in maintaining pulmonary
vascular homeostasis, is a mediator in the pathogenesis of pulmonary
hypertension, and may be a novel therapeutic target. See p
2126.
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EFFECTIVENESS AND SAFETY OF SIROLIMUS-ELUTING STENTS IN THE TREATMENT OF RESTENOSIS AFTER CORONARY STENT PLACEMENT, by Neumann et al.
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The advent of intracoronary stents has been a major advance
in the percutaneous treatment of symptomatic coronary artery
disease. However, in-stent restenosis has been an important
problem limiting the benefit of percutaneous coronary angioplasty.
Other than brachytherapy, clinicians have had few proven alternatives
for treating this problem. In this issue, Neumann and colleagues
have expanded our options for treating in-stent restenosis by
providing convincing evidence that sirolimus-eluting stents
represent a safe and effective means of treating in-stent restenosis.
This study represents an important advance in the percutaneous
treatment of recurrent coronary stenoses. See p
2107.
Visit www.circ.ahajournals.org:
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Images in Cardiovascular Medicine
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Magnetic Resonance Imaging Findings in Temporal Arteritis. See
p
e260.
No Delayed Enhancement on Contrast Magnetic Resonance Imaging With Takotsubo Cardiomyopathy. See p e261. 
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Correspondence
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Letter Regarding Article by McKechnie et al, "Prognostic Implication
of Anemia on In-Hospital Outcomes After Percutaneous Coronary
Intervention." See p
e263.
Letter Regarding Article by Sawhney et al, "Treatment of Left Anterior Descending Coronary Artery Disease With Sirolimus-Eluting Stents." See p e265.
Related Articles:
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Clinical and Echocardiographic Determinants of Long-Term Survival After Surgical Myectomy in Obstructive Hypertrophic Cardiomyopathy
- Anna Woo, William G. Williams, Richard Choi, E. Douglas Wigle, Evelyn Rozenblyum, Katie Fedwick, Samuel Siu, Anthony Ralph-Edwards, and Harry Rakowski
Circulation 2005 111: 2033-2041.
[Abstract]
[Full Text]
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Pivotal Role for Endothelial Tetrahydrobiopterin in Pulmonary Hypertension
- Jeffrey P. Khoo, Lan Zhao, Nicholas J. Alp, Jennifer K. Bendall, Taija Nicoli, Kirk Rockett, Martin R. Wilkins, and Keith M. Channon
Circulation 2005 111: 2126-2133.
[Abstract]
[Full Text]
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Effectiveness and Safety of Sirolimus-Eluting Stents in the Treatment of Restenosis After Coronary Stent Placement
- Franz-Josef Neumann, Walter Desmet, Eberhard Grube, Johannes Brachmann, Patrizia Presbitero, Paolo Rubartelli, Andreas Mügge, Francesco Di Pede, Diana Füllgraf, Wim Aengevaeren, Leonardo Spedicato, and Jeffrey J. Popma
Circulation 2005 111: 2107-2111.
[Abstract]
[Full Text]
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Magnetic Resonance Imaging Findings in Temporal Arteritis
- T.A. Bley, O. Wieben, J. Leupold, and M. Uhl
Circulation 2005 111: e260.
[Extract]
[Full Text]
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No Delayed Enhancement on Contrast Magnetic Resonance Imaging With Takotsubo Cardiomyopathy
- Kunihiko Teraoka, Shintaroh Kiuchi, Noriyo Takada, Masaharu Hirano, and Akira Yamashina
Circulation 2005 111: e261-e262.
[Extract]
[Full Text]
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Letter Regarding Article by McKechnie et al, "Prognostic Implication of Anemia on In-Hospital Outcomes After Percutaneous Coronary Intervention" • Response
- Holger Reinecke, Günter Breithardt, Mauro Moscucci, Ronald McKechnie, Dean Smith, Eva Kline-Rogers, David Share, Cecelia Montoye, Michael J. O’Donnell, Anthony C. DeFranco, William L. Meengs, Richard McNamara, John G. McGinnity, Kirit Patel, Arthur Riba, and Sanjaya Khanal
Circulation 2005 111: e263-e264.
[Extract]
[Full Text]
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Letter Regarding Article by Sawhney et al, "Treatment of Left Anterior Descending Coronary Artery Disease With Sirolimus-Eluting Stents" • Response
- Derk J. Drenth, Felix Zijlstra, Piet W. Boonstra, Neil Sawhney, Paul S. Teirstein, Jeffrey W. Moses, Martin B. Leon, Richard E. Kuntz, Jeffrey J. Popma, William Bachinsky, Theodore Bass, Samuel DeMaio, Edward Fry, and David R. Holmes, Jr
Circulation 2005 111: e265-e266.
[Extract]
[Full Text]
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