Circulation. 2005;111:1865
(Circulation. 2005;111:1865.)
© 2005 American Heart Association, Inc.
Issue Highlights
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ENLARGED WAIST COMBINED WITH ELEVATED TRIGLYCERIDES IS A STRONG PREDICTOR OF ACCELERATED ATHEROGENESIS AND RELATED CARDIOVASCULAR MORTALITY IN POSTMENOPAUSAL WOMEN, by Tankó et al.
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Is it really that easy to predict all-cause and cardiovascular
disease mortality in postmenopausal women—just a waist
circumference >88 cm (35 in) and fasting serum triglyceride
level >1.69 mmol/L (128 mg/dL)? Yes, according to a community-based
study of 557 women (48 to 76 years old) in Denmark who were
followed up for 8.5 years for all-cause and cardiovascular disease
mortality and the annual progression rate of aortic calcification.
With adjustments for age, smoking, and LDL cholesterol, a waist
circumference >88 cm and triglycerides >1.69 was associated
with a 4.7-fold increased risk, compared with 3.2-fold in women
with the metabolic syndrome as defined by the National Cholesterol
Education Program. Although these risks were not different,
more progression of aortic calcification was seen with the simpler
measure (
P<0.05) See p
1883.
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FATNESS IS A BETTER PREDICTOR OF CARDIOVASCULAR DISEASE RISK FACTOR PROFILE THAN AEROBIC FITNESS IN HEALTHY MEN, by Christou et al.
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Is it fatness or is it fitness? The literature is mixed, but
this detailed study of 135 carefully screened healthy men revealed
a relatively weak independent relationship between fitness and
cardiovascular disease risk with a much stronger inverse association
of various measures of fatness and cardiovascular disease risk.
This relative strength of fatness versus fitness was particularly
evident for hemodynamic versus metabolic cardiovascular disease
risk factors. The major limitation of this study is its cross-sectional
nature with already published longitudinal data favoring fitness
more than fatness. The bottom-line message is that neither fitness
nor fatness should be ignored. See p
1904.
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INFLAMMATORY CYTOKINES INTERLEUKIN-6 AND ONCOSTATIN M INDUCE PLASMINOGEN ACTIVATOR INHIBITOR-1 IN HUMAN ADIPOSE TISSUE, by Rega et al.
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Plasminogen activator inhibitor-1 is the primary inhibitor of
plasminogen activation. Levels are increased in obesity, and
adipose tissue is an important source of plasma plasminogen
activator inhibitor-1. Evidence for a novel pathway of plasminogen
activator inhibitor-1 stimulation by the gp130 (inflammatory)
ligands interleukin-6 and oncostatin M from human subcutaneous
and visceral adipose tissue is provided. This pathway of paracrine
regulation in adipose tissue may contribute to the increased
cardiovascular disease risk in patients with obesity. See p
1938.
Visit www.circ.ahajournals.org:
Cardiology Patient Page
Obesity. See p e257.
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ENLARGED WAIST COMBINED WITH...
FATNESS IS A BETTER...