This Article Abstract Full Text (PDF) All Versions of this Article: 111/12/1551    most recent 01.CIR.0000159354.43778.69v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jang, I.-K. Articles by Bouma, B. E. Search for Related Content PubMed PubMed Citation Articles by Jang, I.-K. Articles by Bouma, B. E. Related Collections Pathophysiology Imaging Coronary imaging: angiography/ultrasound/Doppler/CC Other imaging Related Article

(Circulation. 2005;111:1551-1555.)
© 2005 American Heart Association, Inc.

Vascular Medicine

In Vivo Characterization of Coronary Atherosclerotic Plaque by Use of Optical Coherence Tomography

Ik-Kyung Jang, MD, PhD; Guillermo J. Tearney, MD, PhD; Briain MacNeill, MD; Masamichi Takano, MD; Fabian Moselewski, BS; Nicusor Iftima, PhD; Milen Shishkov, PhD; Stuart Houser, MD; H. Thomas Aretz, MD; Elkan F. Halpern, PhD; Brett E. Bouma, PhD

From the Cardiology Division (I.-K.J., B.M., M.T., F.M.), the Wellman Center for Photomedicine (G.J.T., M.T., N.I., M.S., B.E.B.), the Department of Radiology (E.F.H.), and the Department of Pathology (G.J.T., S.H., H.T.A.), Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Correspondence to Ik-Kyung Jang, MD, PhD, Cardiology Division, Gray/Bigelow 800, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114. E-mail ijang{at}partners.org

Received September 25, 2004; revision received December 14, 2004; accepted December 21, 2004.

	Abstract

Top Abstract Introduction Methods Results Discussion References

 
Background— The current understanding of the pathophysiology of coronary artery disease is based largely on postmortem studies. Optical coherence tomography (OCT) is a high-resolution (10 µm), catheter-based imaging modality capable of investigating detailed coronary plaque morphology in vivo.

Methods and Results— Patients undergoing cardiac catheterization were enrolled and categorized according to their clinical presentation: recent acute myocardial infarction (AMI), acute coronary syndromes (ACS) constituting non-ST-segment elevation AMI and unstable angina, or stable angina pectoris (SAP). OCT imaging was performed with a 3.2F catheter. Two observers independently analyzed the images using the previously validated criteria for plaque characterization. Of 69 patients enrolled, 57 patients (20 with AMI, 20 with ACS, and 17 with SAP) had analyzable images. In the AMI, ACS, and SAP groups, lipid-rich plaque (defined by lipid occupying 2 quadrants of the cross-sectional area) was observed in 90%, 75%, and 59%, respectively (P=0.09). The median value of the minimum thickness of the fibrous cap was 47.0, 53.8, and 102.6 µm, respectively (P=0.034). The frequency of thin-cap fibroatheroma (defined by lipid-rich plaque with cap thickness 65 µm) was 72% in the AMI group, 50% in the ACS group, and 20% in the SAP group (P=0.012). No procedure-related complications occurred.

Conclusions— OCT is a safe and effective modality for characterizing coronary atherosclerotic plaques in vivo. Thin-cap fibroatheroma was more frequently observed in patients with AMI or ACS than SAP. This is the first study to compare detailed in vivo plaque morphology in patients with different clinical presentations.

Key Words: arteriosclerosis • coronary disease • imaging • plaque

	Introduction

Top Abstract Introduction Methods Results Discussion References

 
Autopsy studies suggest that acute coronary events most commonly arise from the disruption of thin-cap fibroatheromas (TCFA), known as vulnerable plaques.^1–3 The pathological features of the most common form of vulnerable plaques include a large lipid pool inside a plaque, a thin fibrous cap, and increased macrophage infiltration within the cap, resulting in expression of proteolytic enzymes that weaken the fibrous cap and ultimately promote plaque disruption.^1–3 Plaque disruption allows thrombogenic substrates, such as tissue factor and von Willebrand factor, to be exposed to the coronary circulation, resulting in the formation of a platelet-rich thrombus.^4–6 When the thrombus becomes occlusive, in the absence of collateral blood supply, myocyte ischemia ensues, leading to an acute myocardial infarction (AMI) or acute coronary syndromes (ACS). Conversely, stable angina pectoris (SAP) is thought to arise from angiographically severe or flow-limiting stenoses without plaque disruption or local thrombus formation. As such, SAP is thought to represent a simple mismatch of blood supply and demand. Although widely accepted, these paradigms are based largely on postmortem studies, because it has previously not been possible to accurately define coronary plaque morphology in vivo on a microscopic scale.

Optical coherence tomography (OCT) is an optical analogue of intravascular ultrasound that allows high-resolution (10 µm) tomographic intra-arterial imaging.^7–9 The OCT characteristics for various components of atheromatous plaque have been validated in a histology-controlled study.¹⁰ Furthermore, we have demonstrated the feasibility of OCT imaging in patients undergoing percutaneous coronary intervention (PCI).¹¹ The aim of the present study was to use OCT to evaluate the characteristics of culprit lesions in living patients with various clinical presentations.

	Methods

Top Abstract Introduction Methods Results Discussion References

 
Study Population
Patients with an identifiable culprit lesion in a native coronary artery were enrolled. Patients were excluded if they had significant left main disease, congestive heart failure, or renal insufficiency with baseline serum creatinine >1.8 mg/dL (>133 µmol/L) or required emergency or primary angioplasty. In addition, those with extremely tortuous vessels or with heavy calcification were excluded because of expected difficulty in advancing the OCT catheter. Intravascular ultrasound was performed before OCT imaging. Therefore, when the intravascular ultrasound imaging was not successful because of anatomic reasons, no attempt was made to advance the OCT catheter. The patients were categorized on the basis of their clinical presentation: ST-elevation AMI within the preceding 2 weeks, ACS including non-ST-elevation myocardial infarction and rest angina, or SAP. The institutional review board approved the study, and all patients provided informed consent before participation.

Image Acquisition
The culprit lesion was identified on the basis of a coronary angiogram. Other information from electrocardiography, nuclear or echocardiographic stress test, or intravascular ultrasound was used to confirm the culprit lesion. In patients with stable angina, a tightest lesion on coronary angiogram was selected, whereas a lesion with evidence of plaque rupture with or without local thrombus was chosen as a culprit lesion in patients with ACS and AMI.

The OCT catheter was initially advanced either to the area of the tightest stenosis or to an ulcerated area on the angiogram. After imaging of the center of a plaque, the catheter was moved to the proximal and distal shoulder regions. The technique of intravascular OCT imaging has been described previously.¹¹ Briefly, after administration of intracoronary nitroglycerin (100 to 200 µg), a 3.2F OCT catheter was advanced through a 7F catheter and over a 0.014-inch guidewire under fluoroscopic guidance to the culprit site. Images were obtained during intermittent saline flush (6 to 10 mL) through the guiding catheter to transiently displace blood. Subsequently, the OCT catheter was positioned at the proximal and distal shoulder regions of the culprit plaque, and imaging was repeated. The images were stored digitally for subsequent analysis.

OCT Data Collection and Analysis
Demographic and clinical data were prospectively collected. OCT images were analyzed by 2 independent investigators who were blinded to the clinical presentation using validated criteria for plaque characterization.¹⁰ When there was discordance between the observers, a consensus reading was obtained. For all images with an OCT-determined lipid pool, the fibrous cap thickness was measured at its thinnest part. Cap thicknesses for each image were measured at 3 different times, and the average value was computed. If a patient had more than 1 image within a plaque, the thinnest cap measurement was used for that patient. Lipid was semiquantified as the number of involved quadrants on the cross-sectional OCT image (Figure 1). When lipid was present in 2 quadrants in any of the images within a plaque, it was considered a lipid-rich plaque. For each patient, the cross-sectional image with the highest number of lipid quadrants was used for analysis. TCFA was defined as a plaque with lipid content in 2 quadrants and the thinnest part of a fibrous cap measuring 65 µm. The presence of plaque disruption, calcium, or a thrombus was also noted (Figure 2, A and B). A thrombus was defined as an irregular mass protruding into the lumen that had a measured dimension 250 µm. Interobserver and intraobserver variabilities were assessed by the evaluation of all the OCT images by 2 independent readers and by the same reader at 2 separate time points, respectively.

View larger version (30K): [in this window] [in a new window]   Figure 1. OCT images of 3 different types of atherosclerotic plaques. A, Lipid-rich plaque (L) covered by thin fibrous cap (arrow, magnified inset). B, Another type of lipid-rich plaque, but with thick fibrous cap. C, Dense, eccentric fibrous plaque (F) with no lipid component. A signal-rich, homogeneous reflective pattern is typical for fibrous tissue. In regions with no plaque (between 7 and 10 o’clock positions), intima, media, and adventitia are clearly visualized.

View larger version (59K): [in this window] [in a new window]   Figure 2. Examples of plaque disruption in patients with recent myocardial infarction. A, Large lipid-rich plaque (L) with localized rupture of a fibrous cap with a flap protruding into lumen (arrow). B, Severe disruption of plaque (arrows) with a large mural thrombus (T). Lipid is present in whole circumference (L). G indicates guidewire artifact.

Statistical Analysis
Data are expressed as mean±SD or median with range. Baseline characteristics were analyzed by use of the ² test, Fisher exact test, or a 1-way ANOVA, as appropriate. The frequency of various types of plaques or of TCFA was compared between groups by use of ² test or Fisher exact test. To control for multiple comparisons, pairwise tests of frequency were performed only if the contingency table for all 3 types of disease was significant. Because cap thickness was not normally distributed, a Kruskal-Wallis test was performed to test for significant differences of cap thickness with respect to the clinical presentation. Intraobserver and interobserver variabilities were measured by test of concordance. All analysis was performed using Statistical Analysis Software version 8 (SAS Institute). A P0.05 was required for statistical significance.

	Results

Top Abstract Introduction Methods Results Discussion References

 
A total of 69 patients were enrolled in the study. Twelve patients were excluded because imaging was performed only after PCI (n=7), the image quality precluded analysis (n=4), or the equipment malfunctioned (n=1). Among the remaining 57 patients with successful OCT imaging before coronary intervention, 20 patients presented with recent AMI, 20 patients with ACS, and 17 patients with SAP.

Baseline Characteristics
No significant differences were found in the demographic or baseline characteristics, including coronary risk factors, between the groups (Table 1). The distributions of the culprit artery were comparable among the groups.

View this table: [in this window] [in a new window]   TABLE 1. Baseline Characteristics

In the AMI group, the average time interval between the onset of symptoms and OCT imaging was 4.6±5.3 days. All AMI patients were initially managed medically, without primary PCI. Thrombolysis was administered in 8 patients, and the combination of a thrombolytic agent and a glycoprotein IIb/IIIa inhibitor was administered in 2 additional patients. Six patients received a glycoprotein IIb/IIIa inhibitor without thrombolysis. The combination of aspirin and heparin was used in 2 patients who were clinically stable after a late presentation. Eight patients had postinfarction recurrent angina. In the ACS group, the average time delay between the symptom onset and imaging was 3.3±1.7 days, excluding 1 patient who was imaged 3 weeks after the acute episode.

OCT Imaging
The OCT findings are summarized in Table 2. There was a trend toward higher frequency of lipid-rich plaque in patients with AMI or ACS compared with those with SAP. There were, however, significant differences among the groups with respect to the median values (range) for the minimum fibrous cap thickness: 47.0 (25.3 to 215.5) µm in the AMI group, 53.8 (18.7 to 184.3) µm in the ACS group, and 102.6 (22.0 to 291.1) µm in the SAP group, P=0.034). In addition, cap thicknesses were significantly different between the AMI and SAP groups (P=0.019) and the ACS and SAP groups (P=0.043) but not between the AMI and ACS groups (P=0.38). The frequency of TCFA was also significantly different among the groups (72%, 50%, and 20%, in the AMI, ACS, and SAP groups, respectively; P=0.012) (Figure 3). TCFA frequency was significantly different between the AMI and SAP groups (P=0.003) but not between the ACS and SAP groups (P=0.069) or the AMI and ACS groups (P=0.172). The percentage of patients with plaque disruption was not significantly different among the groups (25%, 15%, and 12%, in the AMI, ACS, and SAP groups, respectively). The difference in the frequency of calcification was significant among the groups (10% in the AMI group, 15% in the ACS group, and 41% in the SAP group, P=0.049). A thrombus was noted in 20% of the patients with AMI, 25% of those with ACS, and 35% of those with SAP.

View this table: [in this window] [in a new window]   TABLE 2. OCT Findings

View larger version (10K): [in this window] [in a new window]   Figure 3. Frequency of TCFA defined by lipid-rich plaque (2 quadrants) and fibrous cap thickness 65 µm. TCFA was observed in 72% of patients with AMI, in 50% of patients with ACS, and in 20% of patients with SAP (P=0.012).

All imaging procedures were performed without complication or adverse events. The average OCT imaging time per lesion site was less than 5 minutes.

Intraobserver and Interobserver Variability
Intraobserver variability yielded acceptable concordance for lipid-rich plaque (=0.86), plaque disruption (=0.68), calcification (=0.88), and thrombus (=0.74). Interobserver variability showed slightly lower concordance: lipid-rich plaque (=0.47), plaque disruption (=0.66), calcification (=57), and thrombus (=0.62).

	Discussion

Top Abstract Introduction Methods Results Discussion References

 
This is the first in vivo study of detailed coronary plaque morphology in patients with various clinical coronary presentations. This study also confirms the feasibility and safety of intravascular OCT for in vivo investigation of coronary atherosclerosis.

The findings of this study support our current understanding of the pathophysiology of coronary artery disease. Although there was a trend toward a higher frequency of lipid-rich plaque in patients with AMI or ACS compared with those with SAP, the differences were not statistically significant. Conversely, a significant difference was found in the thinnest fibrous cap thicknesses among the groups. The frequency of a TCFA was also significantly different among the groups. These findings indicate that although lipid is one of the main components for vulnerable plaque, thin fibrous cap may be a prerequisite for rupture of a plaque leading to AMI or ACS. This is consistent with previous pathological studies.^2,3,12–15

The frequency of plaque disruption was not significantly different between groups. This finding should be interpreted with caution, because we may have missed rupture locations because of the discrete sampling method used in this study and the possibility that the disruptions detected were iatrogenic. A recent intravascular ultrasound study demonstrated that 66% of patients with AMI had evidence of plaque rupture.¹⁶ This indicates that OCT probably underestimates the incidence of plaque rupture because of the discrete sampling method. The frequency of an intraluminal thrombus was not significantly different among the groups. This unexpected finding may have resulted from 2 factors. There was a time delay of up to 2 weeks between the acute event and imaging. It is possible that the prevalence of thrombus might have been higher had we imaged the plaques shortly after acute events in AMI or ACS patients. All the patients received thrombolytic or potent antithrombotic therapy. The combination of pharmacological intervention and an activated endogenous thrombolytic system could have dissolved some thrombi, especially in the AMI patients in whom the average delay between the acute event and the imaging was 4.6±5.3 days. In addition, with our thrombus size threshold of 250 µm, we could have detected small thrombi caused by a guidewire and therefore would have overestimated the frequency of thrombus in the stable angina patients. However, the finding of plaque rupture and thrombus in patients with stable angina is, in fact, not surprising. Similar findings were observed in previous angioscopic studies.^17–19 This may help to explain the benefit of antiplatelet therapy in the stable angina patient population.²⁰

There are several potential applications of this new imaging modality. With its high resolution and unique characteristics, it is a powerful modality for detection of vulnerable coronary plaque. The most frequent variant of a vulnerable plaque is characterized by a lipid pool, a thin fibrous cap, and increased macrophage infiltration,^2,3,12–15 each of which can be detected by OCT.^10,11,21 Quantitative analysis of these parameters over time may allow the monitoring of the effects of therapeutic interventions, including pharmacological therapy, gene therapy, or local mechanical therapy.

Another potential application of OCT is as an adjunct to PCI. Detailed structural information before and after coronary intervention can be evaluated with greater accuracy compared with intravascular ultrasound.^22,23 Over the past decade, the number of interventional devices and techniques has increased significantly. Precise plaque characterization optimizes the choice and evaluation of these percutaneous therapies.

Limitations
An inherent limitation of most light-based imaging modalities is the need to achieve a blood-free imaging zone, which in this study was achieved through intermittent saline flushes through the coronary guide catheter. However, even with this flushing technique, the image acquisition time was only a few seconds, which precluded imaging of long arterial segments. As a result, it is possible that we failed to image an exact rupture site or thrombus within a culprit lesion. A further limitation is the relatively shallow axial penetration (2 mm), but because the most important morphological determinants of plaque vulnerability are superficial, the region of greatest interest is within the imaging range of current OCT systems. Enhancements to OCT technology, including improvements in saline delivery, higher penetration depth, and faster acquisition rates, have already been demonstrated.^24,25 Second-generation OCT systems may allow screening of long coronary segments and eliminate many of the technical limitations of the present study.

Conclusions
The resolution of OCT provides histology-grade definition of the microstructure of coronary plaque in vivo and allows a greater understanding of the mechanisms of coronary artery disease. The frequency of thin fibrous cap and TCFA was significantly higher in patients with AMI and ACS compared with those with stable angina. This new technique may provide an opportunity to detect vulnerable plaques before rupture.

	Acknowledgments

 
This study was funded in part by the Center for Integration of Medicine and Innovative Technology (development of the imaging platform), the National Institutes of Health (grant R01-HL70039), Guidant Corporation, and a generous gift from Dr and Mrs J.S. Chen to the optical diagnostics program of the MGH Wellman Laboratories for Photomedicine. We thank our research staff at the Cardiovascular Clinical Research and nurses and technologists at the cardiac catheterization laboratories of the Massachusetts General Hospital.

Disclosure

Dr Jang served as a consultant for Guidant Corporation during the time this study was conducted.

	References

Top Abstract Introduction Methods Results Discussion References

 
1. Davies MJ. A macro and micro view of coronary vascular insult in ischemic heart disease. Circulation. 1990; 82 (suppl II): II-38–II-46.[Medline] [Order article via Infotrieve]

2. Falk E. Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis: characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi. Br Heart J. 1983; 50: 127–134.[Abstract/Free Full Text]

3. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000; 20: 1262–1275.[Free Full Text]

4. Fuster V, Badimon J, Chesebro JH, Fallon JT. Plaque rupture, thrombosis, and therapeutic implications. Haemostasis. 1996; 26 (suppl 4): 269–284.[Medline] [Order article via Infotrieve]

5. Fuster V, Fayad ZA, Badimon JJ. Acute coronary syndromes: biology. Lancet. 1999; 353: 115–119.

6. Libby P. Current concepts of the pathogenesis of the acute coronary syndromes. Circulation. 2001; 104: 365–372.[Free Full Text]

7. Bouma BE, Tearney GJ. Clinical imaging with optical coherence tomography. Acad Radiol. 2002; 9: 942–953.[CrossRef][Medline] [Order article via Infotrieve]

8. Fujimoto JG, Boppart SA, Tearney GJ, Bouma BE, Pitris C, Brezinski ME. High resolution in vivo intra-arterial imaging with optical coherence tomography. Heart. 1999; 82: 128–133.[Abstract/Free Full Text]

9. Fujimoto JG, Brezinski ME, Tearney GJ, Boppart SA, Bouma BE, Hee MR, Southern JF, Swanson EA. Optical biopsy and imaging using optical coherence tomography. Nat Med. 1995; 1: 970–972.[CrossRef][Medline] [Order article via Infotrieve]

10. Yabushita H, Bouma BE, Houser SL, Aretz HT, Jang IK, Schlendorf KH, Kauffman CR, Shishkov M, Kang DH, Halpern E, Tearney GJ. Characterization of human atherosclerosis by optical coherence tomography. Circulation. 2002; 106: 1640–1645.[Abstract/Free Full Text]

11. Jang IK, Bouma BE, Kang DH, Park SJ, Park SW, Seung KB, Choi KB, Shishkov M, Schlendorf K, Pomerantsev E, Houser SL, Aretz HT, Tearney GJ. Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. J Am Coll Cardiol. 2002; 39: 604–609.[Abstract/Free Full Text]

12. Davies MJ, Thomas A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. N Engl J Med. 1984; 310: 1137–1140.[Abstract]

13. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation. 1995; 92: 657–671.[Free Full Text]

14. Davies M. Stability and instability: two faces of coronary atherosclerosis: the Paul Dudley White Lecture. Circulation. 1995; 94: 2013–2020.

15. Davies MJ, Bland JM, Hangartner JR, Angelini A, Thomas AC. Factors influencing the presence or absence of acute coronary artery thrombi in sudden ischaemic death. Eur Heart J. 1989; 10: 203–208.[Abstract/Free Full Text]

16. Hong MK, Mintz GS, Lee CW, Kim YH, Lee SW, Song JM, Han KH, Kang DH, Song JK, Kim JJ, Park SW, Park SJ. Comparison of coronary plaque rupture between stable angina and acute myocardial infarction: a 3-vessel intravascular ultrasound study in 235 patients. Circulation. 2004; 110: 928–933.[Abstract/Free Full Text]

17. Uchida Y, Nakamura F, Tomaru T, Morita T, Oshima T, Sasaki T, Morizuki S, Hirose J. Prediction of acute coronary syndromes by percutaneous coronary angioscopy in patients with stable angina. Am Heart J. 1995; 30: 195–203.

18. Mizuno K, Miyamoto A, Satomura K, Kurita A, Arai T, Sakurada M, Yanagida S, Nakamura H. Angioscopic coronary macromorphology in patients with acute coronary disorders. Lancet. 1991; 337: 809–812.[CrossRef][Medline] [Order article via Infotrieve]

19. Ueda Y, Kondo N, Hirayama A, Kodama K. Assessment of plaque vulnerability by angioscopic classification of plaque color. Circulation. 2001; 104 (suppl II): II-68. Abstract.

20. de Feyter PJ, Ozaki Y, Baptista J, Escaned J, DiMario C, de Jaegere PP, Serruys PW, Roelandt JR. Ischemia-related lesion characteristics in patients with stable or unstable angina: a study with intracoronary angioscopy and ultrasound. Circulation. 1995; 92: 1408–1413.[Abstract/Free Full Text]

21. Tearney GJ, Yabushita H, Houser SL, Aretz HT, Jang IK, Schelndorf KH, Kauffman CR, Shishkov M, Halpern EF, Bouma BE. Quantification of macrophage content in atherosclerotic plaques by optical coherence tomography. Circulation. 2003; 107: 113–119.[Abstract/Free Full Text]

22. Bouma BE, Tearney GJ, Yabushita H, Shishkov M, Kauffman CR, DeJoseph Gauthier D, MacNeill BD, Houser SL, Aretz HT, Halpern EF, Jang IK. Evaluation of intracoronary stenting by intravascular optical coherence tomography. Heart. 2003; 89: 317–320.[Abstract/Free Full Text]

23. Jang IK, Tearney GJ, Bouma BE. Visualization of tissue prolapse between coronary stent struts by optical coherence tomography: comparison with intravascular ultrasound. Circulation. 2001; 104: 2754.[Free Full Text]

24. Yun SH, Tearney GJ, Bouma BE, Park BH, de Boer JF. High-speed spectral-domain optical coherence tomography at 1.3 µm wavelength. Optics Express. 2003; 11: 3598–3604.[Medline] [Order article via Infotrieve]

25. Yun SH, Tearney GJ, de Boer JF, Iftima N, Bouma BE. High-speed optical frequency-domain imaging. Optics Express. 2003; 11: 2953–2963.[Medline] [Order article via Infotrieve]

Related Article:

Issue Highlights
Circulation 2005 111: 1455. [Extract] [Full Text]

This article has been cited by other articles:

				F. Prati, E. Regar, G. S. Mintz, E. Arbustini, C. Di Mario, I.-K. Jang, T. Akasaka, M. Costa, G. Guagliumi, E. Grube, et al. Expert review document on methodology, terminology, and clinical applications of optical coherence tomography: physical principles, methodology of image acquisition, and clinical application for assessment of coronary arteries and atherosclerosis Eur. Heart J., November 4, 2009; (2009) ehp433v1. [Abstract] [Full Text] [PDF]

				C. M. Matter, M. Stuber, and M. Nahrendorf Imaging of the unstable plaque: how far have we got? Eur. Heart J., November 1, 2009; 30(21): 2566 - 2574. [Abstract] [Full Text] [PDF]

				H. M Garcia-Garcia, N. Gonzalo, E. Regar, and P. W Serruys Virtual histology and optical coherence tomography: from research to a broad clinical application Heart, August 15, 2009; 95(16): 1362 - 1374. [Full Text] [PDF]

				A. Tanaka, T. Imanishi, H. Kitabata, T. Kubo, S. Takarada, T. Tanimoto, A. Kuroi, H. Tsujioka, H. Ikejima, K. Komukai, et al. Lipid-rich plaque and myocardial perfusion after successful stenting in patients with non-ST-segment elevation acute coronary syndrome: an optical coherence tomography study Eur. Heart J., June 1, 2009; 30(11): 1348 - 1355. [Abstract] [Full Text] [PDF]

				H. Otake, J. Shite, J. Ako, T. Shinke, Y. Tanino, D. Ogasawara, T. Sawada, N. Miyoshi, H. Kato, B.-K. Koo, et al. Local Determinants of Thrombus Formation Following Sirolimus-Eluting Stent Implantation Assessed by Optical Coherence Tomography J. Am. Coll. Cardiol. Intv., May 1, 2009; 2(5): 459 - 466. [Abstract] [Full Text] [PDF]

				C. Boudoux, S. C. Leuin, W. Y. Oh, M. J. Suter, A. E. Desjardins, B. J. Vakoc, B. E. Bouma, C. J. Hartnick, and G. J. Tearney Optical Microscopy of the Pediatric Vocal Fold Arch Otolaryngol Head Neck Surg, January 1, 2009; 135(1): 53 - 64. [Abstract] [Full Text] [PDF]

				C. Di Mario, G. R. Heyndrickx, F. Prati, and N. H.J. Pijls CHAPTER 8 Invasive Imaging and Haemodynamics ESC Textbook of Cardiovascular Medicine, January 1, 2009; 2(1): med-9780199566990-chapter - med-9780199566990-chapter. [Abstract] [Full Text] [PDF]

				A. Tanaka, T. Imanishi, H. Kitabata, T. Kubo, S. Takarada, T. Tanimoto, A. Kuroi, H. Tsujioka, H. Ikejima, S. Ueno, et al. Morphology of Exertion-Triggered Plaque Rupture in Patients With Acute Coronary Syndrome: An Optical Coherence Tomography Study Circulation, December 2, 2008; 118(23): 2368 - 2373. [Abstract] [Full Text] [PDF]

				G. J. Tearney, S. Waxman, M. Shishkov, B. J. Vakoc, M. J. Suter, M. I. Freilich, A. E. Desjardins, W.-Y. Oh, L. A. Bartlett, M. Rosenberg, et al. Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging. J. Am. Coll. Cardiol. Img., November 1, 2008; 1(6): 752 - 761. [Abstract] [Full Text] [PDF]

				J. E. Muller and S. R. Dixon Googling the coronary: fiberoptics and a computer provide the answers. J. Am. Coll. Cardiol. Img., November 1, 2008; 1(6): 762 - 764. [Full Text] [PDF]

				M. Zimarino and R. De Caterina Long-term treatment strategies for atherothrombotic disease: do platelets define the course? Eur. Heart J. Suppl., November 1, 2008; 10(suppl_I): I8 - I13. [Abstract] [Full Text] [PDF]

				Y.L. Gu, M.L. Fokkema, and F. Zijlstra The Emerging Role of Thrombus Aspiration in the Management of Acute Myocardial Infarction Circulation, October 28, 2008; 118(18): 1780 - 1782. [Full Text] [PDF]

				F. J. H. Gijsen, J. J. Wentzel, A. Thury, F. Mastik, J. A. Schaar, J. C. H. Schuurbiers, C. J. Slager, W. J. van der Giessen, P. J. de Feyter, A. F. W. van der Steen, et al. Strain distribution over plaques in human coronary arteries relates to shear stress Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1608 - H1614. [Abstract] [Full Text] [PDF]

				O C Raffel, T Akasaka, and I-K Jang Cardiac optical coherence tomography Heart, September 1, 2008; 94(9): 1200 - 1210. [Full Text] [PDF]

				K. Fujii, M. Masutani, T. Okumura, D. Kawasaki, T. Akagami, A. Ezumi, T. Sakoda, T. Masuyama, and M. Ohyanagi Frequency and Predictor of Coronary Thin-Cap Fibroatheroma in Patients With Acute Myocardial Infarction and Stable Angina Pectoris: A 3-Vessel Optical Coherence Tomography Study J. Am. Coll. Cardiol., August 26, 2008; 52(9): 787 - 788. [Full Text] [PDF]

				T. Kubo, T. Imanishi, H. Kitabata, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, S. Takarada, et al. Comparison of vascular response after sirolimus-eluting stent implantation between patients with unstable and stable angina pectoris a serial optical coherence tomography study. J. Am. Coll. Cardiol. Img., July 1, 2008; 1(4): 475 - 484. [Abstract] [Full Text] [PDF]

				T. Sawada, J. Shite, H. M. Garcia-Garcia, T. Shinke, S. Watanabe, H. Otake, D. Matsumoto, Y. Tanino, D. Ogasawara, H. Kawamori, et al. Feasibility of combined use of intravascular ultrasound radiofrequency data analysis and optical coherence tomography for detecting thin-cap fibroatheroma Eur. Heart J., May 1, 2008; 29(9): 1136 - 1146. [Abstract] [Full Text] [PDF]

				B X Chen, F Y Ma, W Luo, J H Ruan, W L Xie, X Z Zhao, S H Sun, X M Guo, F Wang, T Tian, et al. Neointimal coverage of bare-metal and sirolimus-eluting stents evaluated with optical coherence tomography Heart, May 1, 2008; 94(5): 566 - 570. [Abstract] [Full Text] [PDF]

				J. A. Ambrose In Search of the "vulnerable plaque": can it be localized and will focal regional therapy ever be an option for cardiac prevention? J. Am. Coll. Cardiol., April 22, 2008; 51(16): 1539 - 1542. [Abstract] [Full Text] [PDF]

				B. K. Courtney, N. R. Munce, K. J. Anderson, A. S. Thind, G. Leung, P. E. Radau, F. S. Foster, I. A. Vitkin, R. S. Schwartz, A. J. Dick, et al. Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography's blind-spot Eur. Heart J., March 1, 2008; 29(5): 583 - 593. [Abstract] [Full Text] [PDF]

				T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, et al. Implication of plaque color classification for assessing plaque vulnerability a coronary angioscopy and optical coherence tomography investigation. J. Am. Coll. Cardiol. Intv., February 1, 2008; 1(1): 74 - 80. [Abstract] [Full Text] [PDF]

				F Prati, M Zimarino, E Stabile, G Pizzicannella, T Fouad, R Rabozzi, A Filippini, J Pizzicannella, M Cera, and R De Caterina Does optical coherence tomography identify arterial healing after stenting? An in vivo comparison with histology, in a rabbit carotid model Heart, February 1, 2008; 94(2): 217 - 221. [Abstract] [Full Text] [PDF]

				R. Bhindi, S. M. Munir, and K. M. Channon Optical Coherence Tomography in the Setting of an Acute Anterior Myocardial Infarction Circulation, October 2, 2007; 116(14): e366 - e367. [Full Text] [PDF]

				T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, et al. Assessment of Culprit Lesion Morphology in Acute Myocardial Infarction: Ability of Optical Coherence Tomography Compared With Intravascular Ultrasound and Coronary Angioscopy J. Am. Coll. Cardiol., September 4, 2007; 50(10): 933 - 939. [Abstract] [Full Text] [PDF]

				O. C. Raffel, G. J. Tearney, D. D. Gauthier, E. F. Halpern, B. E. Bouma, and I.-K. Jang Relationship Between a Systemic Inflammatory Marker, Plaque Inflammation, and Plaque Characteristics Determined by Intravascular Optical Coherence Tomography Arterioscler Thromb Vasc Biol, August 1, 2007; 27(8): 1820 - 1827. [Abstract] [Full Text] [PDF]

				S. Motoyama, T. Kondo, M. Sarai, A. Sugiura, H. Harigaya, T. Sato, K. Inoue, M. Okumura, J. Ishii, H. Anno, et al. Multislice Computed Tomographic Characteristics of Coronary Lesions in Acute Coronary Syndromes J. Am. Coll. Cardiol., July 24, 2007; 50(4): 319 - 326. [Abstract] [Full Text] [PDF]

				S. K. Nadkarni, M. C. Pierce, B. H. Park, J. F. de Boer, P. Whittaker, B. E. Bouma, J. E. Bressner, E. Halpern, S. L. Houser, and G. J. Tearney Measurement of Collagen and Smooth Muscle Cell Content in Atherosclerotic Plaques Using Polarization-Sensitive Optical Coherence Tomography J. Am. Coll. Cardiol., April 3, 2007; 49(13): 1474 - 1481. [Abstract] [Full Text] [PDF]

				D. Matsumoto, J. Shite, T. Shinke, H. Otake, Y. Tanino, D. Ogasawara, T. Sawada, O. L. Paredes, K.-i. Hirata, and M. Yokoyama Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomography Eur. Heart J., April 2, 2007; 28(8): 961 - 967. [Abstract] [Full Text] [PDF]

				S. Waxman, F. Ishibashi, and J. E. Muller Detection and Treatment of Vulnerable Plaques and Vulnerable Patients: Novel Approaches to Prevention of Coronary Events Circulation, November 28, 2006; 114(22): 2390 - 2411. [Full Text] [PDF]

				M. Kawasaki, B. E. Bouma, J. Bressner, S. L. Houser, S. K. Nadkarni, B. D. MacNeill, I.-K. Jang, H. Fujiwara, and G. J. Tearney Diagnostic Accuracy of Optical Coherence Tomography and Integrated Backscatter Intravascular Ultrasound Images for Tissue Characterization of Human Coronary Plaques J. Am. Coll. Cardiol., July 4, 2006; 48(1): 81 - 88. [Abstract] [Full Text] [PDF]

				B. Ibanez, J. Benezet-Mazuecos, F. Navarro, and J. Farre Takotsubo Syndrome: A Bayesian Approach to Interpreting Its Pathogenesis Mayo Clin. Proc., June 1, 2006; 81(6): 732 - 735. [Full Text] [PDF]

				E. Escolar, G. Weigold, A. Fuisz, and N. J. Weissman New imaging techniques for diagnosing coronary artery disease. Can. Med. Assoc. J., February 14, 2006; 174(4): 487 - 495. [Abstract] [Full Text] [PDF]

				F. L. Ruberg, J. Viereck, A. Phinikaridou, Y. Qiao, J. Loscalzo, and J. A. Hamilton Identification of cholesteryl esters in human carotid atherosclerosis by ex vivo image-guided proton MRS J. Lipid Res., February 1, 2006; 47(2): 310 - 317. [Abstract] [Full Text] [PDF]

This Article Abstract Full Text (PDF) All Versions of this Article: 111/12/1551    most recent 01.CIR.0000159354.43778.69v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jang, I.-K. Articles by Bouma, B. E. Search for Related Content PubMed PubMed Citation Articles by Jang, I.-K. Articles by Bouma, B. E. Related Collections Pathophysiology Imaging Coronary imaging: angiography/ultrasound/Doppler/CC Other imaging Related Article