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(Circulation. 2005;111:1383-1389.)
© 2005 American Heart Association, Inc.
Interventional Cardiology |
From Erasmus Medical Center (M.V., C.A.G.v.M., A.T.L.O., J.A., G.A.R.G., E.P.M., P.J.d.F., E.R., W.J.V.d.G., G.S., P.d.J., R.T.V.D., P.W.S.), and Department of Cardiothoracic Surgery (A.P.K.), Thoraxcenter, and Department of Cardiology, Medical Center Rijnmond Zuid (P.C.S.), Rotterdam, the Netherlands.
Correspondence to P.W. Serruys, MD, PhD, Thoraxcenter, Bd-406, Dr Molewaterplein 40, 3015-GD Rotterdam, The Netherlands. E-mail p.w.j.c.serruys{at}erasmusmc.nl
Received August 3, 2004; revision received December 7, 2004; accepted December 21, 2004.
| Abstract |
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Methods and Results From April 2001 to December 2003, 181 patients underwent percutaneous coronary intervention for LM stenosis at our institution. The first cohort consisted of 86 patients (19 protected LM) treated with bare metal stents (pre-DES group); the second cohort comprised 95 patients (15 protected LM) treated exclusively with DES. The 2 cohorts were well balanced for all baseline characteristics. At a median follow-up of 503 days (range, 331 to 873 days), the cumulative incidence of major adverse cardiovascular events was lower in the DES cohort than in patients in the pre-DES group (24% versus 45%, respectively; hazard ratio [HR], 0.52 [95% CI, 0.31 to 0.88]; P=0.01). Total mortality did not differ between cohorts; however, there were significantly lower rates of both myocardial infarction (4% versus 12%, respectively; HR, 0.22 [95% CI, 0.07 to 0.65]; P=0.006) and target vessel revascularization (6% versus 23%, respectively; HR, 0.26 [95% CI, 0.10 to 0.65]; P=0.004) in the DES group. On multivariate analysis, use of DES, Parsonnet classification, troponin elevation at entry, distal LM location, and reference vessel diameter were independent predictors of major adverse cardiovascular events.
Conclusions When percutaneous coronary intervention is undertaken at LM lesions, routine DES implantation, which reduces the cumulative incidence of myocardial infarction and the need for target vessel revascularization compared with bare metal stents, should currently be the preferred strategy.
Key Words: stents angioplasty arteries
| Introduction |
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The purpose of the present study was to investigate, in this subset of patients undergoing revascularization in a tertiary referral center, the differential impact of DES as opposed to conventional BMS on the occurrence of short- and long-term major cardiovascular events.
| Methods |
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From April 16, 2002, to December 31, 2003, a total of 95 consecutive patients were treated exclusively with
1 DES in the LM as part of an elective or nonelective revascularization procedure and constitute the DES group of the present report. Fifty-two patients in the first cohort (of whom procedural details and medium-term follow-up were previously reported for 317), received SES exclusively (available, at that time, in diameters from 2.25 to 3.00 mm), whereas in the following group of 43 patients, PES (available in diameters from 2.25 to 3.5 mm) were implanted. A control group for comparison was composed of 86 consecutive patients who received conventional BMS (available in diameters from 2.5 to 5.00 mm) for LM treatment in the period immediately before the introduction of SES. The following BMS were used: BX Sonic or BX Velocity in 35% (Cordis, Johnson & Johnson Company), R-Stent in 29% (Orbus Medical Technologies), Multi-Link Penta in 28% (Guidant Corp), Multi-Link Tetra in 8% (Guidant Corp), and other stents in 4%. Therefore, the total study population comprised all 181 consecutive patients who underwent percutaneous LM treatment from April 2001 to December 2003 with either BMS or DES in the 2 study phases, respectively. To stratify the study population into high and lowsurgical risk groups, the Parsonnet surgical risk score was calculated for each patient.8 A score >15 was used to identify patients at high risk, as previously suggested.6,9 Protected LM segment was defined as the presence of at least 1 patent arterial or venous conduit to at least 1 left coronary segment. Nonelective treatment was defined as a procedure performed on referral before the beginning of the next working day.10
This protocol was approved by the hospital ethics committee and is in accordance with the Declaration of Helsinki. Written informed consent was obtained from every patient.
Procedures and Postintervention Medications
All interventions were performed according to current standard guidelines, and the final interventional strategy, including the use of glycoprotein IIb/IIIa inhibitors, was left entirely to the discretion of the operator, except for the stent utilization. Angiographic success was defined as residual stenosis <30% by visual analysis in the presence of Thrombolysis in Myocardial Infarction (TIMI) 3 flow grade. All patients were advised to maintain the use of aspirin lifelong. One-month clopidogrel treatment (75 mg/d) was recommended for patients treated in the pre-DES phase. For patients treated with either SES or PES, clopidogrel was prescribed for 6 months.
End Point Definitions and Clinical Follow-Up
The primary outcome was the occurrence of major adverse cardiac events, defined as (1) death, (2) nonfatal myocardial infarction (MI), or (3) target vessel revascularization. Patients with >1 event have been assigned the highest ranked event, according to the previous list. All deaths were considered to be of cardiac origin unless a noncardiac origin was established clinically or at autopsy. MI was diagnosed by a rise in the creatine kinase level to more than twice the upper normal limit with an increased creatine kinase-MB fraction. Target vessel revascularization was defined as a repeated intervention (surgical or percutaneous) to treat a luminal stenosis within the stent or in the 5-mm distal or proximal segments adjacent to the stent, including the ostium of the left anterior descending artery (LAD) and/or circumflex artery. Information about in-hospital outcomes was obtained from an electronic clinical database for patients maintained at our institution and by review of hospital records for those discharged to referring hospitals (patients were referred from a total of 14 local hospitals). Postdischarge survival status was obtained from the Municipal Civil Registries. Information on occurrence of MI or repeated interventions at follow-up was collected by consulting our institutional electronic database and by contacting referring physicians and institutions and all living patients.
Statistical Analysis
Continuous variables are shown as mean±SD and were compared by Student unpaired t test. Categorical variables are presented as counts and percentages and were compared with the Fisher exact test. Survival curves were generated by the Kaplan-Meier method, and survival among groups was compared with the log-rank test. Cox proportional hazards models were used to assess risk reduction of adverse events. Patients lost to follow-up were considered at risk until the date of last contact, at which point they were censored. Univariate analysis was performed with the consideration of all variables reported in Tables 1 and 2
. Multivariate analyses, with consideration of all variables with a value of P<0.10, were performed to identify independent predictors of adverse events. Probability was significant at a level of <0.05. All statistical tests were 2-tailed. Statistical analysis was performed with the use of Statistica 6.1 (Statsoft Inc).
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| Results |
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Thirty-Day Outcomes
There were no significant differences between the DES and the pre-DES groups in the incidence of major adverse cardiovascular events during the first 30 days (Table 3). In the DES group, all deaths except 3 occurred in patients presenting with ST-segment elevation acute MI and cardiogenic shock at entry. In all these patients except 4 with severe peripheral artery disease, an intra-aortic balloon was placed during PCI. In the elective population, a total of 2 deaths occurred; both patients presented with unstable angina with mild troponin elevation and were refused by surgeons because of old age (84 years), low left ventricular ejection fraction (
30%), and diabetic chronic renal insufficiency in 1 patient and diffuse 3-vessel disease associated with small-caliber vessels in the second. In this second patient the right coronary artery was occluded. The reason for death was pulmonary infection, which developed 19 days after the procedure in the first patient, and cardiogenic shock, which developed during the intervention, resistant to hemodynamic support (left ventricular assist device) in the other patient. In the pre-DES group, all 6 deaths occurred in patients with ST-segment elevation acute MI, of whom 4 were in cardiogenic shock at entry. No documented thrombotic stent occlusion occurred in the first 30 days or thereafter.
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Long-Term Outcome
After a median follow-up of 503 days (range, 331 to 873 days), the cumulative incidence of major adverse cardiovascular events (death, MI, or target vessel revascularization) was significantly lower in the DES patients than in the pre-DES patients (24% versus 45%, respectively; hazard ratio [HR], 0.52 [95% CI, 0.31 to 0.88]; P=0.01) (Figure, A). Mortality was similar in the DES (14%) and pre-DES cohort (16%; HR, 0.79 [95% CI, 0.38 to 1.66]; P=0.54) (Figure, B), whereas there was a significant reduction in both the rate of MI (4% versus 12%, respectively; HR, 0.22 [95% CI, 0.07 to 0.65]; P=0.006) and composite death/MI (Figure, C) as well as in the need for target vessel revascularization (6% versus 23%, respectively; HR, 0.26 [95% CI, 0.10 to 0.65]; P=0.004) (Figure, D) in the DES group. Seventy-four percent of the deaths were cardiac, whereas 3 of 13 in the DES group and 4 of 14 in the pre-DES phase were attributed to extracardiac reasons. In Table 4, the baseline and procedural characteristics of those patients in the DES group who underwent target vessel revascularization during follow-up are reported. In all cases, the lesion was located in the distal LM, in 50% of cases diabetes was present, and all except 1 were women. In 3 cases, in-stent restenosis occurred; in 2 patients intimal hyperplasia developed at the distal edge of the stent, whereas in 1 patient severe ostial side branch restenosis (circumflex artery) necessitated reintervention. In all cases, restenosis was focal (<10 mm in length) and was successfully treated with repeated PCI. In the pre-DES group, 13 cases of pure in-stent restenosis, of which 3 were focal, were treated with PCI (9 patients) or CABG (4 patients). In 2 patients, diffuse intimal hyperplasia associated with progression of atherosclerotic disease in other vessels was treated with CABG, and in 5 patients (3 with ST-segment elevation acute MI as the indication for LM intervention), staged reintervention with CABG (in 4 patients) and PCI (in 1 patient) was performed because revascularization remained incomplete at the time of the index procedure.
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Predictors of Adverse Events
The Parsonnet score, ranging from 2.5 to 55.5 (mean value, 18±2; interquartile range, 16.5) was 16±11 and 19±12 in the pre-DES and DES groups, respectively (P=0.17) (Table 1), with a trend toward a higher rate of patients considered at high surgical risk (58% versus 46%, respectively; P=0.13) in the DES compared with the pre-DES cohort.
On univariate analysis, Parsonnet classification, use of intra-aortic balloon pump, presence of shock at entry, lesion located in the distal LM, nonelective PCI, troponin elevation at entry, TIMI flow grade before and after PCI, reference vessel diameter, left ventricular ejection fraction, and the use of DES were identified as significant predictors of adverse events. On multivariate analysis, Parsonnet classification, troponin elevation at entry, lesions located at distal site, reference vessel diameter, and the use of DES were independent predictors of major adverse cardiovascular events (Table 5).
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| Discussion |
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16%.6 In that series, 28% of the population was at high surgical risk. More than 50% of our study population was at high surgical risk according to the Parsonnet classification, thus explaining the relatively high rate of adverse events we observed. In this setting, when patients treated with DES were compared with those treated with BMS, a marked benefit with respect to the rate of major adverse cardiac events, as evidenced by a 47% relative risk reduction, emerged in the former. This was mainly due to the difference in the incidence of MI (67% relative risk reduction) and target vessel revascularization (65% relative risk reduction), with no effect on mortality. The higher prevalence of 3-vessel disease and bifurcation stenting in the DES group makes the observed benefit even more convincing. The difference in the incidence of events between the 2 groups emerged slowly after the procedure, with no clear advantage at 30 days, possibly reflecting the specific mechanism of action of DES on intimal hyperplasia. The overall advantage of DES remained significant after adjustment for the Parsonnet score, the anatomic site of obstruction, and troponin status at entry. Therefore, our data suggest that when percutaneous treatment of LM coronary artery disease is undertaken, DES should be used as the default strategy.
The LM bifurcation was frequently involved (>60%) in our series, and even when the obstruction was more proximally located and did not directly involve the LAD or left circumflex artery ostia, its treatment often required the management of LM bifurcation. To date, the results of SES implantation to treat bifurcated lesions have been relatively disappointing, with high rates of restenosis in the side branch.11 Our present findings are in keeping with these previous observations, confirming that in the DES era distal LM location is an independent predictor of adverse events at follow-up. Furthermore, because the strategy and technical aspects of bifurcation management were left entirely to the preference of treating physicians, no clear conclusions can be drawn in this regard.
Inconsistent findings have been reported thus far with regard to the effect of DES on long-term cumulative incidence of MI. In the first randomized clinical trials comparing SES or PES with BMS, no difference in the incidence of MI was observed.12,13 Second-generation randomized trials assessing the benefit of DES in patients selected to be at intermediate risk for in-stent restenosis or all-inclusive registries reported trends toward MI reduction in the DES group, but none of them reached statistical significance.14,15 Recently, a clear reduction in the cumulative incidence of MI in the DES group was reported in the SES-SMART trial, in which a selected group of high-risk patients has been evaluated.16 Similarly, in our patient population, a reduced incidence of MI was observed in the DES group. Of note, 2 and 1 cases of MI in the pre-DES phase were related to target vessel revascularization and not related to target vessel revascularization, respectively. Whether this difference between studies is the reflection of a type II error in studies enrolling patients at low or intermediate risk remains unclear, but when the retrospective nature of our investigation is considered, data from prospective studies are needed to confirm our findings.
Limitations of the Study
The present study is a single-center experience from a tertiary referral center and lacks the clear advantages of a multicenter randomized study. In keeping with the aim of our investigation, an "all-comers" population has been enrolled, clearly resulting in a heterogeneous group of patients. Further studies, with larger sample sizes, are required to investigate the differential impact of DES versus BMS in prespecified subgroups, stratified according to clinical presentation (stable versus unstable) or protected versus unprotected type of treatment.
Despite the fact that the study was conducted over a relatively short period, we cannot exclude the possibility that improvements in technique or differences in drug prescription could have partially accounted for the difference observed in terms of major adverse cardiovascular events between groups. However, conducting randomized trials that seek to assess the efficacy of DES versus BMS in this specific subset of patients seems unlikely, and our understanding of the benefit of drug-coated stents to treat this group of patients will probably also rely in the near future on well-conducted registries that are able to record and monitor our daily clinical practice.
Conclusions
The use of DES as a default strategy to treat LM disease was associated with a significant reduction in adverse events. The effectiveness of DES persisted even after adjustment for clinical and procedural variables, including the Parsonnet surgical risk score. Our findings apply to a selected group of patients referred for percutaneous LM treatment and suggest that in this setting routine DES implantation, by reducing the cumulative incidence of major adverse cardiovascular events, should be currently regarded as the strategy of choice. Until new evidence is provided by randomized clinical trials directly comparing the surgical and percutaneous approaches, CABG should remain the preferred revascularization treatment in good surgical candidates presenting with LM coronary artery disease.
| Acknowledgments |
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| References |
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