Circulation. 2005;111:1351
(Circulation. 2005;111:1351.)
© 2005 American Heart Association, Inc.
Issue Highlights
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MOLECULAR MAGNETIC RESONANCE IMAGING OF CORONARY THROMBOSIS AND PULMONARY EMBOLI WITH A NOVEL FIBRIN-TARGETED CONTRAST AGENT, by Spuentrup et al.
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Thrombus formation may be responsible for both coronary and
pulmonary embolic disease; however, localizing thrombi in vivo
is difficult. Imaging techniques that could differentiate the
location of thrombus would be of utility for both diagnosis
and prognosis. In this issue of
Circulation, Spuentrup and colleagues
utilize a novel fibrin-specific contrast agent in targeted magnetic
resonance imaging to attempt to localize thrombi in an animal
model. They report that this method can selectively localize
thrombi in the heart, coronary arteries, and pulmonary vasculature.
Although these are early animal studies, the potential for this
technique to localize thrombus in vivo using magnetic resonance
imaging has obvious clinical implications. See p
1377.
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SHORT- AND LONG-TERM CLINICAL OUTCOME AFTER DRUG-ELUTING STENT IMPLANTATION FOR THE PERCUTANEOUS TREATMENT OF LEFT MAIN CORONARY ARTERY DISEASE: INSIGHTS FROM THE RAPAMYCIN-ELUTING AND TAXUS STENT EVALUATED AT ROTTERDAM CARDIOLOGY HOSPITAL REGISTRIES (RESEARCH AND T-SEARCH), by Valgimigli et al.
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Patients with high-risk lesions for percutaneous coronary intervention,
such as a critical left main stenosis, are often referred for
surgical revascularization because of patient- and lesion-specific
characteristics as well as the potential for major adverse events
with a percutaneous procedure. It has been demonstrated previously
that stent placement in the left main coronary artery is feasible,
and several series have reported on the safety and efficacy
of this procedure in selected patient populations. Despite the
success of this procedure, restenosis remains a serious and
potentially fatal adverse event associated with this strategy.
Although drug-eluting stents have reduced restenosis rates significantly,
the experience with these stents in left main coronary artery
percutaneous revascularization procedures has not been fully
evaluated. In issue of
Circulation, Valgimigli et al report
on the short- and long-term outcomes of patients who underwent
left main revascularization with a drug-eluting stent in the
RESEARCH and T-SEARCH registries. See p
1383.
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PLAQUE RUPTURE AFTER SHORT PERIODS OF FAT FEEDING IN THE APOLIPOPROTEIN E–KNOCKOUT MOUSE: MODEL CHARACTERIZATION AND EFFECTS OF PRAVASTATIN TREATMENT, by Johnson et al.
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It is now well established that acute rupture of atherosclerotic
plaques is the inciting event in most acute manifestations of
atherosclerosis. Unfortunately, our understanding of the events
that result in plaque rupture is very limited. One major obstacle
to studying plaque rupture is the lack of appropriate animal
models and good data on the incidence of plaque rupture during
the development of atherosclerosis. In this issue, work from
the Bristol Heart Institute starts to address these knowledge
gaps with the characterization of plaque rupture in a mouse
model of atherosclerosis. The investigators also have determined
the effects of statin treatment in this model, and this is an
important initial contribution to understanding how plaques
rupture and how we can influence this phenomenon. See p
1422.
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Clinician Update
Treatment of Aortic Disease in Patients With Marfan Syndrome.
See p
e150.
Images in Cardiovascular Medicine
Follow-Up of Cardiac Sarcoidosis by Magnetic Resonance Imaging. See p e158.
Himalayan T Waves in the Congenital Long-QT Syndrome. See p e161. 
Related Articles:
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Molecular Magnetic Resonance Imaging of Coronary Thrombosis and Pulmonary Emboli With a Novel Fibrin-Targeted Contrast Agent
- Elmar Spuentrup, Arno Buecker, Marcus Katoh, Andrea J. Wiethoff, Edward C. Parsons, Jr, Rene M. Botnar, Robert M. Weisskoff, Philip B. Graham, Warren J. Manning, and Rolf W. Günther
Circulation 2005 111: 1377-1382.
[Abstract]
[Full Text]
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Short- and Long-Term Clinical Outcome After Drug-Eluting Stent Implantation for the Percutaneous Treatment of Left Main Coronary Artery Disease: Insights From the Rapamycin-Eluting and Taxus Stent Evaluated At Rotterdam Cardiology Hospital Registries (RESEARCH and T-SEARCH)
- Marco Valgimigli, Carlos A.G. van Mieghem, Andrew T.L. Ong, Jiro Aoki, Gaston A. Rodriguez Granillo, Eugene P. McFadden, Arie Pieter Kappetein, Pim J. de Feyter, Pieter C. Smits, Evelyn Regar, Willem J. Van der Giessen, George Sianos, Peter de Jaegere, Ron T. Van Domburg, and Patrick W. Serruys
Circulation 2005 111: 1383-1389.
[Abstract]
[Full Text]
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Plaque Rupture After Short Periods of Fat Feeding in the Apolipoprotein E–Knockout Mouse: Model Characterization and Effects of Pravastatin Treatment
- Jason Johnson, Kevin Carson, Helen Williams, Sharada Karanam, Andrew Newby, Gianni Angelini, Sarah George, and Christopher Jackson
Circulation 2005 111: 1422-1430.
[Abstract]
[Full Text]
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Treatment of Aortic Disease in Patients With Marfan Syndrome
- Dianna M. Milewicz, Harry C. Dietz, and D. Craig Miller
Circulation 2005 111: e150-e157.
[Full Text]
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Follow-Up of Cardiac Sarcoidosis by Magnetic Resonance Imaging
- Norbert I. Stauder, Birgit Bader, Michael Fenchel, Ulrich Kramer, Volker Kühlkamp, and Stephan Miller
Circulation 2005 111: e158-e160.
[Full Text]
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Himalayan T Waves in the Congenital Long-QT Syndrome
- Dawood Darbar, Dan M. Roden, Muhammed F. Ali, Tao Yang, and Mark S. Wathen
Circulation 2005 111: e161.
[Full Text]
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