(Circulation. 2005;111:1.)
© 2005 American Heart Association, Inc.
Issue Highlights
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FUNCTIONAL INTEGRATION OF ELECTRICALLY ACTIVE CARDIAC DERIVATIVES FROM GENETICALLY ENGINEERED HUMAN EMBRYONIC STEM CELLS WITH QUIESCENT RECIPIENT VENTRICULAR CARDIOMYOCYTES: INSIGHTS INTO THE DEVELOPMENT OF CELL-BASED PACEMAKERS, by Xue et al.
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Feasibility of human embryonic stem cell transplantation for
reestablishing a cardiac pacemaker was tested by harvesting
spontaneously beating outgrowths of human embryoid bodies that
are known to contain cardiomyocytes. These cells are shown to
be capable of electrically driving monolayers of neonatal rat
ventricular myocytes in culture. The beating rate can be manipulated
pharmacologically. Injection into guinea pig ventricle established
a functioning pacemaker that could drive the ventricles in explanted
Langendorff preparations 2 or 3 days after cell transplantation.
This work could lead to genetically engineered pacemakers for
cell transplantation therapy of bradyarrhythmias. See p
11.
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FUNCTIONAL VARIANT OF CYP4A11 20-HYDROXYEICOSATETRAENOIC ACID SYNTHASE IS ASSOCIATED WITH ESSENTIAL HYPERTENSION, by Gainer et al.
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Data from a number of large-scale cohort studies indicate that
a significant component of hypertension is heritable. Except
for a few rare syndromes, however, the precise molecular cause
of hypertension in the general population has been elusive-largely,
it is believed, because of the polygenic nature of hypertension.
In this issue, Gainer and colleagues shed light on one genetic
trait associated with hypertension. The investigators found
a functionally significant polymorphism of a cytochrome p450
isoform that segregates with hypertension. This study could
provide a new focus for the investigation of hypertension and
the role of cytochrome p450 enzymes. See p
63.
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GALLIC ACID ANTAGONIZES P-SELECTIN–MEDIATED PLATELET–LEUKOCYTE INTERACTIONS: IMPLICATIONS FOR THE FRENCH PARADOX, by Appeldoorn et al.
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It is still unclear why there is a lower incidence of cardiovascular
disease in Mediterranean countries despite diets containing
high levels of saturated fat. One hypothesis is that the antioxidant
content of red wines contributes to this ‘French paradox.‘
Appeldoorn and colleagues study whether gallic acid, an abundant
polyphenol and antioxidant found in red wine, alters the adhesion
of leukocytes to the endothelium. They found that gallic acid
interferes with platelet-leukocyte binding and adhesion to the
endothelium by antagonizing P-selectin. These studies suggest
a mechanism by which a common compound contained in red wine
may inhibit the atherosclerotic process. See p
106.
Visit www.circ.ahajournals.org:
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Clinician Update
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Prevention of Venous Thromboembolism Among Hospitalized Medical
Patients. See p
e1.
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Images in Cardiovascular Medicine
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Left Common Carotid Artery Isolation in a Newborn With Tetralogy
of Fallot and DiGeorge Syndrome. See p
e4.
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Correspondence
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Letters Regarding Article by Khot et al, "Radial Artery Bypass
Grafts Have an Increased Occurrence of Angiographically Severe
Stenosis and Occlusion Compared With Left Internal Mammary Arteries
and Saphenous Vein Grafts." See p
e6.
Related Articles:
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Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension
- James V. Gainer, Aouatef Bellamine, Elliott P. Dawson, Kristie E. Womble, Sarah W. Grant, Yarong Wang, L. Adrienne Cupples, Chao-Yu Guo, Serkalem Demissie, Christopher J. O’Donnell, Nancy J. Brown, Michael R. Waterman, and Jorge H. Capdevila
Circulation 2005 111: 63-69.
[Abstract]
[Full Text]
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Functional Integration of Electrically Active Cardiac Derivatives From Genetically Engineered Human Embryonic Stem Cells With Quiescent Recipient Ventricular Cardiomyocytes: Insights Into the Development of Cell-Based Pacemakers
- Tian Xue, Hee Cheol Cho, Fadi G. Akar, Suk-Ying Tsang, Steven P. Jones, Eduardo Marbán, Gordon F. Tomaselli, and Ronald A. Li
Circulation 2005 111: 11-20.
[Abstract]
[Full Text]
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Gallic Acid Antagonizes P-Selectin–Mediated Platelet–Leukocyte Interactions: Implications for the French Paradox
- Chantal C.M. Appeldoorn, Arnaud Bonnefoy, Bianca C.H. Lutters, Kim Daenens, Theo J.C. van Berkel, Marc F. Hoylaerts, and Erik A.L. Biessen
Circulation 2005 111: 106-112.
[Abstract]
[Full Text]
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Prevention of Venous Thromboembolism Among Hospitalized Medical Patients
- Samuel Z. Goldhaber and Alexander G.G. Turpie
Circulation 2005 111: e1-e3.
[Extract]
[Full Text]
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Left Common Carotid Artery Isolation in a Newborn With Tetralogy of Fallot and DiGeorge Syndrome
- Guido Oppido, Carlo Pace Napoleone, Davide Gabbieri, Alessandro Giardini, Roberto Formigari, Sofia Martin-Suarez, Fernando M. Picchio, and Gaetano Gargiulo
Circulation 2005 111: e4-e5.
[Extract]
[Full Text]
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Letters Regarding Article by Khot et al, "Radial Artery Bypass Grafts Have an Increased Occurrence of Angiographically Severe Stenosis and Occlusion Compared With Left Internal Mammary Arteries and Saphenous Vein Grafts" • Letters Regarding Article by Khot et al, "Radial Artery Bypass Grafts Have an Increased Occurrence of Angiographically Severe Stenosis and Occlusion Compared With Left Internal Mammary Arteries and Saphenous Vein Grafts" • Letters Regarding Article by Khot et al, "Radial Artery Bypass Grafts Have an Increased Occurrence of Angiographically Severe Stenosis and Occlusion Compared With Left Internal Mammary Arteries and Saphenous Vein Grafts" • Letters Regarding Article by Khot et al, "Radial Artery Bypass Grafts Have an Increased Occurrence of Angiographically Severe Stenosis and Occlusion Compared With Left Internal Mammary Arteries and Saphenous Vein Grafts" • Response
- Christophe Acar, Richard C. Cook, Shahzad G. Raja, Shahrul Hashim, Inderpaul Birdi, Pallav J. Shah, Robert A. Baker, John J. Knight, Umesh N. Khot, Daniel T. Friedman, Gosta Pettersson, Nicholas G. Smedira, Jianbo Li, and Stephen G. Ellis
Circulation 2005 111: e6-e9.
[Extract]
[Full Text]
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