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(Circulation. 2003;108:983.)
© 2003 American Heart Association, Inc.
Clinical Investigation and Reports |
From the Quebec Heart Institute/Laval Hospital, Laval University, Sainte-Foy, Quebec, Canada.
Correspondence to Dr Pibarot, Quebec Heart Institute, 2725 Chemin Sainte-Foy, Sainte-Foy G1V-4G5, Quebec, Canada. E-mail philippe.pibarot{at}med.ulaval.ca
Received September 13, 2002; de novo received April 24, 2003; revision received June 2, 2003; accepted June 4, 2003.
| Abstract |
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Methods and Results The indexed valve effective orifice area (EOA) was estimated for each type and size of prosthesis being implanted in 1266 consecutive patients and used to define PPM as not clinically significant if >0.85 cm2/m2, as moderate if >0.65 cm2/m2 and
0.85 cm2/m2, and as severe if
0.65 cm2/m2; it was correlated with 30-day mortality and compared with other relevant variables. Moderate or severe PPM was present in 38% of patients. Thirty-day mortality was 4.6% (58/1266 patients) and the strongest independent predictors in multivariate analysis were left ventricular ejection fraction <40% (P=0.007), infectious endocarditis (P=0.002), emergent/salvage operation (P=0.002), cardiopulmonary bypass time >120 minutes (P=0.001), and PPM (P=0.003). Relative risk of mortality was increased 2.1-fold (95% confidence interval, 1.2 to 3.7) in patients with moderate PPM and 11.4-fold (4.4 to 29.5) in those with severe PPM. Moreover, risk of mortality for every category of PPM was higher in patients with a left ventricular ejection fraction <40% as compared with
40% (nonsignificant PPM, 2.7 versus 1.0; moderate PPM, 7.1 versus 1.8; severe PPM, 77.1 versus 11.3).
Conclusion PPM is a strong and independent predictor of short-term mortality among patients undergoing AVR, and its impact is related both to its degree of severity and the status of left ventricular function. In contrast to other risk factors, moderate-severe PPM can be largely avoided with the use of a prospective strategy at the time of operation.
Key Words: valves prosthesis mortality hemodynamics
| Introduction |
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| Methods |
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The indexed EOA for each prosthesis was derived from reference normal values of EOA (Table 1) divided by the patients body surface area, as previously described and validated.4,12 PPM was defined as not clinically significant (ie, mild or no PPM) if the indexed EOA was >0.85 cm2/m2, as moderate if it was >0.65 cm2/m2 and
0.85 cm2/m2, and as severe if it was
0.65 cm2/m2.4,7,13
Short-term mortality was defined as death from any cause within 30 days after operation if the patient was discharged from hospital or within any interval if the patient was not discharged.14,15 Baseline preoperative and operative variables used in this analysis and tested for association with mortality were defined according to the guidelines of the Society of Thoracic Surgeons.16
Statistical Analysis
Differences between groups for baseline variables were tested for statistical significance by t, Chi-squared, or Fischer Exact tests as appropriate. A stepwise logistic regression analysis was used to identify the independent predictors of mortality.
| Results |
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21 mm), concomitant coronary artery bypass graft, and emergent/salvage operation (Table 2).
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The overall short-term mortality in the cohort was 4.6% (58/1266 patients). Mortality rate was 3.0% in the group with nonsignificant PPM, 6.0% in the group with moderate PPM, and 25.9% in the group with severe PPM.
Predictors of Mortality
Nineteen patients died during or within 24 hours after operation, 33 patients died between 1 and 30 days, and 6 patients died between 31 and 132 days. The baseline variables associated with short-term mortality in univariate analysis are presented in Table 3. The independent risk factors for mortality in multivariate analysis were as follows: emergent/salvage operation (P=0.001), cardiopulmonary bypass time >120 minutes (P=0.001), active infectious endocarditis (P=0.002), moderate-severe PPM (P=0.003), preoperative left ventricular ejection fraction <40% (P=0.007), and chronic lung disease (P=0.03) (Table 3).
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Impact of Mismatch Severity on Mortality
The risk of mortality was increased 2.1-fold (95% CI: 1.2 to 3.7) in patients with moderate PPM and 11.4-fold (95% CI: 4.4 to 29.5) in those with severe PPM as compared with patients with nonsignificant PPM (Figure 1). In multivariate analysis, these risk ratios were 2.0 (95% CI: 1.1 to 3.7) for moderate PPM and 12.6 (95% CI: 4.3 to 37.0) for severe PPM. In the subgroup of patients with moderate-severe PPM, the independent predictors of mortality in multivariate analysis were cardiopulmonary bypass time >120 minutes (P=0.002), preoperative left ventricular ejection fraction <40% (P=0.006), and severe PPM (P=0.0003) (Table 4). Moreover, for every category of PPM, the risk of mortality was greater in patients with a preoperative left ventricular ejection fraction <40% as opposed to
40% (Figure 2).
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Table 5 shows the cause of death in relation to the severity of PPM. It should be noted that all patients with severe PPM died from cardiac cause (5 from low cardiac output syndrome and 2 from perioperative myocardial infarction).
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| Discussion |
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Independent Predictors of Short-Term Mortality
Previous studies have identified several independent predictors of short-term mortality related to AVR,15,1822 and most of them were also found to be present in this study (Table 3): emergent/salvage operation, cardiopulmonary bypass time, infectious endocarditis, poor left ventricular ejection fraction, and chronic lung disease. Other factors, also previously reported as independent predictors of mortality but not found to be predictors in the present study were age, female gender, advanced New York Heart Association functional class, diabetes, hypertension, renal failure, coronary artery disease, recent myocardial infarction, left ventricular hypertrophy, and smaller prosthetic valve. However, the influence of PPM was not analyzed in theses studies and it would appear evident that most previously identified risk factors were hardly preventable or modifiable. Hence, although this information could be used to evaluate operative risk, it could not contribute to the development of a prospective strategy that would reduce mortality risk related to AVR.
Mismatch as a Predictor of Short-Term Mortality
To our knowledge, there has been only one other study that has attempted to quantify the influence of PPM on short-term mortality. In a cohort of 2154 patients who underwent AVR, Rao et al10 found that 30-day mortality was significantly higher (7.9% versus 4.6%; P=0.03) in patients with evidence of moderate-severe PPM. In multivariate analysis, PPM was an independent predictor only of long-term valve-related mortality but not short-term mortality. However, in the latter study, no distinction was made between patients with and without left ventricular dysfunction and in vitro rather than in vivo values were used to calculate the indexed EOA, resulting in potentially higher values for indexed EOA.2,4
The indexed valve EOA was also used by Milano et al6 to analyze the influence of PPM in patients undergoing AVR. As in a previous study from our laboratory,7 these authors identified severe PPM as an independent predictor of late cardiac events but not of late mortality. However, short-term mortality was not analyzed nor was left ventricular function taken into account. Nonetheless, when considered collectively, these previous studies6,7,10,11 might indirectly suggest that the greatest impact of PPM with regards to survival is in the early postoperative period when the left ventricle is most vulnerable. Our results also suggest that there could be a natural selection process at that time of operation during which many patients at risk do not survive beyond the early postoperative period, which in turn could explain the relatively better prognosis of moderate-severe PPM beyond that critical period.
Other studies have also purported to analyze the influence of moderate-severe PPM on mortality after AVR8,9 and they could not identify any major influence. It should however be emphasized that in these studies, PPM was defined on the basis of the indexed internal geometric area calculated from the anatomically measured internal diameter of the prosthesis divided by the patients body surface area. However, physiological studies have repeatedly shown that the latter parameter cannot be related to transvalvular pressure gradients and/or left ventricular workload and that it overestimates EOA in varying proportions depending on prosthesis type and geometry.12 Hence, it would appear that the conclusion that PPM is not related to mortality based on measurements of the internal geometric area or labeled valve size is not valid because it has been shown that neither parameter can be used to identify patients who have a high postoperative gradient on the basis of PPM.4,12 In this context, the present study is the first to examine the impact of PPM on short-term mortality based on the only parameter yet demonstrated as being valid to identify PPM, ie, the indexed EOA.24,12
Our results suggest that not only severe PPM but also moderate PPM are independent predictors of short-term mortality. Although the mortality risk ratio of moderate PPM (2.0) is lower than that of severe PPM (12.6), infectious endocarditis (9.2), emergent/salvage operation (5.8), and LV ejection fraction <40% (2.6), it should also be emphasized that its prevalence (36.0%) is much higher than that of these factors (2.2%, 0.9%, 1.7%, and 10.7%, respectively). Hence, according to these results, the total number of deaths related to moderate PPM would be higher than that related to other factors having high risk ratio but low prevalence.
Impact of Mismatch in Patients With Poor Left Ventricular Function
It is striking to note the dramatic increase in mortality risk due to the combination of poor left ventricular function and moderate-severe PPM (Figure 2). This result is indirectly consistent with the study of Connolly et al20 that reported a markedly higher mortality (47 versus 15%; P=0.03) in patients with aortic stenosis and poor left ventricular ejection fraction (
35%) receiving a small (
21 mm) prosthesis as compared with a larger prosthesis. Although this study was not a direct analysis of PPM based on the indexed EOA, it nonetheless underlines the concept that a diseased ventricle is much more sensitive to an increase in afterload than a normal ventricle. The present study further characterizes this phenomenon by establishing a more quantitative relation between the extent of PPM as defined by the indexed EOA and survival rates. From this relation, we would like to propose a refinement of preventive strategies that would go beyond the simplistic paradigm that states that a prosthesis as large as possible should be used.
Clinical Implications: A Preventive Strategy
Contrary to other risk factors for short-term mortality, moderate-severe PPM can be largely prevented by implementing a simple three-step previously validated prospective strategy as follows4,12: (1) Calculate patients body surface area from patients weight and height; (2) Multiply body surface area by 0.85 cm2/m2, the result being the minimal EOA that the prosthesis to be implanted should have in order to avoid moderate-severe PPM; for instance, if patients body surface area is 1.60 m2, then 1.60x0.85=1.36 cm2=minimal EOA to avoid moderate-severe PPM; and (3) Verify if the reference EOA (see Table 1) for the model and size of prosthesis selected by the surgeon is equal or greater than the result of step 2 (ie, >1.36 cm2 in the example chosen); if not, there is a risk of moderate-severe PPM and the surgeon should either attempt to implant another type of prosthesis with a larger EOA (eg, stentless prosthesis, homograft, mechanical prosthesis) or alternatively, perform an aortic root enlargement to accommodate a larger valve of the same type.
Such a strategy was recently utilized by Castro et al17 who systematically performed an aortic root enlargement in 114 of 657 consecutive patients undergoing AVR and in whom the prosthesis initially selected did not meet the minimum requirement of 0.85 cm2/m2 given by step 2. As a result, incidence of moderate-severe PPM in their population was only 2.5% instead of the 17% that would have occurred had this prospective strategy not been used. Moreover, operative mortality was not increased as a result of the aortic root enlargement (overall mortality=3.6%). Nonetheless, in considering the different options, it is important to evaluate the potential benefits of avoiding moderate-severe PPM vis-à-vis the drawbacks of using alternative techniques. In particular, as the results of the present study suggest, a prolongation of the cardiopulmonary bypass time beyond 120 minutes could have a negative impact. In this context, moderate PPM in a relatively inactive and old patient with normal left ventricular function might be acceptable.
Limitation of the Study
Many patients in this study were directly referred to surgery without having had a preoperative echocardiogram in our institution, and as a consequence, reliable measurement of LV mass by echocardiography was available in a limited number of patients. In a subset of 473 patients who had echocardiographic measurements of LV dimensions before operation, Mehta et al22 found that LV hypertrophy was a strong independent risk factor for in-hospital mortality after AVR. These authors did not however include the influence of PPM or prosthesis size in their analysis. Further studies will thus be necessary to determine if PPM is not only important in patients with left ventricular dysfunction but also in those with significant LV hypertrophy, given that PPM has been shown to seriously hamper LV mass regression after AVR.5
The valve EOA indexed for body surface area may potentially overestimate the degree of PPM in obese patients. An alternative method would be to use valve EOA indexed for a power of patients height to define PPM. In our population, the EOA indexed for height squared was not found to be superior compared with the EOA indexed for body surface area for the prediction of short-term mortality. However, one cannot exclude that in a population with a higher proportion of obese patients, this index based on height would have been superior.
Comorbid factors such as older age, female gender, coronary artery disease, hypertension, diabetes, and emergent/salvage operation were more prevalent in patients with moderate-severe PPM and it cannot be completely excluded that they might have contributed to the higher mortality in these patients. However, it should be considered that all these comorbidities, except emergent/salvage operation, were not significantly associated with increased short-term mortality. Also, moderate-severe PPM remained an independent predictor of short-term mortality when these potentially confounding factors were entered in multivariate analysis (Table 3). Finally, the multivariate analysis performed separately in the patients with moderate-severe PPM confirmed that severe PPM is a strong and independent predictor of mortality (Table 4). The coherence of these results suggests that the contribution of other comorbid factors to the PPM-related mortality was minimal. Moreover, it should be emphasized that among these factors, PPM is the only one that can be prospectively prevented.
Conclusion
This study demonstrates that PPM is a strong and independent predictor of short-term mortality and that its impact is dependent both on its degree of severity and the status of left ventricular function. Moreover, moderate-severe PPM can be largely avoided by adopting a simple prospective strategy in every patient undergoing AVR.
| Acknowledgments |
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This work was supported by grants from the Canadian Institutes of Health Research (MOP 57745), Ottawa, Canada. Dr Pibarot is the recipient of a Research Scholar Award from the Heart and Stroke Foundation of Canada. We thank Paul Cartier, MD (deceased), François Dagenais, MD, Richard Bauset, MD, Denis Desaulniers, MD, Michel Lemieux, MD, Patrick Mathieu, MD, Jacques Métras, MD, Jean Perron, MD, and Gilles Raymond, MD, for implanting the prostheses and their participation in the study. We also thank Brigitte Dionne and Martin Briand, MS, for the clinical follow-up of the patients and Peter Bogaty, MD, and Jean-Pierre Després, PhD, for their contribution in the preparation of the manuscript.
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S Bleiziffer, W B Eichinger, I Hettich, D Ruzicka, M Wottke, R Bauernschmitt, and R Lange Impact of patient-prosthesis mismatch on exercise capacity in patients after bioprosthetic aortic valve replacement Heart, May 1, 2008; 94(5): 637 - 641. [Abstract] [Full Text] [PDF] |
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K. Yoshikawa, S. Fukunaga, K. Arinaga, H. Hori, E. Nakamura, T. Ueda, E. Tayama, and S. Aoyagi Long-Term Results of Aortic Valve Replacement With a Small St. Jude Medical Valve in Japanese Patients Ann. Thorac. Surg., April 1, 2008; 85(4): 1303 - 1308. [Abstract] [Full Text] [PDF] |
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S. Nozohoor, J. Nilsson, C. Luhrs, A. Roijer, and J. Sjogren Influence of Prosthesis-Patient Mismatch on Diastolic Heart Failure After Aortic Valve Replacement Ann. Thorac. Surg., April 1, 2008; 85(4): 1310 - 1317. [Abstract] [Full Text] [PDF] |
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A. Kulik, M. Al-Saigh, V. Chan, R. G. Masters, P. Bedard, B.-K. Lam, F. D. Rubens, P. J. Hendry, T. G. Mesana, and M. Ruel Enlargement of the Small Aortic Root During Aortic Valve Replacement: Is There a Benefit? Ann. Thorac. Surg., January 1, 2008; 85(1): 94 - 100. [Abstract] [Full Text] [PDF] |
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T. E. David, C. M. Feindel, J. Bos, J. Ivanov, and S. Armstrong Aortic valve replacement with Toronto SPV bioprosthesis: Optimal patient survival but suboptimal valve durability J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 19 - 24. [Abstract] [Full Text] [PDF] |
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R. W. Emery, A. M. Emery, A. Knutsen, and G. V. Raikar Aortic Valve Replacement with a Mechanical Cardiac Valve Prosthesis Card. Surg. Adult, January 1, 2008; 3(2008): 841 - 856. [Full Text] |
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P. Stelzer Stentless Aortic Valve Replacement: Porcine and Pericardial Card. Surg. Adult, January 1, 2008; 3(2008): 915 - 934. [Full Text] |
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B. A. Youdelman, H. Hirose, H. Jain, J. Y. Kresh, J. W.C. Entwistle III, and A. S. Wechsler Comparison of eight prosthetic aortic valves in a cadaver model. J. Thorac. Cardiovasc. Surg., December 1, 2007; 134(6): 1526 - 1532. [Abstract] [Full Text] [PDF] |
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B. Qizilbash, P. Couture, and A. Denault Impact of Perioperative Transesophageal Echocardiography in Aortic Valve Replacement Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2007; 11(4): 288 - 300. [Abstract] [PDF] |
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J.-L. Monin, M. Monchi, M. E.W. Kirsch, H. Petit-Eisenmann, S. Baleynaud, C. Chauvel, D. Metz, C. Adams, J.-P. Quere, P. Gueret, et al. Low-gradient aortic stenosis: impact of prosthesis-patient mismatch on survival Eur. Heart J., November 1, 2007; 28(21): 2620 - 2626. [Abstract] [Full Text] [PDF] |
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J. Dhareshwar, T. M. Sundt III, J. A. Dearani, H. V. Schaff, D. J. Cook, and T. A. Orszulak Aortic root enlargement: What are the operative risks? J. Thorac. Cardiovasc. Surg., October 1, 2007; 134(4): 916 - 924. [Abstract] [Full Text] [PDF] |
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Y. S. Tjang, Y. van Hees, R. Korfer, D. E. Grobbee, and G. J.M.G. van der Heijden Predictors of mortality after aortic valve replacement Eur. J. Cardiothorac. Surg., September 1, 2007; 32(3): 469 - 474. [Abstract] [Full Text] [PDF] |
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Z. Hachicha, J. G. Dumesnil, P. Bogaty, and P. Pibarot Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis Despite Preserved Ejection Fraction Is Associated With Higher Afterload and Reduced Survival Circulation, June 5, 2007; 115(22): 2856 - 2864. [Abstract] [Full Text] [PDF] |
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M. D. Peterson, M. A. Borger, C. M. Feindel, and T. E. David Aortic Annular Enlargement During Aortic Valve Replacement: Improving Results With Time Ann. Thorac. Surg., June 1, 2007; 83(6): 2044 - 2049. [Abstract] [Full Text] [PDF] |
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P. Pibarot and J. G. Dumesnil Prosthesis-patient mismatch in the mitral position: Old concept, new evidences J. Thorac. Cardiovasc. Surg., June 1, 2007; 133(6): 1405 - 1408. [Full Text] [PDF] |
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B.-K. Lam, V. Chan, P. Hendry, M. Ruel, R. Masters, P. Bedard, B. Goldstein, F. Rubens, and T. Mesana The impact of patient-prosthesis mismatch on late outcomes after mitral valve replacement J. Thorac. Cardiovasc. Surg., June 1, 2007; 133(6): 1464 - 1473. [Abstract] [Full Text] [PDF] |
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M. J. Dalmau, J. Maria Gonzalez-Santos, J. Lopez-Rodriguez, M. Bueno, A. Arribas, and F. Nieto One year hemodynamic performance of the Perimount Magna pericardial xenograft and the Medtronic Mosaic bioprosthesis in the aortic position: a prospective randomized study Interactive CardioVascular and Thoracic Surgery, June 1, 2007; 6(3): 345 - 349. [Abstract] [Full Text] [PDF] |
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I. M. Wagner, W. B. Eichinger, S. Bleiziffer, F. Botzenhardt, I. Gebauer, R. Guenzinger, R. Bauernschmitt, and R. Lange Influence of completely supra-annular placement of bioprostheses on exercise hemodynamics in patients with a small aortic annulus J. Thorac. Cardiovasc. Surg., May 1, 2007; 133(5): 1234 - 1241. [Abstract] [Full Text] [PDF] |
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P. Pibarot and J. G Dumesnil Prevention of valve prosthesis--patient mismatch before aortic valve replacement: does it matter and is it feasible? Heart, May 1, 2007; 93(5): 549 - 551. [Abstract] [Full Text] [PDF] |
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S. Bleiziffer, W. B Eichinger, I. Hettich, R. Guenzinger, D. Ruzicka, R. Bauernschmitt, and R. Lange Prediction of valve prosthesis-patient mismatch prior to aortic valve replacement: which is the best method? Heart, May 1, 2007; 93(5): 615 - 620. [Abstract] [Full Text] [PDF] |
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C. R. Bridges, S. M. O'Brien, J. C. Cleveland, E. B. Savage, J. S. Gammie, F. H. Edwards, E. D. Peterson, and F. L. Grover Association between indices of prosthesis internal orifice size and operative mortality after isolated aortic valve replacement J. Thorac. Cardiovasc. Surg., April 1, 2007; 133(4): 1012 - 1021. [Abstract] [Full Text] [PDF] |
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J. Magne, P. Mathieu, J. G. Dumesnil, D. Tanne, F. Dagenais, D. Doyle, and P. Pibarot Impact of Prosthesis-Patient Mismatch on Survival After Mitral Valve Replacement Circulation, March 20, 2007; 115(11): 1417 - 1425. [Abstract] [Full Text] [PDF] |
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T. Bove, Y. Van Belleghem, K. Francois, F. Caes, H. Van Overbeke, and G. Van Nooten Stentless and stented aortic valve replacement in elderly patients: factors affecting midterm clinical and hemodynamical outcome Eur. J. Cardiothorac. Surg., November 1, 2006; 30(5): 706 - 713. [Abstract] [Full Text] [PDF] |
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T. Kunihara, K. Schmidt, P. Glombitza, V. Dzindzibadze, H. Lausberg, and H.-J. Schafers Root replacement using stentless valves in the small aortic root: a propensity score analysis. Ann. Thorac. Surg., October 1, 2006; 82(4): 1379 - 1384. [Abstract] [Full Text] [PDF] |
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D. Grandmougin and G. Fayad Implantation of a modified freestyle valve with a single inflow suture line: technical patterns and advantages. Ann. Thorac. Surg., September 1, 2006; 82(3): 1128 - 1130. [Abstract] [Full Text] [PDF] |
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W. Flameng, B. Meuris, P. Herijgers, and M.-C. Herregods Prosthesis-Patient Mismatch is Not Clinically Relevant in Aortic Valve Replacement Using the Carpentier-Edwards Perimount Valve Ann. Thorac. Surg., August 1, 2006; 82(2): 530 - 536. [Abstract] [Full Text] [PDF] |
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P Pibarot and J G Dumesnil Prosthesis-patient mismatch: definition, clinical impact, and prevention Heart, August 1, 2006; 92(8): 1022 - 1029. [Abstract] [Full Text] [PDF] |
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A. Kulik, I. G. Burwash, V. Kapila, T. G. Mesana, and M. Ruel Long-Term Outcomes After Valve Replacement for Low-Gradient Aortic Stenosis: Impact of Prosthesis-Patient Mismatch Circulation, July 4, 2006; 114(1_suppl): I-553 - I-558. [Abstract] [Full Text] [PDF] |
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T. Walther, A. Rastan, V. Falk, S. Lehmann, J. Garbade, A. K. Funkat, F. W. Mohr, and J. F. Gummert Patient prosthesis mismatch affects short- and long-term outcomes after aortic valve replacement. Eur. J. Cardiothorac. Surg., July 1, 2006; 30(1): 15 - 19. [Abstract] [Full Text] [PDF] |
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M. J. Dalmau, J. MariaGonzalez-Santos, J. Lopez-Rodriguez, M. Bueno, and A. Arribas The Carpentier-Edwards Perimount Magna aortic xenograft: a new design with an improved hemodynamic performance Interactive CardioVascular and Thoracic Surgery, June 1, 2006; 5(3): 263 - 267. [Abstract] [Full Text] [PDF] |
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J. G. Dumesnil and P. Pibarot Prosthesis-patient mismatch and clinical outcomes: The evidence continues to accumulate J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 952 - 955. [Full Text] [PDF] |
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M. Ruel, H. Al-Faleh, A. Kulik, K. L. Chan, T. G. Mesana, and I. G. Burwash Prosthesis-patient mismatch after aortic valve replacement predominantly affects patients with preexisting left ventricular dysfunction: Effect on survival, freedom from heart failure, and left ventricular mass regression J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 1036 - 1044. [Abstract] [Full Text] [PDF] |
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F. B. Vanky, E. Hakanson, E. Tamas, and R. Svedjeholm Risk Factors for Postoperative Heart Failure in Patients Operated on for Aortic Stenosis Ann. Thorac. Surg., April 1, 2006; 81(4): 1297 - 1304. [Abstract] [Full Text] [PDF] |
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Y. Sakamoto, K. Hashimoto, H. Okuyama, H. Takakura, S. Ishii, S. Taguchi, and H. Kagawa Prevalence and Avoidance of Patient-Prosthesis Mismatch in Aortic Valve Replacement in Small Adults Ann. Thorac. Surg., April 1, 2006; 81(4): 1305 - 1309. [Abstract] [Full Text] [PDF] |
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D. P. Taggart Prosthesis patient mismatch in aortic valve replacement: possible but pertinent? Eur. Heart J., March 2, 2006; 27(6): 644 - 646. [Full Text] [PDF] |
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R. B. A. Van den Brink Evaluation of Prosthetic Heart Valves by Transesophageal Echocardiography: Problems, Pitfalls, and Timing of Echocardiography Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2006; 10(1): 89 - 100. [Abstract] [PDF] |
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C. Blais, I. G. Burwash, G. Mundigler, J. G. Dumesnil, N. Loho, F. Rader, H. Baumgartner, R. S. Beanlands, B. Chayer, L. Kadem, et al. Projected Valve Area at Normal Flow Rate Improves the Assessment of Stenosis Severity in Patients With Low-Flow, Low-Gradient Aortic Stenosis: The Multicenter TOPAS (Truly or Pseudo-Severe Aortic Stenosis) Study Circulation, February 7, 2006; 113(5): 711 - 721. [Abstract] [Full Text] [PDF] |
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M. R. Moon, M. K. Pasque, N. A. Munfakh, S. J. Melby, J. S. Lawton, N. Moazami, J. E. Codd, T. D. Crabtree, H. B. Barner, and R. J. Damiano Jr Prosthesis-Patient Mismatch After Aortic Valve Replacement: Impact of Age and Body Size on Late Survival Ann. Thorac. Surg., February 1, 2006; 81(2): 481 - 489. [Abstract] [Full Text] [PDF] |
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G. Tasca, Z. Mhagna, S. Perotti, P. B. Centurini, T. Sabatini, A. Amaducci, F. Brunelli, M. Cirillo, M. D. Tomba, E. Quiani, et al. Impact of Prosthesis-Patient Mismatch on Cardiac Events and Midterm Mortality After Aortic Valve Replacement in Patients With Pure Aortic Stenosis Circulation, January 31, 2006; 113(4): 570 - 576. [Abstract] [Full Text] [PDF] |
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D. Mohty-Echahidi, J. F. Malouf, S. E. Girard, H. V. Schaff, D. E. Grill, M. E. Enriquez-Sarano, and F. A. Miller Jr Impact of Prosthesis-Patient Mismatch on Long-Term Survival in Patients With Small St Jude Medical Mechanical Prostheses in the Aortic Position Circulation, January 24, 2006; 113(3): 420 - 426. [Abstract] [Full Text] [PDF] |
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P. Pibarot, J. G. Dumesnil, G. Tasca, C. G. Koch, F. Khandwala, F. G. Estafanous, F. D. Loop, and E. H. Blackstone Letter Regarding Article by Koch et al, "Impact of Prothesis-Patient Size on Functional Recovery After Aortic Valve Replacement" * Response Circulation, November 22, 2005; 112(21): e333 - e333. [Full Text] [PDF] |
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D. Perez de Arenaza, B. Lees, M. Flather, F. Nugara, T. Husebye, M. Jasinski, M. Cisowski, M. Khan, M. Henein, J. Gaer, et al. Randomized Comparison of Stentless Versus Stented Valves for Aortic Stenosis: Effects on Left Ventricular Mass Circulation, October 25, 2005; 112(17): 2696 - 2702. [Abstract] [Full Text] [PDF] |
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R. Guenzinger, W. B. Eichinger, F. Botzenhardt, S. Bleiziffer, I. Wagner, R. Bauernschmitt, S. M. Wildhirt, and R. Lange Rest and Exercise Performance of the Medtronic Advantage Bileaflet Valve in the Aortic Position Ann. Thorac. Surg., October 1, 2005; 80(4): 1319 - 1326. [Abstract] [Full Text] [PDF] |
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M. D. Maganti, V. Rao, M. A. Borger, J. Ivanov, and T. E. David Predictors of Low Cardiac Output Syndrome After Isolated Aortic Valve Surgery Circulation, August 30, 2005; 112(9_suppl): I-448 - I-452. [Abstract] [Full Text] [PDF] |
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J. Odim, H. Laks, V. Allada, J. Child, S. Wilson, and D. Gjertson Results of Aortic Valve-Sparing and Restoration With Autologous Pericardial Leaflet Extensions in Congenital Heart Disease Ann. Thorac. Surg., August 1, 2005; 80(2): 647 - 654. [Abstract] [Full Text] [PDF] |
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M. Briand, J. G. Dumesnil, L. Kadem, A. G. Tongue, R. Rieu, D. Garcia, and P. Pibarot Reduced Systemic Arterial Compliance Impacts Significantly on Left Ventricular Afterload and Function in Aortic Stenosis: Implications for Diagnosis and Treatment J. Am. Coll. Cardiol., July 19, 2005; 46(2): 291 - 298. [Abstract] [Full Text] [PDF] |
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F. Botzenhardt, W. B. Eichinger, S. Bleiziffer, R. Guenzinger, I. M. Wagner, R. Bauernschmitt, and R. Lange Hemodynamic Comparison of Bioprostheses for Complete Supra-Annular Position in Patients With Small Aortic Annulus J. Am. Coll. Cardiol., June 21, 2005; 45(12): 2054 - 2060. [Abstract] [Full Text] [PDF] |
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T. E. David Is Prosthesis-Patient Mismatch a Clinically Relevant Entity? Circulation, June 21, 2005; 111(24): 3186 - 3187. [Full Text] [PDF] |
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C. G. Koch, F. Khandwala, F. G. Estafanous, F. D. Loop, and E. H. Blackstone Impact of Prosthesis-Patient Size on Functional Recovery After Aortic Valve Replacement Circulation, June 21, 2005; 111(24): 3221 - 3229. [Abstract] [Full Text] [PDF] |
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A. Penta de Peppo, J. Zeitani, P. Nardi, G. Iaci, P. Polisca, R. De Paulis, and L. Chiariello Small "Functional" Size after Mechanical Aortic Valve Replacement: No Risk in Young to Middle-Age Patients Ann. Thorac. Surg., June 1, 2005; 79(6): 1915 - 1920. [Abstract] [Full Text] [PDF] |
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F. Dagenais, P. Cartier, P. Voisine, D. Desaulniers, J. Perron, R. Baillot, G. Raymond, J. Metras, D. Doyle, and P. Mathieu Which biologic valve should we select for the 45- to 65-year-old age group requiring aortic valve replacement? J. Thorac. Cardiovasc. Surg., May 1, 2005; 129(5): 1041 - 1049. [Abstract] [Full Text] [PDF] |
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W. B. Eichinger, F. Botzenhardt, A. Keithahn, R. Guenzinger, S. Bleiziffer, I. Wagner, R. Bauernschmitt, and R. Lange Exercise hemodynamics of bovine versus porcine bioprostheses: A prospective randomized comparison of the mosaic and perimount aortic valves J. Thorac. Cardiovasc. Surg., May 1, 2005; 129(5): 1056 - 1063. [Abstract] [Full Text] [PDF] |
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M. Li, J. G. Dumesnil, P. Mathieu, and P. Pibarot Impact of valve prosthesis-patient mismatch on pulmonary arterial pressure after mitral valve replacement J. Am. Coll. Cardiol., April 5, 2005; 45(7): 1034 - 1040. [Abstract] [Full Text] [PDF] |
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E. Otero, J. L. Pomar, J. M. Revuelta, and J. J. Rufilanchas Comparative Evaluation of Small-Size Sorin Slimline and St. Jude HP Heart Valve Prostheses Ann. Thorac. Surg., April 1, 2005; 79(4): 1284 - 1290. [Abstract] [Full Text] [PDF] |
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R. G. Fuster, J. A. M. Argudo, O. G. Albarova, F. H. Sos, S. C. Lopez, M. B. Codoner, J. A. B. Minano, and I. R. Albarran Patient-prosthesis mismatch in aortic valve replacement: really tolerable? Eur. J. Cardiothorac. Surg., March 1, 2005; 27(3): 441 - 449. [Abstract] [Full Text] [PDF] |
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C. Amarelli, A. Della Corte, G. Romano, G. Iasevoli, G. Dialetto, L. S. De Santo, M. De Feo, M. Torella, M. Scardone, and M. Cotrufo Left ventricular mass regression after aortic valve replacement with 17-mm St Jude Medical mechanical prostheses in isolated aortic stenosis J. Thorac. Cardiovasc. Surg., March 1, 2005; 129(3): 512 - 517. [Abstract] [Full Text] [PDF] |
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G. Tasca, F. Brunelli, M. Cirillo, M. DallaTomba, Z. Mhagna, G. Troise, and E. Quaini Impact of Valve Prosthesis-Patient Mismatch on Left Ventricular Mass Regression Following Aortic Valve Replacement Ann. Thorac. Surg., February 1, 2005; 79(2): 505 - 510. [Abstract] [Full Text] [PDF] |
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G. P. Aurigemma and W. H. Gaasch Low flow-low gradient aortic stenosis: The pathologist weighs in J. Am. Coll. Cardiol., November 2, 2004; 44(9): 1856 - 1858. [Full Text] [PDF] |
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T. Walther, S. Lehmann, V. Falk, S. Metz, N. Doll, A. Rastan, M. Viehweg, M. Richter, J. Gummert, and F. W. Mohr Prospectively Randomized Evaluation of Stented Xenograft Hemodynamic Function in the Aortic Position Circulation, September 14, 2004; 110(11_suppl_1): II-74 - II-78. [Abstract] [Full Text] [PDF] |
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D. S. Bach, N. D. Kon, J. G. Dumesnil, C. F. Sintek, and D. B. Doty Eight-year results after aortic valve replacement with the Freestyle stentless bioprosthesis J. Thorac. Cardiovasc. Surg., June 1, 2004; 127(6): 1657 - 1663. [Abstract] [Full Text] [PDF] |
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J. G. Dumesnil and P. Pibarot Prosthesis size and prosthesis-patient size are unrelated to prosthesis-patient mismatch J. Thorac. Cardiovasc. Surg., June 1, 2004; 127(6): 1852 - 1852. [Full Text] [PDF] |
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E. H. Blackstone, A. M. Gillinov, and D. M. Cosgrove Reply to the Editor J. Thorac. Cardiovasc. Surg., June 1, 2004; 127(6): 1852 - 1854. [Full Text] [PDF] |
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A. Weerasinghe, M. Yusuf, T. Athanasiou, A. Wood, P. Magee, and R. Uppal Role of transvalvular gradient in outcome from valve replacement for aortic stenosis Ann. Thorac. Surg., April 1, 2004; 77(4): 1266 - 1271. [Abstract] [Full Text] [PDF] |
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Prosthesis-Patient Mismatch Predicts Short-Term Post-AVR Mortality Journal Watch Cardiology, December 12, 2003; 2003(1212): 5 - 5. [Full Text] |
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R. SoRelle Cardiovascular News Circulation, August 26, 2003; 108 (8): e9014 - e9015. [Full Text] |
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