This Article Abstract Full Text (PDF) All Versions of this Article: 108/7/857    most recent 01.CIR.0000084547.93252.9Av1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Culbert, E. L. Articles by McCrindle, B. W. Search for Related Content PubMed PubMed Citation Articles by Culbert, E. L. Articles by McCrindle, B. W. Related Collections Behavioral/psychosocial - CV surgery Pediatric and congenital heart disease, including cardiovascular surgery

(Circulation. 2003;108:857.)
© 2003 American Heart Association, Inc.

Clinical Investigation and Reports

Quality of Life of Children After Repair of Transposition of the Great Arteries

Erin L. Culbert, MD; David A. Ashburn, MD; Geraldine Cullen-Dean, RN, MN; Jay A. Joseph, MSc; William G. Williams, MD; Eugene H. Blackstone, MD; Brian W. McCrindle, MD, MPH, and the Congenital Heart Surgeons Society

From the Congenital Heart Surgeons Society Data Center (E.L.C., D.A.A., G.C.-D., J.A.J., W.G.W., B.W.M.), Division of Cardiovascular Surgery (D.A.A., W.G.W.), and Division of Cardiology (B.W.M.), Hospital for Sick Children, University of Toronto, Ontario, Canada, and Department of Thoracic and Cardiovascular Surgery and Department of Biostatistics and Epidemiology (E.H.B.), Cleveland Clinic Foundation, Cleveland, Ohio.

Correspondence to William G. Williams MD, Hospital for Sick Children, Division of Cardiovascular Surgery, 555 University Ave, Toronto, Ontario M5G 1X8. E-mail bill.williams{at}sickkids.ca

Received March 5, 2003; revision received May 29, 2003; accepted May 29, 2003.

	Abstract

Top Abstract Introduction Methods Results Discussion Appendix References

 
Background— We sought to assess quality of life of children with transposition of the great arteries (TGA) enrolled during transition in management strategy from atrial to arterial switch operation.

Methods and Results— Neonates enrolled by the Congenital Heart Surgeons Society in a prospective study of TGA between 1985 and 1989 were eligible. A Child Health Questionnaire was sent for completion by the child between February and June 2000. Data were compared with published normative values. Child Health Questionnaires were completed by 306 of 708 survivors at a mean age of 13±1 years. Diagnosis included TGA (n=202, 66%), TGA/ventricular septal defect (VSD) (n=84, 27%), and TGA/VSD/pulmonary stenosis (n=20, 7%). Repair type was arterial switch (n=189, 62%), atrial switch (n=105, 34%; Senning=58, Mustard=47), or Rastelli (n=12, 4%). Children with TGA scored significantly higher than published norms in all categories except self-esteem. TGA/VSD/pulmonary stenosis was associated with lower scores than TGA and TGA/VSD in physical functioning (P=0.002), general health perceptions (P=0.012), and mental health (P=0.048). Arterial repair was associated with higher scores than atrial or Rastelli repair in physical functioning (P<0.001), pain (P=0.004), mental health (P=0.019), self-esteem (P=0.004), and general health perceptions (P<0.001). By multivariable analyses, the most common independent factors impacting scores were repair type, perfusion parameters, and gender.

Conclusions— Quality of life and health status as perceived by children 11 to 15 years after TGA repair is excellent when compared with published normative data and is better after arterial switch operation than after atrial repair.

Key Words: heart defects, congenital • transposition of great vessels • pediatrics • quality of life

	Introduction

Top Abstract Introduction Methods Results Discussion Appendix References

 
Traditionally, outcomes in children with transposition of the great arteries (TGA) have been measured in terms of morbidity and mortality. Because children with TGA now have excellent long-term survival after surgical repair, quality of life of these children is increasingly important. The World Health Organization defines health as "a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity."¹ Children’s health is conceptualized to have physical and psychosocial (emotional, behavioral, and social) dimensions, and deficits in either may affect the ability to perform important social roles.²

Quality of life assessment instruments measure these dimensions of health and assess impact of disease on the child’s daily life. Global quality of life instruments have recently been developed for use in children.^2–5 One previous study used a parent-completed instrument to assess quality of life in children surviving repair of TGA.⁶ Using an instrument designed for completion by the child, we sought to assess quality of life of children undergoing repair of TGA during transition in management strategy from atrial repair to arterial switch operation (ASO).

	Methods

Top Abstract Introduction Methods Results Discussion Appendix References

 
Patients
Neonates with TGA (n=829) admitted to 1 of 24 Congenital Heart Surgeons Society (CHSS) institutions at age <15 days were prospectively enrolled in a multi-institutional study between January 1985 and March 1989.^7–11 During this period, a major transition in surgical management of TGA occurred from atrial inversion technique (Mustard or Senning operation) to ASO. Treatment was nonrandomized and selected by the enrolling institution based on surgeon and institutional knowledge, experience, and preference. There were 708 surviving children at the time of ongoing cross-sectional follow-up between February and June 2000 eligible for participation.

Measurements
Contact of surviving children was attempted by the CHSS Data Center (n=478) or enrolling institution (n=230). Only children whose enrolling institution had obtained institutional review board approval were contacted, thereby excluding 113 children from follow-up contact. A copy of Child Health Questionnaire (CHQ) Version CF-87 was sent to 595 children. If no response was received within 6 weeks of initial mailing, a reminder was sent, followed by 2 attempts to complete follow-up by telephone.

Child Health Questionnaire
Version CF-87 was chosen for our study because children in our population were age 11 years or older at follow-up. It is an 87-item validated questionnaire that assesses self-perceived physical and psychosocial well-being of children aged 11 years and older.² Most pediatric quality of life instruments focus on parents’ perception of children’s disease.^3–5 In contrast, the CHQ focuses on an individual’s subjective perception of his or her health. Version CF-87 is designed for completion by the child.

The CHQ measures 11 child health concepts, with each being scored on a scale from 0 to 100 (Appendix [Table 6]). Higher scores indicate better self-perceived function. Published scores obtained from 278 healthy children aged 10 to 15 years from a middle school in northeast United States were used as normative reference.¹² Although ethnic and gender distribution of the reference population is not similar to our study subjects, sample size and age distribution are similar.

Data Analysis
Data are described as frequencies, medians with ranges, or means with standard deviations. Response bias was sought by comparing categorical data for responders versus nonresponders using ² or Fisher’s exact tests. General linear regression was used to assess possible associations between each CHQ concept and gender, TGA morphology, and type of surgical repair. Multiple linear regression was performed for scores on each of 11 CHQ scales using variables listed in the Appendix (Table 7). Variables meeting significance criterion of P<0.15 were entered into multivariable analysis, and those with P<0.10 were retained in final multivariable models. Analyses were performed using SAS statistical software Version 8 (SAS Institute).

	Results

Top Abstract Introduction Methods Results Discussion Appendix References

 
Of 595 children sent a CHQ, 317 (53%) returned a CHQ to the Data Center. Of these, 306 CHQs were analyzed. Eleven CHQs were excluded from analysis for the following reasons: parent completion (n=1), insufficiently completed CHQ (n=3), or unable to complete CHQ because of severe learning or intellectual disabilities (n=7). The latter had either ASO (simple TGA, n=2; TGA/VSD, n=1) or Mustard (simple TGA, n=3; TGA/VSD/pulmonary stenosis [PS], n=1) repair. The following potential explanatory factors for neurological deficits were identified in 5 subjects: prolonged circulatory arrest of 86 minutes (n=1), persistent severe cyanosis before Mustard (n=1), severe ventricular arrhythmia after ASO (n=1), and persistent low cardiac output syndrome (Mustard, n=1; ASO, n=1).

Mean age at follow-up was 13±1 years. Morphology and type of repair for responders are given in Table 1. There were no significant differences between CHQ responders and nonresponders in gender (70% versus 71% male; P=0.88), morphology (67% versus 64% simple, 27% versus 30% TGA/VSD, 6% versus 6% TGA/VSD/PS; P=0.27), and repair type (62% versus 63% ASO, 15% versus 12% Mustard, 19% versus 22% Senning, 4% versus 3% Rastelli; P=0.73).

View this table: [in this window] [in a new window]   TABLE 1. Diagnosis and Repair Type

CHQ scores of children with TGA were significantly higher than those from the published normative population (indicating better self-perceived health status) in all categories except self-esteem (Table 2). By univariable comparison, girls had higher mean scores in behavioral social limits (97 versus 87, P=0.003) and boys had higher general health perception scores (68 versus 60, P=0.02). Children with simple TGA or TGA/VSD had significantly higher CHQ scores than those with TGA/VSD/PS in the categories of physical functioning, general health perceptions, and mental health (Table 3). Children having ASO scored significantly higher in the categories of physical functioning, bodily pain, mental health, self-esteem, and general health perceptions than those having atrial repair or Rastelli procedure (Table 4). Children who had ASO scored higher than either atrial repair subgroup (Mustard or Senning). There were no significant differences between children who had Mustard or Senning.

View this table: [in this window] [in a new window]   TABLE 2. Mean CHQ Scores for TGA Group and Published Norms

View this table: [in this window] [in a new window]   TABLE 3. Mean CHQ Scores by Morphology

View this table: [in this window] [in a new window]   TABLE 4. Mean CHQ Scores by Repair Type

Multivariable regression analysis was performed for scores on each CHQ concept (Table 5). Although statistically significant, the percent variation in CHQ concept scores explained by the factors is small, with R² values ranging from 0.024 to 0.26. Repair type was associated with scores on all but 2 CHQ concepts (emotional and behavior social limits). For each, atrial repair was associated with lower scores than ASO. Perfusion parameters such as circulatory arrest, ischemic time, duration of cardiopulmonary bypass, and cooling temperature were associated with lower scores on social limits and behavior concepts. Male gender was associated with lower scores in emotional and behavioral concepts, and female gender was associated with lower general health perceptions.

View this table: [in this window] [in a new window]   TABLE 5. Summary of Multiple Regression Analysis for Independent Factors Associated With Lower Scores on Individual CHQ Concepts

	Discussion

Top Abstract Introduction Methods Results Discussion Appendix References

 
Compared with the normal population, children after TGA repair have been reported to have more frequent neurologic impairment, learning disabilities, behavior disorders, and poorer motor, vocabulary, and acquired abilities.^6,13 Our study suggests that children and adolescents surviving repair of TGA seem to be functioning well, both physically and psychosocially. Our study population scored significantly higher than published norms in all categories except self-esteem. Although statistically significant, the magnitude of differences between TGA and control children is small. At present, this difference is of unknown clinical relevance.

Our study is unique because data were obtained directly from children. Most studies of this type survey parents, and few investigators have relied on direct responses from children with congenital heart defects.¹⁴ Guyatt et al¹⁵ noted that parents of children aged 11 years or older provided little information regarding their child’s quality of life beyond that obtained directly from the child.

Clearly, self-perception of disease is multifactorial. The finding of low R² values in our study indicates that a large portion of variability in CHQ scores is explained by variables not included in our data set. Such variables may include home and school environment, economic status, and genetic or geographic factors. In a study of cognitive development after Fontan operation by Wernovsky et al,¹⁶ surgical and diagnostic factors explained 6% of variation in achievement and IQ scores. The addition of socioeconomic status to their analysis increased explained variation nearly 4-fold. The inference from our study is that diagnostic and surgical factors are small but important determinants in children’s psychosocial development.

Previous reports show that 96% of children are without symptoms or limitation of physical activity up to 5 years after ASO.^17,18 Masterson et al⁶ used a parent-completed version of the CHQ to evaluate general health status in 160 children at 8 years of age. They found that the overall physical and psychosocial health status after ASO was similar to a normative population. Furthermore, children who underwent ASO have preserved systemic ventricular function with sustained sinus rhythm and near-total avoidance of cardiac medication.^18–20 Functional outcomes published to date are reassuring to the findings of our study. There is concordance between children’s self-perception of physical and psychosocial health and that objectively documented in clinical studies. Although our study extends follow-up of physical and psychosocial outcomes of ASO patients to 13 years, later evaluation is necessary to monitor for subsequent deterioration in subjective and objective measures of health status.

In contrast to ASO patients, there is often discordance between subjective history and objective findings in patients having atrial repair of TGA. Paul and Wessel²¹ found that most patients with atrial repair report a self-perception of normal physical function and ability. However, when assessed systematically, others have found that 40% to 77% of patients report some degree of physical restriction.^22,23 Objective exercise testing after atrial repair reveals diminished aerobic capacity with limited cardiac output because of reduced stroke volume and attenuated heart rate response.^21,24

In our study, multivariable regression analyses reveal that repair type was significant for all but 2 CHQ concepts, with atrial switch being associated with lower scores than ASO. Although no significant differences were found between scores for children with Mustard and Senning by univariable comparison, Mustard repair was independently associated with lower scores on several CHQ concepts. This finding cannot be readily explained. Previous data suggest a survival advantage for patients with Mustard and a rhythm advantage for patients with Senning, but no important differences in functional class have been found to date.^22,25

Long-term psychological outcomes after atrial repair remain unclear. Alden et al²⁶ reported that 26% of children had behavioral problems, although psychosocial performance and self-esteem are often normal. Their patients were repaired 20 years earlier than our patients during a time when definitive correction was delayed for months. Longer duration of cyanosis in these children may be a factor explaining differences in behavior and cognitive outcomes.²⁷

Other factors may explain higher scores in ASO children. Because they were operated on at younger age than those after atrial or Rastelli repair, they had a shorter cumulative duration of cyanosis. They may also have fewer long-term limitations because of ventricular failure and arrhythmia. Ellerbeck et al²⁸ compared the cognitive and motor development of children after atrial and ASO repair. They noted no difference in neurologic impairment, learning disabilities, behavior disorders, and motor, vocabulary, and acquired abilities. Our finding that the ASO group had better CHQ scores may be attributable to a difference in the age of our patients, their duration of follow-up, or our method of data collection that excluded a few patients with important learning disabilities.

Perfusion techniques are often implicated in neuropsychological outcomes. Others have shown that use of circulatory arrest during TGA repair is associated with fine and gross motor deficits but is generally well tolerated, with no cognitive or other neurologic deficits identified by formal testing.^13,27 By multivariable regression, our study revealed that perfusion parameters may be important in behavior and social limits concepts. Use of circulatory arrest, but not duration, was associated with lower CHQ scores, suggesting that any period of cerebral ischemia may be detrimental. That lower nadir core temperature may be associated with lower scores in behavior concepts is perhaps unexpected. We speculate that attaining lower nadir temperature could be associated with longer duration of cardiopulmonary bypass, higher flow rates, and more extreme rates of cooling and rewarming in the 1985 to 1989 era. Variations in such parameters were previously linked to lower scores on formal neurologic testing.²⁹ Inferences regarding perfusion parameters would require additional information, such as pH and blood-gas management.

Study Limitations
The response rate was suboptimal, possibly contributing to undetected response bias. Although similar to responders in age, diagnosis, and repair type, nonresponders may differ in other important ways that potentially impact health-related quality of life. Albeit few, children with severe disabilities are not reflected in CHQ scores because they could not complete the questionnaire. Lastly, there may be important differences in social, demographic, and economic characteristics of our study children and published norms.

Summary
Self-perceived quality of life is excellent in most children who underwent repair of TGA 10 to 15 years earlier. Diagnostic and surgical factors are small but important determinants of children’s perception of health-related quality of life. ASO is associated with improved physical and psychosocial functioning compared with other methods of repair. These differences may be additionally exacerbated with longer follow-up.

	Appendix

Top Abstract Introduction Methods Results Discussion Appendix References

 

View this table: [in this window] [in a new window]   TABLE 6. Description and Interpretation of Child Health Concepts Measured in Child Health Questionnaire Version CF-87

View this table: [in this window] [in a new window]   TABLE 7. Variables Considered in Multivariable Regression Analysis of CHQ Concept Scores

	References

Top Abstract Introduction Methods Results Discussion Appendix References

 
1. World Health Organization. Constitution of the World Health Organization. In: Basic Documents. Geneva: World Health Organization; 1948.

2. Landgraf JM, Abetz L, Ware JE. Child Health Questionnaire (CHQ): A User’s Manual. Boston: The Health Institute, New England Medical Center; 1996.

3. Lewis CC, Pantell RH, Kieckhefer GM. Assessment of children’s health status: field test of new approaches. Med Care. 1989; 27 (suppl 3): S54–S65.[CrossRef][Medline] [Order article via Infotrieve]

4. Pal DK. Quality of life assessment in children: a review of conceptual and methodological issues in multi-dimensional issues in health status measures. J Epidemiol Community Health. 1996; 50: 391–396.[Abstract/Free Full Text]

5. Vivier PM, Bernier JA, Starfield B. Current approaches to measuring health outcomes in pediatric research. Curr Opinion Pediatr. 1994; 6: 530–537.[Medline] [Order article via Infotrieve]

6. Masterson CD, Wypij D, Bellinger DC, et al. General health status of children with D-transposition of the great arteries after the arterial switch operation. Circulation. 2001; 104 (suppl I): I-138–I-142.[Medline] [Order article via Infotrieve]

7. Norwood WI, Dobell AR, Freed MD, et al. Intermediate results of the arterial switch repair. J Thorac Cardiovasc Surg. 1988; 96: 854–862.[Abstract]

8. Trusler GA, Castaneda AR, Rosenthal A, et al. Current results of management in transposition of the great arteries with special emphasis on patients with associated ventricular septal defect. J Am Coll Cardiol. 1987; 10: 1061–1071.[Abstract]

9. Castaneda AR, Trusler GA, Paul MH, et al. The early results of treatment of simple transposition in the current era. J Thorac Cardiovasc Surg. 1988; 95: 14–27.[Abstract]

10. Kirklin JW, Blackstone EH, Tchervenkov CI, et al. Clinical outcomes after the arterial switch operation for transposition: patient, support, procedural, and institutional risk factors. Circulation. 1992; 86: 1501–1515.[Abstract/Free Full Text]

11. Williams WG, Quaegebeur JM, Kirklin JW, et al. Outflow obstruction after the arterial switch operation: a multi-institutional study. J Thorac Cardiovasc Surg. 1997; 114: 975–990.[Abstract/Free Full Text]

12. Landgraf JM, Abetz LN. Functional status and well-being of children representing three cultural groups: initial self-reports using the CHQ-CF87. Psychol Health. 1997; 12: 839–854.[CrossRef]

13. Bellinger DC, Wypij D, Kuban KC, et al. Development and neurological status of children at 4 years of age after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. Circulation. 1999; 100: 526–532.[Abstract/Free Full Text]

14. Tong EM, Sparacino PS, Messias DK, et al. Growing up with congenital heart disease: the dilemmas of adolescents and young adults. Cardiol Young. 1998; 8: 303–309.[Medline] [Order article via Infotrieve]

15. Guyatt GH, Juniper EF, Griffith LE, et al. Children and adult perceptions of childhood asthma. Pediatrics. 1997; 99: 165–168.[Abstract/Free Full Text]

16. Wernovsky G, Stiles KM, Gauvreau K, et al. Cognitive development after the Fontan operation. Circulation. 2000; 102: 883–889.[Abstract/Free Full Text]

17. Quaegebeur JM, Rohmer J, Ottenkamp J, et al. The arterial operation: an eight-year experience. J Thorac Cardiovasc Surg. 1986; 92: 361–384.[Abstract]

18. Hovels-Gurich HH, Seghaye MC, Dabritz S, et al. Cardiological and general health status in preschool- and school-age children after arterial switch operation. Eur J Cardiothorac Surg. 1997; 12: 593–601.[Abstract]

19. Losay J, Touchot A, Serraf A, et al. Late outcome after arterial switch operation for transposition of the great arteries. Circulation. 2001; 104 (suppl I): I-121–I-126.[Medline] [Order article via Infotrieve]

20. Turley K, Verrier ED, and Congenital Heart Surgeons Society Database. Intermediate results from the period of the Congenital Heart Surgeons transposition study: 1985 to 1989. Ann Thorac Surg. 1995; 60: 505–510.[Abstract/Free Full Text]

21. Paul MH, Wessel HU. Exercise studies in patients with transposition of the great arteries after atrial repair operations (Mustard/Senning): a review. Pediatr Cardiol. 1999; 20: 49–55.[CrossRef][Medline] [Order article via Infotrieve]

22. Wells WJ, Blackstone EH, for the Congenital Heart Surgeons Society. Intermediate outcome after Mustard and Senning procedures: a study by the Congenital Heart Surgeons Society. Semin Thorac Cardiovasc Surg. 2000; 3: 186–197.

23. Meijboom F, Szatmari A, Deckers JW, et al. Long-term follow-up (10–17 years) after Mustard repair for transposition of the great arteries. J Thorac Cardiovasc Surg. 1996; 111: 1158–1168.[Abstract/Free Full Text]

24. Fredrikson PM, Veldtman G, Hechter S, et al. Aerobic capacity in adults with various congenital heart diseases. Am J Cardiol. 2001; 87: 310–314.[CrossRef][Medline] [Order article via Infotrieve]

25. Helbing WA, Hansen B, Ottenkamp J, et al. Long-term results of atrial correction for transposition of the great arteries: comparison of Mustard and Senning operations. J Thorac Cardiovasc Surg. 1994; 108: 363–372.[Abstract/Free Full Text]

26. Alden B, Gilljam T, Gillberg C. Long-term psychological outcome of children after surgery for transposition of the great arteries. Acta Pediatr. 1998; 87: 405–410.[CrossRef][Medline] [Order article via Infotrieve]

27. Hovels-Gurich HH, Seghaye MC, Dabritz S, et al. Cognitive and motor development in preschool and school-aged children after neonatal arterial switch operation. J Thorac Cardiovasc Surg. 1997; 114: 578–585.[Abstract/Free Full Text]

28. Ellerbeck KA, Smith ML, Holden EW, et al. Neurodevelopmental outcomes in children surviving d-transposition of the great arteries. Dev Behav Pediatr. 1998; 19: 335–341.[Medline] [Order article via Infotrieve]

29. Gomelsky A, Holden EW, Ellerbeck KA, et al. Predictors of developmental outcomes in children with complex transposition. Cardiol Young. 1998; 8: 352–357.[Medline] [Order article via Infotrieve]

This article has been cited by other articles:

				B. S. Marino, R. S. Tomlinson, D. Drotar, E. S. Claybon, A. Aguirre, R. Ittenbach, J. S. Welkom, M. A. Helfaer, G. Wernovsky, and J. A. Shea Quality-of-Life Concerns Differ Among Patients, Parents, and Medical Providers in Children and Adolescents With Congenital and Acquired Heart Disease Pediatrics, April 1, 2009; 123(4): e708 - e715. [Abstract] [Full Text] [PDF]

				C. A. Warnes, R. G. Williams, T. M. Bashore, J. S. Child, H. M. Connolly, J. A. Dearani, P. del Nido, J. W. Fasules, T. P. Graham Jr, Z. M. Hijazi, et al. ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines on the Management of Adults With Congenital Heart Disease) Developed in Collaboration With the American Society of Echocardiography, Heart Rhythm Society, International Society for Adult Congenital Heart Disease, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons J. Am. Coll. Cardiol., December 2, 2008; 52(23): e143 - e263. [Full Text] [PDF]

				C. A. Warnes, R. G. Williams, T. M. Bashore, J. S. Child, H. M. Connolly, J. A. Dearani, P. del Nido, J. W. Fasules, T. P. Graham Jr, Z. M. Hijazi, et al. ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines on the Management of Adults With Congenital Heart Disease): Developed in Collaboration With the American Society of Echocardiography, Heart Rhythm Society, International Society for Adult Congenital Heart Disease, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons Circulation, December 2, 2008; 118(23): e714 - e833. [Full Text] [PDF]

				J. Horer, E. Karl, G. Theodoratou, C. Schreiber, J. Cleuziou, Z. Prodan, M. Vogt, and R. Lange Incidence and results of reoperations following the Senning operation: 27 years of follow-up in 314 patients at a single center Eur. J. Cardiothorac. Surg., June 1, 2008; 33(6): 1061 - 1067. [Abstract] [Full Text] [PDF]

				K. D. Bakshi, B. Vaidyanathan, K. R. Sundaram, S. J. Roth, K. Shivaprakasha, S. G. Rao, S. G. Nair, S. Chengode, and R. K. Kumar Determinants of early outcome after neonatal cardiac surgery in a developing country J. Thorac. Cardiovasc. Surg., September 1, 2007; 134(3): 765 - 771. [Abstract] [Full Text] [PDF]

				K. M. Amark, T. Karamlou, A. O'Carroll, C. MacDonald, R. M. Freedom, S.-J. Yoo, W. G. Williams, G. S. Van Arsdell, C. A. Caldarone, and B. W. McCrindle Independent Factors Associated With Mortality, Reintervention, and Achievement of Complete Repair in Children With Pulmonary Atresia With Ventricular Septal Defect J. Am. Coll. Cardiol., April 4, 2006; 47(7): 1448 - 1456. [Abstract] [Full Text] [PDF]

				A. Dodge-Khatami, A. Kadner, F. Berger, H. Dave, M. I. Turina, and R. Pretre In the Footsteps of Senning: Lessons Learned From Atrial Repair of Transposition of the Great Arteries Ann. Thorac. Surg., April 1, 2005; 79(4): 1433 - 1444. [Abstract] [Full Text] [PDF]

				P. Moons, K. Van Deyk, W. Budts, and S. De Geest Caliber of Quality-of-Life Assessments in Congenital Heart Disease: A Plea for More Conceptual and Methodological Rigor Arch Pediatr Adolesc Med, November 1, 2004; 158(11): 1062 - 1069. [Abstract] [Full Text] [PDF]

				I. E. Konstantinov, V. V. Alexi-Meskishvili, W. G. Williams, R. M. Freedom, and R. Van Praagh Atrial switch operation: past, present, and future Ann. Thorac. Surg., June 1, 2004; 77(6): 2250 - 2258. [Abstract] [Full Text] [PDF]

This Article Abstract Full Text (PDF) All Versions of this Article: 108/7/857    most recent 01.CIR.0000084547.93252.9Av1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Culbert, E. L. Articles by McCrindle, B. W. Search for Related Content PubMed PubMed Citation Articles by Culbert, E. L. Articles by McCrindle, B. W. Related Collections Behavioral/psychosocial - CV surgery Pediatric and congenital heart disease, including cardiovascular surgery