Published online before print March 11, 2002, doi: 10.1161/01.CIR.0000012543.55874.47
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(Circulation. 2002;105:1567.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Risk Stratification for Postoperative Cardiovascular Events via Noninvasive Assessment of Endothelial Function
A Prospective Study
From Evans Department of Medicine and Whitaker Cardiovascular Institute (N.G., J.F.K., L.M.H., J.A.V.), Boston University School of Medicine, Boston, Mass; Surgical Service (M.T.W.), VA Boston Healthcare System and Department of Surgery, Boston University School of Medicine, Boston, Mass; and Department of Surgery (J.O.M.), Boston University School of Medicine, Boston, Mass.
Correspondence to Joseph A. Vita, MD, Section of Cardiology, Boston Medical Center, 88 E Newton St, Boston, MA 02118. E-mail jvita{at}bu.edu
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Abstract |
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Background— Brachial artery endothelial function is impaired in individuals with atherosclerosis and coronary risk factors and improves with risk reduction therapy. However, the predictive value of brachial artery endothelial dysfunction for future cardiovascular events is unknown.
Methods and Results— We preoperatively examined brachial artery vasodilation using ultrasound in 187 patients undergoing vascular surgery. Patients were prospectively followed for 30 days after surgery. Forty-five patients had a postoperative event, including cardiac death (3), myocardial infarction (12), unstable angina/ischemic ventricular fibrillation (2), stroke (3), or elevated troponin I, reflecting myocardial necrosis (25). Preoperative endothelium-dependent flow-mediated dilation was significantly lower in patients with an event (4.9±3.1%) than in those without an event (7.3±5%; P<0.001), whereas endothelium-independent vasodilation to nitroglycerin was similar in both groups. In a Cox proportional-hazards model, the independent predictors of events were age (P=0.001), renal insufficiency (P=0.03), noncarotid surgery (P=0.05), and lower brachial artery flow-mediated dilation (P=0.007). If troponin I elevation was not considered an event, low flow-mediated dilation remained an independent predictor of risk (odds ratio 9.0, 95% CI 1.2 to 68; P=0.03). When a flow-mediated dilation cutpoint of 8.1% was used, endothelial function had a sensitivity of 95%, specificity of 37%, and negative predictive value of 98% for events.
Conclusions— Impaired brachial artery endothelial function independently predicts postoperative cardiac events, which supports a role for endothelial dysfunction in the pathogenesis of cardiovascular disease. The strong negative predictive value of preserved endothelial function raises the possibility that assessment of brachial artery flow-mediated dilation will be useful in the management of patients undergoing vascular surgery.
Key Words: endothelium • surgery • risk factors
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Introduction |
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The vascular endothelium plays a central role in the regulation of vascular tone, thrombosis, and inflammation through elaboration of a number of paracrine factors, including nitric oxide.1 Impaired endothelium-dependent dilation in the coronary circulation is associated with coronary atherosclerosis2 and coronary risk factors3 and improves with risk reduction therapies.4 Several previous studies using invasive methodology have suggested a link between endothelial dysfunction in the coronary and peripheral circulations and cardiovascular risk.5–8
Ultrasound assessment of brachial artery flow-mediated dilation during reactive hyperemia has recently emerged as a noninvasive and broadly applicable method for examination of endothelial function.9 The dilator response depends on nitric oxide synthesis,10 is impaired in patients with coronary disease and risk factors,9 and improves in response to interventions known to reduce cardiovascular disease risk.11 Furthermore, impaired flow-mediated dilation in the brachial artery predicts endothelial dysfunction in the coronary circulation.12,13 On the basis of these observations, investigators have speculated that endothelial function in the brachial artery may reflect the integrated effects of systemic risk factors on the entire vasculature.14 Thus, brachial artery flow-mediated dilation might prove useful to assess cardiovascular risk, guide therapy, and judge the potential utility of new interventions for cardiovascular disease.15 To date, however, no study has shown that the presence of endothelial dysfunction detected noninvasively in the brachial artery provides independent prognostic information.
To investigate this issue, we sought a population with high short-term cardiovascular risk. Patients undergoing vascular surgery frequently have subclinical or overt coronary artery disease, and 7% to 19% of patients have been reported to have cardiovascular events within 30 days of surgery.16–18 The purpose of the present study was to determine the relation between brachial artery endothelial function and cardiovascular risk in patients undergoing vascular surgery.
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Methods |
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Patient Population
Patients undergoing nonemergent vascular surgery between November 1998 and March 2001 at Boston Medical Center and the VA Boston Healthcare System were eligible for participation in the study. Operations included thoracic or abdominal aortic aneurysm repair, carotid endarterectomy, aortofemoral or femoral-distal vessel bypass, axillary-femoral bypass, and amputations. Approximately 500 vascular surgical procedures were performed during this time period in both institutions. Patients with recent (within 1 month) unstable angina, myocardial infarction, stroke, decompensated heart failure, or malignant cardiac arrhythmias were excluded. All patients provided written informed consent as approved by the institutional review boards.
Study Protocol
Up to 1 month before surgery, endothelium-dependent flow-mediated dilation of the brachial artery was examined noninvasively by an established method.19,20 Briefly, 2D images of the brachial artery and pulsed-Doppler flow velocity signals were obtained above the antecubital crease at baseline and during a period of reactive hyperemia induced by 5-minute cuff occlusion of the upper arm. Images were obtained at baseline and 60 seconds after cuff release with a Toshiba 140A ultrasound system equipped with a 7.5-MHz linear array transducer (Toshiba Medical, Inc). After a 10-minute rest period to allow restoration of baseline conditions, we assessed the extent of non–endothelium-dependent brachial artery dilation by obtaining 2D images before and 3 minutes after administration of sublingual nitroglycerin (0.4 mg). Nitroglycerin was omitted if the patient refused or if the patient had a history of migraine headaches, systolic blood pressure <100 mm Hg, previous adverse reaction to nitrates, or critical carotid artery stenosis. An investigator blinded to image sequence and clinical information performed offline analysis of digitized end-diastolic images. Patients also had preoperative 12-lead ECGs and measurement of lipid profile, complete blood count, and serum creatinine.
Assessment of Cardiovascular Events
Starting on the day of surgery and continuing throughout hospitalization, a cardiologist monitored the patient’s course for cardiovascular events. In addition, an ECG, serum troponin I levels, and creatine kinase with MB fractionation were obtained on postoperative days 1 and 3. Cardiovascular events were prospectively defined to include (1) cardiac death; (2) myocardial infarction (new Q waves >0.03 seconds or ST-segment depression 
1 mm in 1 or more leads plus creatine kinase-MB fraction elevation); (3) unstable angina/ischemic ventricular fibrillation; (4) acute nonhemorrhagic stroke (judged clinically and by evidence of abnormal head CT scan or MRI); and (5) elevated serum troponin I (>0.4 ng/mL, reflecting myocardial necrosis but otherwise not meeting the criteria for myocardial infarction).16 If an event occurred, the patient’s primary physician performed additional tests and guided management as he or she deemed appropriate. Medical records were reviewed, and a telephone call was made to the patient or family after discharge to identify additional events occurring within 30 days of surgery. Three cardiologists blinded to the ultrasound results adjudicated all events by review of medical records. One event per patient was included in the analysis. For patients with >1 event, the coded event was selected by the hierarchical order listed above.
Statistical Analysis
The prospectively determined primary end point was any postoperative cardiovascular event, as defined above. Kaplan-Meier analysis with the log-rank test was used to plot and compare event-free survival distributions according to tertile of brachial artery flow-mediated dilation. Two patients died of noncardiac causes before 30 days and were censored in the survival analysis. Relations among potential confounders, events, and flow-mediated dilation were examined with the Student t test, 1-way ANOVA, 
2 test, or Fisher exact test, as appropriate. Potential confounders included age, sex, race, diabetes mellitus, hypertension, chronic renal insufficiency (creatinine >1.2 mg/dL), known coronary disease, history of smoking, history of hypercholesterolemia, white blood cell count, hematocrit, ACE-inhibitor therapy, ß-blocker therapy, nitroglycerin-mediated dilation, and baseline brachial artery diameter. A Cox proportional-hazards model was used to control for the confounders identified by univariate analysis (inclusion criterion P<0.10).21 Because the Kaplan-Meier curves for the lowest and middle tertiles of flow-mediated dilation overlapped and differed from the highest tertile, patients were dichotomized in this multivariate analysis as having high (upper tertile) or low (lower 2 tertiles) flow-mediated dilation. By the same approach, a separate analysis was completed after exclusion of elevated troponin I as a postoperative event. The analyses were completed with SPSS for Windows version 10.1 (SPSS Inc). Data are presented as mean±SD.
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Results |
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Study Patients
A total of 187 patients were enrolled in the study and underwent a vascular operation, including carotid endarterectomy (47 patients), femoral-popliteal or other peripheral bypass (100), aortic aneurysm repair (24), and limb amputation (16). Thirty-day follow-up was obtained for all patients. Forty-five patients had a cardiovascular event, including cardiac death (3 patients), myocardial infarction (12), unstable angina (1), ischemic ventricular fibrillation (1), stroke (3), and elevated troponin I (25). Two patients died of noncardiac causes (1 of sepsis on postoperative day 26 and 1 with a ruptured abdominal aortic aneurysm 28 days after femoral-popliteal bypass).
Patient characteristics are displayed in Table 1. As shown, patients with a postoperative cardiovascular event were older and were more likely to be female and have diabetes, hypertension, chronic renal insufficiency, and known coronary artery disease. Total, LDL, and HDL cholesterol were lower and creatinine was higher in the patients with an event. Carotid endarterectomy was less common in patients with an event than in those without an event. Unexpectedly, patients with an event were more likely to be taking an ACE inhibitor and ß-blockers and less likely to have a history of smoking, possibly related to the greater preponderance of patients with coronary disease and hypertension in this group, which may have resulted in altered medical management and behavior.
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Brachial Artery Ultrasound Results
Average flow-mediated dilation was 6.7±4.7% (n=187), and average nitroglycerin-mediated dilation was 10.6±6.3% (n=64). Brachial artery parameters for patients with and without a cardiovascular disease event are displayed in Table 2. As shown, patients with an event had significantly lower flow-mediated dilation and larger baseline brachial artery diameter. Extent of reactive hyperemia and responses to nitroglycerin did not predict events. Clinical characteristics categorized by tertile of flow-mediated dilation are displayed in Table 3. Patients with diabetes were more likely to have lower flow-mediated dilation, and there was a trend for an inverse relation between white blood cell count and endothelial function.
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Predictive Value of Endothelial Function
As shown in the Figure, event-free survival differed according to tertile of flow-mediated dilation by log-rank test. Notably, the survival curves overlapped for patients in the lower 2 tertiles. Table 4 displays the number of cardiovascular disease events when patients were categorized as having low flow-mediated dilation (lower 2 tertiles, 
8.1%) or high flow-mediated dilation (upper tertile, >8.1%). As shown, patients with high flow-mediated dilation had significantly fewer events than patients with low flow-mediated dilation. The presence of low brachial artery flow-mediated dilation had a sensitivity of 89%, a specificity of 40%, a positive predictive value of 32%, and a negative predictive value of 92% for cardiovascular disease events.
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The variables that met the entry criterion (univariate P<0.10) and were included in the Cox proportional-hazards model were age, chronic renal insufficiency, carotid surgery, flow-mediated dilation, sex, diabetes mellitus, hypertension, history of coronary disease, history of congestive heart failure, history of smoking, and baseline brachial diameter. The independent predictors of cardiovascular disease events were older age, chronic renal insufficiency, noncarotid surgery, and lower brachial artery flow-mediated dilation (Table 5).
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Troponin I is a well-recognized marker of myocardial necrosis and adverse outcome and has been suggested to be a better indicator of perioperative infarction than creatine kinase-MB fraction.22 However, it is not uniformly recognized as an end point in studies of surgical risk. We therefore repeated the analysis after exclusion of troponin I elevation as an event. As shown in the Figure, brachial artery flow-mediated dilation remained a significant predictor of outcome by log-rank test. With this definition of an event, low brachial artery flow-mediated dilation had a sensitivity of 95%, a specificity of 37%, a positive predictive value of 15%, and a negative predictive value of 98% for cardiovascular disease events. In the Cox proportional-hazards model, the independent predictors of events were decade of age (OR 2.0, 95% CI 1.2 to 3.3; P=0.006) and low brachial artery flow-mediated dilation (OR 9.0, 95% CI 1.2 to 68; P=0.03).
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Discussion |
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This prospective study demonstrated that impaired flow-mediated dilation of the brachial artery independently predicts short-term cardiovascular events in patients undergoing vascular surgery. No relation was observed between nitroglycerin-mediated dilation and events or extent of reactive hyperemia and events, and the predictive value of flow-mediated dilation was independent of vessel size. These latter observations imply that the results cannot be explained by altered function of vascular smooth muscle, variation in the stimulus for vasodilation, or the larger vessel size in patients with events, which is known to be associated with decreased flow-mediated dilation. Thus, the study supports a relation between brachial artery endothelial dysfunction and cardiovascular events.
Two previous invasive studies examined the relation between endothelial dysfunction in the coronary circulation and cardiovascular risk. Suwaidi and colleagues5 tested endothelial function by intracoronary acetylcholine infusion in 157 patients with mild coronary atherosclerosis. During 28-month follow-up, 6 patients had a cardiovascular event, and all 6 had evidence of severe endothelial dysfunction. Schächinger and colleagues6 assessed coronary endothelial vasomotor function in response to acetylcholine and nitroglycerin infusion, the cold pressor test, and/or increased flow in 147 patients undergoing cardiac catheterization. During 7.7-year follow-up, 16 patients had a cardiovascular event, and both endothelium-dependent vasodilation and endothelium-independent vasodilation were worse in those patients with an event.
Although the total numbers of events were small, those 2 studies suggest a pathogenic link between coronary endothelial dysfunction and cardiovascular disease. It has been increasingly recognized that events such as acute myocardial infarction, unstable angina, and ischemic stroke often result from plaque rupture with subsequent thrombosis formation and vasospasm.23 An important relation between inflammation and plaque vulnerability has also been recognized.24 Loss of the vasodilator, antithrombotic, and anti-inflammatory properties of the endothelium likely contributes to these events.25
Several prior studies addressed the question of whether study of endothelial function in a peripheral artery also provides prognostic information about cardiac events. Perticone and colleagues7 examined endothelial function in forearm microvessels in response to intra-arterial agonist infusion in 225 patients with newly diagnosed hypertension. Patients with lower vasodilator responses to acetylcholine were more likely to suffer a cardiac or vascular event.7 In a recent study, Heitzer and coworkers8 demonstrated that coronary disease patients with impaired forearm microvessel responses to acetylcholine developed more cardiovascular events over a 4.5-year follow-up period. In a retrospective noninvasive study using brachial ultrasound, Neunteufl and colleagues26 observed an inverse relation between flow-mediated dilation and events in a group of 74 patients undergoing cardiac catheterization. However, the majority of events in that small study were revascularization procedures, and the predictive value of endothelial dysfunction for this outcome was lost after controlling for extent of coronary artery disease. Thus, the present study is the first study to demonstrate that noninvasive assessment of brachial artery endothelial function provides independent prognostic information and is the only prospective study using noninvasive methodology.
One implication of the present study is the possible role of endothelial function in assessment of postoperative risk in patients undergoing vascular surgery. Average flow-mediated and nitroglycerin-mediated dilation were low in this group of patients with peripheral atherosclerosis compared with normal subjects.27 However, many subjects had relatively preserved endothelial function, and the high negative predictive value of the test suggests that it potentially could be useful for identifying individuals at lower risk for perioperative cardiovascular events. Preoperative risk assessment is an important clinical problem,28 and the utility of other modalities for assessing preoperative risk has been questioned.18,22 One potential approach would be to combine the results of endothelial function testing with other tests or clinical scoring systems of surgical risk.
Given the relatively small number of subjects, it is clear that further studies will be required before this methodology can be considered a clinical tool for preoperative risk assessment. Because we studied only a minority of patients undergoing vascular surgery during the period of recruitment, another limitation is the possibility of enrollment bias. However, this issue seems unlikely to be important, because the patient characteristics in the present study are quite similar to prior studies of this question.18,29
Although the present study suggests that brachial artery endothelial dysfunction predicts short-term risk in a high-risk group of patients, the long-term predictive value in lower-risk populations remains an open question. Endothelial dysfunction is an early occurrence in the atherogenic process30 and might serve as a surrogate marker of cardiovascular disease with utility for risk assessment and evaluation of new therapies. Other modalities have been proposed for this purpose, including electron-beam CT scanning and assessment of carotid intimal thickness.31 A potential advantage of testing flow-mediated dilation is the unique information gained about vascular function. In contrast, the other modalities largely provide information about the presence and severity of fixed anatomic disease, which may be less relevant to the pathogenesis of events.
In summary, this prospective study of consecutive patients undergoing nonemergent vascular surgery demonstrates that endothelial dysfunction is an independent predictor of postoperative cardiovascular events. In particular, the patients with relatively preserved endothelial function had a very low risk. These findings add to the growing evidence that endothelial dysfunction contributes to the pathogenesis of cardiovascular disease. In addition, the study demonstrates that noninvasive assessment of endothelial function in a peripheral artery provides prognostic information. Ongoing studies will provide further information about the clinical utility of studying brachial artery endothelial function.
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Acknowledgments |
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Dr Gokce is the recipient of a Mentored Patient-Oriented Research Career Transition Award from the National Institutes of Health (NIH) (K23 HL04425). Dr Watkins is supported by NIH grant HL-48152 and a grant from the Research Administration of the Department of Veterans Affairs. Drs Vita and Keaney are the recipients of Established Investigator Awards from the American Heart Association. The work was supported by a Specialized Center of Research in Ischemic Heart Disease grant from the NIH (HL-55993) and NIH grants HL-60886 and HL-52936. The authors gratefully acknowledge Monika Holbrook, David Kahn, MD, and Maryann Barry for their assistance with data collection for this study.
Received December 28, 2001; revision received January 25, 2002; accepted January 28, 2002.
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References |
|---|
|
TopAbstractIntroductionMethodsResultsDiscussionReferences |
|---|
1. Vane JR, Anggard EE, Botting RM. Regulatory functions of the vascular endothelium. N Engl J Med. 1990; 323: 27–36.
2. Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986; 315: 1046–1051.
3. Vita JA, Treasure CB, Nabel EG, et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation. 1990; 81: 491–497.
4. Vita JA, Keaney JF Jr. Exercise: toning up the endothelium? N Engl J Med. 2000; 342: 503–505.
5. Suwaidi JA, Hamasaki S, Higano ST, et al. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation. 2000; 101: 948–954.
6. Schächinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation. 2000; 101: 1899–1906.
7. Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation. 2001; 104: 191–196.
8. Heitzer T, Schlinzig T, Krohn K, et al. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation. 2001; 104: 2673–2678.
9. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992; 340: 1111–1115.
10. Lieberman EH, Gerhard MD, Uehata A, et al. Flow-induced vasodilation of the human brachial artery is impaired in patients <40 years of age with coronary artery disease. Am J Cardiol. 1996; 78: 1210–1214.
11. Gokce N, Keaney JF, Jr, Vita JA. Endotheliopathies: clinical manifestations of endothelial dysfunction. In: Loscalzo J, Shafer AI, eds. Thrombosis and Hemorrhage. Baltimore, Md: Williams & Wilkins; 1998: 901–924.
12. Anderson TJ, Uehata A, Gerhard MD, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol. 1995; 26: 1235–1241.
13. Takase B, Uehata A, Takashi A, et al. Endothelium-dependent flow-mediated vasodilation in coronary and brachial arteries in suspected coronary artery disease. Am J Cardiol. 1998; 82: 1535–1539.
14. Vogel RA, Corretti MC. Estrogens, progestins, and heart disease: can endothelial function divine the benefit? Circulation. 1998; 97: 1223–1226.
15. Celermajer DS. Endothelial dysfunction: does it matter? Is it reversible? J Am Coll Cardiol. 1997; 30: 325–333.
16. Raby K, Goldman L, Creager M, et al. Correlation between preoperative ischemia and major cardiac events after peripheral vascular surgery. N Engl J Med. 1989; 321: 1296–1300.
17. Poldermans D, Boersma E, Bax JJ, et al. The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. N Engl J Med. 1999; 341: 1789–1794.
18. Baron JF, Mundler O, Bertrand M, et al. Dipyridamole-thallium scintigraphy and gated radionuclide angiography to assess cardiac risk before abdominal aortic surgery. N Engl J Med. 1994; 330: 663–669.
19. Levine GN, Frei B, Koulouris SN, et al. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation. 1996; 96: 1107–1113.
20. Gokce N, Keaney JF, Jr, Frei B, et al. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation. 1999; 99: 3234–3240.
21. Cox DR. Regression and life tables. J Royal Stat Soc. 1972; 34: 187–220.
22. Goldman L. Assessment of perioperative cardiac risk. N Engl J Med. 1994; 330: 707–709.
23. Fuster V, Badimon L, Badimon JJ, et al. The pathogenesis of coronary artery disease and the acute coronary syndromes (part 1). N Engl J Med. 1992; 326: 242–250.
24. Libby P. Molecular basis of the acute coronary syndromes. Circulation. 1995; 91: 2844–2850.
25. Levine GN, Keaney JF, Jr, Vita JA. Cholesterol reduction in cardiovascular disease: clinical benefits and possible mechanisms. N Engl J Med. 1995; 332: 512–521.
26. Neunteufl T, Heher S, Katzenschlager R, et al. Late prognostic value of flow-mediated dilation in the brachial artery of patients with chest pain. Am J Cardiol. 2000; 86: 207–210.
27. Gokce N, Holbrook M, Biegelsen ES, et al. Effects of race and hypertension on flow-mediated and nitroglycerin-mediated dilation of the brachial artery. Hypertension. 2001; 38: 1349–1354.
28. AHA/ACC Task Force Report. Guidelines for perioperative cardiovascular evaluation for noncardiac surgery. Circulation. 1996; 93: 1278–1317.
29. Gillespie DL, LaMorte WW, Josephs LG, et al. Characteristics of patients at risk for perioperative myocardial infarction after infrainguinal bypass surgery: an exploratory study. Ann Vasc Surg. 1995; 9: 155–162.
30. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999; 340: 115–126.
31. Greenland P, Abrams J, Aurigemma GP, et al. Prevention conference V: beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III. Circulation. 2000; 101: E16–E22.
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 S. M. Shenouda and J. A. Vita Effects of Flavonoid-Containing Beverages and EGCG on Endothelial Function J. Am. Coll. Nutr., August 1, 2007; 26(4): 366S - 372S. [Abstract] [Full Text] [PDF]
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 |
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 Y. Le Manach, G. Godet, P. Coriat, C. Martinon, M. Bertrand, M.-H. Fleron, and B. Riou The Impact of Postoperative Discontinuation or Continuation of Chronic Statin Therapy on Cardiac Outcome After Major Vascular Surgery Anesth. Analg., June 1, 2007; 104(6): 1326 - 1333. [Abstract] [Full Text] [PDF]
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S. Lavi, J. P. McConnell, C. S. Rihal, A. Prasad, V. Mathew, L. O. Lerman, and A. Lerman Local Production of Lipoprotein-Associated Phospholipase A2 and Lysophosphatidylcholine in the Coronary Circulation: Association With Early Coronary Atherosclerosis and Endothelial Dysfunction in Humans Circulation, May 29, 2007; 115(21): 2715 - 2721. [Abstract] [Full Text] [PDF]
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S. Lavi, A. Prasad, E. H. Yang, V. Mathew, R. D. Simari, C. S. Rihal, L. O. Lerman, and A. Lerman Smoking Is Associated With Epicardial Coronary Endothelial Dysfunction and Elevated White Blood Cell Count in Patients With Chest Pain and Early Coronary Artery Disease Circulation, May 22, 2007; 115(20): 2621 - 2627. [Abstract] [Full Text] [PDF]
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T. J. Anderson Prognostic Significance of Brachial Flow-Mediated Vasodilation Circulation, May 8, 2007; 115(18): 2373 - 2375. [Full Text] [PDF]
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J. Yeboah, J. R. Crouse, F.-C. Hsu, G. L. Burke, and D. M. Herrington Brachial Flow-Mediated Dilation Predicts Incident Cardiovascular Events in Older Adults: The Cardiovascular Health Study Circulation, May 8, 2007; 115(18): 2390 - 2397. [Abstract] [Full Text] [PDF]
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 |
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 S. Razvi, L. Ingoe, G. Keeka, C. Oates, C. McMillan, and J. U. Weaver The Beneficial Effect of L-Thyroxine on Cardiovascular Risk Factors, Endothelial Function, and Quality of Life in Subclinical Hypothyroidism: Randomized, Crossover Trial J. Clin. Endocrinol. Metab., May 1, 2007; 92(5): 1715 - 1723. [Abstract] [Full Text] [PDF]
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 |
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 I. J. Kullo and A. R. Malik Arterial Ultrasonography and Tonometry as Adjuncts to Cardiovascular Risk Stratification J. Am. Coll. Cardiol., April 3, 2007; 49(13): 1413 - 1426. [Abstract] [Full Text] [PDF]
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 |
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 D. W. Brock, C. K. Davis, B. A. Irving, J. Rodriguez, E. J. Barrett, A. Weltman, A. G. Taylor, and G. A. Gaesser A High-Carbohydrate, High-Fiber Meal Improves Endothelial Function in Adults With the Metabolic Syndrome Diabetes Care, October 1, 2006; 29(10): 2313 - 2315. [Full Text] [PDF]
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M. Juonala, J. S.A. Viikari, T. Ronnemaa, H. Helenius, L. Taittonen, and O. T. Raitakari Elevated Blood Pressure in Adolescent Boys Predicts Endothelial Dysfunction: The Cardiovascular Risk in Young Finns Study Hypertension, September 1, 2006; 48(3): 424 - 430. [Abstract] [Full Text] [PDF]
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M. J Roman, T. Z Naqvi, J. M Gardin, M. Gerhard-Herman, M. Jaff, and E. Mohler American Society of Echocardiography Report: Clinical application of noninvasive vascular ultrasound in cardiovascular risk stratification: a report from the American Society of Echocardiography and the Society for Vascular Medicine and Biology Vascular Medicine, August 1, 2006; 11(3): 201 - 211. [PDF]
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|
|
|
M. Juonala, J. S. A. Viikari, L. Rasanen, H. Helenius, M. Pietikainen, and O. T. Raitakari Young Adults With Family History of Coronary Heart Disease Have Increased Arterial Vulnerability to Metabolic Risk Factors: The Cardiovascular Risk in Young Finns Study Arterioscler. Thromb. Vasc. Biol., June 1, 2006; 26(6): 1376 - 1382. [Abstract] [Full Text] [PDF]
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R. S. Vasan Biomarkers of Cardiovascular Disease: Molecular Basis and Practical Considerations Circulation, May 16, 2006; 113(19): 2335 - 2362. [Full Text] [PDF]
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 |
|
 J. La Fontaine, L. B. Harkless, C. E. Davis, M. A. Allen, and P. K. Shireman Current concepts in diabetic microvascular dysfunction. J Am Podiatr Med Assoc, May 1, 2006; 96(3): 245 - 252. [Abstract] [Full Text] [PDF]
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C. N. Bairey Merz, L. J. Shaw, S. E. Reis, V. Bittner, S. F. Kelsey, M. Olson, B. D. Johnson, C. J. Pepine, S. Mankad, B. L. Sharaf, et al. Insights From the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part II: Gender Differences in Presentation, Diagnosis, and Outcome With Regard to Gender-Based Pathophysiology of Atherosclerosis and Macrovascular and Microvascular Coronary Disease J. Am. Coll. Cardiol., February 7, 2006; 47(3_Suppl_S): S21 - S29. [Abstract] [Full Text] [PDF]
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L. Lind, N. Fors, J. Hall, K. Marttala, and A. Stenborg A Comparison of Three Different Methods to Evaluate Endothelium-Dependent Vasodilation in the Elderly: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): 2368 - 2375. [Abstract] [Full Text] [PDF]
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K. E Pyke and M. E Tschakovsky The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function J. Physiol., October 15, 2005; 568(2): 357 - 369. [Abstract] [Full Text] [PDF]
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M. Frick, A. Suessenbacher, H. F. Alber, W. Dichtl, H. Ulmer, O. Pachinger, and F. Weidinger Prognostic Value of Brachial Artery Endothelial Function and Wall Thickness J. Am. Coll. Cardiol., September 20, 2005; 46(6): 1006 - 1010. [Abstract] [Full Text] [PDF]
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B. Meyer, D. Mortl, K. Strecker, M. Hulsmann, V. Kulemann, T. Neunteufl, R. Pacher, and R. Berger Flow-Mediated Vasodilation Predicts Outcome in Patients With Chronic Heart Failure: Comparison With B-Type Natriuretic Peptide J. Am. Coll. Cardiol., September 20, 2005; 46(6): 1011 - 1018. [Abstract] [Full Text] [PDF]
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Y. Kitta, T. Nakamura, Y. Kodama, H. Takano, K. Umetani, D. Fujioka, Y. Saito, K.-i. Kawabata, J.-e. Obata, Y. Ichigi, et al. Endothelial Vasomotor Dysfunction in the Brachial Artery Is Associated With Late In-Stent Coronary Restenosis J. Am. Coll. Cardiol., August 16, 2005; 46(4): 648 - 655. [Abstract] [Full Text] [PDF]
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E. D. Beishuizen, J. T. Tamsma, J. W. Jukema, M. A. van de Ree, J. C. M. van der Vijver, A. E. Meinders, and M. V. Huisman The Effect of Statin Therapy on Endothelial Function in Type 2 Diabetes Without Manifest Cardiovascular Disease Diabetes Care, July 1, 2005; 28(7): 1668 - 1674. [Abstract] [Full Text] [PDF]
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R. T. Yan, T. J. Anderson, F. Charbonneau, L. Title, S. Verma, E. Lonn, and on behalf of the FATE Investigators Relationship Between Carotid Artery Intima-Media Thickness and Brachial Artery Flow-Mediated Dilation in Middle-Aged Healthy Men J. Am. Coll. Cardiol., June 21, 2005; 45(12): 1980 - 1986. [Abstract] [Full Text] [PDF]
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D. R. Witte, J. Westerink, E. J. de Koning, Y. van der Graaf, D. E. Grobbee, and M. L. Bots Is the Association Between Flow-Mediated Dilation and Cardiovascular Risk Limited to Low-Risk Populations? J. Am. Coll. Cardiol., June 21, 2005; 45(12): 1987 - 1993. [Abstract] [Full Text] [PDF]
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D. S. Celermajer Primary and a Half Prevention: Can We Identify Asymptomatic Subjects With High Vascular Risk? J. Am. Coll. Cardiol., June 21, 2005; 45(12): 1994 - 1996. [Full Text] [PDF]
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C. Schmidt-Lucke, L. Rossig, S. Fichtlscherer, M. Vasa, M. Britten, U. Kamper, S. Dimmeler, and A. M. Zeiher Reduced Number of Circulating Endothelial Progenitor Cells Predicts Future Cardiovascular Events: Proof of Concept for the Clinical Importance of Endogenous Vascular Repair Circulation, June 7, 2005; 111(22): 2981 - 2987. [Abstract] [Full Text] [PDF]
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 A. L. Moens, I. Goovaerts, M. J. Claeys, and C. J. Vrints Flow-Mediated Vasodilation: A Diagnostic Instrument, or an Experimental Tool? Chest, June 1, 2005; 127(6): 2254 - 2263. [Abstract] [Full Text] [PDF]
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 A D Gavin and A D Struthers Allopurinol reduces B-type natriuretic peptide concentrations and haemoglobin but does not alter exercise capacity in chronic heart failure Heart, June 1, 2005; 91(6): 749 - 753. [Abstract] [Full Text] [PDF]
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 P. K. Witting, B. J. Wu, M. Raftery, P. Southwell-Keely, and R. Stocker Probucol Protects against Hypochlorite-induced Endothelial Dysfunction: IDENTIFICATION OF A NOVEL PATHWAY OF PROBUCOL OXIDATION TO A BIOLOGICALLY ACTIVE INTERMEDIATE J. Biol. Chem., April 22, 2005; 280(16): 15612 - 15618. [Abstract] [Full Text] [PDF]
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 A. Huang, Y.-Y. Zhang, K. Chen, K. Hatakeyama, and J. F. Keaney Jr Cytokine-Stimulated GTP Cyclohydrolase I Expression in Endothelial Cells Requires Coordinated Activation of Nuclear Factor-{kappa}B and Stat1/Stat3 Circ. Res., February 4, 2005; 96(2): 164 - 171. [Abstract] [Full Text] [PDF]
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T. M. Powell, J. D. Paul, J. M. Hill, M. Thompson, M. Benjamin, M. Rodrigo, J. P. McCoy, E. J. Read, H. M. Khuu, S. F. Leitman, et al. Granulocyte Colony-Stimulating Factor Mobilizes Functional Endothelial Progenitor Cells in Patients With Coronary Artery Disease Arterioscler. Thromb. Vasc. Biol., February 1, 2005; 25(2): 296 - 301. [Abstract] [Full Text] [PDF]
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G. Patti, V. Pasceri, R. Melfi, C. Goffredo, M. Chello, A. D'Ambrosio, R. Montesanti, and G. Di Sciascio Impaired Flow-Mediated Dilation and Risk of Restenosis in Patients Undergoing Coronary Stent Implantation Circulation, January 4, 2005; 111(1): 70 - 75. [Abstract] [Full Text] [PDF]
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 J. A Vita Polyphenols and cardiovascular disease: effects on endothelial and platelet function Am. J. Clinical Nutrition, January 1, 2005; 81(1): 292S - 297S. [Abstract] [Full Text] [PDF]
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|
F. Wiesmann, S. E. Petersen, P. M. Leeson, J. M. Francis, M. D. Robson, Q. Wang, R. Choudhury, K. M. Channon, and S. Neubauer Global impairment of brachial, carotid, and aortic vascular function in young smokers: Direct quantification by high-resolution magnetic resonance imaging J. Am. Coll. Cardiol., November 16, 2004; 44(10): 2056 - 2064. [Abstract] [Full Text] [PDF]
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D. J Green, A. Maiorana, G. O'Driscoll, and R. Taylor Effect of exercise training on endothelium-derived nitric oxide function in humans J. Physiol., November 15, 2004; 561(1): 1 - 25. [Abstract] [Full Text] [PDF]
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M. Juonala, J. S.A. Viikari, T. Laitinen, J. Marniemi, H. Helenius, T. Ronnemaa, and O. T. Raitakari Interrelations Between Brachial Endothelial Function and Carotid Intima-Media Thickness in Young Adults: The Cardiovascular Risk in Young Finns Study Circulation, November 2, 2004; 110(18): 2918 - 2923. [Abstract] [Full Text] [PDF]
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S. Fazel, R. D. Weisel, and S. Verma A novel technique to assess flow-mediated vasodilation J. Am. Coll. Cardiol., October 6, 2004; 44(7): 1478 - 1480. [Full Text] [PDF]
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|
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|
S. Fichtlscherer, S. Breuer, and A. M. Zeiher Prognostic Value of Systemic Endothelial Dysfunction in Patients With Acute Coronary Syndromes: Further Evidence for the Existence of the "Vulnerable" Patient Circulation, October 5, 2004; 110(14): 1926 - 1932. [Abstract] [Full Text] [PDF]
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S. Verma, C.-H. Wang, E. Lonn, F. Charbonneau, J. Buithieu, L. M. Title, M. Fung, S. Edworthy, A. C. Robertson, T. J. Anderson, et al. Cross-sectional evaluation of brachial artery flow-mediated vasodilation and C-reactive protein in healthy individuals Eur. Heart J., October 1, 2004; 25(19): 1754 - 1760. [Abstract] [Full Text] [PDF]
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|
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|
 R. Stocker and J. F. Keaney Jr. Role of Oxidative Modifications in Atherosclerosis Physiol Rev, October 1, 2004; 84(4): 1381 - 1478. [Abstract] [Full Text] [PDF]
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 |
|
 D. H. Endemann and E. L. Schiffrin Endothelial Dysfunction J. Am. Soc. Nephrol., August 1, 2004; 15(8): 1983 - 1992. [Abstract] [Full Text] [PDF]
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|
T. Kondo, M. Hayashi, K. Takeshita, Y. Numaguchi, K. Kobayashi, S. Iino, Y. Inden, and T. Murohara Smoking Cessation Rapidly Increases Circulating Progenitor Cells in Peripheral Blood in Chronic Smokers Arterioscler. Thromb. Vasc. Biol., August 1, 2004; 24(8): 1442 - 1447. [Abstract] [Full Text] [PDF]
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 |
|
 S. I. Sokol, E. L. Portnay, J. P. Curtis, M. A. Nelson, P. R. Hebert, J. F. Setaro, and J. M. Foody Modulation of the renin-angiotensin-aldosterone system for the secondary prevention of stroke Neurology, July 27, 2004; 63(2): 208 - 213. [Abstract] [Full Text] [PDF]
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|
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|
S. Fichtlscherer, S. Breuer, C. Heeschen, S. Dimmeler, and A. M. Zeiher Interleukin-10 serum levels and systemic endothelial vasoreactivity in patients with coronary artery disease J. Am. Coll. Cardiol., July 7, 2004; 44(1): 44 - 49. [Abstract] [Full Text] [PDF]
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A. H. Slyper What Vascular Ultrasound Testing Has Revealed about Pediatric Atherogenesis, and a Potential Clinical Role for Ultrasound in Pediatric Risk Assessment J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3089 - 3095. [Abstract] [Full Text] [PDF]
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J E Macdonald, N Kennedy, and A D Struthers Effects of spironolactone on endothelial function, vascular angiotensin converting enzyme activity, and other prognostic markers in patients with mild heart failure already taking optimal treatment Heart, July 1, 2004; 90(7): 765 - 770. [Abstract] [Full Text] [PDF]
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J. N. Cohn, A. A. Quyyumi, N. K. Hollenberg, and K. A. Jamerson Surrogate Markers for Cardiovascular Disease: Functional Markers Circulation, June 29, 2004; 109(25_suppl_1): IV-31 - IV-46. [Full Text] [PDF]
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J. Davignon Beneficial Cardiovascular Pleiotropic Effects of Statins Circulation, June 15, 2004; 109(23_suppl_1): III-39 - III-43. [Abstract] [Full Text]
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T. Suhara, K. Fukuo, O. Yasuda, M. Tsubakimoto, Y. Takemura, H. Kawamoto, T. Yokoi, M. Mogi, T. Kaimoto, and T. Ogihara Homocysteine Enhances Endothelial Apoptosis via Upregulation of Fas-Mediated Pathways Hypertension, June 1, 2004; 43(6): 1208 - 1213. [Abstract] [Full Text] [PDF]
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M. E. Otto, A. Svatikova, R. B. d. M. Barretto, S. Santos, M. Hoffmann, B. Khandheria, and V. Somers Early Morning Attenuation of Endothelial Function in Healthy Humans Circulation, June 1, 2004; 109(21): 2507 - 2510. [Abstract] [Full Text] [PDF]
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U. Landmesser, B. Hornig, and H. Drexler Endothelial Function: A Critical Determinant in Atherosclerosis? Circulation, June 1, 2004; 109(21_suppl_1): II-27 - II-33. [Abstract] [Full Text] [PDF]
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I. Eskurza, K. D. Monahan, J. A. Robinson, and D. R. Seals Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing J. Physiol., April 1, 2004; 556(1): 315 - 324. [Abstract] [Full Text] [PDF]
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R. Fathi, B. Haluska, N. Isbel, L. Short, and T. H. Marwick The relative importance of vascular structure and function in predicting cardiovascular events J. Am. Coll. Cardiol., February 18, 2004; 43(4): 616 - 623. [Abstract] [Full Text] [PDF]
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G. B. J. Mancini Vascular structure versus function: is endothelial dysfunction of independent prognostic importance or not? J. Am. Coll. Cardiol., February 18, 2004; 43(4): 624 - 628. [Full Text] [PDF]
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|
 V. Fonseca, C. Desouza, S. Asnani, and I. Jialal Nontraditional Risk Factors for Cardiovascular Disease in Diabetes Endocr. Rev., February 1, 2004; 25(1): 153 - 175. [Abstract] [Full Text] [PDF]
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S. Verma and P. E. Szmitko Coxibs and the endothelium J. Am. Coll. Cardiol., November 19, 2003; 42(10): 1754 - 1756. [Full Text] [PDF]
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|
P. Ganz and J. A. Vita Testing Endothelial Vasomotor Function: Nitric Oxide, a Multipotent Molecule Circulation, October 28, 2003; 108(17): 2049 - 2053. [Full Text] [PDF]
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S. Verma, M. R. Buchanan, and T. J. Anderson Endothelial Function Testing as a Biomarker of Vascular Disease Circulation, October 28, 2003; 108(17): 2054 - 2059. [Full Text] [PDF]
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G. Brevetti, A. Silvestro, V. Schiano, and M. Chiariello Endothelial Dysfunction and Cardiovascular Risk Prediction in Peripheral Arterial Disease: Additive Value of Flow-Mediated Dilation to Ankle-Brachial Pressure Index Circulation, October 28, 2003; 108(17): 2093 - 2098. [Abstract] [Full Text] [PDF]
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M. E. Widlansky, N. Gokce, J. F. Keaney Jr, and J. A. Vita The clinical implications of endothelial dysfunction J. Am. Coll. Cardiol., October 1, 2003; 42(7): 1149 - 1160. [Abstract] [Full Text] [PDF]
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|
 J. A. Vita Tea Consumption and Cardiovascular Disease: Effects on Endothelial Function J. Nutr., October 1, 2003; 133(10): 3293S - 3297. [Abstract] [Full Text] [PDF]
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S. Y. Chan, G. B. J. Mancini, L. Kuramoto, M. Schulzer, J. Frohlich, and A. Ignaszewski The prognostic importance of endothelial dysfunction and carotid atheromaburden in patients with coronary artery disease J. Am. Coll. Cardiol., September 17, 2003; 42(6): 1037 - 1043. [Abstract] [Full Text] [PDF]
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M. E. Widlansky, D. T. Price, N. Gokce, R. T. Eberhardt, S. J. Duffy, M. Holbrook, C. Maxwell, J. Palmisano, J. F. Keaney Jr, J. D. Morrow, et al. Short- and Long-Term COX-2 Inhibition Reverses Endothelial Dysfunction in Patients With Hypertension Hypertension, September 1, 2003; 42(3): 310 - 315. [Abstract] [Full Text] [PDF]
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T. Suzuki, K. Fukuo, T. Suhara, O. Yasuda, N. Sato, Y. Takemura, M. Tsubakimoto, and T. Ogihara Eicosapentaenoic Acid Protects Endothelial Cells Against Anoikis Through Restoration of cFLIP Hypertension, September 1, 2003; 42(3): 342 - 348. [Abstract] [Full Text] [PDF]
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S. Amar, N. Gokce, S. Morgan, M. Loukideli, T. E. Van Dyke, and J. A. Vita Periodontal Disease Is Associated With Brachial Artery Endothelial Dysfunction and Systemic Inflammation Arterioscler. Thromb. Vasc. Biol., July 1, 2003; 23(7): 1245 - 1249. [Abstract] [Full Text] [PDF]
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J. T. Kuvin and R. H. Karas Clinical Utility of Endothelial Function Testing: Ready for Prime Time? Circulation, July 1, 2003; 107(25): 3243 - 3247. [Full Text] [PDF]
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|
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R. J. Bisoendial, G. K. Hovingh, J. H.M. Levels, P. G. Lerch, I. Andresen, M. R. Hayden, J. J.P. Kastelein, and E. S.G. Stroes Restoration of Endothelial Function by Increasing High-Density Lipoprotein in Subjects With Isolated Low High-Density Lipoprotein Circulation, June 17, 2003; 107(23): 2944 - 2948. [Abstract] [Full Text] [PDF]
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R. A. Vogel Heads and Hearts: The Endothelial Connection Circulation, June 10, 2003; 107(22): 2766 - 2768. [Full Text] [PDF]
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P. V. Targonski, P. O. Bonetti, G. M. Pumper, S. T. Higano, D. R. Holmes Jr, and A. Lerman Coronary Endothelial Dysfunction Is Associated With an Increased Risk of Cerebrovascular Events Circulation, June 10, 2003; 107(22): 2805 - 2809. [Abstract] [Full Text] [PDF]
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J. M. Meinders, L. Kornet, and A. P. G. Hoeks Assessment of spatial inhomogeneities in intima media thickness along an arterial segment using its dynamic behavior Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H384 - H391. [Abstract] [Full Text] [PDF]
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N. Gokce, J. F. Keaney Jr, L. M. Hunter, M. T. Watkins, Z. S. Nedeljkovic, J. O. Menzoian, and J. A. Vita Predictive value of noninvasivelydetermined endothelial dysfunction for long-term cardiovascular events inpatients with peripheral vascular disease J. Am. Coll. Cardiol., May 21, 2003; 41(10): 1769 - 1775. [Abstract] [Full Text] [PDF]
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J. J. Oliver and D. J. Webb Noninvasive Assessment of Arterial Stiffness and Risk of Atherosclerotic Events Arterioscler. Thromb. Vasc. Biol., April 1, 2003; 23(4): 554 - 566. [Abstract] [Full Text] [PDF]
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A. M. Kaunitz, M. B. Sorensen, P. Collins, P. J.L. Ong, C. M. Webb, C. S. Hayward, E. A. Asbury, P. D. Gatehouse, A. G. Elkington, G. Z. Yang, et al. Long-Term Use of Contraceptive Depot Medroxyprogesterone Acetate in Young Women Impairs Arterial Endothelial Function Assessed by Cardiovascular Magnetic Resonance * Response Circulation, March 11, 2003; 107 (9): e67 - e68. [Full Text] [PDF]
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 |
|
 J. M. Hill, G. Zalos, J. P.J. Halcox, W. H. Schenke, M. A. Waclawiw, A. A. Quyyumi, and T. Finkel Circulating Endothelial Progenitor Cells, Vascular Function, and Cardiovascular Risk N. Engl. J. Med., February 13, 2003; 348(7): 593 - 600. [Abstract] [Full Text] [PDF]
|
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 J. P. Cooke Flow, NO, and atherogenesis PNAS, February 4, 2003; 100(3): 768 - 770. [Full Text] [PDF]
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P. O. Bonetti, L. O. Lerman, and A. Lerman Endothelial Dysfunction: A Marker of Atherosclerotic Risk Arterioscler. Thromb. Vasc. Biol., February 1, 2003; 23(2): 168 - 175. [Abstract] [Full Text] [PDF]
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E. Poggianti, L. Venneri, V. Chubuchny, Z. Jambrik, L. A. Baroncini, and E. Picano Aortic valve sclerosis is associatedwith systemic endothelial dysfunction J. Am. Coll. Cardiol., January 1, 2003; 41(1): 136 - 141. [Abstract] [Full Text] [PDF]
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N. Gokce, M. Holbrook, L. M. Hunter, J. Palmisano, E. Vigalok, J. F. Keaney Jr, and J. A. Vita Acute effects of vasoactive drug treatment on brachial artery reactivity J. Am. Coll. Cardiol., August 21, 2002; 40(4): 761 - 765. [Abstract] [Full Text] [PDF]
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J. A. Vita and J. F. Keaney Jr Endothelial Function: A Barometer for Cardiovascular Risk? Circulation, August 6, 2002; 106(6): 640 - 642. [Full Text] [PDF]
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