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(Circulation. 2000;102:494.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
Moderate Alcohol Consumption and Risk of Coronary Heart Disease Among Women With Type 2 Diabetes Mellitus
From the Division of Women’s Health (C.G.S.), Channing Laboratory (F.B.H., M.J.S., G.A.C., F.E.S., E.B.R., W.C.W., J.E.M.), Division of Preventive Medicine (J.E.M.), Department of Medicine, Brigham and Women’s Hospital and the Departments of Nutrition (F.B.H., M.J.S., E.B.R., W.C.W.) and Epidemiology (M.J.S., G.A.C., E.B.R., W.C.W., J.E.M.), Harvard School of Public Health, Boston, Mass.
Correspondence to Caren G. Solomon, Division of Women’s Health, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115. E-mail cgsolomon{at}bics.bwh.harvard.edu
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Abstract |
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Background—Moderate alcohol consumption is associated with reduced risk for coronary heart disease (CHD) in generally healthy populations. We assessed prospectively the association between moderate alcohol intake and CHD risk in women with type 2 diabetes mellitus, a group at high risk for cardiovascular disease.
Methods and Results—We studied women in the Nurses’ Health Study
who reported a diagnosis of diabetes mellitus at 
30 years of age.
During 39 092 person-years of follow-up from 1980 to 1994, there were
295 CHD events documented among this population, including 194 cases of
nonfatal myocardial infarction and 101 cases of fatal CHD. Odds ratios
derived from logistic regression were used to estimate relative risks
(RRs) for CHD as a function of usual alcohol intake, with adjustment
for potential confounders. Compared with diabetic women reporting no
alcohol intake, the age-adjusted RR for nonfatal or fatal CHD among
diabetic women reporting usual intake of 0.1 to 4.9 g (<0.5
drinks) of alcohol daily was 0.74 (95% CI 0.56 to 0.98), and among
those reporting usual intake 5 g/d, it was 0.48 (95% CI 0.32 to
0.72) (P for trend <0.0001). Inverse associations
between alcohol intake and CHD risk remained significant in
multivariate analysis adjusting for several
other coronary risk factors (0.1 to 4.9 g/d: RR 0.72 [95% CI
0.54 to 0.96]; 5 g/d: RR 0.45 [0.29 to 0.68]).
Conclusions—Although potential risks of alcohol consumption must be considered, these data suggest that moderate alcohol consumption is associated with reduced CHD risk in women with diabetes and should not be routinely discouraged.
Key Words: diabetes mellitus • coronary disease • alcohol • risk factors
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Introduction |
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TopAbstractIntroductionMethodsResultsDiscussionReferences |
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Type 2 diabetes mellitus (DM) is associated with a 3-fold increase in risk for coronary heart disease (CHD), independent of other coronary risk factors,1 and appears to confer particular risk in women.2 Presumed contributors to the increased coronary risk in DM include associated dyslipidemia,3 hypertension,4 insulin resistance,5 and hypercoagulability.6 It is important to determine whether approaches that reduce CHD risk in nondiabetic populations may also have a role in the setting of diabetes.
Moderate alcohol intake has been associated with a significant reduction in risk for myocardial infarction (MI) among generally nondiabetic populations,7 8 9 10 11 12 but the effect of alcohol on cardiovascular risk in those with diabetes has been little studied. A recent report noted an inverse association between alcohol consumption and CHD mortality among older-onset diabetic individuals.13 Observations that several coronary risk factors associated with DM, including dyslipidemia,7 hyperinsulinemia,14 and coagulation disturbances,15 may be favorably affected by alcohol likewise suggest the potential for particular cardiovascular benefit of moderate alcohol use in this high-risk group. We therefore assessed in a large prospective cohort study of nurses whether moderate alcohol intake is associated with a reduced risk for CHD among diabetic women.
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Methods |
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TopAbstractIntroductionMethodsResultsDiscussionReferences |
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The Nurses’ Health Study (NHS) is a prospective cohort study of 121 700 female nurses aged 30 to 55 years at study inception in 1976 and residing in 1 of 11 US states. Participants complete biennial questionnaires on lifestyle factors and medical conditions, the details of which have been reported previously.16 The present investigation included 5103 women who reported a physician diagnosis of DM at
30 years of age, from baseline through 1992; were
free of CHD (including MI, angina, and/or coronary revascularization),
stroke, or cancer (other than nonmelanoma skin cancer) at or before the
1980 questionnaire (when alcohol intake was first assessed); and who
provided information on usual alcohol consumption.
Confirmation of DM
Women were included who reported the diagnosis of DM at 30
years of age. In a previous validation study,1 84% of a
random subset of these women had the diagnosis of type 2 DM confirmed
on medical record review based on National Diabetes Data Group
criteria for DM17 (ie, fasting plasma glucose level 140
mg/dL and/or random plasma glucose level or plasma glucose level 2
hours after 75-g glucose load 200 mg/dL, on 2 or more occasions), in
the absence of ketoacidosis.
We sent supplementary questionnaires to all women who self-reported a diagnosis of diabetes; the questionnaire asked about details of diagnosis (eg, diagnostic tests and symptoms) and therapy. Women were considered to have definite type 2 DM if they reported 2 or more glucose levels diagnostic of diabetes on the basis of National Diabetes Data Group criteria and the absence of ketoacidosis at the time of diagnosis. As described in a previous report,1 the diagnosis of type 2 DM was confirmed by medical record review in 61 (98.4%) of 62 women considered to have definite type 2 DM by supplementary questionnaire. A secondary set of analyses was conducted that included only women with definite type 2 DM by these criteria.
Alcohol Consumption
A food frequency questionnaire was included on the biennial NHS
questionnaire in 1980, 1984, 1986, and 1990 that asked about the
average frequency of consumption of specified foods and beverages
during the preceding 12 months. Questions about intake of beer, wine,
and spirits were included separately. Total alcohol intake was
calculated in grams by adding usual intake of alcoholic beverages,
assuming the following content: 1 12-oz can of beer, 12.8 g; 1
4-oz glass of wine, 11.0 g; standard drink of spirits, 14.0
g.18 A previous validation study among a subset of
participants indicated a high correlation between reported alcohol
intake on the questionnaire and dietary records
(r=0.9).19 Also, high correlations
were noted between alcohol consumption reported on the 1980 and 1984
questionnaires and between these parameters and direct
measures of HDL cholesterol.19
Other Covariates
Because alcohol intake was first assessed in 1980,
baseline information for these analyses was derived from the
1980 questionnaire, including the following: weight; smoking;
menopausal status; postmenopausal hormone use; personal history of
diabetes mellitus, hypertension, and
hypercholesterolemia; parental history of MI;
physical activity level; aspirin use; dietary fat; multivitamin use;
and use of vitamin E supplements. Information on these covariates was
also updated subsequently. Body mass index was calculated with height
reported on the baseline questionnaire in 1976.
CHD End Points
Women were asked on biennial questionnaires whether they had had
a diagnosis of MI in the preceding 2-year interval. Women who reported
MI were asked for permission to review their medical records.
Self-reports of nonfatal MI were considered confirmed if information in the medical record met the following World Health Organization criteria: characteristic symptoms with either diagnostic ECG changes and/or cardiac enzyme elevation. "Silent" MIs discovered on a routine ECG were excluded. If no records were available for self-reported MI but there was confirmation of hospitalization and information from an interview or letter supporting the diagnosis, self-reported diagnosis was considered probable; probable cases were also included in these analyses (17% of total cases).
Deaths were generally reported by family members of participants or were identified by search of the National Death Index. The follow-up rate was >98%. For mortality attributed to cardiovascular disease, permission was requested from the next of kin to review records. A fatal MI was confirmed if medical records or autopsy report indicated this diagnosis. Coronary death was diagnosed if the death certificate reported coronary disease as the cause of death, there was no other more likely cause apparent, and the participant was reported to have coronary disease previously (by questionnaire or per next of kin). A diagnosis of fatal coronary disease was never made on the basis of the death certificate alone. We also included in the coronary death category those who had sudden death, ie, death within 1 hour of symptom onset in a woman without known disease that could explain the death.
Data Analysis
Person-time for each participant was calculated from the time of
return of the 1980 questionnaire (when alcohol intake was first
assessed) for women diagnosed with diabetes in 1980 or before or, if
diabetes was diagnosed after 1980, from the time that diabetes was
first reported until a nonfatal MI, death, or June 1, 1994. Women
reporting cardiovascular disease on a questionnaire
were excluded from subsequent follow-up. If a participant had a
nonfatal MI and then subsequently died of CHD, we considered only the
nonfatal MI in the analysis.
Women were divided into categories based on usual daily alcohol consumption. Incidence rates were calculated by dividing the number of events by the person-time of follow-up for each category of intake. Relative risks (RRs) were calculated as the rate for a given category of alcohol intake compared with the referent category ("no alcohol"). Tests for trend were performed by assigning the median value to increasing categories of alcohol use; a 2-tailed P value <0.05 was considered statistically significant. Pooled logistic regression was used to model coronary disease event rates over each 2-year follow-up interval in relation to alcohol intake reported on the prior questionnaire, with adjustment for other potential confounders. Covariates were updated biennially when possible (age, cigarette smoking, body mass index, menopausal status/postmenopausal hormone use, multivitamin use, and vitamin E supplement use). Aspirin use was assessed in 1980, 1982, 1984, and 1988 and was updated accordingly. Vigorous exercise was assessed in 1980. Hypoglycemic medication use was assessed by supplementary questionnaire sent to all participants after a new report of diabetes and also in 1988; women reporting sulfonylurea or insulin use or both on at least 1 of these assessments were considered in subgroup analyses to be users of hypoglycemic medication.
Primary analyses included all women self-reporting diabetes at age 30 years and older; a second set of analyses were limited to women who met criteria for definite type 2 DM by supplementary questionnaire.
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Results |
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TopAbstractIntroductionMethodsResultsDiscussionReferences |
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Alcohol intake tended to be light to moderate in this cohort of diabetic women. Women who reported no alcohol intake accounted for 58.1% of person-time, and women who consumed 0.1 to 4.9 g of alcohol per day (one third to one half drink per day) accounted for 26.4% of person-time. Only 5.7% of the person-time reflected women who consumed
15 g of alcohol daily. Because of the limited
person-time represented by this higher category, the
primary analyses were conducted with those who drank 5 g of
alcohol daily (15.5% of person-time) as the highest category.
Baseline (1980) characteristics of the cohort, specifically those who
reported diabetes in 1980 or before, are shown in Table 1
. Compared with women who
reported drinking no alcohol, women who reported any regular alcohol
intake tended to have lower body mass index and less hypertension and
were more likely to use postmenopausal hormones and vitamin supplements
and to engage in regular physical activity. However, women who reported
regular alcohol intake were also more likely to be smokers.
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During 39 092 person-years of follow-up from 1980 to 1994, we documented 295 CHD events among this population, including 194 cases of nonfatal MI and 101 cases of fatal CHD.
Age-adjusted rates of CHD were significantly lower in women who
reported moderate alcohol intake than in those who reported drinking no
alcohol. The age-adjusted risk for nonfatal or fatal CHD associated
with drinking 0.1 to 4.9 g of alcohol daily was 0.74 (95% CI 0.56
to 0.98); for drinking 5 g of alcohol daily, it was 0.48 (95% CI
0.32 to 0.72) (P for trend <0.0001). These reduced risks
remained statistically significant in a multivariate
analysis that also adjusted for body mass index, smoking,
family history of MI, hypertension,
hypercholesterolemia, menopausal status,
postmenopausal hormone use, aspirin use, multivitamin use, vitamin E
intake, and physical activity level. After adjustment for these
factors, the RR for nonfatal or fatal CHD associated with intake of 0.1
to 4.9 g/d alcohol was 0.72 (95% CI 0.54 to 0.96), and for 5 g/d, it
was 0.45 (0.29 to 0.68). Risk reductions associated with modest alcohol
intake were similar for nonfatal and fatal events (Table 2).
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There was no evidence that risk reductions for CHD associated
with alcohol differed by other CHD risk factor status. Stratification
by smoking status, body mass index, presence of hypertension, and
family history of MI yielded similar results, although confidence
intervals for the estimates of risk reduction associated with modest
alcohol intake tended to include 1 because of smaller sample sizes.
(Table 3).
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Because women consuming little or no alcohol might conceivably have
limited their alcohol intake secondary to illness, we conducted
secondary analyses excluding women who reported on the 1980
questionnaire that they had greatly reduced their alcohol consumption
over the last decade. Compared with nondrinkers, the
multivariate RR for CHD among women reporting usual
alcohol intake of 0.1 to 4.9 g/d was 0.72 (95% CI 0.51 to 1.01); among
those reporting alcohol intake of 5 g/d, it was 0.51 (95% CI 0.32 to
0.80) (P for trend 0.006).
We also conducted analyses excluding the first 2 years of
follow-up after alcohol consumption was reported (ie, excluding 62
cases), and again results were essentially unchanged. Compared with
women reporting no alcohol consumption, the
multivariate RR for CHD was 0.67 (95% CI 0.48 to 0.93)
among those drinking 0.1 to 4.9 g/d and 0.43 (95% CI 0.27 to 0.69)
among those drinking 5 g/d.
Insofar as women with more severe diabetes might be less apt to consume
alcohol and might independently be at greater risk for CHD, we also
attempted to control for severity of diabetes. Results were similar in
analyses that controlled for duration of diabetes and for
history of insulin or sulfonylurea use, as assessed at 2 different time
points. With adjustment for duration of diabetes, the
multivariate RR for CHD associated with daily intake of
0.1 to 4.9 g of alcohol was 0.72 (95% CI 0.53 to 1.00) and that
associated with daily intake of 5 g was 0.48 (95% CI 0.30 to 0.75).
Similarly, after adjustment for hypoglycemic medication, daily intake
of 0.1 to 4.9 g of alcohol was associated with a
multivariate RR for CHD of 0.74 (95% CI 0.54 to 1.01),
and intake of 5 g/d was associated with an RR of 0.52 (95% CI 0.33
to 0.81).
In analyses limited to the subgroup of women who reported
insulin or sulfonylurea therapy (who made up 54% of the total
person-time), there still appeared to be a reduction in CHD risk
associated with moderate alcohol intake. Multivariate
RRs for CHD were 0.58 (95% CI 0.39 to 0.87) for 0.1 to 4.9 g/d and
0.59 (95% CI 0.34 to 1.02) for 5 g/d. Among women not reporting use
of these medications, corresponding multivariate RRs
were 1.26 (95% CI 0.73 to 2.20) and 0.48 (95% CI 0.21 to 1.07).
We also conducted analyses of alcohol and CHD risk limited to
women whose diabetes was considered to be definite type 2 DM based on
the supplementary questionnaire (n=249 cases). The distribution of
alcohol intake in this subgroup was highly comparable to that in the
cohort as a whole. Among these confirmed cases, modest alcohol
consumption was likewise associated with reduced CHD risk.
Multivariate RR for CHD associated with intake of 0.1
to 4.9 g/d alcohol was 0.74 (95% CI 0.54 to 1.02), and for 5 g/d, it
was 0.66 (95% CI 0.43 to 1.00).
As noted, few women in our cohort reported alcohol intake of 15 g/d,
and they contributed only 13 cases of CHD. When we examined this group
separately, the RR for CHD among women consuming 5 to 14.9 g/d alcohol
was 0.38 (95% CI 0.21 to 0.67), and among those consuming 15 g/d, it
was 0.56 (95% CI 0.31 to 0.99).
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Discussion |
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TopAbstractIntroductionMethodsResultsDiscussionReferences |
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Women with type 2 DM are at high risk for subsequent CHD events. The present findings suggest that light to moderate alcohol intake is associated with an approximate halving of this risk. The RR reduction for CHD associated with modest alcohol consumption among diabetic women in this cohort is comparable to that seen in other women,8 and given the high risk for CHD associated with DM, the absolute risk reduction would be expected to be even greater.
Several plausible biological explanations exist for a beneficial effect of alcohol on CHD risk in individuals with type 2 DM. Effects on lipids are likely to be a major contributor. Although excessive alcohol consumption can raise triglyceride levels, alcohol intake also is associated with higher levels of HDL, including HDL2 and HDL3,7 and in small intervention studies has directly raised HDL levels.20 Reduced HDL levels are both characteristic of DM3 and a strong independent predictor of CHD events.21 Indeed, the inverse association between alcohol consumption and CHD has been noted to be attenuated markedly when HDL levels are taken into consideration.7
Effects of alcohol on reducing coagulability15 likewise are particularly relevant in the diabetic population. Type 2 DM is associated with a clear tendency to thrombosis,6 including increased levels of plasminogen activator inhibitor-1,22 impaired fibrinolysis,23 and increased platelet adhesion and aggregability by in vitro testing.24
Other coronary risk factors are more common in type 2 DM and also may be improved with modest alcohol consumption. Half or more of type 2 diabetics have hypertension.4 Although excessive alcohol intake is associated with increased blood pressure, moderate (<2 drinks/d) intake may be associated with lower blood pressures, at least in women.25 26 Fasting insulin levels are elevated in type 2 DM and may be reduced in the setting of regular alcohol consumption.14 Hyperinsulinemia has been reported to predict CHD in men, although this remains controversial in women.5
Data are scarce regarding the association between alcohol consumption
and CHD in the setting of diabetes. A recently published study of 983
female and male participants in the Wisconsin Epidemiologic Study of
Diabetic Retinopathy (WESDR) revealed a significant
inverse association between alcohol use and CHD
mortality.13 As in the present study, usual alcohol
intake was modest among that cohort. Compared with nondrinkers,
reductions in CHD mortality were 40% for participants consuming <2 g
of alcohol daily, 55% for those consuming 2 to 13 g of alcohol
daily, and 73% for those consuming 14 g/d. Females, who constituted
55% of the cohort, were not evaluated separately, however, and
nonfatal CHD was not assessed in that report.
Among males but not females with type 2 DM participating in the WHO Multinational Study of Vascular Disease in Diabetes,27 moderate alcohol consumption was also associated with significant reduction in CHD mortality. However, this report involved only 123 diabetic women and likewise did not consider nonfatal CHD events.
The potential benefits of alcohol consumption must of course be balanced against potential risks. Risks particularly relevant in the setting of diabetes include exacerbation of diabetic neuropathy28 and retinopathy29 and suppression of hepatic gluconeogenesis,30 with attendant risk of hypoglycemia. However, effects on the nervous system,28 retina,29 and hepatic glucose output and ketogenesis31 tend to be dose related and less a risk with modest alcohol consumption. Also, risk for hypoglycemia can be minimized by consuming alcohol with a meal rather than in the unfed state. Despite reports that alcohol may cause deterioration in glucose tolerance32 or even precipitate ketoacidosis31 in the setting of DM, other studies have found no significant effects of modest alcohol intake with meals on insulin requirement33 or on postprandial insulin and glucose levels34 in diabetic individuals. Data were not available in the present cohort to address hypoglycemia or other potential correlates of alcohol consumption.
Alcohol consumption tended to be modest in this cohort, and we thus cannot address the associations between heavier alcohol consumption and CHD in the setting of diabetes. However, observations of a U-shaped relationship between alcohol intake and CHD risk in generally healthy populations11 12 suggest a caution against more than moderate intake of alcohol. As emphasized in a recent editorial,35 the fact that some individuals cannot effectively limit themselves to light to moderate intake further reinforces the need to be cautious in any report on the potential benefits of alcohol consumption.
These observational data cannot prove that alcohol causes a reduction in CHD risk. Conceivably, women who consume modest amounts of alcohol may be healthier in general than nondrinkers. Our observations that women reporting modest alcohol intake did not appear to differ markedly from nondrinkers in many potential confounders, and, moreover, that adjustment for potential confounders in multivariate analyses did not significantly affect results, support an independent effect of alcohol intake on CHD risk; still, the possibility of unmeasured or incompletely controlled confounding cannot be excluded. Additionally, the consistency of results after the exclusion of those who reported a reduction in alcohol intake and after adjustment for hypoglycemic medication use or duration of diabetes suggests that greater severity of illness or associated medication use does not wholly explain the higher CHD risk in nondrinkers. Also, the biological plausibility of a causal relationship between modest alcohol intake and reduction in CHD risk through effects on lipids and coagulability, as well as the consistency of the present findings with findings among nondiabetic populations, supports the likelihood of a causal association.
Other limitations of the present study warrant consideration. Because diabetes is self-reported, there is potential for misclassification. Nonetheless, self-report of this diagnosis has previously been shown to be valid in this cohort.1 Diagnostic criteria for DM have changed recently36 such that some women who would not have been considered to have diabetes by standards used when this cohort reported diabetes would now be considered to have this diagnosis. Nonetheless, this would not affect the case status of the women included in the present report. Additionally, hypoglycemic medication use was not assessed at regular follow-up intervals, and thus this exposure is also subject to misclassification. Although many women who did not report use of these medications through 1988 may have used them subsequently, the natural history of diabetes makes it less likely that women who report their use will have discontinued use over follow-up; hence, the finding of an association between alcohol consumption and reduced CHD risk even in women using hypoglycemic medications remains reassuring. Finally, this study does not address the relationship between alcohol consumption and coronary events among diabetic women with prevalent CHD.
Among this cohort of women with type 2 DM, light to moderate alcohol intake was associated with significant reduction in risk for fatal or nonfatal CHD. Although observed associations cannot prove causation, and although all diabetic patients should be counseled regarding the potential risks of alcohol intake, particularly in excess or in the absence of food intake, the present findings suggest that modest alcohol consumption may have favorable cardiovascular effects and should not be routinely discouraged in this population.
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Acknowledgments |
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This research was supported by NIH grants CA40356 and DK36798. Dr Solomon was also supported by an American Heart Association Clinician Scientist Award and a Harvard Medical School Scholar in Medicine Fellowship, and Dr Hu by an American Diabetes Association Research Award. We are indebted to the Nurses’ Health Study participants for their commitment to the study and to Maureen Ireland, Gary Chase, Karen Corsano, and Barbara Egan for their assistance.
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Footnotes |
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Dr Rimm occasionally conducts talks at academic conferences sponsored by the alcohol industry.
Received December 17, 1999; revision received March 4, 2000; accepted March 9, 2000.
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References |
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TopAbstractIntroductionMethodsResultsDiscussionReferences |
|---|
1. Manson JE, Colditz GA, Stampfer MJ, et al. A prospective study of maturity-onset diabetes and risk for coronary heart disease and stroke in women. Arch Intern Med. 1991;151:1141–1147.
2. Barrett-Connor E, Orchard T. Diabetes and heart disease. In: Harris MI, Hamman RF, eds. Diabetes in America. Bethesda, Md: National Institutes of Health; 1985:1–41. NIH publication No. 85-1468.
3.
Cowie CC, Howard BV, Harris MI. Serum lipoproteins in
African Americans and whites with non–insulin-dependent diabetes in
the US population. Circulation. 1994;90:1185–1193.
4. Treatment of hypertension in diabetes: consensus statement. Diabetes Care. 1993;16:1394–1401.[Medline] [Order article via Infotrieve]
5. Haffner SM, Miettinen H. Insulin resistance implications for type 2 diabetes mellitus and coronary heart disease. Am J Med. 1997;103:152–162.[Medline] [Order article via Infotrieve]
6. Colwell JA. Vascular thrombosis in type 2 diabetes mellitus. Diabetes. 1993;42:8–10.[Medline] [Order article via Infotrieve]
7.
Gaziano M, Buring JE, Breslow JL, et al. Moderate
alcohol intake, increased levels of high-density lipoprotein and its
subfractions, and decreased risk of myocardial infarction. N
Engl J Med. 1993;329:1829–1834.
8. Stampfer MJ, Colditz GA, Willett WC, et al. A prospective study of moderate alcohol consumption and the risk of coronary heart disease and stroke in women. N Engl J Med. 1988;319:267–273.[Abstract]
9. Rimm EB, Giovanucci EL, Willett WC, et al. Prospective study of alcohol consumption and risk of coronary disease in men. Lancet. 1991;338:464–468.[Medline] [Order article via Infotrieve]
10.
Rimm EB, Klatsky A, Grobbee D, et al. Review of
moderate alcohol consumption and reduced risk of coronary heart
disease: is the effect due to beer, wine, or spirits? Br Med
J. 1996;312:731–736.
11. Klatsky AL, Friedman GD, Siegelaub AB. Alcohol use and cardiovascular disease: the Kaiser-Permanente experience. Circulation. 1981;64(pt 2):III-32–III-41.
12. Criqui MH. Alcohol and coronary heart disease: consistent relationship and public health implications. Clin Chim Acta. 1996;246:51–57.[Medline] [Order article via Infotrieve]
13.
Valmadrid CT, Klein R, Moss SE, et al. Alcohol intake
and the risk of coronary heart disease mortality in persons
with older-onset diabetes mellitus. JAMA. 1999;282:239–246.
14.
Kiechl S, Willeit W, Poewe W, et al. Insulin
sensitivity and regular alcohol consumption: large, prospective, cross
sectional population study (Bruneck study). Br Med J. 1996;313:1040–1044.
15.
Renaud SC, Beswick AD, Fehily AM, et al. Alcohol and
platelet aggregation: the Caerphilly Prospective Heart Disease
Study. Am J Clin Nutr. 1992;55:1012–1017.
16.
Colditz GA, Willett WC, Stampfer MJ, et al. Weight as a risk
factor for clinical diabetes in women. Am J Epidemiol.. 1990;132:501–513.
17. National Diabetes Data Group. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 1979;28:1039–1057.[Medline] [Order article via Infotrieve]
18. USDA Nutrient Database for Standard Reference, Standard Release 12. Washington, DC: US Dept of Agriculture, Agricultural Research Service; 1998.
19.
Giovannucci E, Colditz G, Stampfer M, et al. The
assessment of alcohol consumption by a simple self-administered
questionnaire. Am J Epidemiol. 1991;133:810–817.
20. Crouse JR, Grundy SM. Effects of alcohol on plasma lipoproteins and cholesterol and triglyceride metabolism in man. J Lipid Res. 1984;25:486–496.[Abstract]
21. Gordon T, Castelli WP, Hjortland MC, et al. High density lipoprotein as a protective factor against coronary heart disease. Am J Med. 1977;62:707–714.[Medline] [Order article via Infotrieve]
22. Juhan-Vague I, Alessi MC, Vague P. Increased plasma plasminogen activator inhibitor-1 levels: a possible link between insulin resistance and atherothrombosis. Diabetologia. 1991;34:457–462.[Medline] [Order article via Infotrieve]
23. Schneider DJ, Nordt TK, Sobel BE. Attenuated fibrinolysis and accelerated atherogenesis in type 2 diabetic patients. Diabetes. 1993;42:1–6.[Abstract]
24. Colwell JA, Winocour PD, Lopes-Virella MF. Platelet function and platelet interactions in atherosclerosis and diabetes mellitus. In: Rifkin H, Porte D, eds. Diabetes Mellitus: Theory and Practice. New York, NY: Elsevier; 1989.
25. Klatsky L, Friedman GD, Siegelaub AB, et al. Alcohol consumption and blood pressure. N Engl J Med. 1977;296:1194–1200.[Abstract]
26. Camargo CA, Rimm EB. Epidemiologic research on moderate alcohol consumption and blood pressure. In: Alcohol and the Cardiovascular System. Bethesda Md: National Institute on Alcohol Abuse and Alcoholism; 1996:25–62. NIH publication No. 96-4133. Research monograph 31.
27. Diem P, Fajfr R, Mueller B, et al. Effects of alcohol consumption on mortality in type 2 DM subjects. Diabetes. 1999;48(suppl):A86.
28. McCulloch DK, Campbell IW, Prescott RJ, et al. Effect of alcohol intake on symptomatic peripheral neuropathy in diabetic men. Diabetes Care. 1980;3:245–247.[Abstract]
29. Young RJ, McCulloch DK, Prescott RJ, et al. Alcohol: another risk factor for diabetic retinopathy? Br Med J. 1984;288:1035–1037.
30.
Yki-Jarvinen H, Kovesti VA, Ylikahri R, et al. Acute
effects of ethanol and acetate on glucose kinetics in normal subjects.
Am J Physiol. 1988;254:E175–E180.
31.
Jenkins DW, Eckel RE, Craig JW. Alcoholic ketoacidosis.
JAMA. 1971;217:177–183.
32. Sereny G, Endrenyi L. Mechanisms and significance of carbohydrate intolerance. Metabolism. 1978;27:1041–1046.[Medline] [Order article via Infotrieve]
33. Gin H, Morlat P, Raynaud JM, et al. Short-term effect of red wine (consumed during meals) on insulin requirements and glucose tolerance in diabetic patients. Diabetes Care. 1992;15:546–548.[Abstract]
34. Koivisto VA, Tulokas S, Toivonen M, et al. Alcohol with a meal has no adverse effects on postprandial glucose homeostasis in diabetic patients. Diabetes Care. 1993;16:1612–1614.[Abstract]
35.
Criqui MH, Golomb BA. Should patients with diabetes
drink to their health? JAMA. 1999;282:279–280.
36. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1998;21:S5–S19.
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 P. E. Szmitko and S. Verma Antiatherogenic potential of red wine: clinician update Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2023 - H2030. [Abstract] [Full Text] [PDF]
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 A. A. Howard, J. H. Arnsten, and M. N. Gourevitch Effect of Alcohol Consumption on Diabetes Mellitus: A Systematic Review Ann Intern Med, February 3, 2004; 140(3): 211 - 219. [Abstract] [Full Text] [PDF]
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C. H. Kroenke, N.-F. Chu, N. Rifai, D. Spiegelman, S. E. Hankinson, J. E. Manson, and E. B. Rimm A Cross-Sectional Study of Alcohol Consumption Patterns and Biologic Markers of Glycemic Control Among 459 Women Diabetes Care, July 1, 2003; 26(7): 1971 - 1978. [Abstract] [Full Text] [PDF]
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 V. A. Jackson, H. D. Sesso, J. E. Buring, and J. M. Gaziano Alcohol Consumption and Mortality in Men With Preexisting Cerebrovascular Disease Arch Intern Med, May 26, 2003; 163(10): 1189 - 1193. [Abstract] [Full Text] [PDF]
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R. R. Zilkens, V. Burke, G. Watts, L. J. Beilin, and I. B. Puddey The Effect of Alcohol Intake on Insulin Sensitivity in Men: A randomized controlled trial Diabetes Care, March 1, 2003; 26(3): 608 - 612. [Abstract] [Full Text] [PDF]
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A. D. Mooradian Cardiovascular Disease in Type 2 Diabetes Mellitus: Current Management Guidelines Arch Intern Med, January 13, 2003; 163(1): 33 - 40. [Abstract] [Full Text] [PDF]
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 J. C Barefoot, M. Gronbaek, J. R Feaganes, R S. McPherson, R. B Williams, and I. C Siegler Alcoholic beverage preference, diet, and health habits in the UNC Alumni Heart Study Am. J. Clinical Nutrition, August 1, 2002; 76(2): 466 - 472. [Abstract] [Full Text] [PDF]
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D. E. Cooper, D. C. Goff Jr., R. A. Bell, D. Zaccaro, E. J. Mayer-Davis, and A. J. Karter Is Insulin Sensitivity a Causal Intermediate in the Relationship Between Alcohol Consumption and Carotid Atherosclerosis?: The Insulin Resistance and Atherosclerosis Study Diabetes Care, August 1, 2002; 25(8): 1425 - 1431. [Abstract] [Full Text] [PDF]
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 L. Djousse, R. H. Myers, M. A. Province, S. C. Hunt, J. H. Eckfeldt, G. Evans, J. M. Peacock, and R. C. Ellison Influence of Apolipoprotein E, Smoking, and Alcohol Intake on Carotid Atherosclerosis: National Heart, Lung, and Blood Institute Family Heart Study Stroke, May 1, 2002; 33(5): 1357 - 1361. [Abstract] [Full Text] [PDF]
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 K. P. Strohl Invited Commentary: To Sleep, Perchance to Discover Am. J. Epidemiol., March 1, 2002; 155(5): 394 - 395. [Full Text] [PDF]
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M. J. Franz, J. P. Bantle, C. A. Beebe, J. D. Brunzell, J.-L. Chiasson, A. Garg, L. A. Holzmeister, B. Hoogwerf, E. Mayer-Davis, A. D. Mooradian, et al. Evidence-Based Nutrition Principles and Recommendations for the Treatment and Prevention of Diabetes and Related Complications Diabetes Care, January 1, 2002; 25(1): 148 - 198. [Full Text] [PDF]
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 M. Tanasescu, F. B. Hu, W. C. Willett, M. J. Stampfer, and E. B. Rimm Alcohol consumption and risk of coronary heart disease among men with type 2 diabetes mellitus J. Am. Coll. Cardiol., December 1, 2001; 38(7): 1836 - 1842. [Abstract] [Full Text] [PDF]
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 L M Hines and E B Rimm Moderate alcohol consumption and coronary heart disease: a review Postgrad. Med. J., December 1, 2001; 77(914): 747 - 752. [Full Text] [PDF]
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 J. L. Abramson, S. A. Williams, H. M. Krumholz, and V. Vaccarino Moderate Alcohol Consumption and Risk of Heart Failure Among Older Persons JAMA, April 18, 2001; 285(15): 1971 - 1977. [Abstract] [Full Text] [PDF]
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A. L. Klatsky Should Patients With Heart Disease Drink Alcohol? JAMA, April 18, 2001; 285(15): 2004 - 2006. [Full Text] [PDF]
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 K. H. Johnson, M. Bazargan, and E. G. Bing Alcohol Consumption and Compliance Among Inner-city Minority Patients With Type 2 Diabetes Mellitus Arch Fam Med, November 1, 2000; 9(10): 964 - 970. [Abstract] [Full Text] [PDF]
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 Moderate Alcohol Consumption Is Protective Against CHD in Diabetic Women Journal Watch Women's Health, September 5, 2000; 2000(905): 9 - 9. [Full Text]
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T. J. Regan Moderate Alcohol Consumption and Risk of Coronary Heart Disease Among Women With Type 2 Diabetes Mellitus Circulation, August 1, 2000; 102(5): 487 - 488. [Full Text] [PDF]
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U. A. Ajani, J. M. Gaziano, P. A. Lotufo, S. Liu, C. H. Hennekens, J. E. Buring, and J. E. Manson Alcohol Consumption and Risk of Coronary Heart Disease by Diabetes Status Circulation, August 1, 2000; 102(5): 500 - 505. [Abstract] [Full Text] [PDF]
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