Hypercholesterolemia Stimulates Angiotensin Peptide Synthesis and Contributes to Atherosclerosis Through the AT1A Receptor
Circulation Daugherty et al.
110: 3849
Data Supplement
Files in this Data Supplement:
- Figure I
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(Microsoft PowerPoint) (83.5 kb). Examples of the PCR screen for the genotyping of mice for AT1a or AT2 receptors.
- Figure II
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(Microsoft PowerPoint) (5.20 MB). Macrophages are the predominant cell type in atherosclerotic lesions from both male and female AT1a receptor wild type and deficient mice. Sections from the aortic root were immunostained for macrophages using a rabbit anti-mouse macrophage antibody at 1:3000 and red chromagen. (A) and (B) are from male mice, AT1a wild type and deficient, respectively. (C) and (D) are from female mice, AT1a wild type and deficient, respectively.
- Figure III
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(Microsoft PowerPoint) (3.52 MB). Deficiency of AT1a receptors did not produce overt changes in the distribution of VCAM-1.