Gene Transfer of Stromal Cell–Derived Factor-1
Enhances Ischemic Vasculogenesis and Angiogenesis via Vascular Endothelial Growth Factor/Endothelial Nitric Oxide Synthase–Related Pathway: Next-Generation Chemokine Therapy for Therapeutic Neovascularization
Circulation Hiasa et al.
109: 2454
Data Supplement
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(JPEG) (197 kb). Commitment of EPCs to Neovascularization in SDF-1α--containing Matrigel Plugs in vivo. A, Hematoxylin-eosin--stained histopathologic pictures of matrigel plug sections with or without SDF-1α. “S” indicates stroma surrounding the plugs; arrow, new vessel that contains red blood cells. Scale bar indicates 100 μm. B, Fluorescence immunohistochemistry of the SDF-1α--containing matrigels 7 days after injection. Micrographs are stained with CD31 in green. Micrographs are also stained with c-kit or CXCR4 in red. Single fluorescence-positive cells appeared green or red, whereas double-positive cells appeared yellow. Scale bar: 20 μm.
