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(Circulation. 2008;117:1121-1123.)
© 2008 American Heart Association, Inc.

Clinical Summaries

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	Dietary Fish and -3 Fatty Acid Consumption and Heart Rate Variability in US Adults

 
Consumption of fish and -3 fatty acid reduces risk of cardiac death, but mechanisms are not well established. Heart rate variability (HRV) predicts cardiac death and reflects specific electrophysiological pathways and influences. To elucidate electrophysiological influences and support effects on clinical risk, we evaluated the associations between habitual consumption of fish and marine -3 fatty acids and HRV, assessed by both 12-lead ECG (n=4263) and 24-hour Holter monitoring (n=1152), in a population-based cohort of older US adults. After multivariable adjustment, consumption of tuna or other broiled/baked fish was associated with specific HRV components, including indices suggestive of greater vagal predominance and moderated baroreceptor responses (eg, higher root mean square successive differences of normal-to-normal intervals, higher normalized high-frequency power, and lower low-frequency/high-frequency ratio) and less erratic sinoatrial node firing (eg, lower Poincaré ratio and higher short-term fractal scaling exponent). Findings were similar for estimated dietary consumption of marine -3 fatty acids. For the magnitudes of the observed differences in HRV comparing the highest with the lowest category of fish intake, the differences in relative risk of coronary heart disease death during 10.8 years of follow-up ranged from 1.1% lower risk for the difference in standard deviation of normal-to-normal intervals to 5.9% and 8.4% lower risk for the differences in the Poincaré ratio and short-term fractal scaling exponent, respectively. Thus, habitual consumption of tuna/other fish and marine -3 fatty acid are associated with specific and clinically relevant differences in HRV in older adults, including indices of more favorable vagal activity, baroreceptor responses, . . . [Full Text of this Article]

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