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(Circulation. 2006;113:2675.)
© 2006 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	SINGLE-GENE MUTATIONS AND INCREASED LEFT VENTRICULAR WALL THICKNESS IN THE COMMUNITY: THE FRAMINGHAM HEART STUDY, by Morita et al.

 
Left ventricular hypertrophy (LVH) is associated with stroke, coronary heart disease, heart failure, and cardiovascular and all-cause mortality. LVH results from increases in LV wall thickness (LVWT), LV mass, and LV volume. Unexplained increases in LVWT (LVWT 13mm) contribute to LVH in 3% of the general population over the age of 45. Mutations in sarcomere protein, PRKAG2, LAMP2, -galactosidase A (GLA), and several mitochondrial genes are associated with rare familial cardiomyopathies; their contribution to LVH in the community is unknown, however. Morita et al identified the prevalence and clinical features of single-gene mutations in adults in the community with increased LVWT in the absence of obvious secondary forms of hypertrophy. Among 1862 Framingham Heart Study participants, 50 had unexplained increased LVWT. Eight subjects (16%) had sarcomere protein gene mutations and one (2%) had a GLA mutation. Therefore, approximately 0.5% of the general population over age 45 has increased unexplained LVWT and a single-gene mutation that probably accounts for their hypertrophy. Increased LVWT in the community is a heterogeneous condition, and additional investigation of the prevalence and clinical features of single-gene mutations in other community-based cohorts will help improve our understanding of the broad spectrum of genetic causes of increased LVWT. See p 2697.

	AEROBIC CAPACITY IN PATIENTS ENTERING CARDIAC REHABILITATION, by Ades et al.

 
Exercise training is a key component of comprehensive cardiac rehabilitation/secondary prevention programs and generally yields marked improvements in exercise capacity, particularly among those with the lowest initial fitness levels. In this issue of Circulation, Ades et al provide normative values for . . . [Full Text of this Article]

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