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(Circulation. 2005;111:3341.)
© 2005 American Heart Association, Inc.
Issue Highlights
An extract of the first 250 words of the full text is provided, because this article has no abstract. |
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IS OBESITY A RISK FACTOR FOR MORTALITY IN CORONARY ARTERY BYPASS SURGERY? by Jin et al. |
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This article investigates the role of body size on operative mortality after isolated coronary artery bypass graft surgery in 16 218 patients. Prior reports on body size (body mass index) have resulted in conflicting results. Body mass index in a logistic regression model was not found to be a statistically significant risk factor for mortality. The lowest mortality was observed in the high, normal, and overweight subgroups as compared with obese and underweight subgroups. However, obesity does remain a risk factor for sternal wound complications and negatively impacts late cardiovascular health. A little fat may be protective to get you through surgery, and being underweight increases the operative risk. See p 3359.
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EFFECTS OF EXERCISE AND ISCHEMIA ON MOBILIZATION AND FUNCTIONAL ACTIVATION OF BLOOD-DERIVED PROGENITOR CELLS IN PATIENTS WITH ISCHEMIC SYNDROMES: RESULTS OF 3 RANDOMIZED STUDIES, by Sandri et al. |
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Exercise training reduces myocardial ischemia in patients with coronary artery disease and lower-limb ischemia in patients with peripheral arterial disease. Several mechanisms may account for these findings, including an improvement in regional perfusion. Previous studies have demonstrated that exercise training induces changes in vascular endothelial function and leads to enhanced vasodilation in local vascular beds. In this provocative study, Sandri and colleagues evaluated whether regular exercise may induce a regeneration of diseased endothelium by circulating progenitor cells or circulating progenitor cell-derived vasculogenesis, and whether ischemic stimuli are required to effect such changes. Their findings provide important new insights into this complex process. See p 3391.
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IMPROVED MYOCARDIAL ß-ADRENERGIC RESPONSIVENESS AND SIGNALING WITH EXERCISE TRAINING IN HYPERTENSION, by MacDonnell et al. |
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Myocardial ß-adrenergic receptor responsiveness is depressed in pressure overload-induced cardiac hypertrophy, in association with multiple alterations in the signaling pathway that couples the ß-adrenergic receptor to calcium handling and myocyte function.
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