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(Circulation. 2005;111:2275.)
© 2005 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	CORONARY CIRCULATORY DYSFUNCTION IN INSULIN RESISTANCE, IMPAIRED GLUCOSE TOLERANCE, AND TYPE 2 DIABETES MELLITUS, by Prior et al.

 
The notion that diabetes contributes importantly to the development of atherosclerosis and cardiovascular disease has long been known. Consistent with this notion, diabetes is also associated with impaired vascular function, a preclinical marker of atherosclerosis. However, the extent to which impaired glucose tolerance and insulin resistance are also injurious to the vasculature is not known. In this issue, Prior and colleagues examine vascular function across the entire spectrum of insulin resistance and diabetes. They report that vascular dysfunction is present very early in the process toward development of diabetes, and they highlight the notion that insulin resistance makes a strong contribution to the development of vascular disease. See p 2291.

	CONTRIBUTIONS OF DEPRESSIVE MOOD AND CIRCULATING INFLAMMATORY MARKERS TO CORONARY HEART DISEASE IN HEALTHY EUROPEAN MEN: THE PROSPECTIVE EPIDEMIOLOGICAL STUDY OF MYOCARDIAL INFARCTION (PRIME), by Empana et al.

 
Depressive symptoms are associated with worse prognosis in patients with coronary heart disease. Some investigators have suggested that the relationship might be mediated by inflammation. In a prospective, observational study that seeks to identify risk factors for coronary heart disease and explain the gradient in risk between Belfast and France, investigators studied 335 individuals who subsequently developed a first ischemic coronary event and 670 age and center-matched controls to determine the relationship between depressive symptoms and markers of inflammation on this risk of angina pectoris, nonfatal myocardial infarction, and coronary death. This study provides some insight about whether the association of depressive symptoms with outcomes in this population is explained by the levels of their inflammatory markers. See p 2299.

	LEFT VENTRICULAR SYSTOLIC PERFORMANCE, FUNCTION, AND CONTRACTILITY IN PATIENTS WITH DIASTOLIC HEART FAILURE, by Baicu et al.

 
Clinical heart failure in a patient with a normal left ventricular ejection fraction is referred to as diastolic . . . [Full Text of this Article]

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