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(Circulation. 2004;110:2277.)
© 2004 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

SELECTING PATIENTS WITH ATRIAL FIBRILLATION FOR ANTICOAGULATION: STROKE RISK STRATIFICATION IN PATIENTS TAKING ASPIRIN, by Gage et al.

Quantifying a patient’s precise risk of ischemic stroke in atrial fibrillation is important for determining whether he or she would have a greater benefit from warfarin or aspirin. Gage and colleagues studied data from >2500 participants with nonvalvular atrial fibrillation who were entered into one of 6 large multicenter trials and determined the predictive accuracy of 5 distinct stroke risk stratification schemes. They found that all of the methods stratified the risk of stroke better than chance but that they varied widely in the number of patients who were identified as being at low or high risk. Although all of the schemes adequately identified the low-risk patients, success was variable for identification of the high-risk schemes. The authors conclude that a patient’s risk of stroke can be reliably identified and that this can guide the choice of antithrombotic agent. See p 2287.

STATIN-INDUCED CHOLESTEROL LOWERING AND PLAQUE REGRESSION AFTER 6 MONTHS OF MAGNETIC RESONANCE IMAGING–MONITORED THERAPY, by Lima et al.

In vivo monitoring of atherosclerosis regression has been challenging, as invasive imaging methods often have been used in the past. More recently, it has been demonstrated that magnetic resonance imaging can depict plaque area and volume, quantify lumen area, and allow an interrogation of plaque components. In this issue of Circulation, Lima and colleagues use a novel magnetic resonance technique combining standard magnetic resonance with an esophageal probe to obtain high-resolution images of the aortic wall and lumen. They demonstrate that plaque regression can be seen with 6 months of statin therapy and that the magnitude of plaque regression is related to the change in LDL . . . [Full Text of this Article]

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