Circulation. 1998;97:2195-2196
(Circulation. 1998;97:2195-2196.)
© 1998 American Heart Association, Inc.
Antiphospholipid Syndrome in the Elderly: Caution
Jean-Charles Piette, MD;
; Patrice Cacoub, MD
From the Service de Médecine Interne, Groupe Hospitalier
Pitié-Salpêtrière, Paris, France.
Correspondence to Jean-Charles Piette, Service de Médecine Interne, Groupe Hospitalier Pitié-Salpêtrière, 83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France. E-mail jean-charles.piette@psl.ap-hop-paris.fr
Key Words: Editorials • coagulation • immunology • thrombosis • aging
Ten years after its
identification, thousands of articles and 2 books have made the APS
popular. Subsequently, the diagnosis of a possible APS is now
frequently considered in daily practice, not only by subspecialists but
also by general practitioners, in patients with thrombosis,
sometimes whatever their age at the time of the first vascular event.
We wish to emphasize here the potential hazards associated with a
diagnosis of APS in elderly patients.
Historically, APS was first identified as a subset of patients
with SLE because of the strong association observed in this disorder
between the occurrence of thrombosis, either arterial or
venous, and/or miscarriages and the presence of aPL (ie, Lupus
anticoagulant) and/or aCL. Later, APS was also recognized in patients
who had no features of SLE, leading to the concept of a "primary
APS."1 A set of criteria has been proposed to
discriminate primary from SLE-related APS.2 Although aPL
may be encountered in multiple circumstances, primary and SLE-related
appear to be the 2 major variants of APS.2 3 4
APS usually affects young patients. This is obviously true for
SLE-related APS, given that spontaneously occurring SLE is restricted
primarily to women with functional ovaries. This also applies to
primary APS, as illustrated by data summarized in the
Table
. In reported series,1 3 4 5 6 7 8 9 10 the
first vascular event usually occurs in young adults and rarely in
people >60 years old. This age distribution not only reflects a
possible bias, ie, the younger the age at first thrombosis, the higher
the likelihood of having . . . [Full Text of this Article]
This article has been cited by other articles:
|
|
|
|
 
A Tincani, M Filippini, M Scarsi, M Galli, and P. Meroni
European attempts for the standardisation of the antiphospholipid antibodies
Lupus,
September 1, 2009;
18(10):
913 - 919.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Debiais, I. Bonnaud, N. Ferreira-Maldent, E. Mercier, and B. de Toffol
NEUROPSYCHIATRIC DISORDERS REVEALING PRIMARY ANTIPHOSPHOLIPID SYNDROME IN AN ELDERLY PATIENT
Neurology,
April 14, 2009;
72(15):
1362 - 1363.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D Ben-Ami, E Bar-Meir, and Y Shoenfeld
Stenosis in Antiphospholipid Syndrome: A New Finding with Clinical Implications
Lupus,
July 1, 2006;
15(7):
466 - 472.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. R. Sangle, D. P. D'Cruz, I. C. Abbs, M. A. Khamashta, and G. R. V. Hughes
Renal artery stenosis in hypertensive patients with antiphospholipid (Hughes) syndrome: outcome following anticoagulation
Rheumatology,
March 1, 2005;
44(3):
372 - 377.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Ramos-Casals, M Garcia-Carrasco, M P Brito, A Lopez-Soto, and J Font
Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly
Lupus,
May 1, 2003;
12(5):
341 - 355.
[Abstract]
[PDF]
|
|
|
|
|
|
|
G Castellino, M J Cuadrado, T Godfrey, M A Khamashta, and G R V Hughes
Characteristics of patients with antiphospholipid syndrome with major bleeding after oral anticoagulant treatment
Ann Rheum Dis,
May 1, 2001;
60(5):
527 - 530.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-H. Yang, F. S. Fan, P.-M. Chen, J.-H. Liu, T.-J. Chiou, W.-S. Wang, and C.-C. Yen
Venous Gangrene in a Patient with Adenocarcinoma of the Lung
Jpn. J. Clin. Oncol.,
June 1, 2000;
30(6):
276 - 278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-C. Piette, Z. Amoura, and A. Foucher-Lavergne
"Catastrophic" Diagnosis of the Antiphospholipid Syndrome
Ann Intern Med,
November 16, 1999;
131(10):
798 - 799.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Cretel, P. Cacoub, D. L. Thi Huong, A. Gompel, Z. Amoura, and J.-C. Piette
Massive ovarian haemorrhage complicating oral anticoagulation in the Antiphospholipid Syndrome: a report of three cases
Lupus,
July 1, 1999;
8(6):
482 - 485.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J-C. Piette
Review : Towards improved criteria for the antiphospholipid syndrome
Lupus,
January 1, 1998;
7(2_suppl):
S149 - S157.
[Abstract]
[PDF]
|
|
|
