Circulation. 1998;97:2079-2090
(Circulation. 1998;97:2079-2090.)
© 1998 American Heart Association, Inc.
Clinical Cardiology: New Frontiers |
Mechanical Circulatory Support and Cardiac Transplantation
Sharon A. Hunt, MD;
O.H. Frazier, MD;
; with the technical assistance of Timothy J. Myers, BS, CRA, RCVT
From the Cardiovascular Surgery Research Department (T.J.M., O.H.F.) and
the Cardiopulmonary Transplantation Department (O.H.F.) of the Texas Heart
Institute, Houston; and the Division of Cardiovascular Medicine (S.A.H.),
Stanford University Medical Center, Palo Alto, Calif.
Key Words: transplantation • heart-assist device • survival
Congestive heart
failure is not a specific disease but rather a clinical syndrome of
diverse etiologies. This syndrome is characterized by
ventricular dysfunction leading to decreased cardiac
output; consequent neurohumoral activation leading to salt and water
retention, with congestion in the pulmonary and systemic
circulation; a "vicious circle" of blood-flow maldistribution; and
eventual hypoperfusion of vital organs. In North America, the most
common underlying cause of CHF is atherosclerosis
resulting in ischemic dysfunction of the
myocardium. A second important underlying cause is
valvular malfunction leading to pressure and/or volume
overloading of the ventricles. Other important causes of CHF include
primary myocardial disease (idiopathic, infiltrative, or inflammatory)
and congenital cardiac malformations.
The incidence of heart failure is increasing, probably not only because
of aging of the population, but also because effective palliative
therapies are extending the lives of many CHF victims. In addition,
many patients have undergone successful emergency intervention for
otherwise fatal acute coronary events only to develop CHF at a
later date. The American Heart Association estimates that at least
400 000 new cases of CHF are diagnosed each
year.1 In the United States, more than $34
billion is spent each year for the medical care of CHF
patients.2 Despite the advent of more effective
therapy, CHF is the principal cause of 40 000 deaths per year in the
United States and is a contributing factor in another 250 000
deaths.1
The short-term goal of CHF therapy is to improve the patient's quality
of life by relieving his or . . . [Full Text of this Article]
This article has been cited by other articles:
|
|
|
|
 
R. F. Padera Jr. and F. J. Schoen
Pathology of Cardiac Surgery
Card. Surg. Adult,
January 1, 2008;
3(2008):
111 - 178.
[Full Text]
|
|
|
|
|
|
|
J. Haft, W. Armstrong, D. B. Dyke, K. D. Aaronson, T. M. Koelling, D. J. Farrar, and F. D. Pagani
Hemodynamic and Exercise Performance With Pulsatile and Continuous-Flow Left Ventricular Assist Devices
Circulation,
September 11, 2007;
116(11_suppl):
I-8 - I-15.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Liang, H. Lin, Y. Weng, M. Dandel, and R. Hetzer
Prediction of cardiac function after weaning from ventricular assist devices
J. Thorac. Cardiovasc. Surg.,
December 1, 2005;
130(6):
1555 - 1560.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. E. DeBakey
Development of Mechanical Heart Devices
Ann. Thorac. Surg.,
June 1, 2005;
79(6):
S2228 - S2231.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Klotz, M. C. Deng, J. Stypmann, J. Roetker, M. J. Wilhelm, D. Hammel, H. H. Scheld, and C. Schmid
Left ventricular pressure and volume unloading during pulsatile versus nonpulsatile left ventricular assist device support
Ann. Thorac. Surg.,
January 1, 2004;
77(1):
143 - 149.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. W. Miller
Patient selection for the use of ventricular assist devices as a bridge to transplantation
Ann. Thorac. Surg.,
June 1, 2003;
75(90060):
S66 - 71.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Rao, M. C. Oz, M. A. Flannery, K. A. Catanese, M. Argenziano, and Y. Naka
Revised screening scale to predict survival after insertion of a left ventricular assist device
J. Thorac. Cardiovasc. Surg.,
April 1, 2003;
125(4):
855 - 862.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Ito, M. Nakayama, F. Hasan, X. Yan, M. D. Schneider, and B. H. Lorell
Contractile Reserve and Calcium Regulation Are Depressed in Myocytes From Chronically Unloaded Hearts
Circulation,
March 4, 2003;
107(8):
1176 - 1182.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Schoen and R. F. Padera Jr.
Cardiac Surgical Pathology
Card. Surg. Adult,
January 1, 2003;
2(2003):
119 - 185.
[Full Text]
|
|
|
|
|
|
|
R. Gradaus, S. Kerber, D. Bocker, H. H. Scheld, G. Breithardt, and M. C. Deng
Therapeutic options and heart failure survival score predictability in an academic heart failure center: an analysis of 120 consecutive patients during a 1-year period
Eur J Heart Fail,
March 1, 2002;
4(2):
207 - 214.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Ochiai, L. A.R. Golding, A. L. Massiello, A. L. Medvedev, R. L. Gerhart, J.-F. Chen, M. Takagaki, and K. Fukamachi
In vivo hemodynamic performance of the Cleveland Clinic CorAide blood pump in calves
Ann. Thorac. Surg.,
September 1, 2001;
72(3):
747 - 752.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Hetzer, J. H. Muller, Y.-g. Weng, R. Meyer, and M. Dandel
Bridging-to-recovery
Ann. Thorac. Surg.,
March 1, 2001;
71
(2007):
S109 - S113.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Albes, F. S. Eckstein, M. K. Heinemann, and G. Ziemer
Successful weaning of a transplanted heart from biventricular assist device
Ann. Thorac. Surg.,
July 1, 2000;
70(1):
277 - 278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Loebe, T. Drews, E. Potapov, D.-V. Ngo, R. zu Dohna, and R. Hetzer
Device selection in mechanical circulatory support
Perfusion,
July 1, 2000;
15(4):
313 - 318.
[PDF]
|
|
|
|
|
|
|
C. Knosalla, Y.-g. Weng, S. Buz, M. Loebe, and R. Hetzer
Pseudoaneurysm of the outflow graft in a patient with novacor N100 LVAD system
Ann. Thorac. Surg.,
May 1, 2000;
69(5):
1594 - 1596.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Schmid, M. Wilhelm, M. Rothenburger, D. Nabavi, M. C. Deng, D. Hammel, and H. H. Scheld
Effect of high dose platelet inhibitor treatment on thromboembolism in Novacor patients
Eur. J. Cardiothorac. Surg.,
March 1, 2000;
17(3):
331 - 335.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Mohacsi, M. C. Deng, R. Murphy, C.-H. Bergh, E. Gronda, M. Komajda, R. Pacher, J. Spinar, K. Swedberg, and J. F. Cleland
Implantable left ventricular assist systems (LVAS): Recent results. A report from a series of meetings sponsored by the Study Group on Advanced Heart Failure of the Working Group on Heart Failure
Eur J Heart Fail,
March 1, 2000;
2(1):
13 - 18.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. W. Kjellman, P. Hallgren, C.-H. Bergh, J. Lycke, A. Oldfors, and L. Wiklund
Weaning from mechanical support in a patient with acute heart failure and multiple sclerosis
Ann. Thorac. Surg.,
February 1, 2000;
69(2):
628 - 630.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Shah, R. E. Lilly, A. P. Kypson, O. Tai, J. A. Hata, A. Pippen, S. C. Silvestry, R. J. Lefkowitz, D. D. Glower, and W. J. Koch
Intracoronary Adenovirus-Mediated Delivery and Overexpression of the {beta}2-Adrenergic Receptor in the Heart : Prospects for Molecular Ventricular Assistance
Circulation,
February 1, 2000;
101(4):
408 - 414.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Deng, T. D.T. Tjan, B. Asfour, and H. H. Scheld
Left ventricular assist devices -- reasons to be enthusiastic
Eur J Heart Fail,
August 31, 1999;
1(3):
289 - 291.
[Full Text]
[PDF]
|
|
|
|
|
|
|
O.H. Frazier and T. J. Myers
Left ventricular assist system as a bridge to myocardial recovery
Ann. Thorac. Surg.,
August 1, 1999;
68(2):
734 - 741.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Hollenberg, C. J. Kavinsky, and J. E. Parrillo
Cardiogenic Shock
Ann Intern Med,
July 6, 1999;
131(1):
47 - 59.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Mann and J. T. Willerson
Left Ventricular Assist Devices and the Failing Heart : A Bridge to Recovery, a Permanent Assist Device, or a Bridge Too Far?
Circulation,
December 1, 1998;
98(22):
2367 - 2369.
[Full Text]
[PDF]
|
|
|
