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(Circulation. 2007;115:945.)
© 2007 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	C-REACTIVE PROTEIN AND PREDICTION OF CORONARY HEART DISEASE AND GLOBAL VASCULAR EVENTS IN THE PROSPECTIVE STUDY OF PRAVASTATIN IN THE ELDERLY AT RISK (PROSPER), by Sattar et al.

 
Prospective data relating C-reactive protein (CRP) to the risk of cardiovascular disease in the elderly are limited, with available studies yielding conflicting results. In this issue of Circulation, Sattar and colleagues use data from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) to evaluate whether CRP levels predict vascular events in the elderly, add to risk prediction beyond traditional risk factors, and whether levels correlate with the response to statin therapy. The authors report that higher CRP was associated with increased risk of vascular events in the PROSPER sample, but knowledge of CRP minimally enhances cardiovascular disease prediction beyond established risk factors as judged by the increment in the C statistic for models with and without CRP. Moreover, CRP levels did not predict response to statin therapy in elderly subjects at risk. These data suggest that measurement of CRP in elderly people may have limited clinical utility for cardiovascular disease risk stratification or for predicting response to statin therapy. Additional studies are warranted to confirm these observations. See p 981.

	EXPOSURE TO SECONDHAND SMOKE AND BIOMARKERS OF CARDIOVASCULAR DISEASE RISK IN NEVER-SMOKING ADULTS, by Venn and Britton

 
Venn and Britton examine the association between secondhand smoke and biomarkers of cardiovascular disease using data from almost 8000 never-smoking adults participating in the third National Health and Nutrition Examination Survey. The investigators used cotinine concentrations to objectively quantify secondhand tobacco smoke exposure. They observed that individuals with low cotinine concentrations had significantly higher homocysteine and fibrinogen concentrations compared with individuals with undetectable concentrations. Of interest, the passive smoke exposure was associated with increased biomarker . . . [Full Text of this Article]

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