This Article Free upon publication Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Related Collections Related Articles

(Circulation. 2007;115:2683.)
© 2007 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	LOCAL PRODUCTION OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 AND LYSOPHOSPHATIDYLCHOLINE IN THE CORONARY CIRCULATION: ASSOCIATION WITH EARLY CORONARY ATHEROSCLEROSIS AND ENDOTHELIAL DYSFUNCTION IN HUMANS, by Lavi et al.

 
Endothelial dysfunction is a hallmark of atherosclerosis and vascular disease. However, the mechanisms for this dysfunction remain elusive. In this issue, Lavi and colleagues report on a human study in which they measured lipoprotein-associated phospholipase A₂, an enzyme that is involved in cleaving oxidation products of lipids from both membranes and lipoproteins. They found that patients with endothelial dysfunction had increased levels of both the enzyme and the cleaved oxidation product in the coronary circulation, suggesting that oxidation processes contribute to endothelial dysfunction in patients with early atherosclerosis. See p 2715.

	RISK FACTORS FOR THE PROGRESSION OF CORONARY ARTERY CALCIFICATION IN ASYMPTOMATIC SUBJECTS: RESULTS FROM THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), by Kronmal et al.

 
Investigators from the Multi-Ethnic Study of Atherosclerosis (MESA) report the incidence and predictors of coronary artery calcium (CAC) progression in a community-based, geographically and racially diverse cohort. As opposed to previous referral-based studies, their study provides estimates of the rates of progression that can be expected in unselected routinely studied individuals. The researchers detected new CAC in 6.6% of individuals per year, and they noted that men and women had a median annual CAC progression of 21 and 14 Agatston units per year, respectively. Not surprisingly, cardiovascular disease risk factors predicted CAC incidence and progression, indirectly raising the possibility that aggressive risk factor modification could potentially slow or arrest the progression of CAC. See p 2722.

	SUSTAINED BENEFIT AT 2 YEARS OF PRIMARY FEMOROPOPLITEAL STENTING COMPARED WITH BALLOON ANGIOPLASTY WITH OPTIONAL STENTING, by Schillinger et al.

 
Peripheral arterial disease is an important cause of morbidity. Frequently, the superficial femoral artery is obstructed and is the underlying cause of claudication. Although balloon angioplasty is an established treatment for this condition—as already introduced by Andreas Grüntzig in the . . . [Full Text of this Article]

Related Articles:

Intracardiac Correlate of the Epsilon Wave in a Patient With Arrhythmogenic Right Ventricular Dysplasia

David N. Kenigsberg, Gautham Kalahasty, John D. Grizzard, Mark A. Wood, and Kenneth A. Ellenbogen
Circulation 2007 115: e538-e539. [Extract] [Full Text]

Loculated Pericardial Hematoma Complicating Complex Coronary Interventions: A Rare but Often Missed Diagnosis?

Alessio La Manna, Didier A. Locca, Sanjay K. Prasad, and Carlo Di Mario
Circulation 2007 115: e540-e541. [Extract] [Full Text]

Percutaneous Pericardial Access for Mapping and Ablation of Epicardial Ventricular Tachycardias

Eduardo Sosa and Mauricio Scanavacca
Circulation 2007 115: e542-e544. [Extract] [Full Text]

Letter by Wiggers et al Regarding Article by Tuunanen et al, "Free Fatty Acid Depletion Acutely Decreases Cardiac Work and Efficiency in Cardiomyopathic Heart Failure"

Henrik Wiggers, Mads Halbirk, and Helene Nørrelund
Circulation 2007 115: e545. [Extract] [Full Text]

Local Production of Lipoprotein-Associated Phospholipase A₂ and Lysophosphatidylcholine in the Coronary Circulation: Association With Early Coronary Atherosclerosis and Endothelial Dysfunction in Humans

Shahar Lavi, Joseph P. McConnell, Charanjit S. Rihal, Abhiram Prasad, Verghese Mathew, Lilach O. Lerman, and Amir Lerman
Circulation 2007 115: 2715-2721. [Abstract] [Full Text]

Risk Factors for the Progression of Coronary Artery Calcification in Asymptomatic Subjects: Results From the Multi-Ethnic Study of Atherosclerosis (MESA)

Richard A. Kronmal, Robyn L. McClelland, Robert Detrano, Steven Shea, João A. Lima, Mary Cushman, Diane E. Bild, and Gregory L. Burke
Circulation 2007 115: 2722-2730. [Abstract] [Full Text]

Sustained Benefit at 2 Years of Primary Femoropopliteal Stenting Compared With Balloon Angioplasty With Optional Stenting

Martin Schillinger, Schila Sabeti, Petra Dick, Jasmin Amighi, Wolfgang Mlekusch, Oliver Schlager, Christian Loewe, Manfred Cejna, Johannes Lammer, and Erich Minar
Circulation 2007 115: 2745-2749. [Abstract] [Full Text]