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(Circulation. 2006;114:257.)
© 2006 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	SURGICAL CORRECTION OF MITRAL REGURGITATION IN THE ELDERLY: OUTCOMES AND RECENT IMPROVEMENTS, by Detaint et al.

 
With an aging population and the traditionally high risks for surgical repair of mitral regurgitation, contemporary surgical results are of great importance. In this issue of Circulation, Detaint et al analyzed the results of mitral valve surgery for mitral regurgitation in elderly patients 75 years old compared to patients 65–74 and <65 years of age. They found an incremental comorbidity index in the elderly. Most important, the long-term observed and expected survival rates were similar in each group. The multivariable analysis confirmed the ability of mitral valve surgery to restore life expectancy as well in the elderly as in younger patients. Current surgical practice should be able to offer mitral valve operations to these elderly, higher-risk patients with operative mortality rates around 5%; a high reliability to repair the mitral valve for degenerative pathology causing mitral regurgitation and the restoration of the life expectancy. See p 265.

	CLINICAL RELEVANCE OF C-REACTIVE PROTEIN DURING FOLLOW-UP OF PATIENTS WITH ACUTE CORONARY SYNDROMES IN THE AGGRASTAT-TO-ZOCOR TRIAL, by Morrow et al.

 
The role of measuring inflammatory markers in the setting of acute coronary syndromes is evolving. While high sensitivity C-reactive protein (hsCRP) is the most widely studied marker, it is unknown whether the associated risk of elevated levels can be modified. In this issue of Circulation, Morrow and colleagues substantially move the field forward with their analysis of 3813 patients with acute coronary syndromes in the Aggrastat-to-Zocor trial. In this prospective study, they report the association of hsCRP levels with long-term risk of death and the effect of aggressive statin therapy (simvastatin) on these levels. These important data suggest that monitoring . . . [Full Text of this Article]

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