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(Circulation. 2005;112:1.)
© 2005 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	PERIODONTAL DISEASE AND CORONARY HEART DISEASE: A REAPPRAISAL OF THE EXPOSURE, by Beck et al.

 
There currently is great interest in understanding the role of certain chronic infections as risk factors for cardiovascular disease. In this regard, prior studies have suggested that chronic periodontal disease is associated with increased cardiovascular risk, although it remains possible that the confounding effects of smoking and other classical risk factors explain the association. In this issue of Circulation, Beck and colleagues investigated the relation between periodontal disease and prevalent coronary heart disease in 5002 participants in the fourth examination of the Atherosclerosis Risk in Communities Study. They observed that elevated serum IgG antibodies to several oral pathogens were associated with coronary heart disease, but findings on oral examination were not. Although further prospective studies of this question are needed, the present study suggests that the host response to oral infection may be more important for cardiovascular risk than the local extent of periodontal disease. See p 19.

	EFFECTS OF CANDESARTAN ON THE DEVELOPMENT OF A NEW DIAGNOSIS OF DIABETES MELLITUS IN PATIENTS WITH HEART FAILURE, by Yusuf et al.

 
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers (ARBs) have been associated with a lower incidence of diabetes mellitus in clinical trials of hypertensives and other high-risk patients. However, it is less clear if use of renin-angiotensin axis inhibitors lowers the risk of diabetes in patients with heart failure. In this issue of Circulation, Yusuf and colleagues analyze data from the CHARM trial to assess the risk of developing new-onset diabetes (a prespecified secondary outcome) in more than 5000 heart failure patients randomized to candesartan (an ARB) or placebo. The investigators report that candesartan use was associated with a 22% . . . [Full Text of this Article]

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Periodontal Disease and Coronary Heart Disease: A Reappraisal of the Exposure

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Effects of Candesartan on the Development of a New Diagnosis of Diabetes Mellitus in Patients With Heart Failure

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