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(Circulation. 2005;111:533.)
© 2005 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	IMPACT OF REGULAR PHYSICAL ACTIVITY ON THE NAD(P)H OXIDASE AND ANGIOTENSIN RECEPTOR SYSTEM IN PATIENTS WITH CORONARY ARTERY DISEASE, by Adams et al.

 
It has long been known that exercise and physical activity contribute to a healthy lifestyle. Moreover, regular physical activity tends to promote a favorable lipoprotein profile, manifested principally as an increase in high-density lipoprotein cholesterol. As reported in this issue, German investigators have probed the effect of exercise training on the arterial wall. They found that regular exercise limited the arterial content of angiotensin type I receptors and enhanced expression of angiotensin type II receptors. In concert with these observations, they found that arterial production of reactive oxygen species was also significantly reduced by exercise training. In total, these effects produced an improvement in endothelial function. These data provide tangible evidence that exercise training has a direct impact on the vascular wall. See p 555.

	PERIODONTAL MICROBIOTA AND CAROTID INTIMA-MEDIA THICKNESS: THE ORAL INFECTIONS AND VASCULAR DISEASE EPIDEMIOLOGY STUDY (INVEST), by Desvarieux et al.

 
It is now clear that atherosclerosis is a chronic inflammatory disease induced in large part by traditional cardiovascular risk factors. Currently, there is great interest in identifying additional sources of inflammation that might contribute to the development of atherosclerosis. In this issue, Desvarieux and colleagues report an association between periodontal infection and carotid artery atherosclerosis in 657 subjects without known cardiovascular disease. This association was maintained after adjusting for traditional risk factors and serum levels of C-reactive protein. These findings contribute to the growing body of evidence linking periodontal disease to atherosclerosis. Prospective studies will be needed to investigate the intriguing possibility that aggressive periodontal treatment might reduce cardiovascular risk. See p 576.

	EFFECT OF TAMOXIFEN ON VENOUS THROMBOEMBOLIC EVENTS IN A BREAST CANCER PREVENTION TRIAL, by Decensi et al.

 
Tamoxifen use is known to decrease mortality in patients with . . . [Full Text of this Article]