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(Circulation. 2005;111:2151.)
© 2005 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	PERCUTANEOUS MITRAL VALVE REPAIR FOR CHRONIC ISCHEMIC MITRAL REGURGITATION: A REAL-TIME THREE-DIMENSIONAL ECHOCARDIOGRAPHIC STUDY IN AN OVINE MODEL, by Daimon et al.

 
Ischemic mitral regurgitation is associated with adverse prognosis in patients with chronic heart failure as well as after myocardial infarction and coronary revascularization. There is great interest in surgical remodeling procedures and mitral valve reconstruction to correct the mitral regurgitation and potentially improve prognosis. One of the limitations to this approach has been the relatively high operative morbidity and even mortality associated with such surgical procedures. In this issue of Circulation, Daimon et al demonstrate the utility of percutaneous placement of an annuloplasty device in a sheep model of chronic ischemic mitral regurgitation. They demonstrate the benefit of this approach in reducing mitral regurgitation as well as beneficially improving mitral annular dimension and functional closure of the valve. This study supports the clinical potential of percutaneous nonsurgical approaches to treating patients with ischemic mitral regurgitation. See p 2183.

	INFLAMMATION AND CAROTID ARTERY—RISK FOR ATHEROSCLEROSIS STUDY (ICARAS), by Schillinger et al.

 
Prior studies have demonstrated that inflammatory markers such as C-reactive protein (CRP) are related to prevalent and incident cardiovascular events. However, the temporality of the relations between inflammation and atherosclerosis has been less clear. Inflammation may predispose to atherosclerosis, but it is equally plausible that atherosclerosis predisposes to inflammation. In a prospective study of almost 1300 patients, Schillinger and colleagues examined the relation between CRP and serum amyloid A and ultrasound progression of carotid atherosclerosis. In adjusted analyses compared with the bottom quartile, individuals in the top quartiles of CRP and serum amyloid A, respectively, were about 4 and 2 times more likely to develop progression of carotid atherosclerosis. This study . . . [Full Text of this Article]

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