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(Circulation. 2005;111:1.)
© 2005 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	FUNCTIONAL INTEGRATION OF ELECTRICALLY ACTIVE CARDIAC DERIVATIVES FROM GENETICALLY ENGINEERED HUMAN EMBRYONIC STEM CELLS WITH QUIESCENT RECIPIENT VENTRICULAR CARDIOMYOCYTES: INSIGHTS INTO THE DEVELOPMENT OF CELL-BASED PACEMAKERS, by Xue et al.

 
Feasibility of human embryonic stem cell transplantation for reestablishing a cardiac pacemaker was tested by harvesting spontaneously beating outgrowths of human embryoid bodies that are known to contain cardiomyocytes. These cells are shown to be capable of electrically driving monolayers of neonatal rat ventricular myocytes in culture. The beating rate can be manipulated pharmacologically. Injection into guinea pig ventricle established a functioning pacemaker that could drive the ventricles in explanted Langendorff preparations 2 or 3 days after cell transplantation. This work could lead to genetically engineered pacemakers for cell transplantation therapy of bradyarrhythmias. See p 11.

	FUNCTIONAL VARIANT OF CYP4A11 20-HYDROXYEICOSATETRAENOIC ACID SYNTHASE IS ASSOCIATED WITH ESSENTIAL HYPERTENSION, by Gainer et al.

 
Data from a number of large-scale cohort studies indicate that a significant component of hypertension is heritable. Except for a few rare syndromes, however, the precise molecular cause of hypertension in the general population has been elusive-largely, it is believed, because of the polygenic nature of hypertension. In this issue, Gainer and colleagues shed light on one genetic trait associated with hypertension. The investigators found a functionally significant polymorphism of a cytochrome p450 isoform that segregates with hypertension. This study could provide a new focus for the investigation of hypertension and the role of cytochrome p450 enzymes. See p 63.

	GALLIC ACID ANTAGONIZES P-SELECTIN–MEDIATED PLATELET–LEUKOCYTE INTERACTIONS: IMPLICATIONS FOR THE FRENCH PARADOX, by Appeldoorn et al.

 
It is still unclear why there is a lower incidence of cardiovascular disease in Mediterranean countries despite diets containing high levels of saturated fat. One hypothesis is that the antioxidant content of red wines contributes to this ‘French paradox.‘ Appeldoorn and colleagues study whether gallic acid, an abundant polyphenol and antioxidant found . . . [Full Text of this Article]

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Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension

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Letters Regarding Article by Khot et al, "Radial Artery Bypass Grafts Have an Increased Occurrence of Angiographically Severe Stenosis and Occlusion Compared With Left Internal Mammary Arteries and Saphenous Vein Grafts" • Letters Regarding Article by Khot et al, "Radial Artery Bypass Grafts Have an Increased Occurrence of Angiographically Severe Stenosis and Occlusion Compared With Left Internal Mammary Arteries and Saphenous Vein Grafts" • Letters Regarding Article by Khot et al, "Radial Artery Bypass Grafts Have an Increased Occurrence of Angiographically Severe Stenosis and Occlusion Compared With Left Internal Mammary Arteries and Saphenous Vein Grafts" • Letters Regarding Article by Khot et al, "Radial Artery Bypass Grafts Have an Increased Occurrence of Angiographically Severe Stenosis and Occlusion Compared With Left Internal Mammary Arteries and Saphenous Vein Grafts" • Response

Christophe Acar, Richard C. Cook, Shahzad G. Raja, Shahrul Hashim, Inderpaul Birdi, Pallav J. Shah, Robert A. Baker, John J. Knight, Umesh N. Khot, Daniel T. Friedman, Gosta Pettersson, Nicholas G. Smedira, Jianbo Li, and Stephen G. Ellis
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