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(Circulation. 2004;110:2977.)
© 2004 American Heart Association, Inc.

Issue Highlights

An extract of the first 250 words of the full text is provided, because this article has no abstract.

EXTRACORPOREAL CARDIAC SHOCK WAVE THERAPY MARKEDLY AMELIORATES ISCHEMIA-INDUCED MYOCARDIAL DYSFUNCTION IN PIGS IN VIVO, by Nishida et al.

Extracorporeal shock wave therapy (SW) has been used for the treatment of nephrolithiasis for several years. This study represents the first attempt at using SW for the treatment of a cardiovascular disorder, viz., chronic myocardial ischemia and resulting ischemic cardiomyopathy. On the basis of studies with cultured endothelial cells in which SW induced the expression of vascular endothelial growth factor and one of its receptors, the study investigators reasoned that application of SW to a chronically ischemic animal would stimulate angiogenesis, improve myocardial perfusion, and enhance left ventricular function. Using a porcine model of chronic myocardial ischemia, they demonstrated that SW induced complete recovery of left ventricular function and improved regional myocardial blood flow. These striking results suggest that this therapy should be considered for prospective study in patients with chronic myocardial ischemia. See p 3055.

MULTISCALE MOTION MAPPING: A NOVEL COMPUTER VISION TECHNIQUE FOR QUANTITATIVE, OBJECTIVE ECHOCARDIOGRAPHIC MOTION MEASUREMENT INDEPENDENT OF DOPPLER: FIRST CLINICAL DESCRIPTION AND VALIDATION, by Sühling et al.

Conventional echocardiographic techniques that attempt to quantify cardiac function often are limited by the need for operator interaction in the assignment of borders and acquisition factors such as angle dependency. Moreover, complex parameters such as rotational deformation are challenging to quantify. In this issue of Circulation, Sühling, Jansen, and colleagues present the first clinical validation and application of multiscale motion mapping, a novel echocardiographic technique that uses concepts derived from the human visual system to create fully quantitative functional maps depicting motion and deformation that are not dependent on Doppler interrogation or on border definitions. The robust validation data in models and in a series of human studies suggest potential clinical usefulness. . . . [Full Text of this Article]

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