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(Circulation. 2003;108:e9036.)
© 2003 American Heart Association, Inc.

Cardiovascular News

Ruth SoRelle, MPH

Circulation Newswriter

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Autologous Culture-Modified Mononuclear Cells Could Enhance Vascular Repair

Delivering culture-modified mononuclear cells to the site of injury in arteries that have been injured by balloon (mimicking injuries from percutaneous interventions) could present a new method of vasoprotection, said researchers from the Mayo Clinic in Rochester, Minn, in a report in the September 23, 2003, issue of the journal Circulation (Circulation. 2003;108:1520–1526).

The researchers, led by Rajiv Gulati, MD, of the Mayo Clinic, cultured rabbit peripheral blood mononuclear cells in endothelial growth media to produce highly proliferative cells with a phenotype similar to that of endothelial cells. Rabbits with balloon carotid injuries immediately received autologous culture-modified mononuclear cells or buffered saline solution. Four weeks after the delivery of the culture-modified mononuclear cells, fluorescence-labeled mononuclear cells were detected in all vessel layers in the treated animals. Animals that received the culture-modified mononuclear cells showed more endothelialization than did those who received the saline solution. The treatment with the culture-modified cells also reduced neointimal formation by 55% at 4 weeks compared with the saline-treated animals.

The authors wrote, "The results reported here show that the effect of CMMC [culture-modified mononuclear cell] delivery is an overall reduction in cellular accumulation. This reduction may be mediated in part by accelerated restoration of an endothelial barrier. It is also conceivable that the provision of supplementary sources of NO [nitric oxide] and other secreted factors deeper in the vessel wall may suppress activation and recruitment of additional plaque-forming cells. . . . Overall, the findings reported in this study expand the potential applications . . . [Full Text of this Article]