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(Circulation. 2003;107:e9053.)
© 2003 American Heart Association, Inc.

Cardiovascular News

Ruth SoRelle, MPH

Circulation Newswriter

An extract of the first 250 words of the full text is provided, because this article has no abstract.

Heat-Shock Protein and Acute Coronary Syndromes

Chlamydia pneumoniae heat-shock protein 60 appeared significantly associated with the presence of acute coronary syndromes (ACS), said Italian researchers in this week’s issue of the journal Circulation (Circulation. 2003;107:3015–3017).

When researchers from the Institute of Cardiology, Universita Cattolica in Rome, Medical Mycology, Istituto Superiore di Sinita in Rome, and the Cardiothoracic and Vascular Department in Universita Vita e Salute in Milan, Italy, led by Luigi M. Biasucci, MD, measured the levels of antibodies to Chlamydia pneumoniae and Chlamydia pneumoniae immune globulin in 179 patients with unstable angina, 49 patients with myocardia infarction, 40 patients with stable angina, and 100 normal subjects, they found that 99% of those with ACS were positive for antibodies to the Chlamydia pneumoniae heat shock protein 60, but only 20% of those with stable angina were positive.

They concluded: "Seropositivity for Cp-HSP60 [Chlamydia pneumoniae heat shock protein 60] appears to be a very sensitive and specific marker of ACS. . . . Its causal involvement in instability and its diagnostic role in ACS deserve further studies."

New AHA Statement Stresses Physical Activity for Health Professionals and Their Patients
Physical activity and exercise training play key roles in preventing atherosclerotic coronary artery disease as well as in managing the risk factors of the disease and treating diseases such as coronary artery disease, heart failure, and claudication, according to a new statement from the American Heart Association’s Council on Clinical Cardiology Subcommittee on Exercise, Rehabilitation, and Prevention, and the Council on Nutrition, Physical Activity, and Metabolism Subcommittee on Physical Activity. The statement appears in this week’s issue . . . [Full Text of this Article]