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(Circulation. 2002;106:3163.)
© 2002 American Heart Association, Inc.

ATP III Final Report

II. Rationale for Intervention

An extract of the first 250 words of the full text is provided, because this article has no abstract.

	1. Basic description of lipids and lipoproteins

 
Cholesterol is a fat-like substance (lipid) that is present in cell membranes and is a precursor of bile acids and steroid hormones. Cholesterol travels in the blood in distinct particles containing both lipid and proteins (lipoproteins). Three major classes of lipoproteins are found in the serum of a fasting individual: low density lipoproteins (LDL), high density lipoproteins (HDL), and very low density lipoproteins (VLDL). Another lipoprotein class, intermediate density lipoprotein (IDL), resides between VLDL and LDL; in clinical practice, IDL is included in the LDL measurement.

LDL cholesterol typically makes up 60-70 percent of the total serum cholesterol. It contains a single apolipoprotein, namely apo B-100 (apo B). LDL is the major atherogenic lipoprotein and has long been identified by NCEP as the primary target of cholesterol-lowering therapy. This focus on LDL has been strongly validated by recent clinical trials, which show the efficacy of LDL-lowering therapy for reducing risk for CHD.

HDL cholesterol normally makes up 20-30 percent of the total serum cholesterol. The major apolipoproteins of HDL are apo A-I and apo A-II. HDL-cholesterol levels are inversely correlated with risk for CHD. Some evidence indicates that HDL protects against the development of atherosclerosis, although a low HDL level often reflects the presence of other atherogenic factors.

The VLDL are triglyceride-rich lipoproteins, but contain 10-15 percent of the total serum cholesterol. The major apolipoproteins of VLDL are apo B-100, apo Cs (C-I, C-II, and C-III), and apo E. VLDL are produced by the liver and are precursors of LDL; . . . [Full Text of this Article]

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References
Circulation 2002 106: 3373-3421. [Extract] [Full Text]

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