Articles
The endothelin system. A new target for therapeutic intervention
M Yanagisawa
| You have reached the most complete version of this article accessible without further authentication.
More complete versions are available. Link to article |
Article topics:
- Endocrinology..Endothelin
- Medicine..Genetics
- Medicine..Genes
- Cell Biology..Endothelial Cells
- Oncology..Endothelin Receptors
- Medicine..Cardiovascular Genetics
This article has been cited by other articles:
 |
|
 |
|
  A.-k. Khimji, R. Shao, and D. C. Rockey Divergent Transforming Growth Factor-{beta} Signaling in Hepatic Stellate Cells after Liver Injury: Functional Effects on ECE-1 Regulation Am. J. Pathol., September 1, 2008; 173(3): 716 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Yamada, S. Ohtani, T. Sakurai, T. Tsuji, T. Kunieda, and M. Yanagisawa Reduced Expression of the Endothelin Receptor Type B Gene in Piebald Mice Caused by Insertion of a Retroposon-like Element in Intron 1 J. Biol. Chem., April 21, 2006; 281(16): 10799 - 10807. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E Baker and R. H. Hockman Inhaled Iloprost in Pulmonary Arterial Hypertension Ann. Pharmacother., July 1, 2005; 39(7): 1265 - 1274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Shi-Wen, Y. Chen, C. P. Denton, M. Eastwood, E. A. Renzoni, G. Bou-Gharios, J. D. Pearson, M. Dashwood, R. M. du Bois, C. M. Black, et al. Endothelin-1 Promotes Myofibroblast Induction through the ETA Receptor via a rac/Phosphoinositide 3-Kinase/Akt-dependent Pathway and Is Essential for the Enhanced Contractile Phenotype of Fibrotic Fibroblasts Mol. Biol. Cell, June 1, 2004; 15(6): 2707 - 2719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Shi-wen, S. L. Howat, E. A. Renzoni, A. Holmes, J. D. Pearson, M. R. Dashwood, G. Bou-Gharios, C. P. Denton, R. M. du Bois, C. M. Black, et al. Endothelin-1 Induces Expression of Matrix-associated Genes in Lung Fibroblasts through MEK/ERK J. Biol. Chem., May 28, 2004; 279(22): 23098 - 23103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Shao, Z. Shi, P. J. Gotwals, V. E. Koteliansky, J. George, and D. C. Rockey Cell and Molecular Regulation of Endothelin-1 Production during Hepatic Wound Healing Mol. Biol. Cell, June 1, 2003; 14(6): 2327 - 2341. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yokomori, M. Oda, M. Ogi, K. Yoshimura, M. Nomura, K. Fujimaki, Y. Kamegaya, N. Tsukada, and H. Ishii Endothelin-1 Suppresses Plasma Membrane Ca++-ATPase, Concomitant with Contraction of Hepatic Sinusoidal Endothelial Fenestrae Am. J. Pathol., February 1, 2003; 162(2): 557 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Asai, T. Ohkubo, T. Katsuya, J. Higaki, Y. Fu, M. Fukuda, A. Hozawa, M. Matsubara, H. Kitaoka, I. Tsuji, et al. Endothelin-1 Gene Variant Associates With Blood Pressure in Obese Japanese Subjects: The Ohasama Study Hypertension, December 1, 2001; 38(6): 1321 - 1324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yokomori, M. Oda, Y. Yasogawa, Y. Nishi, M. Ogi, M. Takahashi, and H. Ishii Enhanced Expression of Endothelin B Receptor at Protein and Gene Levels in Human Cirrhotic Liver Am. J. Pathol., October 1, 2001; 159(4): 1353 - 1362. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Tadano, J. Suzuki, K. Hanada, M. Nakao, R. Nakao, S. Uehara, H. Ohta, T. Miyauchi, and M. Nishikibe Pathophysiological Roles of Endogenous Endothelin-1 in Dogs with Chronic Heart Failure Produced by Rapid Right Ventricular Pacing J. Pharmacol. Exp. Ther., August 1, 2001; 298(2): 729 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Prasanna, A. Dibas, C. Hulet, and T. Yorio Inhibition of Na+/K+-ATPase by Endothelin-1 in Human Nonpigmented Ciliary Epithelial Cells J. Pharmacol. Exp. Ther., March 1, 2001; 296(3): 966 - 971. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. Morin, P. Paradis, A. Aries, and M. Nemer Serum Response Factor-GATA Ternary Complex Required for Nuclear Signaling by a G-Protein-Coupled Receptor Mol. Cell. Biol., February 15, 2001; 21(4): 1036 - 1044. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Shichiri, M. Yokokura, F. Marumo, and Y. Hirata Endothelin-1 Inhibits Apoptosis of Vascular Smooth Muscle Cells Induced by Nitric Oxide and Serum Deprivation via MAP Kinase Pathway Arterioscler Thromb Vasc Biol, April 1, 2000; 20(4): 989 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Takebayashi-Suzuki, M Yanagisawa, R. Gourdie, N Kanzawa, and T Mikawa In vivo induction of cardiac Purkinje fiber differentiation by coexpression of preproendothelin-1 and endothelin converting enzyme-1 Development, January 8, 2000; 127(16): 3523 - 3532. [Abstract] [PDF]
|
|
|
|
|
|
K. Ikeda, N. Emoto, S. B. Raharjo, Y. Nurhantari, K. Saiki, M. Yokoyama, and M. Matsuo Molecular Identification and Characterization of Novel Membrane-bound Metalloprotease, the Soluble Secreted Form of Which Hydrolyzes a Variety of Vasoactive Peptides J. Biol. Chem., November 5, 1999; 274(45): 32469 - 32477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Choussat, L. Hittinger, F. Barbe, G. Maistre, A. Carayon, B. Crozatier, and J. Su Acute effects of an endothelin-1 receptor antagonist bosentan at different stages of heart failure in conscious dogs Cardiovasc Res, September 1, 1998; 39(3): 580 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Suzuki, N. Ohte, Z.-M. Wang, D. L. Williams Jr., W. C. Little, and C.-P. Cheng Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy Cardiovasc Res, September 1, 1998; 39(3): 589 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. SHENNIB, A. G. L. LEE, J. Q. KUANG, M. YANAGISAWA, E. H. OHLSTEIN, and A. GIAID Efficacy of Administering an Endothelin-receptor Antagonist (SB209670) in Ameliorating Ischemia-Reperfusion Injury in Lung Allografts Am. J. Respir. Crit. Care Med., June 1, 1998; 157(6): 1975 - 1981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tanaka, K. Moroi, J. Iwai, H. Takahashi, N. Ohnuma, S. Hori, M. Takimoto, M. Nishiyama, T. Masaki, M. Yanagisawa, et al. Novel Mutations of the Endothelin B Receptor Gene in Patients with Hirschsprung's Disease and Their Characterization J. Biol. Chem., May 1, 1998; 273(18): 11378 - 11383. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Lecoin, T. Sakurai, M.-T. Ngo, Y. Abe, M. Yanagisawa, and N. M. Le Douarin Cloning and characterization of a novel endothelin receptor subtype in the avian class PNAS, March 17, 1998; 95(6): 3024 - 3029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Borgeson, J. A. Grantham, E. E. Williamson, A. Luchner, M. M. Redfield, T. J. Opgenorth, and J. C. Burnett Jr Chronic Oral Endothelin Type A Receptor Antagonism in Experimental Heart Failure Hypertension, March 1, 1998; 31(3): 766 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shichiri, J. M. Sedivy, F. Marumo, and Y. Hirata Endothelin-1 Is a Potent Survival Factor for c-Myc-Dependent Apoptosis Mol. Endocrinol., February 1, 1998; 12(2): 172 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Clouthier, K Hosoda, J. Richardson, S. Williams, H Yanagisawa, T Kuwaki, M Kumada, R. Hammer, and M Yanagisawa Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice Development, January 3, 1998; 125(5): 813 - 824. [Abstract] [PDF]
|
|
|
|
|
|
H Yanagisawa, M Yanagisawa, R. Kapur, J. Richardson, S. Williams, D. Clouthier, D de Wit, N Emoto, and R. Hammer Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene Development, January 3, 1998; 125(5): 825 - 836. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Shichiri, S. Adachi, J. M. Sedivy, F. Marumo, and Y. Hirata Biphasic Regulation of the Preproendothelin-1 Gene by c-myc Endocrinology, November 1, 1997; 138(11): 4584 - 4590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shichiri, H. Kato, F. Marumo, and Y. Hirata Endothelin-1 as an Autocrine/Paracrine Apoptosis Survival Factor for Endothelial Cells Hypertension, November 1, 1997; 30(5): 1198 - 1203. [Abstract] [Full Text]
|
|
|
|
|
|
J. Angulo, C. F. Sanchez-Ferrer, C. Peiro, J. Marin, and L. Rodriguez-Manas Impairment of Endothelium-Dependent Relaxation by Increasing Percentages of Glycosylated Human Hemoglobin: Possible Mechanisms Involved Hypertension, October 1, 1996; 28(4): 583 - 592. [Abstract] [Full Text]
|
|
|
|
|
|
A. Horstmeyer, H. Cramer, T. Sauer, W. Muller-Esterl, and C. Schroeder Palmitoylation of Endothelin Receptor A. DIFFERENTIAL MODULATION OF SIGNAL TRANSDUCTION ACTIVITY BY POST-TRANSLATIONAL MODIFICATION J. Biol. Chem., August 23, 1996; 271(34): 20811 - 20819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Cannan, J. C. Burnett Jr, and A. Lerman Enhanced Coronary Vasoconstriction to Endothelin-BReceptor Activation in Experimental Congestive Heart Failure Circulation, February 15, 1996; 93(4): 646 - 651. [Abstract] [Full Text]
|
|
|
|
|
|
J. H. Traverse, D. Judd, and R. J. Bache Dose-Dependent Effect of Endothelin-1 on Blood Flow to Normal and Collateral-Dependent Myocardium Circulation, February 1, 1996; 93(3): 558 - 566. [Abstract] [Full Text]
|
|
|
|
|
|
M. S. Simonson, Y. Wang, and W. H. Herman Nuclear Signaling by Endothelin-1 Requires Src Protein-tyrosine Kinases J. Biol. Chem., January 5, 1996; 271(1): 77 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Yoshida, T Kunisada, M Kusakabe, S Nishikawa, and S. Nishikawa Distinct stages of melanocyte differentiation revealed by anlaysis of nonuniform pigmentation patterns Development, January 4, 1996; 122(4): 1207 - 1214. [Abstract] [PDF]
|
|
|
|
|
|
Y. Takeda, I. Miyamori, P. Wu, T. Yoneda, K. Furukawa, and R. Takeda Effects of an Endothelin Receptor Antagonist in Rats With Cyclosporine-Induced Hypertension Hypertension, December 1, 1995; 26(6): 932 - 936. [Abstract] [Full Text]
|
|
|
|
|
|
R. A. Cohen and P. M. Vanhoutte Endothelium-Dependent Hyperpolarization : Beyond Nitric Oxide and Cyclic GMP Circulation, December 1, 1995; 92(11): 3337 - 3349. [Full Text]
|
|
|
|
|
|
H. M. Wright and K. U. Malik Prostacyclin Synthesis Elicited by Endothelin-1 in Rat Aorta Is Mediated by an ETA Receptor via Influx of Calcium and Is Independent of Protein Kinase C Hypertension, December 1, 1995; 26(6): 1035 - 1040. [Abstract] [Full Text]
|
|
|
|
|
|
A. Lerman, D. R. Holmes Jr, M. R. Bell, K. N. Garratt, R. A. Nishimura, and J. C. Burnett Jr Endothelin in Coronary Endothelial Dysfunction and Early Atherosclerosis in Humans Circulation, November 1, 1995; 92(9): 2426 - 2431. [Abstract] [Full Text]
|
|
|
|
|
|
N. Emoto and M. Yanagisawa Endothelin-converting Enzyme-2 Is a Membrane-bound, Phosphoramidon-sensitive Metalloprotease with Acidic pH Optimum J. Biol. Chem., June 23, 1995; 270(25): 15262 - 15268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kitazono, D. D. Heistad, and F. M. Faraci Enhanced Responses of the Basilar Artery to Activation of Endothelin-B Receptors in Stroke-Prone Spontaneously Hypertensive Rats Hypertension, April 1, 1995; 25(4): 490 - 494. [Abstract] [Full Text]
|
|
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||