Published Online
on February 26, 2007

A more recent version of this article appeared on March 27, 2007

This Article Free upon publication Full Text (PDF) All Versions of this Article: 115/12/1634    most recent CIRCULATIONAHA.106.181424v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Antman, E. M. Articles by Taubert, K. A. Search for Related Content PubMed PubMed Citation Articles by Antman, E. M. Articles by Taubert, K. A. Pubmed/NCBI databases Medline Plus Health Information Stroke Related Collections Cardiovascular Pharmacology AHA Statements and Guidelines

Submitted on ,
Accepted on ,

Use of Nonsteroidal Antiinflammatory Drugs. An Update for Clinicians. A Scientific Statement From the American Heart Association

Elliott M. Antman MD, FAHA, Joel S. Bennett MD, Alan Daugherty PhD, FAHA, Curt Furberg MD, PhD, FAHA, Harold Roberts MD, FAHA, and Kathryn A. Taubert PhD, FAHA

Key words: AHA Scientific Statements • aspirin • inhibitors • drugs • antiinflammatory agents, nonsteroidal • coxibs • cyclooxygenase 2 inhibitors

This article has been cited by other articles:

				A. M. Tucker, R. A. Vogel, A. E. Lincoln, R. E. Dunn, D. C. Ahrensfield, T. W. Allen, L. W. Castle, R. A. Heyer, E. J. Pellman, P. J. Strollo Jr, et al. Prevalence of Cardiovascular Disease Risk Factors Among National Football League Players JAMA, May 27, 2009; 301(20): 2111 - 2119. [Abstract] [Full Text] [PDF]

				S. Soodvilai, Z. Jia, M.-H. Wang, Z. Dong, and T. Yang mPGES-1 deletion impairs diuretic response to acute water loading Am J Physiol Renal Physiol, May 1, 2009; 296(5): F1129 - F1135. [Abstract] [Full Text] [PDF]

				M. M. Bertagnolli, A. G. Zauber, and S. Solomon Prostaglandin Inhibition and Cardiovascular Risk: Maybe Timing Really Is Everything Cancer Prevention Research, March 1, 2009; 2(3): 195 - 196. [Full Text] [PDF]

				C. Patrono and C. Baigent Low-Dose Aspirin, Coxibs, and other NSAIDS: A Clinical Mosaic Emerges Mol. Interv., February 1, 2009; 9(1): 31 - 39. [Abstract] [Full Text] [PDF]

				G. H. Gislason, J. N. Rasmussen, S. Z. Abildstrom, T. K. Schramm, M. L. Hansen, E. L. Fosbol, R. Sorensen, F. Folke, P. Buch, N. Gadsboll, et al. Increased Mortality and Cardiovascular Morbidity Associated With Use of Nonsteroidal Anti-inflammatory Drugs in Chronic Heart Failure Arch Intern Med, January 26, 2009; 169(2): 141 - 149. [Abstract] [Full Text] [PDF]

				Writing Committee Members, D. L. Bhatt, J. Scheiman, N. S. Abraham, E. M. Antman, F. K.L. Chan, C. D. Furberg, D. A. Johnson, K. W. Mahaffey, and E. M. Quigley ACCF/ACG/AHA 2008 Expert Consensus Document on Reducing the Gastrointestinal Risks of Antiplatelet Therapy and NSAID Use: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents Circulation, October 28, 2008; 118(18): 1894 - 1909. [Full Text] [PDF]

				K. Brune, H. A. Katus, J. Moecks, E. Spanuth, A. S. Jaffe, and E. Giannitsis N-Terminal Pro-B-Type Natriuretic Peptide Concentrations Predict the Risk of Cardiovascular Adverse Events from Antiinflammatory Drugs: A Pilot Trial Clin. Chem., July 1, 2008; 54(7): 1149 - 1157. [Abstract] [Full Text] [PDF]

				C. L. Roumie, E. F. Mitchel Jr, L. Kaltenbach, P. G. Arbogast, P. Gideon, and M. R. Griffin Nonaspirin NSAIDs, Cyclooxygenase 2 Inhibitors, and the Risk for Stroke Stroke, July 1, 2008; 39(7): 2037 - 2045. [Abstract] [Full Text] [PDF]

				V. F. Panoulas, G. S. Metsios, A. V. Pace, H. John, G. J. Treharne, M. J. Banks, and G. D. Kitas Hypertension in rheumatoid arthritis Rheumatology, May 29, 2008; (2008) ken159v2. [Abstract] [Full Text] [PDF]

				S. D. Solomon, J. Wittes, P. V. Finn, R. Fowler, J. Viner, M. M. Bertagnolli, N. Arber, B. Levin, C. L. Meinert, B. Martin, et al. Cardiovascular Risk of Celecoxib in 6 Randomized Placebo-Controlled Trials: The Cross Trial Safety Analysis Circulation, April 22, 2008; 117(16): 2104 - 2113. [Abstract] [Full Text] [PDF]

				B. I. Jugdutt and A. Jelani Aging and Defective Healing, Adverse Remodeling, and Blunted Post-Conditioning in the Reperfused Wounded Heart J. Am. Coll. Cardiol., April 8, 2008; 51(14): 1399 - 1403. [Full Text] [PDF]

				P. Patrignani, M. L Capone, and S. Tacconelli NSAIDs and cardiovascular disease Heart, April 1, 2008; 94(4): 395 - 397. [Full Text] [PDF]

				C. Jacobshagen, M. Gruber, N. Teucher, A. G. Schmidt, B. W. Unsold, K. Toischer, P. Nguyen Van, L. S. Maier, H. Kogler, and G. Hasenfuss Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction Eur J Heart Fail, April 1, 2008; 10(4): 334 - 342. [Abstract] [Full Text] [PDF]

				C. Patrono and B. Rocca Aspirin: Promise and Resistance in the New Millennium Arterioscler. Thromb. Vasc. Biol., March 1, 2008; 28(3): s25 - s32. [Abstract] [Full Text] [PDF]

				American College of Cardiology/American Heart Asso, Developed in Collaboration With the Canadian Cardi, Endorsed by the American Academy of Family Physici, 2007 Writing Group to Review New Evidence and Upda, E. M. Antman, M. Hand, P. W. Armstrong, E. R. Bates, L. A. Green, L. K. Halasyamani, et al. 2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction J. Am. Coll. Cardiol., January 15, 2008; 51(2): 210 - 247. [Full Text] [PDF]

				E. M. Antman, M. Hand, P. W. Armstrong, E. R. Bates, L. A. Green, L. K. Halasyamani, J. S. Hochman, H. M. Krumholz, G. A. Lamas, C. J. Mullany, et al. 2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the Canadian Cardiovascular Society Endorsed by the American Academy of Family Physicians: 2007 Writing Group to Review New Evidence and Update the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction, Writing on Behalf of the 2004 Writing Committee Circulation, January 15, 2008; 117(2): 296 - 329. [Full Text] [PDF]

				C. Iwata, M. R. Kano, A. Komuro, M. Oka, K. Kiyono, E. Johansson, Y. Morishita, M. Yashiro, K. Hirakawa, M. Kaminishi, et al. Inhibition of Cyclooxygenase-2 Suppresses Lymph Node Metastasis via Reduction of Lymphangiogenesis Cancer Res., November 1, 2007; 67(21): 10181 - 10189. [Abstract] [Full Text] [PDF]

				K. Oselin and K. Anier Inhibition of Human Thiopurine S-Methyltransferase by Various Nonsteroidal Anti-inflammatory Drugs in Vitro: A Mechanism for Possible Drug Interactions Drug Metab. Dispos., September 1, 2007; 35(9): 1452 - 1454. [Abstract] [Full Text] [PDF]

				J. L. Anderson, C. D. Adams, E. M. Antman, C. R. Bridges, R. M. Califf, D. E. Casey Jr, W. E. Chavey II, F. M. Fesmire, J. S. Hochman, T. N. Levin, et al. ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine J. Am. Coll. Cardiol., August 14, 2007; 50(7): e1 - e157. [Full Text] [PDF]

				J. L. Anderson, C. D. Adams, E. M. Antman, C. R. Bridges, R. M. Califf, D. E. Casey Jr, W. E. Chavey II, F. M. Fesmire, J. S. Hochman, T. N. Levin, et al. ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine J. Am. Coll. Cardiol., August 14, 2007; 50(7): 652 - 726. [Full Text] [PDF]

				J. L Sullivan The Big Idea: the coxib crisis Iron, aspirin and heart disease risk revisited J R Soc Med, July 1, 2007; 100(7): 346 - 349. [Full Text] [PDF]

				A Stepwise Approach to NSAID Use Journal Watch Cardiology, March 28, 2007; 2007(328): 1 - 1. [Full Text]