(Circulation. 1999;99:942-948.)
© 1999 American Heart Association, Inc.
Basic Science Reports |
Myocardial Oxygenation During High Work States in Hearts With Postinfarction Remodeling
From the Departments of Medicine, Biochemistry, and Radiology and the Center for Magnetic Resonance Research, University of Minnesota, and the Department of Veterans Affairs Medical Center, Minneapolis, Minn.
Correspondence to Jianyi Zhang, MD, PhD, Box 508, University of Minnesota Health Science Center, 420 Delaware St SE, Minneapolis, MN 55455. E-mail zhang047{at}maroon.tc.umn.edu
Background—Postinfarction left ventricular remodeling (LVR) is associated with reductions in myocardial high-energy phosphate (HEP) levels, which are more severe in animals that develop overt congestive heart failure (CHF). During high work states, further HEP loss occurs, which suggests demand-induced ischemia. This study tested the hypothesis that inadequate myocyte oxygen availability is the basis for these HEP abnormalities.
Methods and Results—Myocardial infarction was produced by left
circumflex coronary artery ligation in swine. Studies were
performed in 20 normal animals, 14 animals with compensated LVR, and 9
animals with CHF. Phosphocreatine (PCr)/ATP was determined with
31P NMR and deoxymyoglobin (Mb-
) with 1H NMR
in myocardium remote from the infarct. Basal PCr/ATP tended
to be decreased in postinfarct hearts, and this was significant in
animals with CHF. Infusion of dobutamine (20 µg ·
kg-1 · min-1 IV) caused doubling of
the rate-pressure product in both normal and LVR hearts and
resulted in comparable significant decreases of PCr/ATP in both groups.
This decrease in PCr/ATP was not associated with detectable Mb-. In
CHF hearts, rate-pressure product increased only 40% in response
to dobutamine; this attenuated response also was not
associated with detectable Mb-.
Conclusions—Thus, the decrease of PCr/ATP during dobutamine infusion is not the result of insufficient myocardial oxygen availability. Furthermore, in CHF hearts, the low basal PCr/ATP and the attenuated response to dobutamine occurred in the absence of myocardial hypoxia, indicating that the HEP and contractile abnormalities were not the result of insufficient oxygen availability.
Key Words: myocardial infarction • phosphates • myoglobin • dobutamine • heart failure
This article has been cited by other articles:
 |
|
 |
|
  J. S. Ingwall Energy metabolism in heart failure and remodelling Cardiovasc Res, February 15, 2009; 81(3): 412 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Wu, E. Y. Zhang, J. Zhang, R. J. Bache, and D. A. Beard Phosphate metabolite concentrations and ATP hydrolysis potential in normal and ischaemic hearts J. Physiol., September 1, 2008; 586(17): 4193 - 4208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Feygin, Q. Hu, C. Swingen, and J. Zhang Relationships between regional myocardial wall stress and bioenergetics in hearts with left ventricular hypertrophy Am J Physiol Heart Circ Physiol, May 1, 2008; 294(5): H2313 - H2321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. O. McFalls, R. F. Kelly, Q. Hu, A. Mansoor, J. Lee, M. Kuskowski, J. Sikora, H. B. Ward, and J. Zhang The energetic state within hibernating myocardium is normal during dobutamine despite inhibition of ATP-dependent potassium channel opening with glibenclamide Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2945 - H2951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Feygin, A. Mansoor, P. Eckman, C. Swingen, and J. Zhang Functional and bioenergetic modulations in the infarct border zone following autologous mesenchymal stem cell transplantation Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1772 - H1780. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zeng, Q. Hu, X. Wang, A. Mansoor, J. Lee, J. Feygin, G. Zhang, P. Suntharalingam, S. Boozer, A. Mhashilkar, et al. Bioenergetic and Functional Consequences of Bone Marrow-Derived Multipotent Progenitor Cell Transplantation in Hearts With Postinfarction Left Ventricular Remodeling Circulation, April 10, 2007; 115(14): 1866 - 1875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Neubauer The Failing Heart -- An Engine Out of Fuel N. Engl. J. Med., March 15, 2007; 356(11): 1140 - 1151. [Full Text] [PDF]
|
|
|
|
|
|
Q. Hu, X. Wang, J. Lee, A. Mansoor, J. Liu, L. Zeng, C. Swingen, G. Zhang, J. Feygin, K. Ochiai, et al. Profound bioenergetic abnormalities in peri-infarct myocardial regions Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H648 - H657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang, Q. Hu, Y. Nakamura, J. Lee, G. Zhang, A. H.L. From, and J. Zhang The Role of the Sca-1+/CD31- Cardiac Progenitor Cell Population in Postinfarction Left Ventricular Remodeling Stem Cells, July 1, 2006; 24(7): 1779 - 1788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, Q. Hu, A. Mansoor, J. Lee, Z. Wang, T. Lee, A. H. L. From, and J. Zhang Bioenergetic and functional consequences of stem cell-based VEGF delivery in pressure-overloaded swine hearts Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1393 - H1405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Naumova, V. P. Chacko, R. Ouwerkerk, L. Stull, E. Marban, and R. G. Weiss Xanthine oxidase inhibitors improve energetics and function after infarction in failing mouse hearts Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H837 - H843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Ejike, L. S. L. Arakaki, D. A. Beard, W. A. Ciesielski, E. O. Feigl, and K. A. Schenkman Myocardial oxygenation and adenosine release in isolated guinea pig hearts during changes in contractility Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2062 - H2067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Portman, K. Qian, J. Krueger, and X.-H. Ning Direct action of T3 on phosphorylation potential in the sheep heart in vivo Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2484 - H2490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, Q. Hu, Z. Wang, C. Xu, X. Wang, G. Gong, A. Mansoor, J. Lee, M. Hou, L. Zeng, et al. Autologous stem cell transplantation for myocardial repair Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H501 - H511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Ingwall and R. G. Weiss Is the Failing Heart Energy Starved?: On Using Chemical Energy to Support Cardiac Function Circ. Res., July 23, 2004; 95(2): 135 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Nikolaidis, D. Trumble, T. Hentosz, A. Doverspike, R. Huerbin, M. A. Mathier, Y.-T. Shen, and R. P. Shannon Catecholamines restore myocardial contractility in dilated cardiomyopathy at the expense of increased coronary blood flow and myocardial oxygen consumption (MvO2 cost of catecholamines in heart failure) Eur J Heart Fail, June 1, 2004; 6(4): 409 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. V. Gourine, Q. Hu, P. R. Sander, A. I. Kuzmin, N. Hanafy, S. A. Davydova, D. V. Zaretsky, and J. Zhang Interstitial purine metabolites in hearts with LV remodeling Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H677 - H684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. van Bilsen, P. J.H Smeets, A. J Gilde, and G. J van der Vusse Metabolic remodelling of the failing heart: the cardiac burn-out syndrome? Cardiovasc Res, February 1, 2004; 61(2): 218 - 226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Wittenberg and B. A. Wittenberg Myoglobin function reassessed J. Exp. Biol., June 15, 2003; 206(12): 2011 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Schenkman Cardiac performance as a function of intracellular oxygen tension in buffer-perfused hearts Am J Physiol Heart Circ Physiol, December 1, 2001; 281(6): H2463 - H2472. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Tian, N. Musi, J. D'Agostino, M. F. Hirshman, and L. J. Goodyear Increased Adenosine Monophosphate-Activated Protein Kinase Activity in Rat Hearts With Pressure-Overload Hypertrophy Circulation, October 2, 2001; 104(14): 1664 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ochiai, J. Zhang, G. Gong, Y. Zhang, J. Liu, Y. Ye, X. Wu, H. Liu, Y. Murakami, R. J. Bache, et al. Effects of augmented delivery of pyruvate on myocardial high-energy phosphate metabolism at high workstate Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1823 - H1832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu, C. Wang, Y. Murakami, G. Gong, Y. Ishibashi, C. Prody, K. Ochiai, R. J. Bache, C. Godinot, and J. Zhang Mitochondrial ATPase and high-energy phosphates in failing hearts Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1319 - H1326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Johannsson, P. K. Lunde, C. Heddle, I. Sjaastad, M. J. Thomas, L. Bergersen, A. P. Halestrap, T. W. Blackstad, O. P. Ottersen, and O. M. Sejersted Upregulation of the Cardiac Monocarboxylate Transporter MCT1 in a Rat Model of Congestive Heart Failure Circulation, August 7, 2001; 104(6): 729 - 734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. K. Cho, H. Merkle, J. Zhang, N. V. Tsekos, R. J. Bache, and K. Ugurbil Noninvasive measurements of transmural myocardial metabolites using 3-D 31P NMR spectroscopy Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H489 - H497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ausma, W. A Coumans, H. Duimel, G. J Van der Vusse, M. A Allessie, and M. Borgers Atrial high energy phosphate content and mitochondrial enzyme activity during chronic atrial fibrillation Cardiovasc Res, September 1, 2000; 47(4): 788 - 796. [Abstract] [Full Text] [PDF]
|
|