(Circulation. 1999;99:763-770.)
© 1999 American Heart Association, Inc.
Clinical Investigation and Reports |
From the Department of Internal Medicine/Cardiology, German Heart Institute and Charité Campus Virchow, Humboldt University, Berlin, Germany.
Correspondence to Eike Nagel, MD, Internal Medicine/Cardiology, Deutsches Herzzentrum Berlin und Charité Campus Virchow, Humboldt University, Augustenburger Platz 1, D-13353 Berlin, FRG. E-mail eike.nagel{at}charite.de
BackgroundThe analysis of wall motion abnormalities with dobutamine stress echocardiography (DSE) is an established method for the detection of myocardial ischemia. With ultrafast magnetic resonance tomography, identical stress protocols as used for echocardiography can be applied.
Methods and ResultsIn 208 consecutive patients (147 men, 61
women) with suspected coronary artery disease, DSE with
harmonic imaging and dobutamine stress magnetic resonance
(DSMR) (1.5 T) were performed before cardiac
catheterization. DSMR images were acquired during short
breath-holds in 3 short-axis views and a 4- and a 2-chamber view
(gradient echo technique). Patients were examined at rest and during a
standard dobutamine-atropine scheme until submaximal heart
rate was reached. Regional wall motion was assessed in a 16-segment
model. Significant coronary heart disease was defined as
50%
diameter stenosis. Eighteen patients could not be examined by
DSMR (claustrophobia 11 and adipositas 6) and 18 patients by DSE (poor
image quality). Four patients did not reach target heart rate. In 107
patients, coronary artery disease was found. With DSMR,
sensitivity was increased from 74.3% to 86.2% and specificity from
69.8% to 85.7% (both P<0.05) compared with DSE.
Analysis for women yielded similar results.
ConclusionsHigh-dose dobutamine magnetic resonance tomography can be performed with a standard dobutamine/atropine stress protocol. Detection of wall motion abnormalities by DSMR yields a significantly higher diagnostic accuracy in comparison to DSE.
Key Words: magnetic resonance imaging echocardiography coronary artery disease
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G. Theilmeier, P. Verhamme, S. Dymarkowski, H. Beck, H. Bernar, M. Lox, S. Janssens, M.-C. Herregods, E. Verbeken, D. Collen, et al. Hypercholesterolemia in Minipigs Impairs Left Ventricular Response to Stress: Association With Decreased Coronary Flow Reserve and Reduced Capillary Density Circulation, August 27, 2002; 106(9): 1140 - 1146. [Abstract] [Full Text] [PDF] |
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H. Mahrholdt, A. Wagner, R.M. Judd, and U. Sechtem Assessment of myocardial viability by cardiovascular magnetic resonance imaging Eur. Heart J., April 2, 2002; 23(8): 602 - 619. [Full Text] [PDF] |
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B. B. Chin, G. Esposito, and D. L. Kraitchman Myocardial Contractile Reserve and Perfusion Defect Severity with Rest and Stress Dobutamine 99mTc-Sestamibi SPECT in Canine Stunning and Subendocardial Infarction J. Nucl. Med., April 1, 2002; 43(4): 540 - 550. [Abstract] [Full Text] [PDF] |
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S. Achenbach and W. G. Daniel Noninvasive Coronary Angiography -- An Acceptable Alternative? N. Engl. J. Med., December 27, 2001; 345(26): 1909 - 1910. [Full Text] [PDF] |
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S. B. Reeder, Y. P. Du, J. A. C. Lima, and D. A. Bluemke Advanced Cardiac MR Imaging of Ischemic Heart Disease RadioGraphics, July 1, 2001; 21(4): 1047 - 1074. [Abstract] [Full Text] [PDF] |
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D. Pennell IMAGING TECHNIQUES: Cardiovascular magnetic resonance Heart, May 1, 2001; 85(5): 581 - 589. [Full Text] |
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G. K. von Schulthess and J. Schwitter Cardiac MR Imaging: Facts and Fiction Radiology, February 1, 2001; 218(2): 326 - 328. [Full Text] |
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W. Moshage, S. Achenbach, and W. G. Daniel Novel approaches to the non-invasive diagnosis of coronary-artery disease Nephrol. Dial. Transplant., January 1, 2001; 16(1): 21 - 28. [Full Text] [PDF] |
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N. Al-Saadi, E. Nagel, M. Gross, B. Schnackenburg, I. Paetsch, C. Klein, and E. Fleck Improvement of myocardial perfusion reserve early after coronary intervention: assessment with cardiac magnetic resonance imaging J. Am. Coll. Cardiol., November 1, 2000; 36(5): 1557 - 1564. [Abstract] [Full Text] [PDF] |
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K. Rajappan, N. G. Bellenger, L. Anderson, and D. J. Pennell The role of cardiovascular magnetic resonance in heart failure Eur J Heart Fail, September 1, 2000; 2(3): 241 - 252. [Abstract] [Full Text] [PDF] |
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