(Circulation. 1999;99:3110-3117.)
© 1999 American Heart Association, Inc.
Clinical Investigation and Reports |
Expression of Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 in Human Atherosclerotic Lesions
From the Departments of Geriatric Medicine (H.K., N.K., M.M., H.M., T. Murase, T.K.) and Neurosurgery (S.M., N.H.), Graduate School of Medicine, Kyoto University, Kyoto, Japan, and Department of Bioscience, National Cardiovascular Center Research Institute, Osaka, Japan (T.S., T. Masaki).
Correspondence to Noriaki Kume, MD, PhD, Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan. E-mail nkume{at}kuhp.kyoto-u.ac.jp
Background—Oxidized LDL (Ox-LDL) seems to play key roles in atherogenesis. Lectinlike Ox-LDL receptor-1 (LOX-1) is a recently identified cell-surface receptor for Ox-LDL. The relationship of this novel receptor for Ox-LDL to atherogenesis, however, has not yet been clarified. In this study, we explored the expression of LOX-1 in the atherosclerotic lesions of human carotid arteries.
Methods and Results—Using carotid endarterectomy specimens obtained from 21 patients and 2 samples of normal human aortas, we examined LOX-1 expression by reverse transcription–polymerase chain reaction and immunohistochemistry. In aortas without atherosclerosis, LOX-1 expression was undetectable by immunohistochemistry and negligible by reverse transcription–polymerase chain reaction. In carotid arteries, luminal endothelial cells covering early atherosclerotic lesions were more frequently positive for LOX-1 expression than those in advanced atherosclerotic lesions. Endothelial cells in the intimal neovasculature of advanced lesions also expressed LOX-1. In addition, macrophages and smooth muscle cells in the intima of advanced atherosclerotic plaques were positive for LOX-1 expression.
Conclusions—LOX-1 may play important roles in Ox-LDL uptake and subsequent functional alteration in the luminal endothelium in early atherosclerotic lesions and in intimal neovascular endothelial cells in advanced plaques. Furthermore, LOX-1 may also be involved in Ox-LDL uptake and subsequent foam cell transformation in macrophages and smooth muscle cells in the atherosclerotic intima.
Key Words: atherosclerosis • cholesterol, LDL • immunohistochemistry
This article has been cited by other articles:
 |
|
 |
|
  L. Zhang, Y. Liu, X. T. Lu, Y. L. Wu, C. Zhang, X. P. Ji, R. Wang, C. X. Liu, J. B. Feng, H. Jiang, et al. Traditional Chinese medication Tongxinluo dose-dependently enhances stability of vulnerable plaques: a comparison with a high-dose simvastatin therapy Am J Physiol Heart Circ Physiol, December 1, 2009; 297(6): H2004 - H2014. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Sugimoto, T. Ishibashi, T. Sawamura, N. Inoue, M. Kamioka, H. Uekita, H. Ohkawara, T. Sakamoto, N. Sakamoto, Y. Okamoto, et al. LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells Cardiovasc Res, October 1, 2009; 84(1): 127 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Rasouli, A. Yao-Borengasser, V. Varma, H. J. Spencer, R. E. McGehee Jr, C. A. Peterson, J. L. Mehta, and P. A. Kern Association of Scavenger Receptors in Adipose Tissue With Insulin Resistance in Nondiabetic Humans Arterioscler Thromb Vasc Biol, September 1, 2009; 29(9): 1328 - 1335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. F. Schaeffer, M. Riazy, K. S. Parhar, J. H. Chen, V. Duronio, T. Sawamura, and U. P. Steinbrecher LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma J. Lipid Res., August 1, 2009; 50(8): 1676 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Kim, H. Moradi, J. Yuan, K. Norris, and N. D. Vaziri Renal mass reduction results in accumulation of lipids and dysregulation of lipid regulatory proteins in the remnant kidney Am J Physiol Renal Physiol, June 1, 2009; 296(6): F1297 - F1306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Eichhorn, G. Muller, A. Leuner, T. Sawamura, U. Ravens, and H. Morawietz Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet Cardiovasc Res, June 1, 2009; 82(3): 493 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lu, J.-H. Yang, A. R. Burns, H.-H. Chen, D. Tang, J. P. Walterscheid, S. Suzuki, C.-Y. Yang, T. Sawamura, and C.-H. Chen Mediation of Electronegative Low-Density Lipoprotein Signaling by LOX-1: A Possible Mechanism of Endothelial Apoptosis Circ. Res., March 13, 2009; 104(5): 619 - 627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sankaralingam, Y. Xu, T. Sawamura, and S. T. Davidge Increased Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Expression in the Maternal Vasculature of Women With Preeclampsia: Role for Peroxynitrite Hypertension, February 1, 2009; 53(2): 270 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. V. Sangle, R. Zhao, and G. X. Shen Transmembrane signaling pathway mediates oxidized low-density lipoprotein-induced expression of plasminogen activator inhibitor-1 in vascular endothelial cells Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E1243 - E1254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Brinkley, N. Kume, H. Mitsuoka, M. D. Brown, D. A. Phares, R. E. Ferrell, T. Kita, and J. M. Hagberg Variation in the human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gene is associated with plasma soluble LOX-1 levels Exp Physiol, September 1, 2008; 93(9): 1085 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Thum and J. Borlak LOX-1 Receptor Blockade Abrogates oxLDL-induced Oxidative DNA Damage and Prevents Activation of the Transcriptional Repressor Oct-1 in Human Coronary Arterial Endothelium J. Biol. Chem., July 11, 2008; 283(28): 19456 - 19464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. B. Tan, S. W. M. Shiu, Y. Wong, L. Leng, and R. Bucala Soluble lectin-like oxidized low density lipoprotein receptor-1 in type 2 diabetes mellitus J. Lipid Res., July 1, 2008; 49(7): 1438 - 1444. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Murphy, R. S. Vohra, S. Dunn, Z. G. Holloway, A. P. Monaco, S. Homer-Vanniasinkam, J. H. Walker, and S. Ponnambalam Oxidised LDL internalisation by the LOX-1 scavenger receptor is dependent on a novel cytoplasmic motif and is regulated by dynamin-2 J. Cell Sci., July 1, 2008; 121(13): 2136 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Gratchev, J. Kzhyshkowska, S. Kannookadan, M. Ochsenreiter, A. Popova, X. Yu, S. Mamidi, E. Stonehouse-Usselmann, I. Muller-Molinet, L. Gooi, et al. Activation of a TGF-{beta}-Specific Multistep Gene Expression Program in Mature Macrophages Requires Glucocorticoid-Mediated Surface Expression of TGF-{beta} Receptor II J. Immunol., May 15, 2008; 180(10): 6553 - 6565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Marwali, C.-P. Hu, B. Mohandas, A. Dandapat, P. Deonikar, J. Chen, I. Cawich, T. Sawamura, M. Kavdia, and J. L. Mehta Modulation of ADP-Induced Platelet Activation by Aspirin and Pravastatin: Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1, Nitric Oxide, Oxidative Stress, and Inside-Out Integrin Signaling J. Pharmacol. Exp. Ther., September 1, 2007; 322(3): 1324 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Morawietz LOX-1 and Atherosclerosis: Proof of Concept in LOX-1-Knockout Mice Circ. Res., June 8, 2007; 100(11): 1534 - 1536. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ishigaki, I. Ohki, N. Utsunomiya-Tate, and S.-i. Tate Chimeric Structural Stabilities in the Coiled-Coil Structure of the NECK Domain in Human Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 (LOX-1) J. Biochem., June 1, 2007; 141(6): 855 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kamei, K. Yoneda, N. Kume, M. Suzuki, H. Itabe, K.-i. Matsuda, T. Shimaoka, M. Minami, S. Yonehara, T. Kita, et al. Scavenger Receptors for Oxidized Lipoprotein in Age-Related Macular Degeneration Invest. Ophthalmol. Vis. Sci., April 1, 2007; 48(4): 1801 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Xu, X. Gao, B. J. Potter, J.-M. Cao, and C. Zhang Anti-LOX-1 Rescues Endothelial Function in Coronary Arterioles in Atherosclerotic ApoE Knockout Mice Arterioscler Thromb Vasc Biol, April 1, 2007; 27(4): 871 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J. Moore and M. W. Freeman Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake Arterioscler Thromb Vasc Biol, August 1, 2006; 26(8): 1702 - 1711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ueda, N. Kume, K. Hayashida, A. Inui-Hayashida, M. Asai, T. Kita, and G. Kominami ELISA for Soluble Form of Lectin-Like Oxidized LDL Receptor-1, A Novel Marker of Acute Coronary Syndrome. Clin. Chem., June 1, 2006; 52(6): 1210 - 1211. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ghazalpour, X. Wang, A. J. Lusis, and M. Mehrabian Complex Inheritance of the 5-Lipoxygenase Locus Influencing Atherosclerosis in Mice Genetics, June 1, 2006; 173(2): 943 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Hofnagel, B. Luechtenborg, H. Eschert, G. Weissen-Plenz, N. J. Severs, and H. Robenek Pravastatin Inhibits Expression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 (LOX-1) in Watanabe Heritable Hyperlipidemic Rabbits: A New Pleiotropic Effect of Statins Arterioscler Thromb Vasc Biol, March 1, 2006; 26(3): 604 - 610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Mehta, J. Chen, P. L. Hermonat, F. Romeo, and G. Novelli Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): A critical player in the development of atherosclerosis and related disorders Cardiovasc Res, January 1, 2006; 69(1): 36 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Chen, J. Chen, Y. Liu, J. Xie, D. Li, T. Sawamura, P. L. Hermonat, and J. L. Mehta Adhesion Molecule Expression in Fibroblasts: Alteration in Fibroblast Biology After Transfection With LOX-1 Plasmids Hypertension, September 1, 2005; 46(3): 622 - 627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hayashida, N. Kume, T. Murase, M. Minami, D. Nakagawa, T. Inada, M. Tanaka, A. Ueda, G. Kominami, H. Kambara, et al. Serum Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels Are Elevated in Acute Coronary Syndrome: A Novel Marker for Early Diagnosis Circulation, August 9, 2005; 112(6): 812 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Inoue, Y. Arai, H. Kurihara, T. Kita, and T. Sawamura Overexpression of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Induces Intramyocardial Vasculopathy in Apolipoprotein E-Null Mice Circ. Res., July 22, 2005; 97(2): 176 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mango, S. Biocca, F. del Vecchio, F. Clementi, F. Sangiuolo, F. Amati, A. Filareto, S. Grelli, P. Spitalieri, I. Filesi, et al. In Vivo and In Vitro Studies Support That a New Splicing Isoform of OLR1 Gene Is Protective Against Acute Myocardial Infarction Circ. Res., July 22, 2005; 97(2): 152 - 158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kazi, C. Zhu, J. Roy, G. Paulsson-Berne, A. Hamsten, J. Swedenborg, U. Hedin, and P. Eriksson Difference in Matrix-Degrading Protease Expression and Activity Between Thrombus-Free and Thrombus-Covered Wall of Abdominal Aortic Aneurysm Arterioscler Thromb Vasc Biol, July 1, 2005; 25(7): 1341 - 1346. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Park, F. G. Adsit, and J. C. Boyington The 1.4 A Crystal Structure of the Human Oxidized Low Density Lipoprotein Receptor Lox-1 J. Biol. Chem., April 8, 2005; 280(14): 13593 - 13599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Greaves and S. Gordon Thematic review series: The Immune System and Atherogenesis. Recent insights into the biology of macrophage scavenger receptors J. Lipid Res., January 1, 2005; 46(1): 11 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Fach, L.-A. Garulacan, J. Gao, Q. Xiao, S. M. Storm, Y. P. Dubaquie, S. A. Hefta, and G. J. Opiteck In Vitro Biomarker Discovery for Atherosclerosis by Proteomics Mol. Cell. Proteomics, December 1, 2004; 3(12): 1200 - 1210. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Honjo, T. Sawamura, J. Hinagata, K. Nakamura, N. Sanada, H. Tanihara, Y. Honda, and J. Kiryu Expression of LOX-1, an Oxidized Low-Density Lipoprotein Receptor, in Choroidal Neovascularization Arch Ophthalmol, December 1, 2004; 122(12): 1873 - 1876. [Full Text] [PDF]
|
|
|
|
|
|
J.L. Mehta, J. Chen, F. Yu, and D.Y. Li Aspirin inhibits ox-LDL-mediated LOX-1 expression and metalloproteinase-1 in human coronary endothelial cells Cardiovasc Res, November 1, 2004; 64(2): 243 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Li, N. Roumeliotis, T. Sawamura, and G. Renier C-Reactive Protein Enhances LOX-1 Expression in Human Aortic Endothelial Cells: Relevance of LOX-1 to C-Reactive Protein-Induced Endothelial Dysfunction Circ. Res., October 29, 2004; 95(9): 877 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Hofnagel, B. Luechtenborg, K. Stolle, S. Lorkowski, H. Eschert, G. Plenz, and H. Robenek Proinflammatory Cytokines Regulate LOX-1 Expression in Vascular Smooth Muscle Cells Arterioscler Thromb Vasc Biol, October 1, 2004; 24(10): 1789 - 1795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Melo, M. Gnecchi, A. S. Pachori, D. Kong, K. Wang, X. Liu, R. E. Pratt, and V. J. Dzau Endothelium-Targeted Gene and Cell-Based Therapies for Cardiovascular Disease Arterioscler Thromb Vasc Biol, October 1, 2004; 24(10): 1761 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. V. Smirnova, M. Kajstura, T. Sawamura, and M. S. Goligorsky Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H782 - H790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Li, T. Sawamura, and G. Renier Glucose Enhances Human Macrophage LOX-1 Expression: Role for LOX-1 in Glucose-Induced Macrophage Foam Cell Formation Circ. Res., April 16, 2004; 94(7): 892 - 901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kume and T. Kita Apoptosis of Vascular Cells by Oxidized LDL: Involvement of Caspases and LOX-1 and Its Implication in Atherosclerotic Plaque Rupture Circ. Res., February 20, 2004; 94(3): 269 - 270. [Full Text] [PDF]
|
|
|
|
|
|
J. L. Mehta, B. Hu, J. Chen, and D. Li Pioglitazone Inhibits LOX-1 Expression in Human Coronary Artery Endothelial Cells by Reducing Intracellular Superoxide Radical Generation Arterioscler Thromb Vasc Biol, December 1, 2003; 23(12): 2203 - 2208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. B. Holven, H. Scholz, B. Halvorsen, P. Aukrust, L. Ose, and M. S. Nenseter Hyperhomocysteinemic Subjects Have Enhanced Expression of Lectin-Like Oxidized LDL Receptor-1 in Mononuclear Cells J. Nutr., November 1, 2003; 133(11): 3588 - 3591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Akiba, Y. Yoneda, S. Ohno, M. Nemoto, and T. Sato Oxidized LDL activates phospholipase A2 to supply fatty acids required for cholesterol esterification J. Lipid Res., September 1, 2003; 44(9): 1676 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Walton, X. Hsieh, N. Gharavi, S. Wang, G. Wang, M. Yeh, A. L. Cole, and J. A. Berliner Receptors Involved in the Oxidized 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated Synthesis of Interleukin-8: A ROLE FOR TOLL-LIKE RECEPTOR 4 AND A GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED PROTEIN J. Biol. Chem., August 8, 2003; 278(32): 29661 - 29666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Li, L. Liu, H. Chen, T. Sawamura, and J. L. Mehta LOX-1, an Oxidized LDL Endothelial Receptor, Induces CD40/CD40L Signaling in Human Coronary Artery Endothelial Cells Arterioscler Thromb Vasc Biol, May 1, 2003; 23(5): 816 - 821. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Li, V. Williams, L. Liu, H. Chen, T. Sawamura, F. Romeo, and J. L. Mehta Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction J. Am. Coll. Cardiol., March 19, 2003; 41(6): 1048 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Honjo, K. Nakamura, K. Yamashiro, J. Kiryu, H. Tanihara, L. M. McEvoy, Y. Honda, E. C. Butcher, T. Masaki, and T. Sawamura Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation PNAS, February 4, 2003; 100(3): 1274 - 1279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Li, L. Liu, H. Chen, T. Sawamura, S. Ranganathan, and J. L. Mehta LOX-1 Mediates Oxidized Low-Density Lipoprotein-Induced Expression of Matrix Metalloproteinases in Human Coronary Artery Endothelial Cells Circulation, February 4, 2003; 107(4): 612 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Y. Li, H. J. Chen, E. D. Staples, K. Ozaki, B. Annex, B. K. Singh, R. Vermani, and J. L. Mehtat Oxidized Low-Density Lipoprotein Receptor LOX-1 and Apoptosis in Human Atherosclerotic Lesions Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2002; 7(3): 147 - 153. [Abstract] [PDF]
|
|
|
|
|
|
D. Li, H. Chen, F. Romeo, T. Sawamura, T. Saldeen, and J. L. Mehta Statins Modulate Oxidized Low-Density Lipoprotein-Mediated Adhesion Molecule Expression in Human Coronary Artery Endothelial Cells: Role of LOX-1 J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 601 - 605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Mehta and D. Li Identification, regulation and function of a novel lectin-like oxidized low-density lipoprotein receptor J. Am. Coll. Cardiol., May 1, 2002; 39(9): 1429 - 1435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Hofnagel, B. Luechtenborg, G. Plenz, H. Robenek, and N. Kume Expression of the Novel Scavenger Receptor SR-PSOX in Cultured Aortic Smooth Muscle Cells and Umbilical Endothelial Cells Arterioscler Thromb Vasc Biol, April 1, 2002; 22(4): 710 - 711. [Full Text] [PDF]
|
|
|
|
|
|
M. Locati, U. Deuschle, M. L. Massardi, F. O. Martinez, M. Sironi, S. Sozzani, T. Bartfai, and A. Mantovani Analysis of the Gene Expression Profile Activated by the CC Chemokine Ligand 5/RANTES and by Lipopolysaccharide in Human Monocytes J. Immunol., April 1, 2002; 168(7): 3557 - 3562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Minami, N. Kume, T. Shimaoka, H. Kataoka, K. Hayashida, Y. Akiyama, I. Nagata, K. Ando, M. Nobuyoshi, M. Hanyuu, et al. Expression of SR-PSOX, a Novel Cell-Surface Scavenger Receptor for Phosphatidylserine and Oxidized LDL in Human Atherosclerotic Lesions Arterioscler Thromb Vasc Biol, November 1, 2001; 21(11): 1796 - 1800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.Y Li, H.J Chen, and J.L Mehta Statins inhibit oxidized-LDL-mediated LOX-1 expression, uptake of oxidized-LDL and reduction in PKB phosphorylation Cardiovasc Res, October 1, 2001; 52(1): 130 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Welch, S. Bretschger, N. Latib, M. Bezouevski, Y. Guo, N. Pleskac, C.-P. Liang, C. Barlow, H. Dansky, J. L. Breslow, et al. Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model PNAS, July 3, 2001; 98(14): 7946 - 7951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kataoka, N. Kume, S. Miyamoto, M. Minami, M. Morimoto, K. Hayashida, N. Hashimoto, and T. Kita Oxidized LDL Modulates Bax/Bcl-2 Through the Lectinlike Ox-LDL Receptor-1 in Vascular Smooth Muscle Cells Arterioscler Thromb Vasc Biol, June 1, 2001; 21(6): 955 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimaoka, N. Kume, M. Minami, K. Hayashida, T. Sawamura, T. Kita, and S. Yonehara LOX-1 Supports Adhesion of Gram-Positive and Gram-Negative Bacteria J. Immunol., April 15, 2001; 166(8): 5108 - 5114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L Mehta and Dayuan Li Facilitative interaction between angiotensin II and oxidised LDL in cultured human coronary artery endothelial cells Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S70 - S76. [Abstract] [PDF]
|
|
|
|
|
|
S. J. White, S. A. Nicklin, T. Sawamura, and A. H. Baker Identification of Peptides That Target the Endothelial Cell-Specific LOX-1 Receptor Hypertension, February 1, 2001; 37(2): 449 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X Shi, S Niimi, T Ohtani, and S Machida Characterization of residues and sequences of the carbohydrate recognition domain required for cell surface localization and ligand binding of human lectin-like oxidized LDL receptor J. Cell Sci., January 4, 2001; 114(7): 1273 - 1282. [Abstract] [PDF]
|
|
|
|
|
|
M. Chen, M. Kakutani, M. Minami, H. Kataoka, N. Kume, S. Narumiya, T. Kita, T. Masaki, and T. Sawamura Increased Expression of Lectinlike Oxidized Low Density Lipoprotein Receptor-1 in Initial Atherosclerotic Lesions of Watanabe Heritable Hyperlipidemic Rabbits Arterioscler Thromb Vasc Biol, April 1, 2000; 20(4): 1107 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Murase, N. Kume, H. Kataoka, M. Minami, T. Sawamura, T. Masaki, and T. Kita Identification of Soluble Forms of Lectin-Like Oxidized LDL Receptor-1 Arterioscler Thromb Vasc Biol, March 1, 2000; 20(3): 715 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kataoka, N. Kume, S. Miyamoto, M. Minami, T. Murase, T. Sawamura, T. Masaki, N. Hashimoto, and T. Kita Biosynthesis and Post-translational Processing of Lectin-like Oxidized Low Density Lipoprotein Receptor-1 (LOX-1). N-LINKED GLYCOSYLATION AFFECTS CELL-SURFACE EXPRESSION AND LIGAND BINDING J. Biol. Chem., February 25, 2000; 275(9): 6573 - 6579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kakutani, T. Masaki, and T. Sawamura A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 PNAS, January 4, 2000; 97(1): 360 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shimaoka, N. Kume, M. Minami, K. Hayashida, H. Kataoka, T. Kita, and S. Yonehara Molecular Cloning of a Novel Scavenger Receptor for Oxidized Low Density Lipoprotein, SR-PSOX, on Macrophages J. Biol. Chem., December 22, 2000; 275(52): 40663 - 40666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Shiffman, T. Mikita, J. T. N. Tai, D. P. Wade, J. G. Porter, J. J. Seilhamer, R. Somogyi, S. Liang, and R. M. Lawn Large Scale Gene Expression Analysis of Cholesterol-loaded Macrophages J. Biol. Chem., November 22, 2000; 275(48): 37324 - 37332. [Abstract] [Full Text] [PDF]
|
|