Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation
Search: search_blue_button Advanced Search
Circulation. 1999;99:2434-2439

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blacher, J.
Right arrow Articles by London, G. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blacher, J.
Right arrow Articles by London, G. M.
Related Collections
Right arrow Cardio-renal physiology/pathophysiology
Right arrow Other diagnostic testing

(Circulation. 1999;99:2434-2439.)
© 1999 American Heart Association, Inc.


Clinical Investigation and Reports

Impact of Aortic Stiffness on Survival in End-Stage Renal Disease

Jacques Blacher, MD; Alain P. Guerin, MD; Bruno Pannier, MD; Sylvain J. Marchais, MD; Michel E. Safar, MD; Gérard M. London, MD

From the Service de Médecine, Hôpital Broussais, Paris (J.B., M.E.S.), and the Hôpital F.H. Manhès, Fleury-Mérogis (A.P.G., B.P., S.J.M., G.M.L.), France.

Correspondence to Dr Gérard London, CH Manhès, 8, Grande Rue, Fleury-Mérogis, 91712 Ste/Geneviève des Bois, France.

Background—Damage to large arteries is a major factor in the high cardiovascular morbidity and mortality of patients with end-stage renal disease (ESRD). Increased arterial stiffness and intima-media thickness, together with increased pulse pressure, are the principal arterial alterations. Whether increased aortic pulse-wave velocity (PWV), a classic marker of increased arterial stiffness, may predict all-cause and/or cardiovascular mortality has never been investigated.

Methods and Results—A cohort of 241 patients with ESRD undergoing hemodialysis was studied between April 1987 and April 1998. The mean duration of follow-up was 72±41 months (mean±SD). Mean age at entry was 51.5±16.3 years. Seventy-three deaths occurred, including 48 cardiovascular and 25 noncardiovascular fatal events. At entry, together with standard clinical and biochemical analyses, patients underwent echocardiography and aortic PWV measured by Doppler ultrasonography. On the basis of Cox analyses, 2 factors emerged as predictors of all-cause and cardiovascular mortality: age and aortic PWV. Hemoglobin and low diastolic pressure interfered to a smaller extent. After adjustment for all the confounding factors, an OR for PWV >12.0 versus <9.4 m/s was 5.4 (95% CI, 2.4 to 11.9) for all-cause mortality and 5.9 (95% CI, 2.3 to 15.5) for cardiovascular mortality. For each PWV increase of 1 m/s in our study population, all-cause mortality–adjusted OR was 1.39 (95% CI, 1.19 to 1.62).

Conclusions—These results provide the first direct evidence that in patients with ESRD, increased aortic stiffness determined by measurement of aortic PWV is a strong independent predictor of all-cause and mainly cardiovascular mortality.


Key Words: aorta • survival • kidney




This article has been cited by other articles:


Home page
J Am Coll CardiolHome page
H. P. Kuhl
Hypertrophic Cardiomyopathy, Fibrosis, and Aortic Stiffness: An Unidentified Association Unraveled by Magnetic Resonance Imaging
J. Am. Coll. Cardiol., July 14, 2009; 54(3): 263 - 264.
[Full Text] [PDF]


Home page
HypertensionHome page
N. Dhaun, I. M. MacIntyre, V. Melville, P. Lilitkarntakul, N. R. Johnston, J. Goddard, and D. J. Webb
Blood Pressure-Independent Reduction in Proteinuria and Arterial Stiffness After Acute Endothelin-A Receptor Antagonism in Chronic Kidney Disease
Hypertension, July 1, 2009; 54(1): 113 - 119.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
M. S. Utescu, A. LeBoeuf, N. Chbinou, S. Desmeules, M. Lebel, and M. Agharazii
The impact of arteriovenous fistulas on aortic stiffness in patients with chronic kidney disease
Nephrol. Dial. Transplant., June 9, 2009; (2009) gfp276v1.
[Abstract] [Full Text] [PDF]


Home page
Int J EpidemiolHome page
C. E Bolton, J. R Cockcroft, R. Sabit, M. Munnery, C. M McEniery, I. B Wilkinson, S. Ebrahim, J. E Gallacher, D. J Shale, and Y. Ben-Shlomo
Lung function in mid-life compared with later life is a stronger predictor of arterial stiffness in men: The Caerphilly Prospective Study
Int. J. Epidemiol., June 1, 2009; 38(3): 867 - 876.
[Abstract] [Full Text] [PDF]


Home page
NDT PlusHome page
H. Eddington and J. G. Heaf
Clinical management of disturbances of calcium and phosphate metabolism in dialysis patients
NDT Plus, April 28, 2009; (2009) sfp044v1.
[Abstract] [Full Text] [PDF]


Home page
Circ Cardiovasc GenetHome page
K. V. Tarasov, S. Sanna, A. Scuteri, J. B. Strait, M. Orru, A. Parsa, P.-I Lin, A. Maschio, S. Lai, M. G. Piras, et al.
COL4A1 Is Associated With Arterial Stiffness by Genome-Wide Association Scan
Circ Cardiovasc Genet, April 1, 2009; 2(2): 151 - 158.
[Abstract] [Full Text] [PDF]


Home page
Arch Intern MedHome page
J. A. Chirinos, S. S. Franklin, R. R. Townsend, and L. Raij
Body Mass Index and Hypertension Hemodynamic Subtypes in the Adult US Population
Arch Intern Med, March 23, 2009; 169(6): 580 - 586.
[Abstract] [Full Text] [PDF]


Home page
Am J EpidemiolHome page
C. A. Peralta, R. Katz, M. Madero, M. Sarnak, H. Kramer, M. H. Criqui, and M. G. Shlipak
The Differential Association of Kidney Dysfunction With Small and Large Arterial Elasticity: The Multiethnic Study of Atherosclerosis
Am. J. Epidemiol., March 15, 2009; 169(6): 740 - 748.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
T. Adragao, A. Pires, R. Birne, J. D. Curto, C. Lucas, M. Goncalves, and A. P. Negrao
A plain X-ray vascular calcification score is associated with arterial stiffness and mortality in dialysis patients
Nephrol. Dial. Transplant., March 1, 2009; 24(3): 997 - 1002.
[Abstract] [Full Text] [PDF]


Home page
QJMHome page
B. Ilyas, N. Dhaun, D. Markie, P. Stansell, J. Goddard, D.E. Newby, and D.J. Webb
Renal function is associated with arterial stiffness and predicts outcome in patients with coronary artery disease
QJM, March 1, 2009; 102(3): 183 - 191.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
I. Dursun, H. M Poyrazoglu, Z. Gunduz, H. Ulger, A. Yykylmaz, R. Dusunsel, T. Patyroglu, and M. Gurgoze
The relationship between circulating endothelial microparticles and arterial stiffness and atherosclerosis in children with chronic kidney disease
Nephrol. Dial. Transplant., February 24, 2009; (2009) gfp066v1.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
J. Maizel, I. Six, M. Slama, C. Tribouilloy, H. Sevestre, S. Poirot, P. Giummelly, J. Atkinson, G. Choukroun, M. Andrejak, et al.
Mechanisms of Aortic and Cardiac Dysfunction in Uremic Mice With Aortic Calcification
Circulation, January 20, 2009; 119(2): 306 - 313.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
M. Rodriguez-Garcia, C. Gomez-Alonso, M. Naves-Diaz, J. B. Diaz-Lopez, C. Diaz-Corte, J. B. Cannata-Andia, and the Asturias Study Group
Vascular calcifications, vertebral fractures and mortality in haemodialysis patients
Nephrol. Dial. Transplant., January 1, 2009; 24(1): 239 - 246.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
O. Cseprekal, E. Kis, P. Schaffer, T. E. H. Othmane, B. Cs. Fekete, A. Vannay, A. J. Szabo, A. Remport, A. Szabo, T. Tulassay, et al.
Pulse wave velocity in children following renal transplantation
Nephrol. Dial. Transplant., January 1, 2009; 24(1): 309 - 315.
[Abstract] [Full Text] [PDF]


Home page
CJASNHome page
N. D. Toussaint, G. J. Elder, and P. G. Kerr
Bisphosphonates in Chronic Kidney Disease; Balancing Potential Benefits and Adverse Effects on Bone and Soft Tissue
Clin. J. Am. Soc. Nephrol., January 1, 2009; 4(1): 221 - 233.
[Abstract] [Full Text] [PDF]


Home page
Eur J EchocardiogrHome page
F. Antonini-Canterin, S. Carerj, V. Di Bello, G. Di Salvo, S. La Carrubba, O. Vriz, D. Pavan, A. Balbarini, G. L. Nicolosi, and On behalf of the Research Group of the Italian Soc
Arterial stiffness and ventricular stiffness: a couple of diseases or a coupling disease? A review from the cardiologist's point of view
Eur J Echocardiogr, January 1, 2009; 10(1): 36 - 43.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
A. Hiukka, J. Westerbacka, E. S. Leinonen, H. Watanabe, O. Wiklund, L. M. Hulten, J. T. Salonen, T.-P. Tuomainen, H. Yki-Jarvinen, A. C. Keech, et al.
Long-Term Effects of Fenofibrate on Carotid Intima-Media Thickness and Augmentation Index in Subjects With Type 2 Diabetes Mellitus
J. Am. Coll. Cardiol., December 16, 2008; 52(25): 2190 - 2197.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
S. R. Lammers, P. H. Kao, H. J. Qi, K. Hunter, C. Lanning, J. Albietz, S. Hofmeister, R. Mecham, K. R. Stenmark, and R. Shandas
Changes in the structure-function relationship of elastin and its impact on the proximal pulmonary arterial mechanics of hypertensive calves
Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1451 - H1459.
[Abstract] [Full Text] [PDF]


Home page
HeartHome page
N C Edwards, C J Ferro, J N Townend, and R P Steeds
Aortic distensibility and arterial-ventricular coupling in early chronic kidney disease: a pattern resembling heart failure with preserved ejection fraction
Heart, August 1, 2008; 94(8): 1038 - 1043.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
J. Karalliedde, A. Smith, L. DeAngelis, V. Mirenda, A. Kandra, J. Botha, P. Ferber, and G. Viberti
Valsartan Improves Arterial Stiffness in Type 2 Diabetes Independently of Blood Pressure Lowering
Hypertension, June 1, 2008; 51(6): 1617 - 1623.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
B. Dursun, E. Dursun, G. Suleymanlar, B. Ozben, I. Capraz, A. Apaydin, and T. Ozben
Carotid artery intima-media thickness correlates with oxidative stress in chronic haemodialysis patients with accelerated atherosclerosis
Nephrol. Dial. Transplant., May 1, 2008; 23(5): 1697 - 1703.
[Abstract] [Full Text] [PDF]


Home page
J Exp BotHome page
T. Knipfer and E. Steudle
Root hydraulic conductivity measured by pressure clamp is substantially affected by internal unstirred layers
J. Exp. Bot., May 1, 2008; 59(8): 2071 - 2084.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
S. S. Najjar, A. Scuteri, V. Shetty, J. G. Wright, D. C. Muller, J. L. Fleg, H. P. Spurgeon, L. Ferrucci, and E. G. Lakatta
Pulse Wave Velocity Is an Independent Predictor of the Longitudinal Increase in Systolic Blood Pressure and of Incident Hypertension in the Baltimore Longitudinal Study of Aging
J. Am. Coll. Cardiol., April 8, 2008; 51(14): 1377 - 1383.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
F. A. Benedetto, G. Tripepi, F. Mallamaci, and C. Zoccali
Rate of Atherosclerotic Plaque Formation Predicts Cardiovascular Events in ESRD
J. Am. Soc. Nephrol., April 1, 2008; 19(4): 757 - 763.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
M. Delahousse, M. Chaignon, L. Mesnard, P. Boutouyrie, M. E. Safar, T. Lebret, M. Pastural-Thaunat, L. Tricot, A. Kolko-Labadens, A. Karras, et al.
Aortic Stiffness of Kidney Transplant Recipients Correlates with Donor Age
J. Am. Soc. Nephrol., April 1, 2008; 19(4): 798 - 805.
[Abstract] [Full Text] [PDF]


Home page
CJASNHome page
P. Stenvinkel, J. J. Carrero, J. Axelsson, B. Lindholm, O. Heimburger, and Z. Massy
Emerging Biomarkers for Evaluating Cardiovascular Risk in the Chronic Kidney Disease Patient: How Do New Pieces Fit into the Uremic Puzzle?
Clin. J. Am. Soc. Nephrol., March 1, 2008; 3(2): 505 - 521.
[Abstract] [Full Text] [PDF]


Home page
Ther Adv Cardiovasc DisHome page
M. E. Safar
Review: Pulse pressure, arterial stiffness and wave reflections (augmentation index) as cardiovascular risk factors in hypertension
Therapeutic Advances in Cardiovascular Disease, February 1, 2008; 2(1): 13 - 24.
[Abstract] [PDF]


Home page
Nephrol Dial TransplantHome page
M. Frimodt-Moller, A. H. Nielsen, A.-L. Kamper, and S. Strandgaard
Reproducibility of pulse-wave analysis and pulse-wave velocity determination in chronic kidney disease
Nephrol. Dial. Transplant., February 1, 2008; 23(2): 594 - 600.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Renal Physiol.Home page
R. Agarwal and R. P. Light
Arterial stiffness and interdialytic weight gain influence ambulatory blood pressure patterns in hemodialysis patients
Am J Physiol Renal Physiol, February 1, 2008; 294(2): F303 - F308.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
M. Essig, B. Escoubet, D. de Zuttere, F. Blanchet, F. Arnoult, E. Dupuis, C. Michel, F. Mignon, F. Mentre, C. Clerici, et al.
Cardiovascular remodelling and extracellular fluid excess in early stages of chronic kidney disease
Nephrol. Dial. Transplant., January 1, 2008; 23(1): 239 - 248.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
P. Eller, K. Hochegger, G. M. Feuchtner, E. Zitt, I. Tancevski, A. Ritsch, F. Kronenberg, A. R. Rosenkranz, J. R. Patsch, and G. Mayer
Impact of ENPP1 genotype on arterial calcification in patients with end-stage renal failure
Nephrol. Dial. Transplant., January 1, 2008; 23(1): 321 - 327.
[Abstract] [Full Text] [PDF]


Home page
CJASNHome page
S. S. DeLoach and R. R. Townsend
Vascular Stiffness: Its Measurement and Significance for Epidemiologic and Outcome Studies
Clin. J. Am. Soc. Nephrol., January 1, 2008; 3(1): 184 - 192.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
D. A. McAllister, J. D. Maclay, N. L. Mills, G. Mair, J. Miller, D. Anderson, D. E. Newby, J. T. Murchison, and W. MacNee
Arterial Stiffness Is Independently Associated with Emphysema Severity in Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., December 15, 2007; 176(12): 1208 - 1214.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
M. M. Lemos, A. D. B. Jancikic, F. M. R. Sanches, D. M. Christofalo, S. A. Ajzen, M. H. Miname, R. D. Santos, F. C. Fachini, A. B. Carvalho, S. A. Draibe, et al.
Pulse wave velocity a useful tool for cardiovascular surveillance in pre-dialysis patients
Nephrol. Dial. Transplant., December 1, 2007; 22(12): 3527 - 3532.
[Abstract] [Full Text] [PDF]


Home page
Vasc MedHome page
M. F. O'Rourke
Arterial aging: pathophysiological principles
Vascular Medicine, November 1, 2007; 12(4): 329 - 341.
[Abstract] [PDF]


Home page
Br J AnaesthHome page
R. A. Payne, D. Isnardi, P. J. D. Andrews, S. R. J. Maxwell, and D. J. Webb
Similarity between the suprasystolic wideband external pulse wave and the first derivative of the intra-arterial pulse wave
Br. J. Anaesth., November 1, 2007; 99(5): 653 - 661.
[Abstract] [Full Text] [PDF]


Home page
CJASNHome page
M. Yoshida, H. Tomiyama, J. Yamada, Y. Koji, K. Shiina, M. Nagata, and A. Yamashina
Relationships among Renal Function Loss within the Normal to Mildly Impaired Range, Arterial Stiffness, Inflammation, and Oxidative Stress
Clin. J. Am. Soc. Nephrol., November 1, 2007; 2(6): 1118 - 1124.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
F. Verbeke, W. Van Biesen, P. Peeters, L. M. Van Bortel, and R. C. Vanholder
Arterial stiffness and wave reflections in renal transplant recipients
Nephrol. Dial. Transplant., October 1, 2007; 22(10): 3021 - 3027.
[Abstract] [Full Text] [PDF]


Home page
Psychosom. Med.Home page
V. K. Yeragani, R. Kumar, K. J. Bar, P. Chokka, and M. Tancer
Exaggerated Differences in Pulse Wave Velocity Between Left and Right Sides Among Patients With Anxiety Disorders and Cardiovascular Disease
Psychosom Med, October 1, 2007; 69(8): 717 - 722.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
N. Cheung, A. R. Sharrett, R. Klein, M. H. Criqui, F.M. A. Islam, K. J. Macura, M. F. Cotch, B. E.K. Klein, and T. Y. Wong
Aortic Distensibility and Retinal Arteriolar Narrowing: The Multi-Ethnic Study of Atherosclerosis
Hypertension, October 1, 2007; 50(4): 617 - 622.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
A. Benjo, R. E. Thompson, D. Fine, C. W. Hogue, D. Alejo, A. Kaw, G. Gerstenblith, A. Shah, D. E. Berkowitz, and D. Nyhan
Pulse Pressure Is an Age-Independent Predictor of Stroke Development After Cardiac Surgery
Hypertension, October 1, 2007; 50(4): 630 - 635.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
K. M. Maki-Petaja, A. D. Booth, F. C. Hall, S. M.L. Wallace, J. Brown, C. M. McEniery, and I. B. Wilkinson
Ezetimibe and Simvastatin Reduce Inflammation, Disease Activity, and Aortic Stiffness and Improve Endothelial Function in Rheumatoid Arthritis
J. Am. Coll. Cardiol., August 28, 2007; 50(9): 852 - 858.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
M. F. O'Rourke and J. Hashimoto
Mechanical Factors in Arterial Aging: A Clinical Perspective
J. Am. Coll. Cardiol., July 3, 2007; 50(1): 1 - 13.
[Abstract] [Full Text] [PDF]


Home page
CJASNHome page
J. Ajiro, B. Alchi, I. Narita, K. Omori, D. Kondo, M. Sakatsume, J. J. Kazama, K. Akazawa, and F. Gejyo
Mortality Predictors after 10 Years of Dialysis: A Prospective Study of Japanese Hemodialysis Patients
Clin. J. Am. Soc. Nephrol., July 1, 2007; 2(4): 653 - 660.
[Abstract] [Full Text] [PDF]


Home page
CJASNHome page
J. Nogueira and M. Weir
The Unique Character of Cardiovascular Disease in Chronic Kidney Disease and Its Implications for Treatment with Lipid-Lowering Drugs
Clin. J. Am. Soc. Nephrol., July 1, 2007; 2(4): 766 - 785.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
M. J. Roman, R. B. Devereux, J. R. Kizer, E. T. Lee, J. M. Galloway, T. Ali, J. G. Umans, and B. V. Howard
Central Pressure More Strongly Relates to Vascular Disease and Outcome Than Does Brachial Pressure: The Strong Heart Study
Hypertension, July 1, 2007; 50(1): 197 - 203.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
A. D. Protogerou, M. E. Safar, P. Iaria, H. Safar, K. Le Dudal, J. Filipovsky, O. Henry, P. Ducimetiere, and J. Blacher
Diastolic Blood Pressure and Mortality in the Elderly With Cardiovascular Disease
Hypertension, July 1, 2007; 50(1): 172 - 180.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Respir. Crit. Care Med.Home page
R. Sabit, C. E. Bolton, P. H. Edwards, R. J. Pettit, W. D. Evans, C. M. McEniery, I. B. Wilkinson, J. R. Cockcroft, and D. J. Shale
Arterial Stiffness and Osteoporosis in Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., June 15, 2007; 175(12): 1259 - 1265.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
P. Raggi, A. Bellasi, E. Ferramosca, G. A. Block, and P. Muntner
Pulse Wave Velocity Is Inversely Related to Vertebral Bone Density in Hemodialysis Patients
Hypertension, June 1, 2007; 49(6): 1278 - 1284.
[Abstract] [Full Text] [PDF]


Home page
ChestHome page
L. F. Drager, L. A. Bortolotto, A. C. Figueiredo, B. C. Silva, E. M. Krieger, and G. Lorenzi-Filho
Obstructive Sleep Apnea, Hypertension, and Their Interaction on Arterial Stiffness and Heart Remodeling
Chest, May 1, 2007; 131(5): 1379 - 1386.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
I. J. Kullo and A. R. Malik
Arterial Ultrasonography and Tonometry as Adjuncts to Cardiovascular Risk Stratification
J. Am. Coll. Cardiol., April 3, 2007; 49(13): 1413 - 1426.
[Abstract] [Full Text] [PDF]


Home page
Diabetes CareHome page
C. Meyer, B. P. McGrath, and H. J. Teede
Effects of Medical Therapy on Insulin Resistance and the Cardiovascular System in Polycystic Ovary Syndrome
Diabetes Care, March 1, 2007; 30(3): 471 - 478.
[Abstract] [Full Text] [PDF]


Home page
Clin Med ResHome page
A. R. Khoshdel, S. L. Carney, B. R. Nair, and A. Gillies
Better Management of Cardiovascular Diseases by Pulse Wave Velocity: Combining Clinical Practice with Clinical Research using Evidence-Based Medicine
Clin. Med. Res., March 1, 2007; 5(1): 45 - 52.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
K. Noma, C. Goto, K. Nishioka, D. Jitsuiki, T. Umemura, K. Ueda, M. Kimura, K. Nakagawa, T. Oshima, K. Chayama, et al.
Roles of Rho-Associated Kinase and Oxidative Stress in the Pathogenesis of Aortic Stiffness
J. Am. Coll. Cardiol., February 13, 2007; 49(6): 698 - 705.
[Abstract] [Full Text] [PDF]


Home page
ANGIOLOGYHome page
A. D. Achimastos, S. P. Efstathiou, T. Christoforatos, T. N. Panagiotou, G. S. Stergiou, and T. D. Mountokalakis
Arterial Stiffness: Determinants and Relationship to the Metabolic Syndrome
Angiology, February 1, 2007; 58(1): 11 - 20.
[Abstract] [PDF]


Home page
Age AgeingHome page
J. Cameron
Ageing and central aortic pulse wave analysis. Commentary on 'Is Augmentation Index a Good Measure of Vascular Stiffness in the Elderly?' by Fantin et al.
Age Ageing, January 1, 2007; 36(1): 3 - 5.
[Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
G. Fernandez-Fresnedo, E. Rodrigo, A. L. M. de Francisco, S. S. de Castro, O. Castaneda, and M. Arias
Role of Pulse Pressure on Cardiovascular Risk in Chronic Kidney Disease Patients
J. Am. Soc. Nephrol., December 1, 2006; 17(12_suppl_3): S246 - S249.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
S. Laurent, J. Cockcroft, L. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I. Wilkinson, H. Struijker-Boudier, et al.
Expert consensus document on arterial stiffness: methodological issues and clinical applications
Eur. Heart J., November 1, 2006; 27(21): 2588 - 2605.
[Abstract] [Full Text] [PDF]


Home page
QJMHome page
N.C. Edwards, R.P. Steeds, C.J. Ferro, and J.N. Townend
The treatment of coronary artery disease in patients with chronic kidney disease
QJM, November 1, 2006; 99(11): 723 - 736.
[Abstract] [Full Text] [PDF]


Home page
HeartHome page
C Vlachopoulos, K Aznaouridis, and C Stefanadis
Clinical appraisal of arterial stiffness: the Argonauts in front of the Golden Fleece
Heart, November 1, 2006; 92(11): 1544 - 1550.
[Abstract] [Full Text] [PDF]


Home page
LupusHome page
N Bjarnegard, C Bengtsson, J Brodszki, G Sturfelt, O Nived, and T Lanne
Increased aortic pulse wave velocity in middle aged women with systemic lupus erythematosus
Lupus, October 1, 2006; 15(10): 644 - 650.
[Abstract] [PDF]


Home page
Nephrol Dial TransplantHome page
A. Covic, N. Mardare, P. Gusbeth-Tatomir, O. Prisada, R. Sascau, and D. J. A. Goldsmith
Arterial wave reflections and mortality in haemodialysis patients--only relevant in elderly, cardiovascularly compromised?
Nephrol. Dial. Transplant., October 1, 2006; 21(10): 2859 - 2866.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
C. M. McEniery, S. Wallace, I. S. Mackenzie, B. McDonnell, Yasmin, D. E. Newby, J. R. Cockcroft, and I. B. Wilkinson
Endothelial Function Is Associated With Pulse Pressure, Pulse Wave Velocity, and Augmentation Index in Healthy Humans
Hypertension, October 1, 2006; 48(4): 602 - 608.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
P. Verdecchia, F. Angeli, and S. Taddei
At the Beginning of Stiffening: Endothelial Dysfunction Meets "Pulsology"
Hypertension, October 1, 2006; 48(4): 541 - 542.
[Full Text] [PDF]


Home page
CirculationHome page
K. M. Maki-Petaja, F. C. Hall, A. D. Booth, S. M.L. Wallace, Yasmin, P. W.P. Bearcroft, S. Harish, A. Furlong, C. M. McEniery, J. Brown, et al.
Rheumatoid Arthritis Is Associated With Increased Aortic Pulse-Wave Velocity, Which Is Reduced by Anti-Tumor Necrosis Factor-{alpha} Therapy
Circulation, September 12, 2006; 114(11): 1185 - 1192.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
V. Persy, A. Postnov, E. Neven, G. Dams, M. De Broe, P. D'Haese, and N. De Clerck
High-Resolution X-Ray Microtomography Is a Sensitive Method to Detect Vascular Calcification in Living Rats With Chronic Renal Failure
Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 2110 - 2116.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
A. D. Stewart, B. Jiang, S. C. Millasseau, J. M. Ritter, and P. J. Chowienczyk
Acute Reduction of Blood Pressure by Nitroglycerin Does Not Normalize Large Artery Stiffness in Essential Hypertension
Hypertension, September 1, 2006; 48(3): 404 - 410.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
Yasmin, C. M. McEniery, K. M. O'Shaughnessy, P. Harnett, A. Arshad, S. Wallace, K. Maki-Petaja, B. McDonnell, M. J. Ashby, J. Brown, et al.
Variation in the Human Matrix Metalloproteinase-9 Gene Is Associated With Arterial Stiffness in Healthy Individuals
Arterioscler. Thromb. Vasc. Biol., August 1, 2006; 26(8): 1799 - 1805.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
E. Kimoto, T. Shoji, K. Shinohara, S. Hatsuda, K. Mori, S. Fukumoto, H. Koyama, M. Emoto, Y. Okuno, and Y. Nishizawa
Regional Arterial Stiffness in Patients with Type 2 Diabetes and Chronic Kidney Disease
J. Am. Soc. Nephrol., August 1, 2006; 17(8): 2245 - 2252.
[Abstract] [Full Text] [PDF]


Home page
StrokeHome page
J. T. Kielstein, F. Donnerstag, S. Gasper, J. Menne, A. Kielstein, J. Martens-Lobenhoffer, F. Scalera, J. P. Cooke, D. Fliser, and S. M. Bode-Boger
ADMA Increases Arterial Stiffness and Decreases Cerebral Blood Flow in Humans
Stroke, August 1, 2006; 37(8): 2024 - 2029.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
M. Cinthio, A. R. Ahlgren, J. Bergkvist, T. Jansson, H. W. Persson, and K. Lindstrom
Longitudinal movements and resulting shear strain of the arterial wall
Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H394 - H402.
[Abstract] [Full Text] [PDF]


Home page
Postgrad. Med. J.Home page
B Jani and C Rajkumar
Ageing and vascular ageing.
Postgrad. Med. J., June 1, 2006; 82(968): 357 - 362.
[Abstract] [Full Text] [PDF]


Home page
Rheumatology (Oxford)Home page
W. F. Ng, F. Fantin, C. Ng, F. Dockery, R. Schiff, K. A. Davies, C. Rajkumar, and J. C. Mason
Takayasu's arteritis: a cause of prolonged arterial stiffness
Rheumatology, June 1, 2006; 45(6): 741 - 745.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
D. Banerjee, S. Brincat, H. Gregson, G. Contreras, C. Streather, D. Oliveira, and S. Nelson
Pulse pressure and inhibition of renin-angiotensin system in chronic kidney disease
Nephrol. Dial. Transplant., April 1, 2006; 21(4): 975 - 978.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
N. Dhaun, J. Goddard, and DavidJ. Webb
The Endothelin System and Its Antagonism in Chronic Kidney Disease
J. Am. Soc. Nephrol., April 1, 2006; 17(4): 943 - 955.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
A. M. Dart, C. D. Gatzka, B. A. Kingwell, K. Willson, J. D. Cameron, Y.-L. Liang, K. L. Berry, L. M.H. Wing, C. M. Reid, P. Ryan, et al.
Brachial Blood Pressure But Not Carotid Arterial Waveforms Predict Cardiovascular Events in Elderly Female Hypertensives
Hypertension, April 1, 2006; 47(4): 785 - 790.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
A. Covic, N. Mardare, P. Gusbeth-Tatomir, O. Brumaru, C. Gavrilovici, M. Munteanu, O. Prisada, and D. J. A. Goldsmith
Increased arterial stiffness in children on haemodialysis
Nephrol. Dial. Transplant., March 1, 2006; 21(3): 729 - 735.
[Abstract] [Full Text] [PDF]


Home page
Nephrol Dial TransplantHome page
M. Sigrist, P. Bungay, M. W. Taal, and C. W. McIntyre
Vascular calcification and cardiovascular function in chronic kidney disease
Nephrol. Dial. Transplant., March 1, 2006; 21(3): 707 - 714.
[Abstract] [Full Text] [PDF]


Home page
HypertensionHome page
A. Paini, P. Boutouyrie, D. Calvet, A.-I. Tropeano, B. Laloux, and S. Laurent
Carotid and Aortic Stiffness: Determinants of Discrepancies
Hypertension, March 1, 2006; 47(3): 371 - 376.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
T. Willum Hansen, J. A. Staessen, C. Torp-Pedersen, S. Rasmussen, L. Thijs, H. Ibsen, and J. Jeppesen
Prognostic Value of Aortic Pulse Wave Velocity as Index of Arterial Stiffness in the General Population
Circulation, February 7, 2006; 113(5): 664 - 670.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
K. K. Naka, A. C. Tweddel, S. N. Doshi, J. Goodfellow, and A. H. Henderson
Flow-mediated changes in pulse wave velocity: a new clinical measure of endothelial function
Eur. Heart J., February 1, 2006; 27(3): 302 - 309.
[Abstract] [Full Text] [PDF]


Home page
HeartHome page
A P Patrianakos, D N Karakitsos, E de Groot, F I Parthenakis, E K Daphnis, and P E Vardas
Alteration of proximal aorta biophysical properties in patients with end stage renal disease
Heart, February 1, 2006; 92(2): 228 - 232.
[Abstract] [Full Text] [PDF]