(Circulation. 1998;98:2666-2671.)
© 1998 American Heart Association, Inc.
Clinical Investigation and Reports |
Measurement of Atherosclerotic Carotid Plaque Size In Vivo Using High Resolution Magnetic Resonance Imaging
From the Department of Radiology (C.Y., L.H.S.) and Division of Vascular Surgery (K.W.B.), University of Washington, Seattle, and Surgical Service (T.S.H.), VA Puget Sound Health Care System, Seattle, Wash.
Correspondence to Thomas S. Hatsukami, MD, VA Puget Sound Health Care System, Surgical Service (112), 1660 South Columbian Way, Seattle, WA 98108. E-mail tomhat{at}u.washington.edu
Background—Current imaging modalities, such as contrast angiography, accurately determine the degree of luminal narrowing but provide no direct information on plaque size. Magnetic resonance imaging (MRI), however, has potential for noninvasively determining arterial wall area (WA). This study was conducted to determine the accuracy of in vivo MRI for measuring the cross-sectional maximum wall area (MaxWA) of atherosclerotic carotid arteries in a group of patients undergoing carotid endarterectomy.
Methods and Results—Fourteen patients scheduled for carotid endarterectomy underwent preoperative carotid MRI using a custom-made phased-array coil. The plaques were excised en bloc and scanned using similar imaging parameters. MaxWA measurements from the ex vivo MRI were used as the reference standard and compared with MaxWA measurements from the corresponding in vivo MR study. Agreement between the in vivo and ex vivo measurement was analyzed using the Bland-Altman method. The paired in vivo and ex vivo MaxWA measurements strongly agreed: the mean difference (in vivo minus ex vivo) in MaxWA was 13.1±6.5 mm2 for T1-weighted (T1W) imaging (mean MaxWA in vivo=94.7 mm2, ex vivo=81.6 mm2) and 14.1±11.7 mm2 for proton density–weighted (PDW) imaging (mean MaxWA in vivo=93.4 mm2, ex vivo=79.3 mm2). Intraobserver and interobserver variability was small, with intraclass correlation coefficients ranging from 0.90 to 0.98.
Conclusions—MRI is highly accurate for in vivo measurement of artery WA in atherosclerotic carotid lesions. This imaging technique has potential application monitoring lesion size in studies examining plaque progression and/or regression.
Key Words: atherosclerosis • magnetic resonance imaging • plaque • carotid arteries
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