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Circulation. 1998;98:2314-2322

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(Circulation. 1998;98:2314-2322.)
© 1998 American Heart Association, Inc.


Basic Science Reports

Cellular Basis for the ECG Features of the LQT1 Form of the Long-QT Syndrome

Effects of ß-Adrenergic Agonists and Antagonists and Sodium Channel Blockers on Transmural Dispersion of Repolarization and Torsade de Pointes

Wataru Shimizu, MD, PhD; ; Charles Antzelevitch, PhD

From the Masonic Medical Research Laboratory, Utica, NY.

Correspondence to Dr Charles Antzelevitch, Masonic Medical Research Laboratory, 2150 Bleecker St, Utica, NY 13501-1787. E-mail ca{at}mmrl.edu

Background—This study examines the cellular basis for the phenotypic appearance of broad-based T waves, increased transmural dispersion of repolarization (TDR), and torsade de pointes (TdP) induced by ß-adrenergic agonists under conditions mimicking the LQT1 form of the congenital long-QT syndrome.

Methods and Results—A transmural ECG and transmembrane action potentials from epicardial, M, and endocardial cells were recorded simultaneously from an arterially perfused wedge of canine left ventricle. Chromanol 293B, a specific IKs blocker, dose-dependently (1 to 100 µmol/L) prolonged the QT interval and action potential duration (APD90) of the 3 cell types but did not widen the T wave, increase TDR, or induce TdP. Isoproterenol 10 to 100 nmol/L in the continued presence of chromanol 293B 30 µmol/L abbreviated the APD90 of epicardial and endocardial cells but not that of the M cell, resulting in widening of the T wave and a dramatic accentuation of TDR. Spontaneous as well as programmed electrical stimulation (PES)-induced TdP was observed only after exposure to the IKs blocker and isoproterenol. Therapeutic concentrations of propranolol (0.5 to 1 µmol/L) prevented the actions of isoproterenol to increase TDR and to induce TdP. Mexiletine 2 to 20 µmol/L abbreviated the APD90 of M cells more than that of epicardial and endocardial cells, thus diminishing TDR and the effect of isoproterenol to induce TdP.

Conclusions—This experimental model of LQT1 indicates that a deficiency of IKs alone does not induce TdP but that the addition of ß-adrenergic influence predisposes the myocardium to the development of TdP by increasing transmural dispersion of repolarization, most likely as a result of a large augmentation of residual IKs in epicardial and endocardial cells but not in M cells, in which IKs is intrinsically weak. Our data provide a mechanistic understanding of the cellular basis for the therapeutic actions of ß-adrenergic blockers in LQT1 and suggest that sodium channel block with class IB antiarrhythmic agents may be effective in suppressing TdP in LQT1, as they are in LQT2 and LQT3, as well as in acquired (drug-induced) forms of the long-QT syndrome.


Key Words: long-QT syndrome • arrhythmia • KvLQT1 • chromanol 293b • isoproterenol




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Home page
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Home page
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[Abstract] [Full Text] [PDF]


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Home page
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[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


Home page
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Circulation, November 5, 2002; 106(19): 2473 - 2478.
[Abstract] [Full Text] [PDF]


Home page
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[Abstract] [Full Text] [PDF]


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Eur Heart JHome page
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Sympathetic modulation of the long QT syndrome
Eur. Heart J., August 2, 2002; 23(16): 1246 - 1252.
[PDF]


Home page
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W. Shimizu, Y. Tanabe, T. Aiba, M. Inagaki, T. Kurita, K. Suyama, N. Nagaya, A. Taguchi, N. Aihara, K. Sunagawa, et al.
Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the lqt1 and lqt2 forms of congenital long qt syndrome
J. Am. Coll. Cardiol., June 19, 2002; 39(12): 1984 - 1991.
[Abstract] [Full Text] [PDF]


Home page
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T. Noda, H. Takaki, T. Kurita, K. Suyama, N. Nagaya, A. Taguchi, N. Aihara, S. Kamakura, K. Sunagawa, K. Nakamura, et al.
Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome
Eur. Heart J., June 2, 2002; 23(12): 975 - 983.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
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Rate-dependent QT shortening mechanism for the LQT3 {Delta}KPQ mutant
Cardiovasc Res, June 1, 2002; 54(3): 624 - 629.
[Abstract] [Full Text] [PDF]


Home page
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Ionic Current Basis of Electrocardiographic Waveforms: A Model Study
Circ. Res., May 3, 2002; 90(8): 889 - 896.
[Abstract] [Full Text] [PDF]


Home page
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Home page
Eur Heart J SupplHome page
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Heterogeneity of cellular repolarization in LQTS: the role of M cells
Eur. Heart J. Suppl., September 1, 2001; 3(suppl_K): K2 - K16.
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Home page
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Inhibition of repolarizing ionic currents by drugs
Eur. Heart J. Suppl., September 1, 2001; 3(suppl_K): K17 - K22.
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Home page
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Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle
Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H689 - H697.
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Home page
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