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From the Service de Pharmacologie, Hôpital
Pitié-Salpêtrière, Paris, France; the Division of
Circulatory Physiology, Columbia University, College of Physicians and
Surgeons, New York, NY; and the Unité de Pharmacologie Clinique,
Hôpitaux de Lyon, Lyon, France.
Background—ß-Blockers have
improved symptoms and reduced the risk of
cardiovascular events in studies of patients with heart
failure, but it is unclear which end points are most sensitive to the
therapeutic effects of these drugs.
Methods and Results—We combined the results of all 18 published
double-blind, placebo-controlled, parallel-group trials of ß-blockers
in heart failure. From this combined database of 3023 patients, we
evaluated the strength of evidence supporting an effect of treatment on
left ventricular ejection fraction, NYHA functional class,
hospitalizations for heart failure, and death. ß-Blockers exerted
their most persuasive effects on ejection fraction and on the combined
risk of death and hospitalization for heart failure. ß-Blockade
increased the ejection fraction by 29%
(P<10-9) and reduced the combined risk of
death or hospitalization for heart failure by 37%
(P<0.001). Both effects remained significant even if
>90% of the trials were eliminated from the analysis or if a
large number of trials with a neutral result were added to the
analysis. In contrast, the effect of ß-blockade on NYHA
functional class was of borderline significance (P=0.04)
and disappeared with the addition or removal of only 1 moderate-size
study. Although ß-blockade reduced all-cause mortality by 32%
(P=0.003), this effect was only moderately robust and
varied according to the type of ß-blocker tested, ie, the reduction
of mortality risk was greater for nonselective ß-blockers than for
ß1-selective agents (49% versus 18%,
P=0.049). However, selective and nonselective
ß-blockers did not differ in their effects on other measures of
clinical efficacy.
Conclusions—These analyses indicate that there is
persuasive evidence supporting a favorable effect of ß-blockade on
ejection fraction and the combined risk of death and hospitalization
for heart failure. In contrast, the effect of these drugs on other end
points requires additional study.
© 1998 American Heart Association, Inc.
Clinical Investigation and Reports
Clinical Effects of ß-Adrenergic Blockade in Chronic Heart Failure
A Meta-Analysis of Double-Blind, Placebo-Controlled, Randomized Trials
Key Words: heart failure • meta-analysis • receptors, adrenergic, ß • trials
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|
|
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 |
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|
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|
|
|
 |
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|
|
|
 |
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|
|
|
 |
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|
|
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|
|
|
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|
|
|
|
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|
|
|
|
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|
|
|
|
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|
|
|
 |
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
 D. Burkhoff New heart failure therapy: The shape of things to come? J. Thorac. Cardiovasc. Surg., March 1, 2003; 125(90030): S50 - 52. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 M. L. Kukin {beta}-Blockers in Chronic Heart Failure: Considerations for Selecting an Agent Mayo Clin. Proc., November 1, 2002; 77(11): 1199 - 1206. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 B. Silke, C. Campbell, and D. King The potential cardiotoxicity of antipsychotic drugs as assessed by heart rate variability J Psychopharmacol, July 1, 2002; 16(4): 355 - 360. [Abstract] [PDF]
|
|
|
|
 |
|
 A. A. El-Solh, E. Bozkanat, J. Mador, and B. J. B. Grant Association Between Plasma Endothelin-1 Levels and Cheyne-Stokes Respiration in Patients With Congestive Heart Failure* Chest, June 1, 2002; 121(6): 1928 - 1934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Ferrara, F Mastrorilli, G Pasanisi, S Censi, N D'aiello, A Fucili, M Valgimigli, and R Ferrari Neurohormonal modulation in chronic heart failure Eur. Heart J. Suppl., April 1, 2002; 4(suppl_D): D3 - D11. [Abstract] [PDF]
|
|
|
|
|
|
O. A. Victal, J. R. Teerlink, E. Gaxiola, A. W. Wallace, S. Najar, D. H. Camacho, A. Gutierrez, G. Herrera, G. Zuniga, F. Mercado-Rios, et al. Left Ventricular Volume Reduction by Radiofrequency Heating of Chronic Myocardial Infarction in Patients With Congestive Heart Failure Circulation, March 19, 2002; 105(11): 1317 - 1322. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Foody, M. H. Farrell, and H. M. Krumholz {beta}-Blocker Therapy in Heart Failure: Scientific Review JAMA, February 20, 2002; 287(7): 883 - 889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. POPPAS and S. ROUNDS Congestive Heart Failure Am. J. Respir. Crit. Care Med., January 1, 2002; 165(1): 4 - 8. [Full Text] [PDF]
|
|
|
|
 |
|
 X. Monnet, B. Ghaleh, P. Colin, O. P. de Curzon, J.-F. Giudicelli, and A. Berdeaux Effects of Heart Rate Reduction with Ivabradine on Exercise-Induced Myocardial Ischemia and Stunning J. Pharmacol. Exp. Ther., December 1, 2001; 299(3): 1133 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Capomolla, G. Pinna, O. Febo, A. Caporotondi, G. Guazzotti, M. T. La Rovere, M. Gnemmi, A. Mortara, R. Maestri, and F. Cobelli Echo-Doppler mitral flow monitoring: an operative tool to evaluate day-to-day tolerance to and effectiveness of beta-adrenergic blocking agent therapy in patients with chronic heart failure J. Am. Coll. Cardiol., November 15, 2001; 38(6): 1675 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Yan, T. D. Bradley, and P. P. Liu The Role of Continuous Positive Airway Pressure in the Treatment of Congestive Heart Failure Chest, November 1, 2001; 120(5): 1675 - 1685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Fonarow Quality Indicators for the Management of Heart Failure in Vulnerable Elders Ann Intern Med, October 16, 2001; 135(8_Part_2): 694 - 702. [Full Text] [PDF]
|
|
|
|
|
|
D. Burkhoff New heart failure therapy: The shape of things to come? J. Thorac. Cardiovasc. Surg., September 1, 2001; 122(3): 421 - 423. [Full Text] [PDF]
|
|
|
|
|
|
H. Kubo, K. B. Margulies, V. Piacentino III, J. P. Gaughan, and S. R. Houser Patients With End-Stage Congestive Heart Failure Treated With {beta}-Adrenergic Receptor Antagonists Have Improved Ventricular Myocyte Calcium Regulatory Protein Abundance Circulation, August 28, 2001; 104(9): 1012 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Steinberg G protein-coupled receptor kinases: gotta real kure for heart failure? J. Am. Coll. Cardiol., August 1, 2001; 38(2): 541 - 545. [Full Text] [PDF]
|
|
|
|
|
|
M D Lowe, E Rowland, M J Brown, and A A Grace {beta}2 Adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium Heart, July 1, 2001; 86(1): 45 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 D. M. Kaye, L. Johnston, G. Vaddadi, H. Brunner-LaRocca, G. L. Jennings, and M. D. Esler Mechanisms of Carvedilol Action in Human Congestive Heart Failure Hypertension, May 1, 2001; 37(5): 1216 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 M. Gomberg-Maitland, D. A. Baran, and V. Fuster Treatment of Congestive Heart Failure: Guidelines for the Primary Care Physician and the Heart Failure Specialist Arch Intern Med, February 12, 2001; 161(3): 342 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Recent advances: Geriatric BMJ, January 13, 2001; 322(7278): 86 - 89. [Full Text] [PDF]
|
|
|
|
|
|
A. P. Maggioni HEART FAILURE: Treatment strategies for heart failure: {beta} blockers and antiarrhythmics Heart, January 1, 2001; 85(1): 97 - 103. [Full Text]
|
|
|
|
|
|
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|
|
|
|
 |
|
 L. L. Clark Perioperative Treatment of Congestive Heart Failure Seminars in Cardiothoracic and Vascular Anesthesia, November 1, 2000; 4(4): 223 - 235. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
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|
|
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|
|
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 |
|
 S. F. Vatner, D. E. Vatner, and C. J. Homcy {beta}-Adrenergic Receptor Signaling: An Acute Compensatory Adjustment--Inappropriate for the Chronic Stress of Heart Failure? : Insights from Gs{alpha} Overexpression and Other Genetically Engineered Animal Models Circ. Res., March 17, 2000; 86(5): 502 - 506. [Full Text] [PDF]
|
|
|
|
|
|
S. Bonet, A. Agusti, J. M. Arnau, X. Vidal, E. Diogene, E. Galve, and J.-R. Laporte {beta}-Adrenergic Blocking Agents in Heart Failure: Benefits of Vasodilating and Nonvasodilating Agents According to Patients' Characteristics: A Meta-analysis of Clinical Trials Arch Intern Med, March 13, 2000; 160(5): 621 - 627. [Abstract] [Full Text] [PDF]
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J.M Cruickshank Beta-blockers continue to surprise us Eur. Heart J., March 1, 2000; 21(5): 354 - 364. [PDF]
|
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|
|
|
K. Witte, S. Thackray, T. Banerjee, A. L. Clark, and J. G.F. Cleland Update of ELITE-II, BEST, CHAMP, and IMPRESS clinical trials in heart failure Eur J Heart Fail, March 1, 2000; 2(1): 107 - 112. [Abstract] [Full Text] [PDF]
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A. S. Shah, R. E. Lilly, A. P. Kypson, O. Tai, J. A. Hata, A. Pippen, S. C. Silvestry, R. J. Lefkowitz, D. D. Glower, and W. J. Koch Intracoronary Adenovirus-Mediated Delivery and Overexpression of the {beta}2-Adrenergic Receptor in the Heart : Prospects for Molecular Ventricular Assistance Circulation, February 1, 2000; 101(4): 408 - 414. [Abstract] [Full Text] [PDF]
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 |
|
 O.-E. Brodde and M. C. Michel Adrenergic and Muscarinic Receptors in the Human Heart Pharmacol. Rev., December 1, 1999; 51(4): 651 - 690. [Abstract] [Full Text] [PDF]
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J. E. Sanderson, S. K. W. Chan, G. Yip, L. Y. C. Yeung, K. W. Chan, K. Raymond, and K. S. Woo Beta-blockade in heart failure: A comparison of carvedilol with metoprolol J. Am. Coll. Cardiol., November 1, 1999; 34(5): 1522 - 1528. [Abstract] [Full Text] [PDF]
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C.H. Davies and Y. Bashir Beta-blockers for heart failure-time to think the unthinkable? QJM, November 1, 1999; 92(11): 673 - 678. [Full Text] [PDF]
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A. Tsunoo and M. Kamijo Non-Cyclic AMP-Dependent, Positive Inotropic Cyclodepsipeptides with Negative Chronotropy J. Pharmacol. Exp. Ther., September 1, 1999; 290(3): 1006 - 1012. [Abstract] [Full Text]
|
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G. Guyatt A 75-Year-Old Man With Congestive Heart Failure JAMA, June 23, 1999; 281(24): 2321 - 2328. [Full Text] [PDF]
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L. E. Limbird and D. E. Vaughan Augmenting beta receptors in the heart: Short-term gains offset by long-term pains? PNAS, June 22, 1999; 96(13): 7125 - 7127. [Full Text] [PDF]
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R. J. Gibbons, K. Chatterjee, J. Daley, J. S. Douglas, S. D. Fihn, J. M. Gardin, M. A. Grunwald, D. Levy, B. W. Lytle, R. A. O'Rourke, et al. ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina) J. Am. Coll. Cardiol., June 1, 1999; 33(7): 2092 - 2197. [Full Text] [PDF]
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J. G. Cleland, J McGowan, A. Clark, and N. Freemantle The evidence for beta blockers in heart failure BMJ, March 27, 1999; 318(7187): 824 - 825. [Full Text]
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 More Favorable Evidence for Beta Blockers in Heart Failure Journal Watch Cardiology, November 13, 1998; 1998(1113): 1 - 1. [Full Text]
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 Pooled Data Indicate Beta-Blockers Beneficial in CHF Journal Watch Dermatology, November 1, 1998; 1998(1101): 20 - 20. [Full Text]
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 Pooled Data Indicate Beta-Blockers Beneficial in CHF Journal Watch (General), September 29, 1998; 1998(929): 1 - 1. [Full Text]
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M. Ino, T. Yoshinaga, M. Wakamori, N. Miyamoto, E. Takahashi, J. Sonoda, T. Kagaya, T. Oki, T. Nagasu, Y. Nishizawa, et al. Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels PNAS, April 24, 2001; 98(9): 5323 - 5328. [Abstract] [Full Text] [PDF]
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