From Cardiovascular Research, Brigham and Women's Hospital, Boston,
Mass.
Correspondence to Victor J. Dzau, MD, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115.
Abstract
Abstract—Entry into and progression
of vascular cells through the cell cycle is considered a key event in
vascular proliferative diseases. Multiple growth factors and
cytokines have been found to regulate vascular cell
proliferation. However, the machinery regulating cell cycle
represents the "final common pathway" of these signaling
cascades and thus provides an attractive therapeutic target for the
prevention of vascular proliferative diseases. This review focuses on
the current understanding of the regulation of the cell cycle machinery
especially as it relates to vascular cell biology and the feasibility
of targeting cell cycle for the prevention of restenosis after
balloon angioplasty and bypass vein graft disease.
© 1998 American Heart Association, Inc.
Current Perspective
Cell Cycle Progression
New Therapeutic Target for Vascular Proliferative Disease
Key Words: atherosclerosis • restenosis • bypass • genes • molecular biology
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