From the Cardiovascular Health Research Unit, Departments of Medicine
(D.S.S., S.W., B.M.P., R.N.L., L.A.C.), Epidemiology (D.S.S., M.A.A., B.M.P.),
and Biostatistics (P.A.), University of Washington, Seattle; the Institute for
Social Research, University of Michigan, Ann Arbor (T.E.R.); and the
Department of Social Medicine, The Hebrew University–Hadassah School of
Public Health, Jerusalem, Israel (Y.F.).
Correspondence to Dr Y. Friedlander, Department of Social Medicine, The Hebrew University–Hadassah School of Public Health, POB 12272, Jerusalem 91120, Israel. E-mail yfried{at}vms.huji.ac.il
Background—The hypothesis that a
family history of myocardial infarction (MI) or primary cardiac arrest
(PCA) is an independent risk factor for primary cardiac arrest was
examined in a population-based case-control study. In addition, we
investigated whether recognized risk factors account for the familial
aggregation of these cardiovascular events.
Methods and Results—PCA cases, 25 to 74 years old, attended by
paramedics during the period 1988 to 1994 and population-based control
subjects matched for age and sex were identified from the community by
random digit dialing. All subjects were free of recognized clinical
heart disease and major comorbidity. A detailed history of MI and PCA
in first-degree relatives was collected in interviews with the spouses
of case and control subjects by trained interviewers using a
standardized questionnaire. For each familial relationship, there was a
higher rate of MI or primary cardiac arrest (MI/PCA) in relatives of
case compared with relatives of control subjects. Overall, the rate of
MI/PCA among first-degree relatives of cardiac arrest patients was
almost 50% higher than that in first-degree relatives of control
subjects (rate ratio [RR]=1.46; 95% CI=1.23 to 1.72). In a
multivariate logistic model, family history of MI/PCA
was associated with PCA (RR=1.57; 95% CI=1.27 to 1.95) even after
adjustment for other common risk factors.
Conclusions—Family history of MI or PCA is positively associated
with the risk of primary cardiac arrest. This association is mostly
independent of familial aggregation of other common risk factors.
© 1998 American Heart Association, Inc.
Clinical Investigation and Reports
Family History as a Risk Factor for Primary Cardiac Arrest
Key Words: risk factors • heart arrest • myocardial infarction
This article has been cited by other articles:
 |
|
 |
|
  E. Ritz and C. Wanner The Challenge of Sudden Death in Dialysis Patients Clin. J. Am. Soc. Nephrol., May 1, 2008; 3(3): 920 - 929. [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Lehtinen, C. Newton-Cheh, J. T. Ziegler, C. D. Langefeld, B. I. Freedman, K. R. Daniel, D. M. Herrington, and D. W. Bowden Association of NOS1AP Genetic Variants With QT Interval Duration in Families From the Diabetes Heart Study Diabetes, April 1, 2008; 57(4): 1108 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. F. Tomaselli A Failure to Adapt: Ankyrins in Congenital and Acquired Arrhythmias Circulation, January 30, 2007; 115(4): 428 - 429. [Full Text] [PDF]
|
|
|
|
|
|
K. S. Kaikkonen, M.-L. Kortelainen, E. Linna, and H. V. Huikuri Family History and the Risk of Sudden Cardiac Death as a Manifestation of an Acute Coronary Event Circulation, October 3, 2006; 114(14): 1462 - 1467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Lopshire and D. P. Zipes Sudden Cardiac Death: Better Understanding of Risks, Mechanisms, and Treatment Circulation, September 12, 2006; 114(11): 1134 - 1136. [Full Text] [PDF]
|
|
|
|
|
|
L. R.C. Dekker, C. R. Bezzina, J. P.S. Henriques, M. W. Tanck, K. T. Koch, M. W. Alings, A. E.R. Arnold, M.-J. de Boer, A. P.M. Gorgels, H. R. Michels, et al. Familial Sudden Death Is an Important Risk Factor for Primary Ventricular Fibrillation: A Case-Control Study in Acute Myocardial Infarction Patients Circulation, September 12, 2006; 114(11): 1140 - 1145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Developed in Collaboration With the European Heart, D. P. Zipes, A. J. Camm, M. Borggrefe, A. E. Buxton, B. Chaitman, M. Fromer, G. Gregoratos, G. Klein, A. J. Moss, et al. ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) J. Am. Coll. Cardiol., September 5, 2006; 48(5): e247 - e346. [Full Text] [PDF]
|
|
|
|
 |
|
 Writing Committee Members, D. P. Zipes, A. J. Camm, M. Borggrefe, A. E. Buxton, B. Chaitman, M. Fromer, G. Gregoratos, G. Klein, A. J. Moss, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society Europace, September 1, 2006; 8(9): 746 - 837. [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Murabito, M. J. Pencina, B.-H. Nam, R. B. D'Agostino Sr, T. J. Wang, D. Lloyd-Jones, P. W. F. Wilson, and C. J. O'Donnell Sibling Cardiovascular Disease as a Risk Factor for Cardiovascular Disease in Middle-aged Adults JAMA, December 28, 2005; 294(24): 3117 - 3123. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Fukuda, S. S. Davies, T. Nakajima, B.-H. Ong, S. Kupershmidt, J. Fessel, V. Amarnath, M. E. Anderson, P. A. Boyden, P. C. Viswanathan, et al. Oxidative Mediated Lipid Peroxidation Recapitulates Proarrhythmic Effects on Cardiac Sodium Channels Circ. Res., December 9, 2005; 97(12): 1262 - 1269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shah, F. G. Akar, and G. F. Tomaselli Molecular Basis of Arrhythmias Circulation, October 18, 2005; 112(16): 2517 - 2529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. F. Tomaselli and D. P. Zipes What Causes Sudden Death in Heart Failure? Circ. Res., October 15, 2004; 95(8): 754 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nasir, E. D. Michos, J. A. Rumberger, J. B. Braunstein, W. S. Post, M. J. Budoff, and R. S. Blumenthal Coronary Artery Calcification and Family History of Premature Coronary Heart Disease: Sibling History Is More Strongly Associated Than Parental History Circulation, October 12, 2004; 110(15): 2150 - 2156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Lloyd-Jones, B.-H. Nam, R. B. D'Agostino Sr, D. Levy, J. M. Murabito, T. J. Wang, P. W. F. Wilson, and C. J. O'Donnell Parental Cardiovascular Disease as a Risk Factor for Cardiovascular Disease in Middle-aged Adults: A Prospective Study of Parents and Offspring JAMA, May 12, 2004; 291(18): 2204 - 2211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Arking, S. S. Chugh, A. Chakravarti, and P. M. Spooner Genomics in Sudden Cardiac Death Circ. Res., April 2, 2004; 94(6): 712 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Wang, B.-H. Nam, R. B. D'Agostino, P. A. Wolf, D. M. Lloyd-Jones, C. A. MacRae, P. W. Wilson, J. F. Polak, and C. J. O'Donnell Carotid Intima-Media Thickness Is Associated With Premature Parental Coronary Heart Disease: The Framingham Heart Study Circulation, August 5, 2003; 108(5): 572 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. V. Huikuri, T. H. Makikallio, M. J. P. Raatikainen, J. Perkiomaki, A. Castellanos, and R. J. Myerburg Prediction of Sudden Cardiac Death: Appraisal of the Studies and Methods Assessing the Risk of Sudden Arrhythmic Death Circulation, July 8, 2003; 108(1): 110 - 115. [Full Text] [PDF]
|
|
|
|
 |
|
 A. P.M Gorgels, C. Gijsbers, J. de Vreede-Swagemakers, A. Lousberg, and H. J.J Wellens Out-of-hospital cardiac arrest-the relevance of heart failure. The Maastricht Circulatory Arrest Registry Eur. Heart J., July 1, 2003; 24(13): 1204 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Scherrer, H. Xian, K. K. Bucholz, S. A. Eisen, M. J. Lyons, J. Goldberg, M. Tsuang, and W. R. True A Twin Study of Depression Symptoms, Hypertension, and Heart Disease in Middle-Aged Men Psychosom Med, July 1, 2003; 65(4): 548 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Zipes Less Heart Is More Circulation, May 27, 2003; 107(20): 2531 - 2532. [Full Text] [PDF]
|
|
|
|
|
|
M. Firouzi and W. A. Groenewegen Gene polymorphisms and cardiac arrhythmias Europace, January 1, 2003; 5(3): 235 - 242. [Full Text] [PDF]
|
|
|
|
|
|
D. M. Roden The problem, challenge and opportunity of genetic heterogeneity in monogenic diseases predisposing to sudden death J. Am. Coll. Cardiol., July 17, 2002; 40(2): 357 - 359. [Full Text] [PDF]
|
|
|
|
|
|
P. M. Spooner and D. P. Zipes Sudden Death Predictors: An Inflammatory Association Circulation, June 4, 2002; 105(22): 2574 - 2576. [Full Text] [PDF]
|
|
|
|
 |
|
 H. V. Huikuri, A. Castellanos, and R. J. Myerburg Sudden Death Due to Cardiac Arrhythmias N. Engl. J. Med., November 15, 2001; 345(20): 1473 - 1482. [Full Text] [PDF]
|
|
|
|
 |
|
 L. Bathum, L. Christiansen, H. Nybo, K. A. Ranberg, D. Gaist, B. Jeune, N. E. Petersen, J. Vaupel, and K. Christensen Association of Mutations in the Hemochromatosis Gene With Shorter Life Expectancy Arch Intern Med, November 12, 2001; 161(20): 2441 - 2444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.G. Priori, E. Aliot, C. Blomstrom-Lundqvist, L. Bossaert, G. Breithardt, P. Brugada, A.J. Camm, R. Cappato, S.M. Cobbe, C. Di Mario, et al. Task Force on Sudden Cardiac Death of the European Society of Cardiology Eur. Heart J., August 2, 2001; 22(16): 1374 - 1450. [PDF]
|
|
|
|
|
|
P. M. Spooner, C. Albert, E. J. Benjamin, R. Boineau, R. C. Elston, A. L. George Jr, X. Jouven, L. H. Kuller, J. W. MacCluer, E. Marban, et al. Sudden Cardiac Death, Genes, and Arrhythmogenesis : Consideration of New Population and Mechanistic Approaches From a National Heart, Lung, and Blood Institute Workshop, Part II Circulation, May 22, 2001; 103(20): 2447 - 2452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J Myerburg and P. M Spooner Opportunities for sudden death prevention: Directions for new clinical and basic research Cardiovasc Res, May 1, 2001; 50(2): 177 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M Albert and J. N Ruskin Risk stratifiers for sudden cardiac death (SCD) in the community: primary prevention of SCD Cardiovasc Res, May 1, 2001; 50(2): 186 - 196. [Full Text] [PDF]
|
|
|
|
|
|
N. Sotoodehnia, A. Zivin, G. H Bardy, and D. S Siscovick Reducing mortality from sudden cardiac death in the community: lessons from epidemiology and clinical applications research Cardiovasc Res, May 1, 2001; 50(2): 197 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mikkelsson, M. Perola, P. Laippala, A. Penttila, and P. J. Karhunen Glycoprotein IIIa PlA1/A2 polymorphism and sudden cardiac death J. Am. Coll. Cardiol., October 1, 2000; 36(4): 1317 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Siscovick, T. E. Raghunathan, D. Lin, S. Weinmann, P. Arbogast, R. N. Lemaitre, B. M. Psaty, R. Alexander, and L. A. Cobb Influenza Vaccination and the Risk of Primary Cardiac Arrest Am. J. Epidemiol., October 1, 2000; 152(7): 674 - 677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gaeta, M. De Michele, S. Cuomo, P. Guarini, M. C. Foglia, M. G. Bond, and M. Trevisan Arterial Abnormalities in the Offspring of Patients with Premature Myocardial Infarction N. Engl. J. Med., September 21, 2000; 343(12): 840 - 846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Sullivan Iron and the Genetics of Cardiovascular Disease Circulation, September 21, 1999; 100(12): 1260 - 1263. [Full Text] [PDF]
|
|
|
|
|
|
X. Jouven, M. Desnos, C. Guerot, and P. Ducimetiere Predicting Sudden Death in the Population : The Paris Prospective Study I Circulation, April 20, 1999; 99(15): 1978 - 1983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zureik, P.-J. Touboul, C. Bonithon-Kopp, D. Courbon, I. Ruelland, and P. Ducimetiere Differential Association of Common Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaques With Parental History of Premature Death From Coronary Heart Disease : The EVA Study Arterioscler. Thromb. Vasc. Biol., February 1, 1999; 19(2): 366 - 371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Zipes and H. J. J. Wellens Sudden Cardiac Death Circulation, November 24, 1998; 98(21): 2334 - 2351. [Full Text] [PDF]
|
|
|
|
 |
|
 Family History as a Risk Factor for Cardiac Arrest Journal Watch Cardiology, February 17, 1998; 1998(217): 2 - 2. [Full Text]
|
|