From the Copenhagen Male Study, Epidemiological Research Unit (J.J.,
H.O.H., P.S., F.G.), Copenhagen University Hospital, and the Glostrup
Population Studies (H.O.H.), Department of Internal Medicine C, Glostrup
University Hospital, Denmark.
Correspondence to Dr Jørgen Jeppesen, The Copenhagen Male Study, Epidemiological Research Unit, Copenhagen University Hospital, Bispebjerg, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
Background—The role of
triglycerides as a risk factor of ischemic heart
disease (IHD) remains controversial. For the present study, we
examined the relation between fasting triglycerides and
risk of IHD in the Copenhagen Male Study.
Methods and Results—Baseline measurements of fasting lipids and
other IHD risk factors were obtained for 2906 white men (age range, 53
to 74 years) who were initially free of overt
cardiovascular disease. During an 8-year follow-up
period, 229 men had a first IHD event. Crude cumulative incidence rates
of IHD were 4.6% for the lowest, 7.7% for the middle, and 11.5% for
the highest third of triglyceride levels (P
for trend <.001). Compared with the lowest third level and adjusted
for age, body mass index, alcohol, smoking, physical activity,
hypertension, non–insulin-dependent diabetes mellitus, social class,
and LDL and HDL cholesterol, relative risks of IHD (95%
confidence interval) were 1.5 (1.0 to 2.3; P=.05) and
2.2 (1.4 to 3.4; P<.001) for the middle and highest
third of triglyceride levels, respectively. When
triglyceride levels were stratified by HDL
cholesterol levels (triglyceride third
multiplied by HDL cholesterol third), a clear gradient of
risk of IHD was found with increasing triglyceride levels
within each level of HDL cholesterol, including high HDL
cholesterol level, which are thought to provide protection
against IHD.
Conclusions—In middle-aged and elderly white men, a high level of
fasting triglycerides is a strong risk factor of IHD
independent of other major risk factors, including HDL
cholesterol.
© 1998 American Heart Association, Inc.
Clinical Investigation and Reports
Triglyceride Concentration and Ischemic Heart Disease
An Eight-Year Follow-up in the Copenhagen Male Study
Key Words: coronary disease • lipids • lipoproteins • risk factors
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 P. Amarenco Hypercholeste |