(Circulation. 1997;96:1386-1389.)
© 1997 American Heart Association, Inc.
Articles |
Amiodarone Inhibits Production of Tumor Necrosis Factor-
by Human Mononuclear Cells
A Possible Mechanism for its Effect in Heart Failure
From the Department of Cardiovascular Medicine, Kyoto University, Japan.
Correspondence to Akira Matsumori, MD, PhD, Department of Cardiovascular Medicine, Kyoto University, 54 Kawaracho Shogoin, Sakyo-ku, Kyoto 606, Japan. E-mail amat{at}kuhp.kyoto-u.ac.jp
Background Recent studies suggest that
cytokines such as tumor necrosis factor (TNF)- and
interleukins (ILs) are capable of modulating
cardiovascular function and that drugs used in the
treatment of heart failure have various modulatory effects on the
production of cytokines. This study was performed to
examine the effects of amiodarone (a drug shown to be
beneficial in some patients suffering from heart failure) versus other
antiarrhythmic agents on the production of cytokines in
vitro.
Methods and Results Human peripheral blood
mononuclear cells (PBMC) were obtained from healthy volunteers. PBMC
were cultured with 0.1, 1, and 10 µmol/L of amiodarone,
quinidine, disopyramide, and lidocaine in the presence of
lipopolysaccharide. After 24 hours' incubation, TNF-,
IL-1ß, and IL-6 were measured in the culture supernatants by an
enzyme-linked immunosorbent assay. TNF- production was
inhibited by amiodarone but stimulated by quinidine in a
concentration-dependent manner. Disopyramide and lidocaine
tended to increase TNF- production. IL-6 production
was decreased by amiodarone in all concentrations but was
increased significantly by disopyramide. Modulation of
IL-1ß production by amiodarone was biphasic and
significantly increased at a concentration of 10 µmol/L.
Conclusions These previously unrecognized immunomodulatory effects of amiodarone may contribute to its beneficial effects in heart failure patients.
Key Words: amiodarone • heart failure • immune system • interleukins
This article has been cited by other articles:
 |
|
 |
|
  H. Tachikawa, M. Kodama, K. Watanabe, T. Takahashi, M. Ma, T. Kashimura, M. Ito, S. Hirono, Y. Okura, K. Kato, et al. Amiodarone Improves Cardiac Sympathetic Nerve Function to Hold Norepinephrine in the Heart, Prevents Left Ventricular Remodeling, and Improves Cardiac Function in Rat Dilated Cardiomyopathy Circulation, February 22, 2005; 111(7): 894 - 899. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Datta, T. Waghray, M. Torres, and S. Glusman Amiodarone Decreases Heat, Cold, and Mechanical Hyperalgesia in a Rat Model of Neuropathic Pain Anesth. Analg., January 1, 2004; 98(1): 178 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Choo, B. Huiskes, J. Jones, S. Fabbri, L. A. Hawkins, K. Chatterjee, T. De Marco, and J. T. Heywood Amiodarone Rescue Therapy for Severe Decompensated Heart Failure Initially Unsuitable for {beta}-Blockers Journal of Cardiovascular Pharmacology and Therapeutics, September 1, 2003; 8(3): 187 - 192. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Deswal, N. J. Petersen, A. M. Feldman, B. G. White, and D. L. Mann Effects of Vesnarinone on Peripheral Circulating Levels of Cytokines and Cytokine Receptors in Patients With Heart Failure : A Report From the Vesnarinone Trial Chest, August 1, 2001; 120(2): 453 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Filippatos, B. D. Uhal, H. Tsutsui, T. Ide, S. Kinugawa, A. Takeshita, and H. Utsumi Effects of Amiodarone on Heart Cells Response Circulation, November 14, 2000; 102 (20): e170 - e170. [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Feldman, A. Combes, D. Wagner, T. Kadakomi, T. Kubota, Y. You Li, and C. McTiernan The role of tumor necrosis factor in the pathophysiology of heart failure J. Am. Coll. Cardiol., March 1, 2000; 35(3): 537 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Tendera and H Wysocki TNF-{alpha} in patients with chronic failure is not only a proinflammatory cytokine Eur. Heart J., October 2, 1999; 20(20): 1445 - 1446. [PDF]
|
|
|
|
 |
|
 S. Sasayama, A. Matsumori, and Y. Kihara New insights into the pathophysiological role for cytokines in heart failure Cardiovasc Res, June 1, 1999; 42(3): 557 - 564. [Full Text] [PDF]
|
|
|
|
|
|
C. Kawai From Myocarditis to Cardiomyopathy: Mechanisms of Inflammation and Cell Death : Learning From the Past for the Future Circulation, March 2, 1999; 99(8): 1091 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Meldrum Tumor necrosis factor in the heart Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1998; 274(3): R577 - R595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Wagner, C. McTiernan, V. J. Sanders, and A. M. Feldman Adenosine Inhibits Lipopolysaccharide-Induced Secretion of Tumor Necrosis Factor-{alpha} in the Failing Human Heart Circulation, February 17, 1998; 97(6): 521 - 524. [Abstract] [Full Text] [PDF]
|
|