(Circulation. 1997;96:1102-1108.)
© 1997 American Heart Association, Inc.
Articles |
Prospective Study of Hemostatic Factors and Incidence of Coronary Heart Disease
The Atherosclerosis Risk in Communities (ARIC) Study
From the Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis (A.R.F.); Division of Hematology, University of Texas Medical School, Houston (K.K.W.); Collaborative Studies Coordinating Center, Chapel Hill, NC (W.D.R., L.E.C.); and NHLBI, NIH, Bethesda, Md (A.R.S.).
Correspondence to Dr Aaron R. Folsom, Division of Epidemiology, School of Public Health, University of Minnesota, Suite 300, 1300 S 2nd St, Minneapolis, MN 55454-1015. E-mail folsom{at}epivax.epi.umn.edu
Background Although hemostatic factors contribute to acute coronary syndromes and atherogenesis, few studies have prospectively evaluated the association between multiple hemostatic factors and coronary heart disease incidence.
Methods and Results The Atherosclerosis
Risk in Communities Study recruited 14 477 adults from 45 to 64 years
of age who were initially free of coronary heart disease.
Coronary disease risk factors and several plasma hemostatic
factors were measured, and incidence of coronary heart disease
was ascertained during an average follow-up of 5.2 years. Age-, race-,
and field center–adjusted relative risks of coronary heart
disease were significantly elevated (P
.05) per higher
value of fibrinogen (relative risk: men, 1.76; women, 1.54), white
blood cell count (men, 1.68; women, 2.23), factor VIII coagulant
activity (women, 1.25), and von Willebrand factor antigen (men,
1.20; women, 1.18). Adjustment for other risk factors attenuated these
associations for fibrinogen (adjusted relative risk: men, 1.48; women,
1.21), and it eliminated the white blood cell count, factor VIII, and
von Willebrand factor associations, consistent with the
other risk factors either confounding or partly operating through their
effects on the hemostatic variables. Adjusted standardized relative
risks of total mortality, ranging from 1.13 to 1.37, were also elevated
(P<.05) in relation to these four factors. There was no
association of coronary disease incidence with factor VII,
protein C, antithrombin III, or platelet count.
Conclusions Elevated levels of fibrinogen, white blood cell count, factor VIII, and von Willebrand factor are risk factors and may play causative roles in coronary heart disease. However, their measurement in healthy adults appears to add little to prediction of coronary events beyond that of more established risk factors.
Key Words: coagulation • coronary disease • von Willebrand factor • fibrinogen • leukocytes
This article has been cited by other articles:
 |
|
 |
|
  A. M. Kucharska-Newton, D. J. Couper, J. S. Pankow, R. J. Prineas, T. D. Rea, N. Sotoodehnia, A. Chakravarti, A. R. Folsom, D. S. Siscovick, and W. D. Rosamond Hemostasis, Inflammation, and Fatal and Nonfatal Coronary Heart Disease: Long-Term Follow-Up of the Atherosclerosis Risk in Communities (ARIC) Cohort Arterioscler Thromb Vasc Biol, December 1, 2009; 29(12): 2182 - 2190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Helfand, D. I. Buckley, M. Freeman, R. Fu, K. Rogers, C. Fleming, and L. L. Humphrey Emerging Risk Factors for Coronary Heart Disease: A Summary of Systematic Reviews Conducted for the U.S. Preventive Services Task Force Ann Intern Med, October 6, 2009; 151(7): 496 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Seehaus, K. Shahzad, M. Kashif, I. A. Vinnikov, M. Schiller, H. Wang, T. Madhusudhan, V. Eckstein, A. Bierhaus, F. Bea, et al. Hypercoagulability Inhibits Monocyte Transendothelial Migration Through Protease-Activated Receptor-1-, Phospholipase-C{beta}-, Phosphoinositide 3-Kinase-, and Nitric Oxide-Dependent Signaling in Monocytes and Promotes Plaque Stability Circulation, September 1, 2009; 120(9): 774 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Chuang, C.-H. Bai, W.-H. Chen, L.-M. Lien, and W.-H. Pan Fibrinogen Independently Predicts the Development of Ischemic Stroke in a Taiwanese Population: CVDFACTS Study Stroke, May 1, 2009; 40(5): 1578 - 1584. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ferraresi, G. Campo, G. Marchetti, M. Pinotti, M. Valgimigli, D. Gemmati, R. Ferrari, and F. Bernardi Temporal and Genotype-Driven Variation of Factor VII Levels in Patients With Acute Myocardial Infarction Clinical and Applied Thrombosis/Hemostasis, February 1, 2009; 15(1): 119 - 122. [PDF]
|
|
|
|
|
|
B. K. Mahmoodi, J.-L. P. Brouwer, N. J.G.M. Veeger, and J. van der Meer Hereditary Deficiency of Protein C or Protein S Confers Increased Risk of Arterial Thromboembolic Events at a Young Age: Results From a Large Family Cohort Study Circulation, October 14, 2008; 118(16): 1659 - 1667. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Liew, J. J. Wang, P. Mitchell, and T. Y. Wong Retinal Vascular Imaging: A New Tool in Microvascular Disease Research Circ Cardiovasc Imaging, September 1, 2008; 1(2): 156 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tholstrup, M. Raff, E. M. Straarup, P. Lund, S. Basu, and J. M. Bruun An Oil Mixture with Trans-10, Cis-12 Conjugated Linoleic Acid Increases Markers of Inflammation and in Vivo Lipid Peroxidation Compared with Cis-9, Trans-11 Conjugated Linoleic Acid in Postmenopausal Women J. Nutr., August 1, 2008; 138(8): 1445 - 1451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Sturgeon, A. R. Folsom, W.T. Longstreth Jr, E. Shahar, W. D. Rosamond, and M. Cushman Hemostatic and Inflammatory Risk Factors for Intracerebral Hemorrhage in a Pooled Cohort Stroke, August 1, 2008; 39(8): 2268 - 2273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R A Pollitt, J S Kaufman, K M Rose, A V Diez-Roux, D Zeng, and G Heiss Cumulative life course and adult socioeconomic status and markers of inflammation in adulthood J Epidemiol Community Health, June 1, 2008; 62(6): 484 - 491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. O. Spiel, J. C. Gilbert, and B. Jilma Von Willebrand Factor in Cardiovascular Disease: Focus on Acute Coronary Syndromes Circulation, March 18, 2008; 117(11): 1449 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Biondi and D. S. Cooper The Clinical Significance of Subclinical Thyroid Dysfunction Endocr. Rev., February 1, 2008; 29(1): 76 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Reich, G. Heiss, L. L. Boland, A. T. Hirsch, K. Wu, and A. R. Folsom Ankle brachial index and hemostatic markers in the Atherosclerosis Risk in Communities (ARIC) study cohort Vascular Medicine, November 1, 2007; 12(4): 267 - 273. [Abstract] [PDF]
|
|
|
|
|
|
F. Bilora, E. Zanon, A. Casonato, A. Bertomoro, F. Petrobelli, M. Cavraro, E. Campagnolo, and A. Girolami Type IIB von Willebrand Disease: Role of Qualitative Defects in Atherosclerosis and Endothelial Dysfunction Clinical and Applied Thrombosis/Hemostasis, October 1, 2007; 13(4): 384 - 390. [Abstract] [PDF]
|
|
|
|
|
|
N. Inami, S. Nomura, Y. Kimura, K. Yamada, H. Nakamori, N. Takahashi, S. Fukuhara, and T. Iwasaka Evaluation of Platelet and Leukocyte Functions in Effort Angina Patients Using High Shear Conditions in Small-Sized Collagen Bead Columns Clinical and Applied Thrombosis/Hemostasis, October 1, 2007; 13(4): 428 - 431. [Abstract] [PDF]
|
|
|
|
 |
|
 K. G. Moulakakis, G. Sfyroeras, P. Pavlidis, N. Besias, D. Maras, and V. Andrikopoulos Hypercoagulable State Due to Alcohol-Paracetamol Syndrome Producing Acute Limb Ischemia Vascular and Endovascular Surgery, September 1, 2007; 41(4): 362 - 365. [Abstract] [PDF]
|
|
|
|
 |
|
 M. Atteritano, H. Marini, L. Minutoli, F. Polito, A. Bitto, D. Altavilla, S. Mazzaferro, R. D'Anna, M. L. Cannata, A. Gaudio, et al. Effects of the Phytoestrogen Genistein on Some Predictors of Cardiovascular Risk in Osteopenic, Postmenopausal Women: A Two-Year Randomized, Double-Blind, Placebo-Controlled Study J. Clin. Endocrinol. Metab., August 1, 2007; 92(8): 3068 - 3075. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M S O'Neill, A Veves, J A Sarnat, A Zanobetti, D R Gold, P A Economides, E S Horton, and J Schwartz Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility Occup. Environ. Med., June 1, 2007; 64(6): 373 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Tzoulaki, G. D. Murray, A. J. Lee, A. Rumley, G. D.O. Lowe, and F. G. R. Fowkes Relative Value of Inflammatory, Hemostatic, and Rheological Factors for Incident Myocardial Infarction and Stroke: The Edinburgh Artery Study Circulation, April 24, 2007; 115(16): 2119 - 2127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Barac, U. Campia, and J. A. Panza Methods for Evaluating Endothelial Function in Humans Hypertension, April 1, 2007; 49(4): 748 - 760. [Full Text] [PDF]
|
|
|
|
|
|
L. M. Steffen, A. R. Folsom, M. Cushman, D. R. Jacobs Jr, and W. D. Rosamond Greater Fish, Fruit, and Vegetable Intakes Are Related to Lower Incidence of Venous Thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology Circulation, January 16, 2007; 115(2): 188 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Campo, M. Valgimigli, P. Ferraresi, P. Malagutti, M. Baroni, C. Arcozzi, D. Gemmati, G. Percoco, G. Parrinello, R. Ferrari, et al. Tissue Factor and Coagulation Factor VII Levels During Acute Myocardial Infarction: Association With Genotype and Adverse Events Arterioscler Thromb Vasc Biol, December 1, 2006; 26(12): 2800 - 2806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Shankar, J. J. Wang, E. Rochtchina, and P. Mitchell Positive Association Between Plasma Fibrinogen Level and Incident Hypertension Among Men: Population-Based Cohort Study Hypertension, December 1, 2006; 48(6): 1043 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sato, H. Iso, H. Noda, A. Kitamura, H. Imano, M. Kiyama, T. Ohira, T. Okada, M. Yao, T. Tanigawa, et al. Plasma Fibrinogen Concentrations and Risk of Stroke and Its Subtypes Among Japanese Men and Women Stroke, October 1, 2006; 37(10): 2488 - 2492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Papazafiropoulou, N. Tentolouris, I. Moyssakis, D. Perrea, and N. Katsilambros The Potential Effect of Some Newer Risk Factors for Atherosclerosis on Aortic Distensibility in Subjects With and Without Type 2 Diabetes Diabetes Care, August 1, 2006; 29(8): 1926 - 1928. [Full Text] [PDF]
|
|
|
|
|
|
S. Mora, N. Rifai, J. E. Buring, and P. M Ridker Additive Value of Immunoassay-Measured Fibrinogen and High-Sensitivity C-Reactive Protein Levels for Predicting Incident Cardiovascular Events Circulation, August 1, 2006; 114(5): 381 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Fibrinogen Studies Collaboration* Plasma Fibrinogen Level and the Risk of Major Cardiovascular Diseases and Nonvascular Mortality: An Individual Participant Meta-analysis JAMA, October 12, 2005; 294(14): 1799 - 1809. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Kawut, E. M. Horn, K. K. Berekashvili, A. C. Widlitz, E. B. Rosenzweig, and R. J. Barst von Willebrand Factor Independently Predicts Long-term Survival in Patients With Pulmonary Arterial Hypertension Chest, October 1, 2005; 128(4): 2355 - 2362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Woodward, G. D.O. Lowe, D. J. Campbell, S. Colman, A. Rumley, J. Chalmers, B. C. Neal, A. Patel, A. J. Jenkins, B. E. Kemp, et al. Associations of Inflammatory and Hemostatic Variables With the Risk of Recurrent Stroke Stroke, October 1, 2005; 36(10): 2143 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.H. L. Kao, W.-C. Hsueh, D. L. Rainwater, D. H. O'Leary, I. G. Imumorin, M. P. Stern, and B. D. Mitchell Family History of Type 2 Diabetes Is Associated With Increased Carotid Artery Intimal-Medial Thickness in Mexican Americans Diabetes Care, August 1, 2005; 28(8): 1882 - 1889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Teede, F. S. Dalais, D. Kotsopoulos, B. P. McGrath, E. Malan, T. E. Gan, and R. E. Peverill Dietary Soy Containing Phytoestrogens Does Not Activate the Hemostatic System in Postmenopausal Women J. Clin. Endocrinol. Metab., April 1, 2005; 90(4): 1936 - 1941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Margolis, J. E. Manson, P. Greenland, R. J. Rodabough, P. F. Bray, M. Safford, R. H. Grimm Jr, B. V. Howard, A. R. Assaf, R. Prentice, et al. Leukocyte Count as a Predictor of Cardiovascular Events and Mortality in Postmenopausal Women: The Women's Health Initiative Observational Study Arch Intern Med, March 14, 2005; 165(5): 500 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Madjid, I. Awan, J. T. Willerson, and S. W. Casscells Leukocyte count and coronary heart disease: Implications for risk assessment J. Am. Coll. Cardiol., November 16, 2004; 44(10): 1945 - 1956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Folsom, G. W. Evans, J. J. Carr, A. E. Stillman, and Atherosclerosis Risk in Communities (ARIC) Study I Association of Traditional and Nontraditional Cardiovascular Risk Factors with Coronary Artery Calcification Angiology, November 1, 2004; 55(6): 613 - 623. [Abstract] [PDF]
|
|
|
|
|
|
S. Sela, R. Mazor, M. Amsalam, C. Yagil, Y. Yagil, and B. Kristal Primed Polymorphonuclear Leukocytes, Oxidative Stress, and Inflammation Antecede Hypertension in the Sabra Rat Hypertension, November 1, 2004; 44(5): 764 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Rothwell, S. C. Howard, D. A. Power, S. A. Gutnikov, A. Algra, J. van Gijn, T. G. Clark, M. F.G. Murphy, C. P. Warlow, and for the Cerebrovascular Cohort Studies Collaborati Fibrinogen Concentration and Risk of Ischemic Stroke and Acute Coronary Events in 5113 Patients With Transient Ischemic Attack and Minor Ischemic Stroke Stroke, October 1, 2004; 35(10): 2300 - 2305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D.O. Lowe, A. Rumley, A. D. McMahon, I. Ford, D. St. J. O'Reilly, C. J. Packard, and for the West of Scotland Coronary Prevention Study Interleukin-6, Fibrin D-Dimer, and Coagulation Factors VII and XIIa in Prediction of Coronary Heart Disease Arterioscler Thromb Vasc Biol, August 1, 2004; 24(8): 1529 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.W.G Yarnell, C.C Patterson, P.M Sweetnam, and G.D.O Lowe Haemostatic/inflammatory markers predict 10-year risk of IHD at least as well as lipids: the Caerphilly collaborative studies Eur. Heart J., June 2, 2004; 25(12): 1049 - 1056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.A. Paramo, J. Orbe, O. Beloqui, A. Benito, I. Colina, E. Martinez-Vila, and J. Diez Prothrombin Fragment 1+2 Is Associated With Carotid Intima-Media Thickness in Subjects Free of Clinical Cardiovascular Disease Stroke, May 1, 2004; 35(5): 1085 - 1089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.E. Morange, C. Simon, M.C. Alessi, G. Luc, D. Arveiler, J. Ferrieres, P. Amouyel, A. Evans, P. Ducimetiere, I. Juhan-Vague, et al. Endothelial Cell Markers and the Risk of Coronary Heart Disease: The Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study Circulation, March 23, 2004; 109(11): 1343 - 1348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Haim, V. Boyko, U. Goldbourt, A. Battler, and S. Behar Predictive Value of Elevated White Blood Cell Count in Patients With Preexisting Coronary Heart Disease: The Bezafibrate Infarction Prevention Study Arch Intern Med, February 23, 2004; 164(4): 433 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Voetsch and J. Loscalzo Genetic Determinants of Arterial Thrombosis Arterioscler Thromb Vasc Biol, February 1, 2004; 24(2): 216 - 229. [Abstract] [Full Text]
|
|
|
|
 |
|
 V. Afshar-Kharghan, N. Matijevic-Aleksic, C. Ahn, E. Boerwinkle, K. K. Wu, and J. A. Lopez The variable number of tandem repeat polymorphism of platelet glycoprotein Ib{alpha} and risk of coronary heart disease Blood, February 1, 2004; 103(3): 963 - 965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H S Gurm, D L Bhatt, A M Lincoff, J E Tcheng, D J Kereiakes, N S Kleiman, G Jia, and E J Topol Impact of preprocedural white blood cell count on long term mortality after percutaneous coronary intervention: insights from the EPIC, EPILOG, and EPISTENT trials Heart, October 1, 2003; 89(10): 1200 - 1204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Tousoulis, G Davies, C Stefanadis, P Toutouzas, and J A Ambrose Inflammatory and thrombotic mechanisms in coronary atherosclerosis Heart, September 1, 2003; 89(9): 993 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Tracy Thrombin, Inflammation, and Cardiovascular Disease: An Epidemiologic Perspective Chest, September 1, 2003; 124 (2009): 49S - 57S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. E. Finnegan, D. Howarth, A. M. Minihane, S. Kew, G. J. Miller, P. C. Calder, and C. M. Williams Plant and Marine Derived (n-3) Polyunsaturated Fatty Acids Do Not Affect Blood Coagulation and Fibrinolytic Factors in Moderately Hyperlipidemic Humans J. Nutr., July 1, 2003; 133(7): 2210 - 2213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Yamashita, Y. Asada, H. Sugimura, H. Yamamoto, K. Marutsuka, K. Hatakeyama, S. Tamura, Y. Ikeda, and A. Sumiyoshi Contribution of von Willebrand Factor to Thrombus Formation on Neointima of Rabbit Stenotic Iliac Artery Under High Blood-Flow Velocity Arterioscler Thromb Vasc Biol, June 1, 2003; 23(6): 1105 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tholstrup, G. J Miller, A. Bysted, and B. Sandstrom Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1125 - 1132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Heper and M. Bayraktaroglu The Importance of von Willebrand Factor Level and Heart Rate Changes in Acute Coronary Syndromes: A Comparison with Chronic Ischemic Conditions Angiology, May 1, 2003; 54(3): 287 - 299. [Abstract] [PDF]
|
|
|
|
|
|
K. K. Wu, N. Aleksic, C. M. Ballantyne, C. Ahn, H. Juneja, and E. Boerwinkle Interaction Between Soluble Thrombomodulin and Intercellular Adhesion Molecule-1 in Predicting Risk of Coronary Heart Disease Circulation, April 8, 2003; 107(13): 1729 - 1732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Burger and D. D. Wagner Platelet P-selectin facilitates atherosclerotic lesion development Blood, April 1, 2003; 101(7): 2661 - 2666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Soria, L. Almasy, J. C. Souto, A. Buil, E. Martinez-Sanchez, J. Mateo, M. Borrell, W. H. Stone, M. Lathrop, J. Fontcuberta, et al. A new locus on chromosome 18 that influences normal variation in activated protein C resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility Blood, January 1, 2003; 101(1): 163 - 167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kittel, F. Leynen, M. Stam, M. Dramaix, P. de Smet, R. Mak, G. De Backer, and M. Kornitzer Job conditions and fibrinogen in 14226 Belgian workers. The Belstress study Eur. Heart J., December 1, 2002; 23(23): 1841 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Stangl, G. Baumann, and K. Stangl Coronary atherogenic risk factors in women Eur. Heart J., November 2, 2002; 23(22): 1738 - 1752. [Full Text] [PDF]
|
|
|
|
|
|
P.H. Whincup, J. Danesh, M. Walker, L. Lennon, A. Thomson, P. Appleby, A. Rumley, and G.D.O. Lowe von Willebrand factor and coronary heart disease. Prospective study and meta-analysis Eur. Heart J., November 2, 2002; 23(22): 1764 - 1770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Bild, D. A. Bluemke, G. L. Burke, R. Detrano, A. V. Diez Roux, A. R. Folsom, P. Greenland, D. R. JacobsJr., R. Kronmal, K. Liu, et al. Multi-Ethnic Study of Atherosclerosis: Objectives and Design Am. J. Epidemiol., November 1, 2002; 156(9): 871 - 881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lindhoff-Last, B. Wenning, M. Stein, F. Gerdsen, R. Bauersachs, and R. Wagnert Risk Factors and Long-term Follow-up of Patients with the Immune Type of Heparin-Induced Thrombocytopenia Clinical and Applied Thrombosis/Hemostasis, October 1, 2002; 8(4): 347 - 352. [Abstract] [PDF]
|
|
|
|
|
|
N. M. Ananyeva, D. V. Kouiavskaia, M. Shima, and E. L. Saenko Intrinsic pathway of blood coagulation contributes to thrombogenicity of atherosclerotic plaque Blood, May 29, 2002; 99(12): 4475 - 4485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Braunstein, D. W. Kershner, P. Bray, G. Gerstenblith, S. P. Schulman, W. S. Post, and R. S. Blumenthal Interaction of Hemostatic Genetics With Hormone Therapy : New Insights To Explain Arterial Thrombosis in Postmenopausal Women Chest, March 1, 2002; 121(3): 906 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Olsen, E. M. Bladbjerg, A. K. Hansen, and P. Marckmann A High Fat Meal Activates Blood Coagulation Factor VII in Rats J. Nutr., March 1, 2002; 132(3): 347 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E Roeters van Lennep, H.T. Westerveld, D.W. Erkelens, and E. E van der Wall Risk factors for coronary heart disease: implications of gender Cardiovasc Res, February 15, 2002; 53(3): 538 - 549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Aleksic, C. Ahn, Y.-W. Wang, H. Juneja, A. R. Folsom, E. Boerwinkle, and K. K. Wu Factor XIIIA Val34Leu Polymorphism Does Not Predict Risk of Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study Arterioscler Thromb Vasc Biol, February 1, 2002; 22(2): 348 - 352. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Salomaa, V. Rasi, S. Kulathinal, E. Vahtera, M. Jauhiainen, C. Ehnholm, and J. Pekkanen Hemostatic Factors as Predictors of Coronary Events and Total Mortality: The FINRISK '92 Hemostasis Study Arterioscler Thromb Vasc Biol, February 1, 2002; 22(2): 353 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pahor, L. V. Franse, S. R. Deitcher, W. C. Cushman, K. C. Johnson, R. I. Shorr, K. Kottke-Marchant, R. P. Tracy, G. W. Somes, and W. B. Applegate Fosinopril Versus Amlodipine Comparative Treatments Study: A Randomized Trial to Assess Effects on Plasminogen Activator Inhibitor-1 Circulation, January 29, 2002; 105(4): 457 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Borawski and M. Mysiwiec Effects of Recombinant Erythropoietin Therapy on Circulating Endothelial Markers in Hemodialysis Patients Clinical and Applied Thrombosis/Hemostasis, January 1, 2002; 8(1): 77 - 84. [Abstract] [PDF]
|
|
|
|
 |
|
 J. D Mills and P. J Grant Insulin resistance, haemostatic factors and cardiovascular risk The British Journal of Diabetes & Vascular Disease, January 1, 2002; 2(1): 19 - 26. [Abstract] [PDF]
|
|
|
|
|
|
V. Palmieri, A. Celentano, M. J. Roman, G. de Simone, M. R. Lewis, L. Best, E. T. Lee, D. C. Robbins, B. V. Howard, and R. B. Devereux Fibrinogen and Preclinical Echocardiographic Target Organ Damage: The Strong Heart Study Hypertension, November 1, 2001; 38(5): 1068 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Lee, A. R. Folsom, F. J. Nieto, L. E. Chambless, E. Shahar, and D. A. Wolfe White Blood Cell Count and Incidence of Coronary Heart Disease and Ischemic Stroke and Mortality from Cardiovascular Disease in African-American and White Men and Women: Atherosclerosis Risk in Communities Study Am. J. Epidemiol., October 15, 2001; 154(8): 758 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Borawski, B. Naumnik, K. Pawlak, and M. Mysliwiec Endothelial dysfunction marker von Willebrand factor antigen in haemodialysis patients: associations with pre-dialysis blood pressure and the acute phase response Nephrol. Dial. Transplant., July 1, 2001; 16(7): 1442 - 1447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yano, J. S. Grove, R. Chen, B. L. Rodriguez, J. D. Curb, and R. P. Tracy Plasma Fibrinogen as a Predictor of Total and Cause-Specific Mortality in Elderly Japanese-American Men Arterioscler Thromb Vasc Biol, June 1, 2001; 21(6): 1065 - 1070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Kamphuisen, J. C. J. Eikenboom, and R. M. Bertina Elevated Factor VIII Levels and the Risk of Thrombosis Arterioscler Thromb Vasc Biol, May 1, 2001; 21(5): 731 - 738. [Full Text] [PDF]
|
|
|
|
|
|
K. K. Wu, N. Aleksic, C. Ahn, E. Boerwinkle, A. R. Folsom, and H. Juneja Thrombomodulin Ala455Val Polymorphism and Risk of Coronary Heart Disease Circulation, March 13, 2001; 103(10): 1386 - 1389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cushman, J. P. Costantino, R. P. Tracy, K. Song, L. Buckley, J. D. Roberts, and D. N. Krag Tamoxifen and Cardiac Risk Factors in Healthy Women : Suggestion of an Anti-inflammatory Effect Arterioscler Thromb Vasc Biol, February 1, 2001; 21(2): 255 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Geffken, M. Cushman, G. L. Burke, J. F. Polak, P. A. Sakkinen, and R. P. Tracy Association between Physical Activity and Markers of Inflammation in a Healthy Elderly Population Am. J. Epidemiol., February 1, 2001; 153(3): 242 - 250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Cooper, G. J. Miller, K. A. Bauer, J. H. Morrissey, T. W. Meade, D. J. Howarth, S. Barzegar, J. P. Mitchell, and R. D. Rosenberg Comparison of Novel Hemostatic Factors and Conventional Risk Factors for Prediction of Coronary Heart Disease Circulation, December 5, 2000; 102(23): 2816 - 2822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Bladbjerg, A.-M. Munster, P. Marckmann, N. Keller, and J. Jespersen Dietary Factor VII Activation Does Not Increase Plasma Concentrations of Prothrombin Fragment 1+2 in Patients With Stable Angina Pectoris and Coronary Atherosclerosis Arterioscler Thromb Vasc Biol, November 1, 2000; 20(11): 2494 - 2499. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Aleksic, H. Juneja, A. R. Folsom, C. Ahn, E. Boerwinkle, L. E. Chambless, and K. K. Wu Platelet PlA2 Allele and Incidence of Coronary Heart Disease : Results From the Atherosclerosis Risk In Communities (ARIC) Study Circulation, October 17, 2000; 102(16): 1901 - 1905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Girelli, C. Russo, P. Ferraresi, O. Olivieri, M. Pinotti, S. Friso, F. Manzato, A. Mazzucco, F. Bernardi, and R. Corrocher Polymorphisms in the Factor VII Gene and the Risk of Myocardial Infarction in Patients with Coronary Artery Disease N. Engl. J. Med., September 14, 2000; 343(11): 774 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sato, M. Nakamura, M. Iida, Y. Naito, A. Kitamura, T. Okamura, Y. Nakagawa, H. Imano, M. Kiyama, H. Iso, et al. Plasma Fibrinogen and Coronary Heart Disease in Urban Japanese Am. J. Epidemiol., September 1, 2000; 152(5): 420 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. Bielak, G. G. Klee, P. F. Sheedy II, S. T. Turner, R. S. Schwartz, and P. A. Peyser Association of Fibrinogen With Quantity of Coronary Artery Calcification Measured by Electron Beam Computed Tomography Arterioscler Thromb Vasc Biol, September 1, 2000; 20(9): 2167 - 2171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Isasi, T. J. Starc, R. P. Tracy, R. Deckelbaum, L. Berglund, and S. Shea Inverse Association of Physical Fitness with Plasma Fibrinogen Level in Children The Columbia University BioMarkers Study Am. J. Epidemiol., August 1, 2000; 152(3): 212 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Souto, L. Almasy, E. Muniz-Diaz, J. M. Soria, M. Borrell, L. Bayen, J. Mateo, P. Madoz, W. Stone, J. Blangero, et al. Functional Effects of the ABO Locus Polymorphism on Plasma Levels of von Willebrand Factor, Factor VIII, and Activated Partial Thromboplastin Time Arterioscler Thromb Vasc Biol, August 1, 2000; 20(8): 2024 - 2028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Saito, A. R. Folsom, F. L. Brancati, B. B. Duncan, L. E. Chambless, and P. G. McGovern Nontraditional Risk Factors for Coronary Heart Disease Incidence among Persons with Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study Ann Intern Med, July 18, 2000; 133(2): 81 - 91. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Montalescot, J. P. Collet, L. Lison, R.e. Choussat, A. Ankri, E. Vicaut, K. Perlemuter, F. Philippe, G.e. Drobinski, and D. Thomas Effects of various anticoagulant treatments on von Willebrand factor release in unstable angina J. Am. Coll. Cardiol., July 1, 2000; 36(1): 110 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kumari, M. Marmot, and E. Brunner Social Determinants of von Willebrand Factor : The Whitehall II Study Arterioscler Thromb Vasc Biol, July 1, 2000; 20(7): 1842 - 1847. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Klein, A. R. Sharrett, B. E. K. Klein, L. E. Chambless, L. S. Cooper, L. D. Hubbard, and G. Evans Are Retinal Arteriolar Abnormalities Related to Atherosclerosis? : The Atherosclerosis Risk in Communities Study Arterioscler Thromb Vasc Biol, June 1, 2000; 20(6): 1644 - 1650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pinotti, R. Toso, D. Girelli, D. Bindini, P. Ferraresi, M. L. Papa, R. Corrocher, G. Marchetti, and F. Bernardi Modulation of factor VII levels by intron 7 polymorphisms: population and in vitro studies Blood, June 1, 2000; 95(11): 3423 - 3428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Soria, L. Almasy, J. C. Souto, I. Tirado, M. Borell, J. Mateo, S. Slifer, W. Stone, J. Blangero, and J. Fontcuberta Linkage analysis demonstrates that the prothrombin G20210A mutation jointly influences plasma prothrombin levels and risk of thrombosis Blood, May 1, 2000; 95(9): 2780 - 2785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Feng, G. H. Tofler, M. G. Larson, C. J. O’Donnell, I. Lipinska, C. Schmitz, P. A. Sutherland, M. T. Johnstone, J. E. Muller, R. B. D’Agostino, et al. Factor VII Gene Polymorphism, Factor VII Levels, and Prevalent Cardiovascular Disease : The Framingham Heart Study Arterioscler Thromb Vasc Biol, February 1, 2000; 20(2): 593 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Folsom, K. K. Wu, M. Rasmussen, L. E. Chambless, N. Aleksic, and F. J. Nieto Determinants of Population Changes in Fibrinogen and Factor VII Over 6 Years : The Atherosclerosis Risk in Communities (ARIC) Study Arterioscler Thromb Vasc Biol, February 1, 2000; 20(2): 601 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Meigs, M. A. Mittleman, D. M. Nathan, G. H. Tofler, D. E. Singer, P. M. Murphy-Sheehy, I. Lipinska, R. B. D'Agostino, and P. W. F. Wilson Hyperinsulinemia, Hyperglycemia, and Impaired Hemostasis: The Framingham Offspring Study JAMA, January 12, 2000; 283(2): 221 - 228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jager, V. W. M. van Hinsbergh, P. J. Kostense, J. J. Emeis, J. S. Yudkin, G. Nijpels, J. M. Dekker, R. J. Heine, L. M. Bouter, and C. D. A. Stehouwer von Willebrand Factor, C-Reactive Protein, and 5-Year Mortality in Diabetic and Nondiabetic Subjects : The Hoorn Study Arterioscler Thromb Vasc Biol, December 1, 1999; 19(12): 3071 - 3078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cushman, C. Legault, E. Barrett-Connor, M. L. Stefanick, C. Kessler, H. L. Judd, P. A. Sakkinen, and R. P. Tracy Effect of Postmenopausal Hormones on Inflammation-Sensitive Proteins : The Postmenopausal Estrogen/Progestin Interventions (PEPI) Study Circulation, August 17, 1999; 100(7): 717 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Folsom, W. D. Rosamond, E. Shahar, L. S. Cooper, N. Aleksic, F. J. Nieto, M. L. Rasmussen, and K. K. Wu Prospective Study of Markers of Hemostatic Function With Risk of Ischemic Stroke Circulation, August 17, 1999; 100(7): 736 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Mariani, J. Conard, F. Bernardi, R. Bertina, V. V. Garcia, H. Prydz, M. Samama, P. M. Sandset, M. Puopolo, M. V. Ciarla, et al. Oral Contraceptives Highlight the Genotype-Specific Association Between Serum Phospholipids and Activated Factor VII Arterioscler Thromb Vasc Biol, August 1, 1999; 19(8): 2024 - 2028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Tracy, A. M. Arnold, W. Ettinger, L. Fried, E. Meilahn, and P. Savage The Relationship of Fibrinogen and Factors VII and VIII to Incident Cardiovascular Disease and Death in the Elderly : Results From the Cardiovascular Health Study Arterioscler Thromb Vasc Biol, July 1, 1999; 19(7): 1776 - 1783. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Maresca, A. Di Blasio, R. Marchioli, and G. Di Minno Measuring Plasma Fibrinogen to Predict Stroke and Myocardial Infarction : An Update Arterioscler Thromb Vasc Biol, June 1, 1999; 19(6): 1368 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Wamala, M. A. Murray, M. Horsten, M. Eriksson, K. Schenck-Gustafsson, A. Hamsten, A. Silveira, and K. Orth-Gomer Socioeconomic Status and Determinants of Hemostatic Function in Healthy Women Arterioscler Thromb Vasc Biol, March 1, 1999; 19(3): 485 - 492. [Abstract] [Full Text] [PDF]
|
|