(Circulation. 1997;96:3587-3592.)
© 1997 American Heart Association, Inc.
Articles |
Intimal Hyperplasia After Balloon Injury Is Attenuated by Blocking Selectins
From the Cardiology Section, Tulane University Medical Center, New Orleans, La.
Correspondence to Alan N. Tenaglia, MD, Tulane University Medical Center, School of Medicine, Department of Medicine, Cardiology Section SL-48, 1430 Tulane Ave, New Orleans, LA 70112-2699. E-mail atenagl{at}tmc.tulane.edu
Background Cell adhesion molecules facilitate the adherence of platelets and leukocytes to the vascular endothelium in response to injury. Restenosis after balloon angioplasty is thought to represent the response to vascular injury. The role of cell adhesion in this process is unclear.
Methods and Results This study was performed in New Zealand White rabbits that underwent balloon angioplasty of the iliac artery. Expression of the cell adhesion molecule E-selectin on endothelium was determined by immunohistochemistry and increased at 6 hours with a peak expression 24 to 48 hours after balloon injury, returning to baseline by 1 week. The expression of L-selectin on circulating leukocytes, measured by flow cytometry, was significantly increased at 48 hours, with return to baseline by 1 week. In seven animals, the selectins were blocked with an analogue of sialyl-LewisX given as an IV bolus of 10 mg/kg followed by 2 mg · kg-1 · h-1 IP infusion for 7 days. After 4 weeks, compared with control animals, the study group had a larger lumen area (57.7 versus 44.7 mm2, P<.05), smaller intima area (9.0 versus 19.2 mm2, P<.01), smaller intima/media ratio (0.4 versus 1.0, P<.01), and a smaller percent area stenosis (15.6% versus 34.3%, P<.01).
Conclusions The cell adhesion molecules E-selectin and L-selectin are expressed after balloon injury. Blockade of the selectins has a favorable effect on the response to vascular injury.
Key Words: angioplasty • balloon • adhesion molecules • restenosis
This article has been cited by other articles:
 |
|
 |
|
  G. Brevetti, V. Schiano, and M. Chiariello Cellular adhesion molecules and peripheral arterial disease Vascular Medicine, February 1, 2006; 11(1): 39 - 47. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Yanaba, K. Komura, M. Horikawa, Y. Matsushita, K. Takehara, and S. Sato P-selectin glycoprotein ligand-1 is required for the development of cutaneous vasculitis induced by immune complex deposition J. Leukoc. Biol., August 1, 2004; 76(2): 374 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Yanaba, K Takehara, and S Sato Serum concentrations of soluble P-selectin glycoprotein ligand-1 are increased in patients with systemic sclerosis: association with lower frequency of pulmonary fibrosis Ann Rheum Dis, May 1, 2004; 63(5): 583 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Colombo and G. Sangiorgi The monocyte: the key in the lock to reduce stent hyperplasia? J. Am. Coll. Cardiol., January 7, 2004; 43(1): 24 - 26. [Full Text] [PDF]
|
|
|
|
 |
|
 J. P.G Sluijter, M. B Smeets, E. Velema, G. Pasterkamp, and D. P.V de Kleijn Increased collagen turnover is only partly associated with collagen fiber deposition in the arterial response to injury Cardiovasc Res, January 1, 2004; 61(1): 186 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takeuchi, K. Ohmori, I. Kondo, A. Oshita, K. Shinomiya, Y. Yu, Y. Takagi, K. Mizushige, K. Kangawa, and M. Kohno Potentiation of C-type natriuretic peptide with ultrasound and microbubbles to prevent neointimal formation after vascular injury in rats Cardiovasc Res, April 1, 2003; 58(1): 231 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Roque, W. J.H. Kim, M. Gazdoin, A. Malik, E. D. Reis, J. T. Fallon, J. J. Badimon, I. F. Charo, and M. B. Taubman CCR2 Deficiency Decreases Intimal Hyperplasia After Arterial Injury Arterioscler. Thromb. Vasc. Biol., April 1, 2002; 22(4): 554 - 559. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.-i. Okamoto, T. Couse, H. De Leon, J. Vinten-Johansen, R. B. Goodman, N. A. Scott, and J. N. Wilcox Perivascular Inflammation After Balloon Angioplasty of Porcine Coronary Arteries Circulation, October 30, 2001; 104(18): 2228 - 2235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ludemann, K.-L. Schulte, O. Hader, S. Brehme, H.-D. Volk, and W.-D. Docke Leukocyte/Endothelium Activation and Interactions During Femoral Percutaneous Transluminal Angioplasty Vascular and Endovascular Surgery, July 1, 2001; 35(4): 293 - 301. [Abstract] [PDF]
|
|
|
|
|
|
J. A. McPherson, K. G. Barringhaus, G. G. Bishop, J. M. Sanders, J. M. Rieger, S. E. Hesselbacher, L. W. Gimple, E. R. Powers, T. Macdonald, G. Sullivan, et al. Adenosine A2A Receptor Stimulation Reduces Inflammation and Neointimal Growth in a Murine Carotid Ligation Model Arterioscler. Thromb. Vasc. Biol., May 1, 2001; 21(5): 791 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Miller, A. R. McPhaden, R. M. Wadsworth, and C. L. Wainwright Inhibition by leukocyte depletion of neointima formation after balloon angioplasty in a rabbit model of restenosis Cardiovasc Res, March 1, 2001; 49(4): 838 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-G. Bienvenu, J.-F. Tanguay, J.-F. Theoret, A. Kumar, R. G. Schaub, and Y. Merhi Recombinant Soluble P-Selectin Glycoprotein Ligand-1-Ig Reduces Restenosis Through Inhibition of Platelet-Neutrophil Adhesion After Double Angioplasty in Swine Circulation, February 27, 2001; 103(8): 1128 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. P. Welt, E. R. Edelman, D. I. Simon, and C. Rogers Neutrophil, Not Macrophage, Infiltration Precedes Neointimal Thickening in Balloon-Injured Arteries Arterioscler. Thromb. Vasc. Biol., December 1, 2000; 20(12): 2553 - 2558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Hayashi, N. Watanabe, K. Nakazawa, J. Suzuki, K. Tsushima, T. Tamatani, S. Sakamoto, and M. Isobe Roles of P-Selectin in Inflammation, Neointimal Formation, and Vascular Remodeling in Balloon-Injured Rat Carotid Arteries Circulation, October 3, 2000; 102(14): 1710 - 1717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Merhi, P. Provost, P. Chauvet, J.-F. Theoret, M. L. Phillips, and J.-G. Latour Selectin Blockade Reduces Neutrophil Interaction With Platelets at the Site of Deep Arterial Injury by Angioplasty in Pigs Arterioscler. Thromb. Vasc. Biol., February 1, 1999; 19(2): 372 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Roque, W. J.H. Kim, M. Gazdoin, A. Malik, E. D. Reis, J. T. Fallon, J. J. Badimon, I. F. Charo, and M. B. Taubman CCR2 Deficiency Decreases Intimal Hyperplasia After Arterial Injury Arterioscler. Thromb. Vasc. Biol., April 1, 2002; 22(4): 554 - 559. [Abstract] [Full Text] [PDF]
|
|